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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC1A3-MAPKAP1 (FusionGDB2 ID:82393)

Fusion Gene Summary for SLC1A3-MAPKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC1A3-MAPKAP1
Fusion gene ID: 82393
HgeneTgene
Gene symbol

SLC1A3

MAPKAP1

Gene ID

6507

79109

Gene namesolute carrier family 1 member 3MAPK associated protein 1
SynonymsEA6|EAAT1|GLAST|GLAST1JC310|MIP1|SIN1|SIN1b|SIN1g
Cytomap

5p13.2

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3target of rapamycin complex 2 subunit MAPKAP1MEKK2-interacting protein 1SAPK-interacting protein 1TORC2 subunit MAPKAP1mSIN1mitogen-activated protein kinase 2-associated protein 1mitogen-activated protein kinase associated protein 1ras inhibitor MG
Modification date2020032020200329
UniProtAcc.

Q9BPZ7

Ensembl transtripts involved in fusion geneENST00000506725, ENST00000265113, 
ENST00000381918, 		ENST00000350766, 
ENST00000373498, ENST00000373511, 
ENST00000265960, ENST00000373503, 
ENST00000394063, ENST00000373497, 
ENST00000394060, ENST00000483937, 
Fusion gene scores* DoF score12 X 10 X 6=72012 X 10 X 10=1200
# samples 1413
** MAII scorelog2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1200*10)=-3.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC1A3 [Title/Abstract] AND MAPKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC1A3(36608706)-MAPKAP1(128420078), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

HgeneSLC1A3

GO:0051938

L-glutamate import

7521911

HgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

HgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

HgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

HgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

HgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check buttonFusion gene breakpoints across SLC1A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAPKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-92-8065-01ASLC1A3chr5

36608706

-MAPKAP1chr9

128420078

-
ChimerDB4LUSCTCGA-92-8065-01ASLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
ChimerDB4LUSCTCGA-92-8065SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-


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Fusion Gene ORF analysis for SLC1A3-MAPKAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000506725ENST00000350766SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-3CDSENST00000506725ENST00000373498SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-3CDSENST00000506725ENST00000373511SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-5UTRENST00000506725ENST00000265960SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-5UTRENST00000506725ENST00000373503SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-5UTRENST00000506725ENST00000394063SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-intronENST00000506725ENST00000373497SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-intronENST00000506725ENST00000394060SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
3UTR-intronENST00000506725ENST00000483937SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000265113ENST00000265960SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000265113ENST00000373503SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000265113ENST00000394063SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000381918ENST00000265960SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000381918ENST00000373503SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-5UTRENST00000381918ENST00000394063SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000265113ENST00000373497SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000265113ENST00000394060SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000265113ENST00000483937SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000381918ENST00000373497SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000381918ENST00000394060SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
5CDS-intronENST00000381918ENST00000483937SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000265113ENST00000350766SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000265113ENST00000373498SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000265113ENST00000373511SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000381918ENST00000350766SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000381918ENST00000373498SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-
In-frameENST00000381918ENST00000373511SLC1A3chr5

36608706

+MAPKAP1chr9

128420078

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265113SLC1A3chr536608706+ENST00000373511MAPKAP1chr9128420078-32306574761735419
ENST00000265113SLC1A3chr536608706+ENST00000373498MAPKAP1chr9128420078-33706574761876466
ENST00000265113SLC1A3chr536608706+ENST00000350766MAPKAP1chr9128420078-32626574761768430
ENST00000381918SLC1A3chr536608706+ENST00000373511MAPKAP1chr9128420078-2849276951354419
ENST00000381918SLC1A3chr536608706+ENST00000373498MAPKAP1chr9128420078-2989276951495466
ENST00000381918SLC1A3chr536608706+ENST00000350766MAPKAP1chr9128420078-2881276951387430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265113ENST00000373511SLC1A3chr536608706+MAPKAP1chr9128420078-0.0023727560.9976273
ENST00000265113ENST00000373498SLC1A3chr536608706+MAPKAP1chr9128420078-0.0021481060.99785197
ENST00000265113ENST00000350766SLC1A3chr536608706+MAPKAP1chr9128420078-0.0025916010.99740845
ENST00000381918ENST00000373511SLC1A3chr536608706+MAPKAP1chr9128420078-0.002574490.9974255
ENST00000381918ENST00000373498SLC1A3chr536608706+MAPKAP1chr9128420078-0.0021772350.99782276
ENST00000381918ENST00000350766SLC1A3chr536608706+MAPKAP1chr9128420078-0.0024697140.9975303

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Fusion Genomic Features for SLC1A3-MAPKAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC1A3-MAPKAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36608706/chr9:128420078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAPKAP1

