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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC22A15-ATP1A1 (FusionGDB2 ID:82448)

Fusion Gene Summary for SLC22A15-ATP1A1

Fusion gene summary

Fusion gene information	Fusion gene name: SLC22A15-ATP1A1
	Fusion gene ID: 82448
		Hgene	Tgene
	Gene symbol	SLC22A15	ATP1A1
	Gene ID	55356	480
	Gene name	solute carrier family 22 member 15	ATPase Na+/K+ transporting subunit alpha 4
	Synonyms	FLIPT1\|PRO34686	ATP1A1\|ATP1AL2
	Cytomap	1p13.1	1q23.2
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like protein	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
	Modification date	20200313	20200313
	UniProtAcc	.	Q5TC04
	Ensembl transtripts involved in fusion gene	ENST00000369502, ENST00000369503, ENST00000481127,	ENST00000369496, ENST00000491156, ENST00000295598, ENST00000537345,
Fusion gene scores	* DoF score	4 X 3 X 4=48	19 X 23 X 5=2185
	# samples	4	24
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/2185*10)=-3.18652696877944 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC22A15 [Title/Abstract] AND ATP1A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC22A15(116519335)-ATP1A1(116926636), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Tgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599

Fusion gene breakpoints across SLC22A15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A48C-01A	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+

Top

Fusion Gene ORF analysis for SLC22A15-ATP1A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000369502	ENST00000369496	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
5CDS-5UTR	ENST00000369503	ENST00000369496	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
5CDS-intron	ENST00000369502	ENST00000491156	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
5CDS-intron	ENST00000369503	ENST00000491156	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
In-frame	ENST00000369502	ENST00000295598	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
In-frame	ENST00000369502	ENST00000537345	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
In-frame	ENST00000369503	ENST00000295598	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
In-frame	ENST00000369503	ENST00000537345	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
intron-3CDS	ENST00000481127	ENST00000295598	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
intron-3CDS	ENST00000481127	ENST00000537345	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
intron-5UTR	ENST00000481127	ENST00000369496	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+
intron-intron	ENST00000481127	ENST00000491156	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000369503

SLC22A15

chr1

116519335

ENST00000295598

ATP1A1

chr1

116926636

3607

217

3276

1069

ENST00000369503

SLC22A15

chr1

116519335

ENST00000537345

ATP1A1

chr1

116926636

3605

217

3276

1069

ENST00000369502

SLC22A15

chr1

116519335

ENST00000295598

ATP1A1

chr1

116926636

3491

101

3160

1048

ENST00000369502

SLC22A15

chr1

116519335

ENST00000537345

ATP1A1

chr1

116926636

3489

101

3160

1048

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369503	ENST00000295598	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+	0.001017267	0.9989827
ENST00000369503	ENST00000537345	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+	0.001015161	0.9989849
ENST00000369502	ENST00000295598	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+	0.001003922	0.9989961
ENST00000369502	ENST00000537345	SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926636	+	0.00100137	0.9989986

Top

Fusion Genomic Features for SLC22A15-ATP1A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926635	+	0.002140919	0.99785906
SLC22A15	chr1	116519335	+	ATP1A1	chr1	116926635	+	0.002140919	0.99785906

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC22A15-ATP1A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116519335/chr1:116926636)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ATP1A1 Q5TC04
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

