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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATP8A1-LDB2 (FusionGDB2 ID:8233)

Fusion Gene Summary for ATP8A1-LDB2

Fusion gene summary

Fusion gene information	Fusion gene name: ATP8A1-LDB2
	Fusion gene ID: 8233
		Hgene	Tgene
	Gene symbol	ATP8A1	LDB2
	Gene ID	10396	9079
	Gene name	ATPase phospholipid transporting 8A1	LIM domain binding 2
	Synonyms	ATPASEII\|ATPIA\|ATPP2	CLIM1\|LDB-2\|LDB1
	Cytomap	4p13	4p15.32
	Type of gene	protein-coding	protein-coding
	Description	phospholipid-transporting ATPase IAATPase IIATPase class I type 8A member 1ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1P4-ATPase flippase complex alpha subunit ATP8A1aminophospholipid translocasechromaffin granule ATPase	LIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1
	Modification date	20200329	20200313
	UniProtAcc	Q9Y2Q0	O43679
	Ensembl transtripts involved in fusion gene	ENST00000264449, ENST00000381668, ENST00000510289,	ENST00000503178, ENST00000503829, ENST00000304523, ENST00000441778, ENST00000502640, ENST00000515064,
Fusion gene scores	* DoF score	9 X 13 X 7=819	5 X 5 X 4=100
	# samples	13	5
	** MAII score	log2(13/819*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP8A1 [Title/Abstract] AND LDB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP8A1(42658842)-LDB2(16760883), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ATP8A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LDB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-CW-5581-01A	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-

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Fusion Gene ORF analysis for ATP8A1-LDB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000264449	ENST00000503178	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
5CDS-intron	ENST00000264449	ENST00000503829	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
5CDS-intron	ENST00000381668	ENST00000503178	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
5CDS-intron	ENST00000381668	ENST00000503829	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
5CDS-intron	ENST00000510289	ENST00000503178	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
5CDS-intron	ENST00000510289	ENST00000503829	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000264449	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000264449	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000264449	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000264449	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000381668	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000381668	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000381668	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000381668	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000510289	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000510289	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000510289	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-
In-frame	ENST00000510289	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000381668	ATP8A1	chr4	42658842	-	ENST00000515064	LDB2	chr4	16760883	-	2367	281	203	1264	353
ENST00000381668	ATP8A1	chr4	42658842	-	ENST00000441778	LDB2	chr4	16760883	-	2516	281	203	1144	313
ENST00000381668	ATP8A1	chr4	42658842	-	ENST00000304523	LDB2	chr4	16760883	-	2373	281	203	1270	355
ENST00000381668	ATP8A1	chr4	42658842	-	ENST00000502640	LDB2	chr4	16760883	-	2626	281	203	1090	295
ENST00000264449	ATP8A1	chr4	42658842	-	ENST00000515064	LDB2	chr4	16760883	-	2355	269	191	1252	353
ENST00000264449	ATP8A1	chr4	42658842	-	ENST00000441778	LDB2	chr4	16760883	-	2504	269	191	1132	313
ENST00000264449	ATP8A1	chr4	42658842	-	ENST00000304523	LDB2	chr4	16760883	-	2361	269	191	1258	355
ENST00000264449	ATP8A1	chr4	42658842	-	ENST00000502640	LDB2	chr4	16760883	-	2614	269	191	1078	295
ENST00000510289	ATP8A1	chr4	42658842	-	ENST00000515064	LDB2	chr4	16760883	-	2355	269	191	1252	353
ENST00000510289	ATP8A1	chr4	42658842	-	ENST00000441778	LDB2	chr4	16760883	-	2504	269	191	1132	313
ENST00000510289	ATP8A1	chr4	42658842	-	ENST00000304523	LDB2	chr4	16760883	-	2361	269	191	1258	355
ENST00000510289	ATP8A1	chr4	42658842	-	ENST00000502640	LDB2	chr4	16760883	-	2614	269	191	1078	295