Q9BPZ7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:23727834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+2101_4760543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+181_4760498.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210346_37660543.0IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210426_45960543.0IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18346_37660498.0IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18426_45960498.0IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210363_36560543.0RegionAspartate binding
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210443_44760543.0RegionAspartate binding
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18363_36560498.0RegionAspartate binding
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18443_44760498.0RegionAspartate binding
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210109_12260543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210146_23660543.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210261_26960543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210298_31860543.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210341_34560543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210377_38560543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210413_42560543.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210460_47260543.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210495_54260543.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+21069_8660543.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18109_12260498.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18146_23660498.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18261_26960498.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18298_31860498.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18341_34560498.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18377_38560498.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18413_42560498.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18460_47260498.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18495_54260498.0Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+1869_8660498.0Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210123_14560543.0TransmembraneHelical%3B Name%3D3
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210237_26060543.0TransmembraneHelical%3B Name%3D4
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210270_29760543.0TransmembraneHelical%3B Name%3D5
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210319_34060543.0TransmembraneHelical%3B Name%3D6
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210386_41260543.0TransmembraneHelical%3B Name%3D7
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+210473_49460543.0TransmembraneHelical%3B Name%3D8
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+21048_6860543.0TransmembraneHelical%3B Name%3D1
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000265113+21087_10860543.0TransmembraneHelical%3B Name%3D2
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18123_14560498.0TransmembraneHelical%3B Name%3D3
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18237_26060498.0TransmembraneHelical%3B Name%3D4
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18270_29760498.0TransmembraneHelical%3B Name%3D5
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18319_34060498.0TransmembraneHelical%3B Name%3D6
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18386_41260498.0TransmembraneHelical%3B Name%3D7
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+18473_49460498.0TransmembraneHelical%3B Name%3D8
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+1848_6860498.0TransmembraneHelical%3B Name%3D1
HgeneSLC1A3chr5:36608706chr9:128420078ENST00000381918+1887_10860498.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for SLC1A3-MAPKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82393_82393_1_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000350766_length(transcript)=3262nt_BP=657nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGA
AGCAGTCGATATTATCTGTACGCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTC
ATGTAGGTACAACAGCAACCAAGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAA
TGGCCAGCGCCAGGGTGCAGGACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCA
GTGCCTACTGCCTGCATATTGCTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTG
GCTTCAGTACTTTGGCCCTGGTTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATG
GATTCTCCCTTATTCAGGTGGACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAG
TTTCAGGTTCAAGGGCAGACGGGGTTTTTGAGGAGGATTCGCAAATTGACATAGCCACAGTACAGGATATGCTTAGCAGCCACCATTACA
AGTCATTCAAAGTCAGCATGATCCACAGACTGCGATTCACAACCGACGTACAGCTAGGTATCTCTGGAGACAAAGTAGAGATAGACCCTG
TTACGAATCAGAAAGCCAGCACTAAGTTTTGGATTAAGCAGAAACCCATCTCAATCGATTCCGACCTGCTCTGTGCCTGTGACCTTGCTG
AAGAGAAAAGCCCCAGTCACGCAATATTTAAACTCACGTATCTAAGCAATCACGACTATAAACACCTCTACTTTGAATCGGACGCTGCTA
CCGTCAATGAAATTGTGCTCAAGGTTAACTACATCCTGGAATCGCGAGCTAGCACTGCCCGGGCTGACTACTTTGCTCAAAAACAAAGAA
AACTGAACAGACGTACGAGCTTCAGCTTCCAGAAGGAGAAGAAATCCGGGCAGCAGTGACACTGGCCTCCAGCCTCAATCTGTTCCGTAG
CTCAGAGCCTGCCTGCCAGGGCCAAGTGCCCTAGAGTCCACCCGGTGTCCTGAAGTCCTCGGGGGGAGGCCAGCCCCTGGCTCACTGGCA
CAGGGCAGGTGGGCTCTCGGGGAAGGTGTCGGGGGCCCCCTAGGAGGGAGCGCTGGGGACATTGCCATGGGACGGAAGTCTGCTTGGCAG
TGGCTTTGATAAGCGATGCTTGGGGGTCAGACCACCCCCTAGAGGAGCCACGTGCCGCCCAGCCACCTTCAATGCCTGCCACCCTGCCCG
AGGATGTACAGAGCCGTGCCCACACATTTCCTTGCAACTTGATCAAATTTCTTAAAGCAAACAACAAAAATGTACATTTCTGTTTTTCCT
TTTAATAAACAGGTGTACTCTTTATCATGGTTGGTATGATGGACCATTCTTTGGGGCGGAGGATTGATTATGTTACTCTCTTTAAAATCT
GTTCCCATATTGAACAGGCAGATTGGAAAAGCTATGGTTCGATTTCTCAGAAGAAATGTTTAGGTCTTAGTCAATAGTTTTAACTATGCC
ATTTGTTTAAATGAGTGCATTTGCTTCGAGGGTAGTGTCTTACTAAAAGTTAGGAACAGAGACCTAGTGGTGTGTCCAAGGCCGTGTCAC
TTTCCCCTTCAGCACACCCCAGCTTCTGACCTCAGAGCCCAGGAGCTGCGTGGACAGTGTGGGGTGCCAGGAGGAGGGGCGGTGGCTGGT
CCTCAGGCACGCTGCACTCCCAGCCAGACATGGTCTTTCCGTTTCTTAAGTAGCAAGTGTAGGTTTCAGCTGGCAGTTCCACCTGCATGT
TCTCTGCTTCGCTGCCTTGGAAGGGGCCACATTCCCCATTCCTCTTCTCCTTACAGCGCCTGCCTCCTTTTTCAAGCAGGCGGAAAGCTG
CTGTTTCTCACGTTTCAGGGAGAGGGGTGAGCGGAGGGAGACCTGTGTCCGTGCCGTCCGGCTCCCTGGGTGGGAACAGGCAAGGGATCA
GATGCCCCTGACACCACGCCTCTGGCCACACCAGATGCCTCTGCAGTCCTCGACAGCCTCTTCAGTGTCCCTCCTGCGGTGATGTCCTTA
CTGTCCCCAGCCAGGGCCGGGGACCGGTGTTTCACTGAGGACCTGCATTAGAAACATTTTTTAAATTGTTGTACAGGAAGAGATGTGTCT
AAAACAGCATCTTAAAGCTGAGTGTATTTCTTTGCACAAGGGGTCATGCTGATGAATTCTTCTTTCATTCTGATCTTTGTTCAGCCAACA
GGAGCGTCCTTTTCTAATGTCTTCCATTCCTACCCCCCACCCAAAAACAAAAGAAATATTTGTAGCTTGCTATCTGTATTTGAATTTTTA
GCAATTTTATATTTAGATACTTTGAAAAATGTAAATGACTAATTTGGTCATTAAATCTTGTGACATATTCGATATTAAAATGATATTAAA

