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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC22A15-MGEA5 (FusionGDB2 ID:82449)

Fusion Gene Summary for SLC22A15-MGEA5

Fusion gene summary

Fusion gene information	Fusion gene name: SLC22A15-MGEA5
	Fusion gene ID: 82449
		Hgene	Tgene
	Gene symbol	SLC22A15	MGEA5
	Gene ID	55356	10724
	Gene name	solute carrier family 22 member 15	O-GlcNAcase
	Synonyms	FLIPT1\|PRO34686	MEA5\|MGEA5\|NCOAT
	Cytomap	1p13.1	10q24.32
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like protein	protein O-GlcNAcaseN-acetyl-beta-D-glucosaminidaseN-acetyl-beta-glucosaminidasebeta-N-acetylglucosaminidasebeta-N-acetylhexosaminidasebeta-hexosaminidasebifunctional protein NCOAThyaluronidase in meningiomameningioma expressed antigen 5 (hyaluroni
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000481127, ENST00000369503, ENST00000369502,	ENST00000361464, ENST00000439817, ENST00000357797, ENST00000370094, ENST00000419011, ENST00000482611,
Fusion gene scores	* DoF score	4 X 3 X 4=48	9 X 10 X 5=450
	# samples	4	12
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC22A15 [Title/Abstract] AND MGEA5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC22A15(116580009)-MGEA5(103553755), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MGEA5	GO:0006044	N-acetylglucosamine metabolic process	11148210
Tgene	MGEA5	GO:0006517	protein deglycosylation	11148210

Fusion gene breakpoints across SLC22A15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MGEA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	61N	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-

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Fusion Gene ORF analysis for SLC22A15-MGEA5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000481127	ENST00000361464	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
3UTR-3CDS	ENST00000481127	ENST00000439817	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
3UTR-intron	ENST00000481127	ENST00000357797	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
3UTR-intron	ENST00000481127	ENST00000370094	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
3UTR-intron	ENST00000481127	ENST00000419011	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
3UTR-intron	ENST00000481127	ENST00000482611	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
5CDS-intron	ENST00000369503	ENST00000357797	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
5CDS-intron	ENST00000369503	ENST00000370094	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
5CDS-intron	ENST00000369503	ENST00000419011	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
5CDS-intron	ENST00000369503	ENST00000482611	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
In-frame	ENST00000369503	ENST00000361464	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
In-frame	ENST00000369503	ENST00000439817	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-3CDS	ENST00000369502	ENST00000361464	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-3CDS	ENST00000369502	ENST00000439817	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-intron	ENST00000369502	ENST00000357797	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-intron	ENST00000369502	ENST00000370094	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-intron	ENST00000369502	ENST00000419011	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-
intron-intron	ENST00000369502	ENST00000482611	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000369503

SLC22A15

chr1

116580009

ENST00000439817

MGEA5

chr10

103553755

4076

1301

2067

666

ENST00000369503

SLC22A15

chr1

116580009

ENST00000361464

MGEA5

chr10

103553755

4067

1301

2067

666

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369503	ENST00000439817	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-	0.000110603	0.9998894
ENST00000369503	ENST00000361464	SLC22A15	chr1	116580009	+	MGEA5	chr10	103553755	-	0.00010954	0.99989045

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Fusion Genomic Features for SLC22A15-MGEA5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC22A15-MGEA5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116580009/chr10:103553755)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