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000381668	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.004534284	0.9954657
ENST00000381668	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.1056633	0.8943367
ENST00000381668	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.004761017	0.995239
ENST00000381668	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.06754948	0.9324505
ENST00000264449	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.004497547	0.9955024
ENST00000264449	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.08090557	0.91909444
ENST00000264449	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.003926731	0.99607325
ENST00000264449	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.07072219	0.92927784
ENST00000510289	ENST00000515064	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.004497547	0.9955024
ENST00000510289	ENST00000441778	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.08090557	0.91909444
ENST00000510289	ENST00000304523	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.003926731	0.99607325
ENST00000510289	ENST00000502640	ATP8A1	chr4	42658842	-	LDB2	chr4	16760883	-	0.07072219	0.92927784

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Fusion Genomic Features for ATP8A1-LDB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP8A1-LDB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:42658842/chr4:16760883)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP8A1 Q9Y2Q0	LDB2 O43679
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (By similarity). Acts as aminophospholipid translocase at the plasma membrane in neuronal cells (By similarity). {ECO:0000250\|UniProtKB:P70704, ECO:0000269\|PubMed:31416931}.	FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1095_1102

1150.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

409_411

1150.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

741_748

1150.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

804_805

1150.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1095_1102

1165.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

409_411

1165.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

741_748

1165.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

804_805

1165.0

Nucleotide binding

ATP

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1000_1005

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1027_1044

1150.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1071_1164

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

116_297

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1_65

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

320_344

1150.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

367_857

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

879_890

1150.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

87_92

1150.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

911_940

1150.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

963_976

1150.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1000_1005

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1027_1044

1165.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1071_1164

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

116_297

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1_65

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

320_344

1165.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

367_857

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

879_890

1165.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

87_92

1165.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

911_940

1165.0

Topological domain

Cytoplasmic

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

963_976

1165.0

Topological domain

Exoplasmic loop

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1006_1026

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

1045_1070

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

298_319

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

345_366

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

66_86

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

858_878

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

891_910

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

93_115

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000264449

941_962

1150.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1006_1026

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

1045_1070

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

298_319

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

345_366

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

66_86

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

858_878

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

891_910

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

93_115

1165.0

Transmembrane

Helical

Hgene

ATP8A1

chr4:42658842

chr4:16760883

ENST00000381668

941_962

1165.0

Transmembrane

Helical

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Fusion Gene Sequence for ATP8A1-LDB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8233_8233_1_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000304523_length(transcript)=2361nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACG
AGGACGAAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCG
CGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAG
ATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGAT
AAAAACTTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCC
CAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGC
GCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGT
GCTCAGGATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAG
TTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTC
TTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTA
GCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGA
ATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCT
TTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTT
CTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATA
TGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAA

>8233_8233_1_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000304523_length(amino acids)=355AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_2_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000441778_length(transcript)=2504nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGGGCTAGGAGCGATCCCGAACTGCAGCCTCAACCCTGGGAGGGATGGAGACC
TGTGTCATTCAACAGCAGTGACCCCTTCTGGCCAATTTAAGGAGAAGCATTGAGGGGCCCTGAAAGGAGTCACTTCCAGTCCTCCTCAGA
GGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACGAAAGGCTAATCACTAGATTAGAAAACACGCA
ATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCC
CGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTG
GGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAACTTTTCCATGCAAATATCTATTTCTAAACCAC
AATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCAC
AGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTT
GAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAGGATCTCATTAATATGCCGAACCTAACTACAG
ATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAAT
CAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTA
ATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCAT
CAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATAT
TTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCT
TTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGT
GTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTG

>8233_8233_2_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000441778_length(amino acids)=313AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_3_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000502640_length(transcript)=2614nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTATTGCTAGCATTGCTCGTTCTCCAGTGTCAGGCTGCGCACTAAGGACATAAA
CTCGCGTGGTTGTTACACATCAGGAGGCGATGTTTATTTCCTGTAGAAATCAAATATGCGTCTCGGCCCCCGACATTGAGACTTGACCCC
GTTGTACAGTACACGAGTGTGTCTGTCCTAGATTCCCCGACTCCTCCCACTGTTATTTTAAGCTGAGCTTCTCTCTCCCAAGGTTTCCCT
GTAATAATGTCAGCTGCTGTTCACAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACGAAAGGC
TAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGGGGAACA
ACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATCGGCACC
AGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAACTTTTCC
ATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAAGCTTCC
ATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCTTCTGGC
ACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAGGATCTC
ATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTTGTTTCA
GTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCATTGGGCA
ACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAAGTGCTG
AAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTATGCATTT
GTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGTGTTTTC
TAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTATGGGGA
CTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCCTCCACA
CATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAATAAACTGTGTTA

>8233_8233_3_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000502640_length(amino acids)=295AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_4_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000515064_length(transcript)=2355nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACG
AAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGG
GGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATC
GGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAAC
TTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAA
GCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCT
TCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAG
GATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTT
GTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCAT
TGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAA
GTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTAT
GCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGT
GTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTA
TGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCC
TCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAATAAACT

>8233_8233_4_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000264449_LDB2_chr4_16760883_ENST00000515064_length(amino acids)=353AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_5_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000304523_length(transcript)=2373nt_BP=281nt
AAGAGCTCGCCCAGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGG
CGGCAGCTCTGCCCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACG
CCGTGACAGGTGCAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTC
GCGCGCCGAAGGATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTT
TGGAAGATGGACCAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGT
ATTACATTCTCAAACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGA
AGCCCATGTTTACCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTA
CCATTAGACAATACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACA
TCACCAGGATGGGGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATA
AAACTTACAACCTCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAA
GGCAACCAACAACCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCA
GCAAGAAGAAGACCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTG
AGTTTGGGGACGAGGACGAAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCA
ACAATTCACCCGCGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGG
CTTCCCAATAAGATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGA
AACAGAAGAGATAAAAACTTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGA
GAGGATTATTCCCAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGA
GAAAACTCTAGCGCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCA
TAAATGCTCAGTGCTCAGGATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACT
TGCATCTGAGAGTTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTT
CTTTATGTTTTCTTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGT
CGACTCAATTTAGCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATT
GGACCCTTAAGAATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAAT
AAACCTGAACCTTTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGC
TCTCACCTGGTTCTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATT
TGCATATTAATATGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAA

>8233_8233_5_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000304523_length(amino acids)=355AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_6_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000441778_length(transcript)=2516nt_BP=281nt
AAGAGCTCGCCCAGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGG
CGGCAGCTCTGCCCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACG
CCGTGACAGGTGCAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTC
GCGCGCCGAAGGATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTT
TGGAAGATGGACCAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGT
ATTACATTCTCAAACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGA
AGCCCATGTTTACCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTA
CCATTAGACAATACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACA
TCACCAGGATGGGGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATA
AAACTTACAACCTCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAA
GGCAACCAACAACCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCA
GCAAGAAGAAGACCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGGGCTAGGAGCGATCCCGAACTGCAGCCTCAACCCTGGGA
GGGATGGAGACCTGTGTCATTCAACAGCAGTGACCCCTTCTGGCCAATTTAAGGAGAAGCATTGAGGGGCCCTGAAAGGAGTCACTTCCA
GTCCTCCTCAGAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACGAAAGGCTAATCACTAGATT
AGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGGGGAACAACAGCCCGTGGAA
CAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATCGGCACCAGAATCCACTGTC
AATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAACTTTTCCATGCAAATATCTA
TTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAAGCTTCCATGACCCTTTCTT
GGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCTTCTGGCACGGTTTTAACAA
CGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAGGATCTCATTAATATGCCGA
ACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTTGTTTCAGTAAAAAAAGAAA
AGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCATTGGGCAACAGCTAAGAGGG
CCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAAGTGCTGAAACAAGAAATGT
CATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTATGCATTTGTAAAGTTGCTGT
TGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGTGTTTTCTAATTGTACCTGA
GTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTATGGGGACTTTTCGTTTTTG
GGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCCTCCACACATGTAAAGGCAC

>8233_8233_6_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000441778_length(amino acids)=313AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_7_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000502640_length(transcript)=2626nt_BP=281nt
AAGAGCTCGCCCAGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGG
CGGCAGCTCTGCCCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACG
CCGTGACAGGTGCAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTC
GCGCGCCGAAGGATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTT
TGGAAGATGGACCAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGT
ATTACATTCTCAAACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGA
AGCCCATGTTTACCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTA
CCATTAGACAATACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACA
TCACCAGGATGGGGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATA
AAACTTACAACCTCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAA
GGCAACCAACAACCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCA
GCAAGAAGAAGACCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTATTGCTAGCATTGCTCGTTCTCCAGTGTCAGGCTGCGCAC
TAAGGACATAAACTCGCGTGGTTGTTACACATCAGGAGGCGATGTTTATTTCCTGTAGAAATCAAATATGCGTCTCGGCCCCCGACATTG
AGACTTGACCCCGTTGTACAGTACACGAGTGTGTCTGTCCTAGATTCCCCGACTCCTCCCACTGTTATTTTAAGCTGAGCTTCTCTCTCC
CAAGGTTTCCCTGTAATAATGTCAGCTGCTGTTCACAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACG
AGGACGAAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCG
CGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAG
ATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGAT
AAAAACTTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCC
CAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGC
GCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGT
GCTCAGGATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAG
TTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTC
TTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTA
GCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGA
ATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCT
TTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTT
CTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATA
TGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAA

>8233_8233_7_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000502640_length(amino acids)=295AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_8_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000515064_length(transcript)=2367nt_BP=281nt
AAGAGCTCGCCCAGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGG
CGGCAGCTCTGCCCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACG
CCGTGACAGGTGCAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTC
GCGCGCCGAAGGATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTT
TGGAAGATGGACCAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGT
ATTACATTCTCAAACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGA
AGCCCATGTTTACCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTA
CCATTAGACAATACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACA
TCACCAGGATGGGGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATA
AAACTTACAACCTCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAA
GGCAACCAACAACCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCA
GCAAGAAGAAGACCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTG
GGGACGAGGACGAAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATT
CACCCGCGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCC
AATAAGATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGA
AGAGATAAAAACTTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGAT
TATTCCCAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAAC
TCTAGCGCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATG
CTCAGTGCTCAGGATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATC
TGAGAGTTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTAT
GTTTTCTTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTC
AATTTAGCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCC
TTAAGAATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCT
GAACCTTTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCAC
CTGGTTCTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATA
TTAATATGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGC

>8233_8233_8_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000381668_LDB2_chr4_16760883_ENST00000515064_length(amino acids)=353AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_9_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000304523_length(transcript)=2361nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACG
AGGACGAAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCG
CGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAG
ATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGAT
AAAAACTTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCC
CAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGC
GCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGT
GCTCAGGATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAG
TTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTC
TTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTA
GCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGA
ATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCT
TTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTT
CTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATA
TGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAA

>8233_8233_9_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000304523_length(amino acids)=355AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_10_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000441778_length(transcript)=2504nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTGGGCTAGGAGCGATCCCGAACTGCAGCCTCAACCCTGGGAGGGATGGAGACC
TGTGTCATTCAACAGCAGTGACCCCTTCTGGCCAATTTAAGGAGAAGCATTGAGGGGCCCTGAAAGGAGTCACTTCCAGTCCTCCTCAGA
GGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACGAAAGGCTAATCACTAGATTAGAAAACACGCA
ATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGGGGAACAACAGCCCGTGGAACAGTAAACCTCC
CGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATCGGCACCAGAATCCACTGTCAATAGGCCCGTG
GGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAACTTTTCCATGCAAATATCTATTTCTAAACCAC
AATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAAGCTTCCATGACCCTTTCTTGGAGGCCTTCAC
AGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCTTCTGGCACGGTTTTAACAACGTGTTTGTGTT
GAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAGGATCTCATTAATATGCCGAACCTAACTACAG
ATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTTGTTTCAGTAAAAAAAGAAAAGACAAAAAAAT
CAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCATTGGGCAACAGCTAAGAGGGCCCAGCAAGGTA
ATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAAGTGCTGAAACAAGAAATGTCATTTTTTTCAT
CAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTATGCATTTGTAAAGTTGCTGTTGATCCAAATAT
TTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGTGTTTTCTAATTGTACCTGAGTTGACCATCCT
TTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTATGGGGACTTTTCGTTTTTGGGCAACTCCAGT
GTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCCTCCACACATGTAAAGGCACAGTGGCTCCGTG

>8233_8233_10_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000441778_length(amino acids)=313AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_11_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000502640_length(transcript)=2614nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGTACCTATTGCTAGCATTGCTCGTTCTCCAGTGTCAGGCTGCGCACTAAGGACATAAA
CTCGCGTGGTTGTTACACATCAGGAGGCGATGTTTATTTCCTGTAGAAATCAAATATGCGTCTCGGCCCCCGACATTGAGACTTGACCCC
GTTGTACAGTACACGAGTGTGTCTGTCCTAGATTCCCCGACTCCTCCCACTGTTATTTTAAGCTGAGCTTCTCTCTCCCAAGGTTTCCCT
GTAATAATGTCAGCTGCTGTTCACAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACGAAAGGC
TAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGGGGAACA
ACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATCGGCACC
AGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAACTTTTCC
ATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAAGCTTCC
ATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCTTCTGGC
ACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAGGATCTC
ATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTTGTTTCA
GTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCATTGGGCA
ACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAAGTGCTG
AAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTATGCATTT
GTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGTGTTTTC
TAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTATGGGGA
CTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCCTCCACA
CATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAATAAACTGTGTTA

>8233_8233_11_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000502640_length(amino acids)=295AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