>82393_82393_1_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000350766_length(amino acids)=430AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGSRADGV
FEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAI

--------------------------------------------------------------
>82393_82393_2_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373498_length(transcript)=3370nt_BP=657nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGA
AGCAGTCGATATTATCTGTACGCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTC
ATGTAGGTACAACAGCAACCAAGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAA
TGGCCAGCGCCAGGGTGCAGGACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCA
GTGCCTACTGCCTGCATATTGCTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTG
GCTTCAGTACTTTGGCCCTGGTTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATG
GATTCTCCCTTATTCAGGTGGACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAG
TTTCAGGCCCTCAGTACCGCCTGGAGAAGCAGAGCGAGCCCAATGTCGCCGTTGACCTGGACAGCACTTTGGAGAGCCAGAGCGCATGGG
AGTTCTGCCTGGTCCGCGAGAACAGTTCAAGGGCAGACGGGGTTTTTGAGGAGGATTCGCAAATTGACATAGCCACAGTACAGGATATGC
TTAGCAGCCACCATTACAAGTCATTCAAAGTCAGCATGATCCACAGACTGCGATTCACAACCGACGTACAGCTAGGTATCTCTGGAGACA
AAGTAGAGATAGACCCTGTTACGAATCAGAAAGCCAGCACTAAGTTTTGGATTAAGCAGAAACCCATCTCAATCGATTCCGACCTGCTCT
GTGCCTGTGACCTTGCTGAAGAGAAAAGCCCCAGTCACGCAATATTTAAACTCACGTATCTAAGCAATCACGACTATAAACACCTCTACT
TTGAATCGGACGCTGCTACCGTCAATGAAATTGTGCTCAAGGTTAACTACATCCTGGAATCGCGAGCTAGCACTGCCCGGGCTGACTACT
TTGCTCAAAAACAAAGAAAACTGAACAGACGTACGAGCTTCAGCTTCCAGAAGGAGAAGAAATCCGGGCAGCAGTGACACTGGCCTCCAG
CCTCAATCTGTTCCGTAGCTCAGAGCCTGCCTGCCAGGGCCAAGTGCCCTAGAGTCCACCCGGTGTCCTGAAGTCCTCGGGGGGAGGCCA
GCCCCTGGCTCACTGGCACAGGGCAGGTGGGCTCTCGGGGAAGGTGTCGGGGGCCCCCTAGGAGGGAGCGCTGGGGACATTGCCATGGGA
CGGAAGTCTGCTTGGCAGTGGCTTTGATAAGCGATGCTTGGGGGTCAGACCACCCCCTAGAGGAGCCACGTGCCGCCCAGCCACCTTCAA
TGCCTGCCACCCTGCCCGAGGATGTACAGAGCCGTGCCCACACATTTCCTTGCAACTTGATCAAATTTCTTAAAGCAAACAACAAAAATG
TACATTTCTGTTTTTCCTTTTAATAAACAGGTGTACTCTTTATCATGGTTGGTATGATGGACCATTCTTTGGGGCGGAGGATTGATTATG
TTACTCTCTTTAAAATCTGTTCCCATATTGAACAGGCAGATTGGAAAAGCTATGGTTCGATTTCTCAGAAGAAATGTTTAGGTCTTAGTC
AATAGTTTTAACTATGCCATTTGTTTAAATGAGTGCATTTGCTTCGAGGGTAGTGTCTTACTAAAAGTTAGGAACAGAGACCTAGTGGTG
TGTCCAAGGCCGTGTCACTTTCCCCTTCAGCACACCCCAGCTTCTGACCTCAGAGCCCAGGAGCTGCGTGGACAGTGTGGGGTGCCAGGA
GGAGGGGCGGTGGCTGGTCCTCAGGCACGCTGCACTCCCAGCCAGACATGGTCTTTCCGTTTCTTAAGTAGCAAGTGTAGGTTTCAGCTG
GCAGTTCCACCTGCATGTTCTCTGCTTCGCTGCCTTGGAAGGGGCCACATTCCCCATTCCTCTTCTCCTTACAGCGCCTGCCTCCTTTTT
CAAGCAGGCGGAAAGCTGCTGTTTCTCACGTTTCAGGGAGAGGGGTGAGCGGAGGGAGACCTGTGTCCGTGCCGTCCGGCTCCCTGGGTG
GGAACAGGCAAGGGATCAGATGCCCCTGACACCACGCCTCTGGCCACACCAGATGCCTCTGCAGTCCTCGACAGCCTCTTCAGTGTCCCT
CCTGCGGTGATGTCCTTACTGTCCCCAGCCAGGGCCGGGGACCGGTGTTTCACTGAGGACCTGCATTAGAAACATTTTTTAAATTGTTGT
ACAGGAAGAGATGTGTCTAAAACAGCATCTTAAAGCTGAGTGTATTTCTTTGCACAAGGGGTCATGCTGATGAATTCTTCTTTCATTCTG
ATCTTTGTTCAGCCAACAGGAGCGTCCTTTTCTAATGTCTTCCATTCCTACCCCCCACCCAAAAACAAAAGAAATATTTGTAGCTTGCTA
TCTGTATTTGAATTTTTAGCAATTTTATATTTAGATACTTTGAAAAATGTAAATGACTAATTTGGTCATTAAATCTTGTGACATATTCGA