111_131

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

141_161

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

165_187

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

201_221

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

226_246

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

22_42

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

303_323

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

338_358

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

368_388

390

548.0

Transmembrane

Helical

Tgene

MGEA5

chr1:116580009

chr10:103553755

ENST00000370094

278_280

678.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

529_535

246.0

Compositional bias

Note=Poly-Glu

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

529_535

390

548.0

Compositional bias

Note=Poly-Glu

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

111_131

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

141_161

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

165_187

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

201_221

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

226_246

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

22_42

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

303_323

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

338_358

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

368_388

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

401_420

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

433_453

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369502

462_482

246.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

401_420

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

433_453

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr10:103553755

ENST00000369503

462_482

390

548.0

Transmembrane

Helical

Tgene

MGEA5

chr1:116580009

chr10:103553755

ENST00000357797

278_280

608

850.0

Region

Substrate binding

Tgene

MGEA5

chr1:116580009

chr10:103553755

ENST00000361464

278_280

661

917.0

Region

Substrate binding

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Fusion Gene Sequence for SLC22A15-MGEA5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82449_82449_1_SLC22A15-MGEA5_SLC22A15_chr1_116580009_ENST00000369503_MGEA5_chr10_103553755_ENST00000361464_length(transcript)=4067nt_BP=1301nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGCTCTACGTGGCCACGGAGGCCATCCTCATTGCACTGGTTGGGGCCACGCCATC
CTACCACTGGGACCTGGCAGAGCTCCTGCCAAATCAGAGCCACGGTAACCAGTCAGCTGGTGAAGACCAGGCCTTTGGGGACTGGCTCCT
GACAGCCAACGGCAGTGAGATCCATAAGCACGTGCATTTCAGCAGCAGCTTCACCTCCATCGCCTCGGAGTGGTTTTTAATTGCCAACAG
ATCCTACAAAGTCAGTGCAGCAAGCTCTTTTTTCTTCAGTGGTGTATTTGTTGGAGTTATCTCTTTTGGTCAGCTTTCAGATCGCTTCGG
AAGGAAAAAAGTCTATCTCACAGGTTTTGCTCTTGACATCTTATTTGCAATTGCAAATGGATTTTCCCCCTCATATGAGTTCTTTGCAGT
AACTCGCTTCCTGGTGGGCATGATGAATGGAGGGATGTCGCTGGTGGCCTTTGTCTTGCTTAATGAATGTGTGGGCACCGCCTACTGGGC
ACTTGCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTCCTGGAGGACCCT
AGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTTGGTTATACTCCCAGGGTCG
ACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAG
GAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTTTGT
GTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGGCCCTGTCTGGCCTCATAGA
GATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAGCATTTCTGTGCCTAGGAGG
ACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGGGTGTCGTAGTCATTCTTCAGCACAATTCTTAATTGGAGACCAAGAACC
CTGGGCCTTTAGAGGTGGTCTAGCAGGAGAGTTCCAGCGTTTGCTGCCAATTGATGGGGCAAATGATCTCTTTTTTCAGCCACCTCCACT
GACTCCTACCTCCAAAGTTTATACTATCAGACCTTATTTTCCTAAGGATGAGGCATCCGTGTACAAGATTTGCAGAGAAATGTATGACGA
TGGAGTGGGTTTACCCTTTCAAAGTCAGCCTGATCTTATTGGAGACAAGTTAGTAGGAGGGCTGCTTTCCCTCAGCCTGGATTACTGCTT
TGTCCTAGAAGATGAAGATGGCATATGTGGTTATGCCTTGGGCACTGTAGATGTGACCCCCTTTATTAAAAAATGTAAAATTTCCTGGAT
CCCCTTCATGCAGGAGAAGTATACCAAGCCAAATGGTGACAAGGAACTCTCTGAGGCTGAGAAAATAATGTTGAGTTTCCATGAAGAACA
GGAAGTACTGCCAGAAACTTTCCTTGCTAATTTCCCTTCTCTGATAAAGATGGACATTCACAAAAAAGTAACTGACCCAAGTGTGGCCAA
AAGCATGATGGCTTGCCTCCTGTCTTCACTGAAGGCTAATGGCTCCCGGGGAGCTTTCTGTGAAGTGAGACCAGATGATAAAAGAATTCT
GGAATTTTACAGCAAGTTAGGATGTTTTGAAATTGCAAAAATGGAAGGATTTCCAAAGGATGTGGTTATACTTGGTCGGAGCCTGTGACA
TTTGTTGACACTGTGAACTGTCCAAAAGTCTCTTAACTGCACCTTGTGAATGGTAGTTGAGGTCTTCATACAGTTCAGCCTCTAGAATGG
TAACAAATCAGCCAATTGGATTCGAAACAAAGAAGACTATGTAAAACTCACCCATCACACTTTGAGACTACTCACTGGTTGGAAGAATAT
AGTATTGCAGCAAATCCTGTATGAAAGAGAGATGTGGGCTTCCTTTTTGAGTCTTGTGTTAGGTGCTGAGACCTTTTACATGGGCTTATA
CAGGGAGAGAGTCTTCAATAAATGTAGTCAGCACTATTTTCTGCATCCAGTGTGGTTGCGTTTCTCACCTGAGAGTAATCAAGATAACAT
CTGTCATCTTCCTTGGTTTATTGAGTGAAATGCCTCTCAGTCTTAGGGGACATGGCAGAGATGAAAGAAAGAAAGAGTGGGTTTCAGAAG
TGTCAGGGTGGAGTGATTCCAAGTGGGATGGTTGTGGCATTAGTTTAAGCTGAATAAATAATTTCAATTTGGGGCAGTTATTCTGCTTTT
TGTAAAGCCGTGGCCAATTGTCTCCTGTAATGACTGTTGGTTCAGGCATGTTGTACTTTGTAGGGACAAATGTGCATTTGTTTGTGGCAA
AAGCCTACAATTGACAAACTTGTAAATTTCTTTGTATATAAACTAGCTGTAACCTGACTATCCTTTGTGTTTACTGTTTTTGTAAATTTT
TTTCCTCTATAAATGAAAGGGTGTTGGTTCAGAATGGCACTTTGAATAATGTAAACCAGTGAAAAGTGGATTTTCTTTACTTTTGTCTTT
GGGTTTGGGGTTGTTTTTGTTCTTTTTGAAGTTTTATTATTTTTAAAGTGCCTCCCACCTAGGCGTAGGCCATGACCATTTGGGGTACGA
GAGCCTAATTTTGTAGGACTTAATCTGTTGAAAAGTGCAGTTACTTCTGGAAATTAACCTCAATATTAGGTCAGCATGTGAAATGTTGGA
TTTGACATGTCAGGTAGGGTTCAGGGACTGATTGGTCCCATTTGCCCTCAGGTCAGTTGTTTAATCTCAAGACCTGTTACTACTGATTTT
ATTAAATCAGAGTCTTTAATTCTTGCATGTTTGTATCTAATTTCTGAATGAATGAGCACACTTTAACCAGTTATTTACAGTTACCTTTTT
CCTTTAACCGGATTGTGAAAGCTTCATGTATTTTAATTTAGATTCTGTGTTTTTAAGGGTTCTGAGCATGAAGCTGGCAGATAGTCGGCA
GGACTCATTTTTTCATCATGGCTGGCTGATTTCTCCATAGATTGATAACAGTATTTTGTTATCTTGCTTCTCTGTAGTTTTGCATCAGCT
GTTTAACTTTGAGCTGAGTGAGGGGAGAGGGGTAAAGAGAAAGAAACTTAAGTTTTCTTTCACAGAACTCCACCATTGTGGGCTTTGAGA
GAGCCCTAAAGCATTGTACCTAGTGGTACCTAGTGACTTCCAACCAAAGCCTTTGAGTATGCACTAAATAGGTGAGAAGAAAGGAGAGAA
GGTTTTTAGGTTAGAAACCTTTAACCGATAGAAGGATATGGTATGTTGTAAAGCTGGAACCAAGTTTGCATTTTTGAGGGCTTGAGATGA
AGGGAAGACTCTTACCAGATAGTAAGACAGCTGAGTTTTCCTCAGTTTTCTCGTCTTAACACTAGTGGACAATTCTAGCATTTTGTTTGG
AGGATTTCAGAGTTAACCTCATGGAATTCAGGATTTTTTAGCAAGTTTGCTTTTGGTTTTATCTTGGCTTTTAGTAATCATGTTGGCTGG
TCTGGTCACAGGTGACTGTGAAACAGATGCCCTGGTCTTGCTTTCATCACTCTAGGATCATGAAGTGCTATGCTATTTCCTGGTTATGAA
TATTAAGGTTGGAATTACATTTTTATTGATTGTTTGGATCAGAGCTCAGTTCCTGTAGAAAACGAACTGTAAAAGACCATGCAAGAGGCA