82_84

1024.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

82_84

993.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

82_84

1024.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

1007_1023

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

109_131

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

153_288

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

309_320

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

339_772

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

6_87

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

793_802

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

824_843

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

867_918

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

939_951

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

971_985

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

1007_1023

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

109_131

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

153_288

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

309_320

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

339_772

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

6_87

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

793_802

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

824_843

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

867_918

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

939_951

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

971_985

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

1007_1023

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

109_131

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

153_288

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

309_320

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

339_772

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

6_87

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

793_802

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

824_843

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

867_918

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

939_951

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

971_985

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

132_152

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

289_308

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

321_338

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

773_792

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

803_823

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

844_866

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

88_108

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

919_938

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

952_970

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000295598

986_1006

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

132_152

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

289_308

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

321_338

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

773_792

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

803_823

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

844_866

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

88_108

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

919_938

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

952_970

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000369496

986_1006

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

132_152

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

289_308

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

321_338

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

773_792

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

803_823

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

844_866

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

88_108

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

919_938

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

952_970

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr1:116519335

chr1:116926636

ENST00000537345

986_1006

1024.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

529_535

246.0

Compositional bias

Note=Poly-Glu

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

529_535

548.0

Compositional bias

Note=Poly-Glu

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

111_131

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

141_161

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

165_187

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

201_221

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

226_246

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

22_42

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

303_323

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

338_358

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

368_388

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

401_420

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

433_453

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369502

462_482

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

111_131

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

141_161

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

165_187

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

201_221

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

226_246

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

22_42

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

303_323

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

338_358

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

368_388

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

401_420

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

433_453

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116519335

chr1:116926636

ENST00000369503

462_482

548.0

Transmembrane

Helical

Top

Fusion Gene Sequence for SLC22A15-ATP1A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82448_82448_1_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369502_ATP1A1_chr1_116926636_ENST00000295598_length(transcript)=3491nt_BP=101nt
GCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCAGATGTACTTGTGCTTCCTGCTGGCCG
TGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGG
ACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCC
GGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCA
AGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTA
CAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAG
AAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAA
ATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCT
GCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGGA
ACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGGGGATCGCACTGTGATGGGAAGAATTG
CCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGT
TCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGTATCATCGTAGCCA
ATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAACT
TAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGACTCAGAACCGGATGACAGTGGCCCACA
TGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTC
TGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATG
CCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATAC
CCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCC
CAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACG
CCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGT
TTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTG
ATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTG
TGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCA
AGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTG
CCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATG
ACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTC
TGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAA
CCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTG
ACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAA
CAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTG
TGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACA
GCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGT
GGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAG
AGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTG
CCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAA
CCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTC
TTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGG
GAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAA

>82448_82448_1_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369502_ATP1A1_chr1_116926636_ENST00000295598_length(amino acids)=1048AA_BP=0
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTS
ARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSS
KIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFF
STNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEG
LLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIA
GLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERIL
DRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGK
CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSP
QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP
EITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAE
NGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALA

--------------------------------------------------------------
>82448_82448_2_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369502_ATP1A1_chr1_116926636_ENST00000537345_length(transcript)=3489nt_BP=101nt
GCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCAGATGTACTTGTGCTTCCTGCTGGCCG
TGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGG
ACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCC
GGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCA
AGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTA
CAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAG
AAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAA
ATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCT
GCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGGA
ACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGGGGATCGCACTGTGATGGGAAGAATTG
CCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGT
TCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGTATCATCGTAGCCA
ATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAACT
TAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGACTCAGAACCGGATGACAGTGGCCCACA
TGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTC
TGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATG
CCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATAC
CCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCC
CAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACG
CCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGT
TTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTG
ATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTG
TGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCA
AGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTG
CCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATG
ACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTC
TGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAA
CCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTG
ACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAA
CAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTG
TGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACA
GCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGT
GGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAG
AGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTG
CCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAA
CCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTC
TTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGG
GAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAA

>82448_82448_2_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369502_ATP1A1_chr1_116926636_ENST00000537345_length(amino acids)=1048AA_BP=0
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTS
ARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSS
KIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFF
STNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEG
LLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIA
GLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERIL
DRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGK
CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSP
QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP
EITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAE
NGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALA

--------------------------------------------------------------
>82448_82448_3_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369503_ATP1A1_chr1_116926636_ENST00000295598_length(transcript)=3607nt_BP=217nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAA
GGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCA
TCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCC
CCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTT
CTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCAT
AACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGAT
TCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGA
CCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCAC
AAATGAAAACCCCCTGGAGACGAGGAACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGG
GGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTAT
CCACATCATCACGGGTGTGGCTGTGTTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCAT
CTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGC
AAGGAAAAACTGCTTAGTGAAGAACTTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGAC
TCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGA
CAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTAT
TCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGA
AAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCA
ACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGA
GGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGA
TGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGAT
TGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAAT
CACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGT
CAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTT
GAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGT
GGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTC
CAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTT
GAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACT
GGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCAT
GAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGC
CCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGA
CCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTT
CTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAA
GATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCC
CCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACG
CCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACAC
CCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTG
GAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGT
GCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTAT

>82448_82448_3_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369503_ATP1A1_chr1_116926636_ENST00000295598_length(amino acids)=1069AA_BP=1
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH
KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGV
VLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEP
QTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILE
YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE
NQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHK
NPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLC
FVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMT
SEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEE
GRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAY
GQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSV

--------------------------------------------------------------
>82448_82448_4_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369503_ATP1A1_chr1_116926636_ENST00000537345_length(transcript)=3605nt_BP=217nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAA
GGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCA
TCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCC
CCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTT
CTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCAT
AACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGAT
TCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGA
CCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCAC
AAATGAAAACCCCCTGGAGACGAGGAACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGG
GGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTAT
CCACATCATCACGGGTGTGGCTGTGTTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCAT
CTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGC
AAGGAAAAACTGCTTAGTGAAGAACTTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGAC
TCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGA
CAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTAT
TCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGA
AAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCA
ACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGA
GGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGA
TGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGAT
TGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAAT
CACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGT
CAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTT
GAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGT
GGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTC
CAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTT
GAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACT
GGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCAT
GAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGC
CCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGA
CCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTT
CTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAA
GATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCC
CCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACG
CCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACAC
CCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTG
GAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGT
GCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTAT

>82448_82448_4_SLC22A15-ATP1A1_SLC22A15_chr1_116519335_ENST00000369503_ATP1A1_chr1_116926636_ENST00000537345_length(amino acids)=1069AA_BP=1
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH
KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGV
VLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEP
QTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILE
YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE
NQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHK
NPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLC
FVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMT
SEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEE
GRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAY
GQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC22A15-ATP1A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SLC22A15-ATP1A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC22A15-ATP1A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source