>82393_82393_2_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373498_length(amino acids)=466AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTN
QKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLN

--------------------------------------------------------------
>82393_82393_3_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373511_length(transcript)=3230nt_BP=657nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGA
AGCAGTCGATATTATCTGTACGCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTC
ATGTAGGTACAACAGCAACCAAGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAA
TGGCCAGCGCCAGGGTGCAGGACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCA
GTGCCTACTGCCTGCATATTGCTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTG
GCTTCAGTACTTTGGCCCTGGTTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATG
GATTCTCCCTTATTCAGGTGGACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAG
TTTCAGGCCCTCAGTACCGCCTGGAGAAGCAGAGCGAGCCCAATGTCGCCGTTGACCTGGACAGCACTTTGGAGAGCCAGAGCGCATGGG
AGTTCTGCCTGGTCCGCGAGAACAGTATCTCTGGAGACAAAGTAGAGATAGACCCTGTTACGAATCAGAAAGCCAGCACTAAGTTTTGGA
TTAAGCAGAAACCCATCTCAATCGATTCCGACCTGCTCTGTGCCTGTGACCTTGCTGAAGAGAAAAGCCCCAGTCACGCAATATTTAAAC
TCACGTATCTAAGCAATCACGACTATAAACACCTCTACTTTGAATCGGACGCTGCTACCGTCAATGAAATTGTGCTCAAGGTTAACTACA
TCCTGGAATCGCGAGCTAGCACTGCCCGGGCTGACTACTTTGCTCAAAAACAAAGAAAACTGAACAGACGTACGAGCTTCAGCTTCCAGA
AGGAGAAGAAATCCGGGCAGCAGTGACACTGGCCTCCAGCCTCAATCTGTTCCGTAGCTCAGAGCCTGCCTGCCAGGGCCAAGTGCCCTA
GAGTCCACCCGGTGTCCTGAAGTCCTCGGGGGGAGGCCAGCCCCTGGCTCACTGGCACAGGGCAGGTGGGCTCTCGGGGAAGGTGTCGGG
GGCCCCCTAGGAGGGAGCGCTGGGGACATTGCCATGGGACGGAAGTCTGCTTGGCAGTGGCTTTGATAAGCGATGCTTGGGGGTCAGACC
ACCCCCTAGAGGAGCCACGTGCCGCCCAGCCACCTTCAATGCCTGCCACCCTGCCCGAGGATGTACAGAGCCGTGCCCACACATTTCCTT
GCAACTTGATCAAATTTCTTAAAGCAAACAACAAAAATGTACATTTCTGTTTTTCCTTTTAATAAACAGGTGTACTCTTTATCATGGTTG
GTATGATGGACCATTCTTTGGGGCGGAGGATTGATTATGTTACTCTCTTTAAAATCTGTTCCCATATTGAACAGGCAGATTGGAAAAGCT
ATGGTTCGATTTCTCAGAAGAAATGTTTAGGTCTTAGTCAATAGTTTTAACTATGCCATTTGTTTAAATGAGTGCATTTGCTTCGAGGGT
AGTGTCTTACTAAAAGTTAGGAACAGAGACCTAGTGGTGTGTCCAAGGCCGTGTCACTTTCCCCTTCAGCACACCCCAGCTTCTGACCTC
AGAGCCCAGGAGCTGCGTGGACAGTGTGGGGTGCCAGGAGGAGGGGCGGTGGCTGGTCCTCAGGCACGCTGCACTCCCAGCCAGACATGG
TCTTTCCGTTTCTTAAGTAGCAAGTGTAGGTTTCAGCTGGCAGTTCCACCTGCATGTTCTCTGCTTCGCTGCCTTGGAAGGGGCCACATT
CCCCATTCCTCTTCTCCTTACAGCGCCTGCCTCCTTTTTCAAGCAGGCGGAAAGCTGCTGTTTCTCACGTTTCAGGGAGAGGGGTGAGCG
GAGGGAGACCTGTGTCCGTGCCGTCCGGCTCCCTGGGTGGGAACAGGCAAGGGATCAGATGCCCCTGACACCACGCCTCTGGCCACACCA
GATGCCTCTGCAGTCCTCGACAGCCTCTTCAGTGTCCCTCCTGCGGTGATGTCCTTACTGTCCCCAGCCAGGGCCGGGGACCGGTGTTTC
ACTGAGGACCTGCATTAGAAACATTTTTTAAATTGTTGTACAGGAAGAGATGTGTCTAAAACAGCATCTTAAAGCTGAGTGTATTTCTTT
GCACAAGGGGTCATGCTGATGAATTCTTCTTTCATTCTGATCTTTGTTCAGCCAACAGGAGCGTCCTTTTCTAATGTCTTCCATTCCTAC
CCCCCACCCAAAAACAAAAGAAATATTTGTAGCTTGCTATCTGTATTTGAATTTTTAGCAATTTTATATTTAGATACTTTGAAAAATGTA