--------------------------------------------------------------
>8233_8233_12_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000515064_length(transcript)=2355nt_BP=269nt
AGCTCTGCGGGCGCCGCCACCTTCGCCGCCACCGCTGCCTTTCTCCTCCTCCTGTCGGCGTGCGGGGGCCGCGCCCGGCGGCAGCTCTGC
CCTAGGTGGGCGGCGGCGCGGCCCAGGCTGCAGCTGAGCGCTCTGCGCGGCGCAGCCGGGTCTCCCGCGTGTACCACGCCGTGACAGGTG
CAGAGTCCGGGCTGAGGACCCACCTGCAGCCGCCGCCGCGATGCCCACCATGCGGAGGACCGTGTCGGAGATCCGCTCGCGCGCCGAAGG
ATAGTGACAACCTCTGGTGGGACGCCTTTGCCACTGAATTTTTTGAAGATGACGCCACATTAACCCTTTCATTTTGTTTGGAAGATGGAC
CAAAGCGATACACTATCGGCAGGACCCTCATCCCCCGTTACTTTAGCACTGTGTTTGAAGGAGGGGTGACCGACCTGTATTACATTCTCA
AACACTCGAAAGAGTCATACCACAACTCATCCATCACGGTGGACTGCGACCAGTGTACCATGGTCACCCAGCACGGGAAGCCCATGTTTA
CCAAGGTATGTACAGAAGGCAGACTGATCTTGGAGTTCACCTTTGATGATCTCATGAGAATCAAAACATGGCACTTTACCATTAGACAAT
ACCGAGAGTTAGTCCCGAGAAGCATCCTAGCCATGCATGCACAAGATCCTCAGGTCCTGGATCAGCTGTCCAAAAACATCACCAGGATGG
GGCTAACAAACTTCACCCTCAACTACCTCAGGTTGTGTGTAATATTGGAGCCAATGCAGGAACTGATGTCGAGACATAAAACTTACAACC
TCAGTCCCCGAGACTGCCTGAAGACCTGCTTGTTTCAGAAGTGGCAGAGGATGGTGGCTCCGCCAGCAGAACCCACAAGGCAACCAACAA
CCAAACGGAGAAAAAGGAAAAATTCCACCAGCAGCACTTCCAACAGCAGCGCTGGGAACAATGCAAACAGCACTGGCAGCAAGAAGAAGA
CCACAGCTGCAAACCTGAGTCTGTCCAGTCAGGATGTGATGGTGGTAGGAGAGCCAACTCTGATGGGAGGTGAGTTTGGGGACGAGGACG
AAAGGCTAATCACTAGATTAGAAAACACGCAATATGATGCGGCCAACGGCATGGACGACGAGGAGGACTTCAACAATTCACCCGCGCTGG
GGAACAACAGCCCGTGGAACAGTAAACCTCCCGCCACTCAAGAGACCAAATCAGAAAACCCCCCACCCCAGGCTTCCCAATAAGATGATC
GGCACCAGAATCCACTGTCAATAGGCCCGTGGGTGATCATTACAATTGCAAATCTTTACTTACAGGAGAGGAAACAGAAGAGATAAAAAC
TTTTCCATGCAAATATCTATTTCTAAACCACAATGATCTGATTTTCTTTCTTCTTTCTTTTTTTCTAATTGAGAGGATTATTCCCAGTAA
GCTTCCATGACCCTTTCTTGGAGGCCTTCACAGGTAATACAGATACTGGCACTGATTGTAATTAAAATGAGAGAAAACTCTAGCGCATCT
TCTGGCACGGTTTTAACAACGTGTTTGTGTTGAATTTCCTTTTTATGCATCAAACGAAGGCCATATTGTCCATAAATGCTCAGTGCTCAG
GATCTCATTAATATGCCGAACCTAACTACAGATGACTTTTTAATATTGTAAAATATTTTCTGCTTTTTGACTTGCATCTGAGAGTTTCTT
GTTTCAGTAAAAAAAGAAAAGACAAAAAAATCAGCTTTGGAAAGTAATTTAAATGTACCTTATTTTTTTTTTCTTTATGTTTTCTTTCAT
TGGGCAACAGCTAAGAGGGCCCAGCAAGGTAATTTATGGTTGAGCTGATGTCAATTGGTTCTTGTCTTGAGTCGACTCAATTTAGCCCAA
GTGCTGAAACAAGAAATGTCATTTTTTTCATCAAAGACACCAGGGCAGATTTTTAAGTAAAGAAAGACAATTGGACCCTTAAGAATTTAT
GCATTTGTAAAGTTGCTGTTGATCCAAATATTTTCAAGCCATGTAATCCATTGGTTTTGTGGGCAGTTTAATAAACCTGAACCTTTGTGT
GTTTTCTAATTGTACCTGAGTTGACCATCCTTTCTTTTTATAGTATATTTCTTGTATGATATTTTGTAAAGCTCTCACCTGGTTCTTTTA
TGGGGACTTTTCGTTTTTGGGCAACTCCAGTGTATTTATGTGAAACTTTATAAGAGAATTAATTTTTCCATTTGCATATTAATATGTTCC
TCCACACATGTAAAGGCACAGTGGCTCCGTGTGTTAAAAAACAGCTGTATTTTATGTATGCTTTACTGATAAGTGTGCCAATAATAAACT

>8233_8233_12_ATP8A1-LDB2_ATP8A1_chr4_42658842_ENST00000510289_LDB2_chr4_16760883_ENST00000515064_length(amino acids)=353AA_BP=26
MRTHLQPPPRCPPCGGPCRRSARAPKDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSK
ESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTN
FTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAA

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Fusion Gene PPI Analysis for ATP8A1-LDB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATP8A1-LDB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATP8A1-LDB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source