>82449_82449_1_SLC22A15-MGEA5_SLC22A15_chr1_116580009_ENST00000369503_MGEA5_chr10_103553755_ENST00000361464_length(amino acids)=666AA_BP=411
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGED
QAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFS
PSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESP
RWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYAN
LALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGAND
LFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFI
KKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEV

--------------------------------------------------------------
>82449_82449_2_SLC22A15-MGEA5_SLC22A15_chr1_116580009_ENST00000369503_MGEA5_chr10_103553755_ENST00000439817_length(transcript)=4076nt_BP=1301nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGCTCTACGTGGCCACGGAGGCCATCCTCATTGCACTGGTTGGGGCCACGCCATC
CTACCACTGGGACCTGGCAGAGCTCCTGCCAAATCAGAGCCACGGTAACCAGTCAGCTGGTGAAGACCAGGCCTTTGGGGACTGGCTCCT
GACAGCCAACGGCAGTGAGATCCATAAGCACGTGCATTTCAGCAGCAGCTTCACCTCCATCGCCTCGGAGTGGTTTTTAATTGCCAACAG
ATCCTACAAAGTCAGTGCAGCAAGCTCTTTTTTCTTCAGTGGTGTATTTGTTGGAGTTATCTCTTTTGGTCAGCTTTCAGATCGCTTCGG
AAGGAAAAAAGTCTATCTCACAGGTTTTGCTCTTGACATCTTATTTGCAATTGCAAATGGATTTTCCCCCTCATATGAGTTCTTTGCAGT
AACTCGCTTCCTGGTGGGCATGATGAATGGAGGGATGTCGCTGGTGGCCTTTGTCTTGCTTAATGAATGTGTGGGCACCGCCTACTGGGC
ACTTGCAGGATCGATTGGCGGCCTGTTCTTTGCAGTTGGCATTGCCCAATATGCCCTGTTAGGATACTTCATCCGCTCCTGGAGGACCCT
AGCCATTCTGGTTAACCTGCAGGGAACGGTGGTCTTTCTCTTATCTTTATTCATTCCTGAATCACCTCGTTGGTTATACTCCCAGGGTCG
ACTGAGTGAGGCTGAAGAGGCGCTGTACCTCATTGCCAAGAGGAACCGCAAACTCAAGTGCACGTTCTCACTAACACACCCAGCCAACAG
GAGCTGCAGGGAGACTGGAAGTTTCCTGGATCTCTTTCGTTACCGGGTCCTGTTAGGACACACTTTGATCCTGATGTTCATCTGGTTTGT
GTGCAGCTTGGTGTATTATGGCCTAACTCTGAGTGCGGGTGATCTAGGTGGAAGTATTTATGCCAACCTGGCCCTGTCTGGCCTCATAGA
GATTCCATCTTACCCTCTCTGTATCTACTTGATTAACCAAAAATGGTTTGGTCGGAAGCGAACATTATCAGCATTTCTGTGCCTAGGAGG
ACTGGCTTGTCTTATTGTAATGTTTCTTCCAGAAAAGAAAGGGTGTCGTAGTCATTCTTCAGCACAATTCTTAATTGGAGACCAAGAACC
CTGGGCCTTTAGAGGTGGTCTAGCAGGAGAGTTCCAGCGTTTGCTGCCAATTGATGGGGCAAATGATCTCTTTTTTCAGCCACCTCCACT
GACTCCTACCTCCAAAGTTTATACTATCAGACCTTATTTTCCTAAGGATGAGGCATCCGTGTACAAGATTTGCAGAGAAATGTATGACGA
TGGAGTGGGTTTACCCTTTCAAAGTCAGCCTGATCTTATTGGAGACAAGTTAGTAGGAGGGCTGCTTTCCCTCAGCCTGGATTACTGCTT
TGTCCTAGAAGATGAAGATGGCATATGTGGTTATGCCTTGGGCACTGTAGATGTGACCCCCTTTATTAAAAAATGTAAAATTTCCTGGAT
CCCCTTCATGCAGGAGAAGTATACCAAGCCAAATGGTGACAAGGAACTCTCTGAGGCTGAGAAAATAATGTTGAGTTTCCATGAAGAACA
GGAAGTACTGCCAGAAACTTTCCTTGCTAATTTCCCTTCTCTGATAAAGATGGACATTCACAAAAAAGTAACTGACCCAAGTGTGGCCAA
AAGCATGATGGCTTGCCTCCTGTCTTCACTGAAGGCTAATGGCTCCCGGGGAGCTTTCTGTGAAGTGAGACCAGATGATAAAAGAATTCT
GGAATTTTACAGCAAGTTAGGATGTTTTGAAATTGCAAAAATGGAAGGATTTCCAAAGGATGTGGTTATACTTGGTCGGAGCCTGTGACA
TTTGTTGACACTGTGAACTGTCCAAAAGTCTCTTAACTGCACCTTGTGAATGGTAGTTGAGGTCTTCATACAGTTCAGCCTCTAGAATGG