>82393_82393_3_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373511_length(amino acids)=419AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDY

--------------------------------------------------------------
>82393_82393_4_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000350766_length(transcript)=2881nt_BP=276nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGAAGCAGTCGATATTATCTGTAC
GCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTCATGTAGGTACAACAGCAACCA
AGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAATGGCCAGCGCCAGGGTGCAGG
ACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCAGTGCCTACTGCCTGCATATTG
CTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTGGCTTCAGTACTTTGGCCCTGG
TTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATGGATTCTCCCTTATTCAGGTGG
ACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAGTTTCAGGTTCAAGGGCAGACG
GGGTTTTTGAGGAGGATTCGCAAATTGACATAGCCACAGTACAGGATATGCTTAGCAGCCACCATTACAAGTCATTCAAAGTCAGCATGA
TCCACAGACTGCGATTCACAACCGACGTACAGCTAGGTATCTCTGGAGACAAAGTAGAGATAGACCCTGTTACGAATCAGAAAGCCAGCA
CTAAGTTTTGGATTAAGCAGAAACCCATCTCAATCGATTCCGACCTGCTCTGTGCCTGTGACCTTGCTGAAGAGAAAAGCCCCAGTCACG
CAATATTTAAACTCACGTATCTAAGCAATCACGACTATAAACACCTCTACTTTGAATCGGACGCTGCTACCGTCAATGAAATTGTGCTCA
AGGTTAACTACATCCTGGAATCGCGAGCTAGCACTGCCCGGGCTGACTACTTTGCTCAAAAACAAAGAAAACTGAACAGACGTACGAGCT
TCAGCTTCCAGAAGGAGAAGAAATCCGGGCAGCAGTGACACTGGCCTCCAGCCTCAATCTGTTCCGTAGCTCAGAGCCTGCCTGCCAGGG
CCAAGTGCCCTAGAGTCCACCCGGTGTCCTGAAGTCCTCGGGGGGAGGCCAGCCCCTGGCTCACTGGCACAGGGCAGGTGGGCTCTCGGG
GAAGGTGTCGGGGGCCCCCTAGGAGGGAGCGCTGGGGACATTGCCATGGGACGGAAGTCTGCTTGGCAGTGGCTTTGATAAGCGATGCTT
GGGGGTCAGACCACCCCCTAGAGGAGCCACGTGCCGCCCAGCCACCTTCAATGCCTGCCACCCTGCCCGAGGATGTACAGAGCCGTGCCC
ACACATTTCCTTGCAACTTGATCAAATTTCTTAAAGCAAACAACAAAAATGTACATTTCTGTTTTTCCTTTTAATAAACAGGTGTACTCT
TTATCATGGTTGGTATGATGGACCATTCTTTGGGGCGGAGGATTGATTATGTTACTCTCTTTAAAATCTGTTCCCATATTGAACAGGCAG
ATTGGAAAAGCTATGGTTCGATTTCTCAGAAGAAATGTTTAGGTCTTAGTCAATAGTTTTAACTATGCCATTTGTTTAAATGAGTGCATT
TGCTTCGAGGGTAGTGTCTTACTAAAAGTTAGGAACAGAGACCTAGTGGTGTGTCCAAGGCCGTGTCACTTTCCCCTTCAGCACACCCCA
GCTTCTGACCTCAGAGCCCAGGAGCTGCGTGGACAGTGTGGGGTGCCAGGAGGAGGGGCGGTGGCTGGTCCTCAGGCACGCTGCACTCCC
AGCCAGACATGGTCTTTCCGTTTCTTAAGTAGCAAGTGTAGGTTTCAGCTGGCAGTTCCACCTGCATGTTCTCTGCTTCGCTGCCTTGGA
AGGGGCCACATTCCCCATTCCTCTTCTCCTTACAGCGCCTGCCTCCTTTTTCAAGCAGGCGGAAAGCTGCTGTTTCTCACGTTTCAGGGA
GAGGGGTGAGCGGAGGGAGACCTGTGTCCGTGCCGTCCGGCTCCCTGGGTGGGAACAGGCAAGGGATCAGATGCCCCTGACACCACGCCT
CTGGCCACACCAGATGCCTCTGCAGTCCTCGACAGCCTCTTCAGTGTCCCTCCTGCGGTGATGTCCTTACTGTCCCCAGCCAGGGCCGGG
GACCGGTGTTTCACTGAGGACCTGCATTAGAAACATTTTTTAAATTGTTGTACAGGAAGAGATGTGTCTAAAACAGCATCTTAAAGCTGA
GTGTATTTCTTTGCACAAGGGGTCATGCTGATGAATTCTTCTTTCATTCTGATCTTTGTTCAGCCAACAGGAGCGTCCTTTTCTAATGTC
TTCCATTCCTACCCCCCACCCAAAAACAAAAGAAATATTTGTAGCTTGCTATCTGTATTTGAATTTTTAGCAATTTTATATTTAGATACT
TTGAAAAATGTAAATGACTAATTTGGTCATTAAATCTTGTGACATATTCGATATTAAAATGATATTAAAATAAAAGTCATATAAATACAC

>82393_82393_4_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000350766_length(amino acids)=430AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGSRADGV
FEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAI

--------------------------------------------------------------
>82393_82393_5_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373498_length(transcript)=2989nt_BP=276nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGAAGCAGTCGATATTATCTGTAC
GCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTCATGTAGGTACAACAGCAACCA
AGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAATGGCCAGCGCCAGGGTGCAGG
ACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCAGTGCCTACTGCCTGCATATTG
CTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTGGCTTCAGTACTTTGGCCCTGG
TTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATGGATTCTCCCTTATTCAGGTGG
ACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAGTTTCAGGCCCTCAGTACCGCC
TGGAGAAGCAGAGCGAGCCCAATGTCGCCGTTGACCTGGACAGCACTTTGGAGAGCCAGAGCGCATGGGAGTTCTGCCTGGTCCGCGAGA
ACAGTTCAAGGGCAGACGGGGTTTTTGAGGAGGATTCGCAAATTGACATAGCCACAGTACAGGATATGCTTAGCAGCCACCATTACAAGT
CATTCAAAGTCAGCATGATCCACAGACTGCGATTCACAACCGACGTACAGCTAGGTATCTCTGGAGACAAAGTAGAGATAGACCCTGTTA
CGAATCAGAAAGCCAGCACTAAGTTTTGGATTAAGCAGAAACCCATCTCAATCGATTCCGACCTGCTCTGTGCCTGTGACCTTGCTGAAG
AGAAAAGCCCCAGTCACGCAATATTTAAACTCACGTATCTAAGCAATCACGACTATAAACACCTCTACTTTGAATCGGACGCTGCTACCG
TCAATGAAATTGTGCTCAAGGTTAACTACATCCTGGAATCGCGAGCTAGCACTGCCCGGGCTGACTACTTTGCTCAAAAACAAAGAAAAC
TGAACAGACGTACGAGCTTCAGCTTCCAGAAGGAGAAGAAATCCGGGCAGCAGTGACACTGGCCTCCAGCCTCAATCTGTTCCGTAGCTC
AGAGCCTGCCTGCCAGGGCCAAGTGCCCTAGAGTCCACCCGGTGTCCTGAAGTCCTCGGGGGGAGGCCAGCCCCTGGCTCACTGGCACAG
GGCAGGTGGGCTCTCGGGGAAGGTGTCGGGGGCCCCCTAGGAGGGAGCGCTGGGGACATTGCCATGGGACGGAAGTCTGCTTGGCAGTGG
CTTTGATAAGCGATGCTTGGGGGTCAGACCACCCCCTAGAGGAGCCACGTGCCGCCCAGCCACCTTCAATGCCTGCCACCCTGCCCGAGG
ATGTACAGAGCCGTGCCCACACATTTCCTTGCAACTTGATCAAATTTCTTAAAGCAAACAACAAAAATGTACATTTCTGTTTTTCCTTTT
AATAAACAGGTGTACTCTTTATCATGGTTGGTATGATGGACCATTCTTTGGGGCGGAGGATTGATTATGTTACTCTCTTTAAAATCTGTT
CCCATATTGAACAGGCAGATTGGAAAAGCTATGGTTCGATTTCTCAGAAGAAATGTTTAGGTCTTAGTCAATAGTTTTAACTATGCCATT
TGTTTAAATGAGTGCATTTGCTTCGAGGGTAGTGTCTTACTAAAAGTTAGGAACAGAGACCTAGTGGTGTGTCCAAGGCCGTGTCACTTT
CCCCTTCAGCACACCCCAGCTTCTGACCTCAGAGCCCAGGAGCTGCGTGGACAGTGTGGGGTGCCAGGAGGAGGGGCGGTGGCTGGTCCT
CAGGCACGCTGCACTCCCAGCCAGACATGGTCTTTCCGTTTCTTAAGTAGCAAGTGTAGGTTTCAGCTGGCAGTTCCACCTGCATGTTCT
CTGCTTCGCTGCCTTGGAAGGGGCCACATTCCCCATTCCTCTTCTCCTTACAGCGCCTGCCTCCTTTTTCAAGCAGGCGGAAAGCTGCTG
TTTCTCACGTTTCAGGGAGAGGGGTGAGCGGAGGGAGACCTGTGTCCGTGCCGTCCGGCTCCCTGGGTGGGAACAGGCAAGGGATCAGAT
GCCCCTGACACCACGCCTCTGGCCACACCAGATGCCTCTGCAGTCCTCGACAGCCTCTTCAGTGTCCCTCCTGCGGTGATGTCCTTACTG
TCCCCAGCCAGGGCCGGGGACCGGTGTTTCACTGAGGACCTGCATTAGAAACATTTTTTAAATTGTTGTACAGGAAGAGATGTGTCTAAA
ACAGCATCTTAAAGCTGAGTGTATTTCTTTGCACAAGGGGTCATGCTGATGAATTCTTCTTTCATTCTGATCTTTGTTCAGCCAACAGGA
GCGTCCTTTTCTAATGTCTTCCATTCCTACCCCCCACCCAAAAACAAAAGAAATATTTGTAGCTTGCTATCTGTATTTGAATTTTTAGCA
ATTTTATATTTAGATACTTTGAAAAATGTAAATGACTAATTTGGTCATTAAATCTTGTGACATATTCGATATTAAAATGATATTAAAATA

>82393_82393_5_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373498_length(amino acids)=466AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTN
QKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLN

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>82393_82393_6_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373511_length(transcript)=2849nt_BP=276nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGCCCAGGAGTTAAAGTCACTGTTTGAAAAAAAATCTCTCAAAGAGAAGCCTCCAATTTCTGGGAAGCAGTCGATATTATCTGTAC
GCCTAGAACAGTGCCCTCTGCAGCTGAATAACCCTTTTAACGAGTATTCCAAATTTGATGGCAAGGGTCATGTAGGTACAACAGCAACCA
AGAAGATCGATGTCTACCTCCCTCTGCACTCGAGCCAGGACAGACTGCTGCCAATGACCGTGGTGACAATGGCCAGCGCCAGGGTGCAGG
ACCTGATCGGGCTCATCTGCTGGCAGTATACAAGCGAAGGACGGGAGCCGAAGCTCAATGACAATGTCAGTGCCTACTGCCTGCATATTG
CTGAGGATGATGGGGAGGTGGACACCGATTTCCCCCCGCTGGATTCCAATGAGCCCATTCATAAGTTTGGCTTCAGTACTTTGGCCCTGG
TTGAAAAGTACTCATCTCCTGGTCTGACATCCAAAGAGTCACTCTTTGTTCGAATAAATGCTGCTCATGGATTCTCCCTTATTCAGGTGG
ACAACACAAAGGTTACCATGAAGGAAATCTTACTGAAGGCAGTGAAGCGAAGAAAAGGATCCCAGAAAGTTTCAGGCCCTCAGTACCGCC
TGGAGAAGCAGAGCGAGCCCAATGTCGCCGTTGACCTGGACAGCACTTTGGAGAGCCAGAGCGCATGGGAGTTCTGCCTGGTCCGCGAGA
ACAGTATCTCTGGAGACAAAGTAGAGATAGACCCTGTTACGAATCAGAAAGCCAGCACTAAGTTTTGGATTAAGCAGAAACCCATCTCAA
TCGATTCCGACCTGCTCTGTGCCTGTGACCTTGCTGAAGAGAAAAGCCCCAGTCACGCAATATTTAAACTCACGTATCTAAGCAATCACG
ACTATAAACACCTCTACTTTGAATCGGACGCTGCTACCGTCAATGAAATTGTGCTCAAGGTTAACTACATCCTGGAATCGCGAGCTAGCA
CTGCCCGGGCTGACTACTTTGCTCAAAAACAAAGAAAACTGAACAGACGTACGAGCTTCAGCTTCCAGAAGGAGAAGAAATCCGGGCAGC
AGTGACACTGGCCTCCAGCCTCAATCTGTTCCGTAGCTCAGAGCCTGCCTGCCAGGGCCAAGTGCCCTAGAGTCCACCCGGTGTCCTGAA
GTCCTCGGGGGGAGGCCAGCCCCTGGCTCACTGGCACAGGGCAGGTGGGCTCTCGGGGAAGGTGTCGGGGGCCCCCTAGGAGGGAGCGCT
GGGGACATTGCCATGGGACGGAAGTCTGCTTGGCAGTGGCTTTGATAAGCGATGCTTGGGGGTCAGACCACCCCCTAGAGGAGCCACGTG
CCGCCCAGCCACCTTCAATGCCTGCCACCCTGCCCGAGGATGTACAGAGCCGTGCCCACACATTTCCTTGCAACTTGATCAAATTTCTTA
AAGCAAACAACAAAAATGTACATTTCTGTTTTTCCTTTTAATAAACAGGTGTACTCTTTATCATGGTTGGTATGATGGACCATTCTTTGG
GGCGGAGGATTGATTATGTTACTCTCTTTAAAATCTGTTCCCATATTGAACAGGCAGATTGGAAAAGCTATGGTTCGATTTCTCAGAAGA
AATGTTTAGGTCTTAGTCAATAGTTTTAACTATGCCATTTGTTTAAATGAGTGCATTTGCTTCGAGGGTAGTGTCTTACTAAAAGTTAGG
AACAGAGACCTAGTGGTGTGTCCAAGGCCGTGTCACTTTCCCCTTCAGCACACCCCAGCTTCTGACCTCAGAGCCCAGGAGCTGCGTGGA
CAGTGTGGGGTGCCAGGAGGAGGGGCGGTGGCTGGTCCTCAGGCACGCTGCACTCCCAGCCAGACATGGTCTTTCCGTTTCTTAAGTAGC
AAGTGTAGGTTTCAGCTGGCAGTTCCACCTGCATGTTCTCTGCTTCGCTGCCTTGGAAGGGGCCACATTCCCCATTCCTCTTCTCCTTAC
AGCGCCTGCCTCCTTTTTCAAGCAGGCGGAAAGCTGCTGTTTCTCACGTTTCAGGGAGAGGGGTGAGCGGAGGGAGACCTGTGTCCGTGC
CGTCCGGCTCCCTGGGTGGGAACAGGCAAGGGATCAGATGCCCCTGACACCACGCCTCTGGCCACACCAGATGCCTCTGCAGTCCTCGAC
AGCCTCTTCAGTGTCCCTCCTGCGGTGATGTCCTTACTGTCCCCAGCCAGGGCCGGGGACCGGTGTTTCACTGAGGACCTGCATTAGAAA