TAACAAATCAGCCAATTGGATTCGAAACAAAGAAGACTATGTAAAACTCACCCATCACACTTTGAGACTACTCACTGGTTGGAAGAATAT
AGTATTGCAGCAAATCCTGTATGAAAGAGAGATGTGGGCTTCCTTTTTGAGTCTTGTGTTAGGTGCTGAGACCTTTTACATGGGCTTATA
CAGGGAGAGAGTCTTCAATAAATGTAGTCAGCACTATTTTCTGCATCCAGTGTGGTTGCGTTTCTCACCTGAGAGTAATCAAGATAACAT
CTGTCATCTTCCTTGGTTTATTGAGTGAAATGCCTCTCAGTCTTAGGGGACATGGCAGAGATGAAAGAAAGAAAGAGTGGGTTTCAGAAG
TGTCAGGGTGGAGTGATTCCAAGTGGGATGGTTGTGGCATTAGTTTAAGCTGAATAAATAATTTCAATTTGGGGCAGTTATTCTGCTTTT
TGTAAAGCCGTGGCCAATTGTCTCCTGTAATGACTGTTGGTTCAGGCATGTTGTACTTTGTAGGGACAAATGTGCATTTGTTTGTGGCAA
AAGCCTACAATTGACAAACTTGTAAATTTCTTTGTATATAAACTAGCTGTAACCTGACTATCCTTTGTGTTTACTGTTTTTGTAAATTTT
TTTCCTCTATAAATGAAAGGGTGTTGGTTCAGAATGGCACTTTGAATAATGTAAACCAGTGAAAAGTGGATTTTCTTTACTTTTGTCTTT
GGGTTTGGGGTTGTTTTTGTTCTTTTTGAAGTTTTATTATTTTTAAAGTGCCTCCCACCTAGGCGTAGGCCATGACCATTTGGGGTACGA
GAGCCTAATTTTGTAGGACTTAATCTGTTGAAAAGTGCAGTTACTTCTGGAAATTAACCTCAATATTAGGTCAGCATGTGAAATGTTGGA
TTTGACATGTCAGGTAGGGTTCAGGGACTGATTGGTCCCATTTGCCCTCAGGTCAGTTGTTTAATCTCAAGACCTGTTACTACTGATTTT
ATTAAATCAGAGTCTTTAATTCTTGCATGTTTGTATCTAATTTCTGAATGAATGAGCACACTTTAACCAGTTATTTACAGTTACCTTTTT
CCTTTAACCGGATTGTGAAAGCTTCATGTATTTTAATTTAGATTCTGTGTTTTTAAGGGTTCTGAGCATGAAGCTGGCAGATAGTCGGCA
GGACTCATTTTTTCATCATGGCTGGCTGATTTCTCCATAGATTGATAACAGTATTTTGTTATCTTGCTTCTCTGTAGTTTTGCATCAGCT
GTTTAACTTTGAGCTGAGTGAGGGGAGAGGGGTAAAGAGAAAGAAACTTAAGTTTTCTTTCACAGAACTCCACCATTGTGGGCTTTGAGA
GAGCCCTAAAGCATTGTACCTAGTGGTACCTAGTGACTTCCAACCAAAGCCTTTGAGTATGCACTAAATAGGTGAGAAGAAAGGAGAGAA
GGTTTTTAGGTTAGAAACCTTTAACCGATAGAAGGATATGGTATGTTGTAAAGCTGGAACCAAGTTTGCATTTTTGAGGGCTTGAGATGA
AGGGAAGACTCTTACCAGATAGTAAGACAGCTGAGTTTTCCTCAGTTTTCTCGTCTTAACACTAGTGGACAATTCTAGCATTTTGTTTGG
AGGATTTCAGAGTTAACCTCATGGAATTCAGGATTTTTTAGCAAGTTTGCTTTTGGTTTTATCTTGGCTTTTAGTAATCATGTTGGCTGG
TCTGGTCACAGGTGACTGTGAAACAGATGCCCTGGTCTTGCTTTCATCACTCTAGGATCATGAAGTGCTATGCTATTTCCTGGTTATGAA
TATTAAGGTTGGAATTACATTTTTATTGATTGTTTGGATCAGAGCTCAGTTCCTGTAGAAAACGAACTGTAAAAGACCATGCAAGAGGCA

>82449_82449_2_SLC22A15-MGEA5_SLC22A15_chr1_116580009_ENST00000369503_MGEA5_chr10_103553755_ENST00000439817_length(amino acids)=666AA_BP=411
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGED
QAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFS
PSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESP
RWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYAN
LALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGAND
LFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFI
KKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEV

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Fusion Gene PPI Analysis for SLC22A15-MGEA5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SLC22A15-MGEA5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC22A15-MGEA5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source