CATTTTTTAAATTGTTGTACAGGAAGAGATGTGTCTAAAACAGCATCTTAAAGCTGAGTGTATTTCTTTGCACAAGGGGTCATGCTGATG
AATTCTTCTTTCATTCTGATCTTTGTTCAGCCAACAGGAGCGTCCTTTTCTAATGTCTTCCATTCCTACCCCCCACCCAAAAACAAAAGA
AATATTTGTAGCTTGCTATCTGTATTTGAATTTTTAGCAATTTTATATTTAGATACTTTGAAAAATGTAAATGACTAATTTGGTCATTAA

>82393_82393_6_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373511_length(amino acids)=419AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDY

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Fusion Gene PPI Analysis for SLC1A3-MAPKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000265960212468_522116.33333333333333523.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000350766211468_522116.33333333333333487.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000373498111468_522116.33333333333333523.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000373503111468_5220331.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000373511211468_522116.33333333333333476.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST0000039406028468_522116.33333333333333324.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000394063010468_5220331.0ATF2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003735031112_1840331.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003940630102_1840331.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003735031112_2670331.0NBN
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003940630102_2670331.0NBN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000002659602122_184116.33333333333333523.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003507662112_184116.33333333333333487.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003734981112_184116.33333333333333523.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003735112112_184116.33333333333333476.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000394060282_184116.33333333333333324.0MAP3K2
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000002659602122_267116.33333333333333523.0NBN
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003507662112_267116.33333333333333487.0NBN
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003734981112_267116.33333333333333523.0NBN
TgeneMAPKAP1chr5:36608706chr9:128420078ENST000003735112112_267116.33333333333333476.0NBN
TgeneMAPKAP1chr5:36608706chr9:128420078ENST00000394060282_267116.33333333333333324.0NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC1A3-MAPKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC1A3-MAPKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource