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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC22A4-SEPT8 (FusionGDB2 ID:82482)

Fusion Gene Summary for SLC22A4-SEPT8

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC22A4-SEPT8
Fusion gene ID: 82482
HgeneTgene
Gene symbol

SLC22A4

SEPT8

Gene ID

6583

23176

Gene namesolute carrier family 22 member 4septin 8
SynonymsDFNB60|OCTN1SEP2|SEPT8
Cytomap

5q31.1

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 22 member 4ET transporterdeafness, autosomal recessive 60ergothioneine transporterintegral membrane transport proteinorganic cation/carnitine transporter 1solute carrier family 22 (organic cation/ergothioneine transporter), memseptin-8
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000200652, ENST00000491257, 
ENST00000378699, ENST00000378701, 
ENST00000378706, ENST00000448933, 
ENST00000458488, ENST00000296873, 
ENST00000378721, ENST00000481030, 
ENST00000378719, 
Fusion gene scores* DoF score3 X 1 X 2=62 X 2 X 2=8
# samples 32
** MAII scorelog2(3/6*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SLC22A4 [Title/Abstract] AND SEPT8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC22A4(131630702)-SEPT8(132101221), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC22A4

GO:0015697

quaternary ammonium group transport

9426230

HgeneSLC22A4

GO:0015879

carnitine transport

16729965


check buttonFusion gene breakpoints across SLC22A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEPT8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238SLC22A4chr5

131630702

+SEPT8chr5

132101221

-


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Fusion Gene ORF analysis for SLC22A4-SEPT8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000200652ENST00000378699SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-5UTRENST00000200652ENST00000378701SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-5UTRENST00000200652ENST00000378706SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-5UTRENST00000200652ENST00000448933SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-5UTRENST00000200652ENST00000458488SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-intronENST00000200652ENST00000296873SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-intronENST00000200652ENST00000378721SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
5CDS-intronENST00000200652ENST00000481030SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
In-frameENST00000200652ENST00000378719SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-3CDSENST00000491257ENST00000378719SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-5UTRENST00000491257ENST00000378699SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-5UTRENST00000491257ENST00000378701SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-5UTRENST00000491257ENST00000378706SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-5UTRENST00000491257ENST00000448933SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-5UTRENST00000491257ENST00000458488SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-intronENST00000491257ENST00000296873SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-intronENST00000491257ENST00000378721SLC22A4chr5

131630702

+SEPT8chr5

132101221

-
intron-intronENST00000491257ENST00000481030SLC22A4chr5

131630702

+SEPT8chr5

132101221

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000200652SLC22A4chr5131630702+ENST00000378719SEPT8chr5132101221-31885671201988622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000200652ENST00000378719SLC22A4chr5131630702+SEPT8chr5132101221-0.0032670920.99673295

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Fusion Genomic Features for SLC22A4-SEPT8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC22A4-SEPT8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131630702/chr5:132101221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+1101_20131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+11021_41131552.0TransmembraneHelical%3B Name%3D1
TgeneSEPT8chr5:131630702chr5:132101221ENST00000296873010320_41310430.0Coiled coilOntology_term=ECO:0000255
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378699111320_4130370.0Coiled coilOntology_term=ECO:0000255
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378719010320_41310484.0Coiled coilOntology_term=ECO:0000255
TgeneSEPT8chr5:131630702chr5:132101221ENST00000448933010320_4130370.0Coiled coilOntology_term=ECO:0000255
TgeneSEPT8chr5:131630702chr5:132101221ENST0000029687301041_30710430.0DomainSeptin-type G
TgeneSEPT8chr5:131630702chr5:132101221ENST0000037869911141_3070370.0DomainSeptin-type G
TgeneSEPT8chr5:131630702chr5:132101221ENST0000037871901041_30710484.0DomainSeptin-type G
TgeneSEPT8chr5:131630702chr5:132101221ENST0000044893301041_3070370.0DomainSeptin-type G
TgeneSEPT8chr5:131630702chr5:132101221ENST00000296873010187_19510430.0Nucleotide bindingGTP
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378699111187_1950370.0Nucleotide bindingGTP
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378719010187_19510484.0Nucleotide bindingGTP
TgeneSEPT8chr5:131630702chr5:132101221ENST00000448933010187_1950370.0Nucleotide bindingGTP
TgeneSEPT8chr5:131630702chr5:132101221ENST00000296873010103_10610430.0RegionG3 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000296873010186_18910430.0RegionG4 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST0000029687301051_5810430.0RegionG1 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378699111103_1060370.0RegionG3 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378699111186_1890370.0RegionG4 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST0000037869911151_580370.0RegionG1 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378719010103_10610484.0RegionG3 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000378719010186_18910484.0RegionG4 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST0000037871901051_5810484.0RegionG1 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000448933010103_1060370.0RegionG3 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST00000448933010186_1890370.0RegionG4 motif
TgeneSEPT8chr5:131630702chr5:132101221ENST0000044893301051_580370.0RegionG1 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110218_225131552.0Nucleotide bindingATP
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110163_171131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110193_197131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110219_232131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110254_257131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110279_337131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110359_371131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110393_399131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110421_426131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+11042_141131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110448_460131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110482_486131552.0Topological domainExtracellular
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110508_551131552.0Topological domainCytoplasmic
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110142_162131552.0TransmembraneHelical%3B Name%3D2
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110172_192131552.0TransmembraneHelical%3B Name%3D3
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110198_218131552.0TransmembraneHelical%3B Name%3D4
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110233_253131552.0TransmembraneHelical%3B Name%3D5
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110258_278131552.0TransmembraneHelical%3B Name%3D6
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110338_358131552.0TransmembraneHelical%3B Name%3D7
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110372_392131552.0TransmembraneHelical%3B Name%3D8
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110400_420131552.0TransmembraneHelical%3B Name%3D9
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110427_447131552.0TransmembraneHelical%3B Name%3D10
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110461_481131552.0TransmembraneHelical%3B Name%3D11
HgeneSLC22A4chr5:131630702chr5:132101221ENST00000200652+110487_507131552.0TransmembraneHelical%3B Name%3D12


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Fusion Gene Sequence for SLC22A4-SEPT8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82482_82482_1_SLC22A4-SEPT8_SLC22A4_chr5_131630702_ENST00000200652_SEPT8_chr5_132101221_ENST00000378719_length(transcript)=3188nt_BP=567nt
CGCCTTCAGCCTGTTTCCCAGGAACGGTCCCCGGCTTCGCGCCCCAATTTCTAACAGCCTGCCTGTCCCCCGGGAACGTTCTAACATCCT
TGGGGAGCGCCCCAGCTACAAGACACTGTCCTGAGAACGCTGTCATCACCCGTAGTTGCAAGTTTCGGAGCGGCAGTGGGAAGCATGCGG
GACTACGACGAGGTGATCGCCTTCCTGGGCGAGTGGGGGCCCTTCCAGCGCCTCATCTTCTTCCTGCTCAGCGCCAGCATCATCCCCAAT
GGCTTCAATGGTATGTCAGTCGTGTTCCTGGCGGGGACCCCGGAGCACCGCTGTCGAGTGCCGGACGCCGCGAACCTGAGCAGCGCCTGG
CGCAACAACAGTGTCCCGCTGCGGCTGCGGGACGGCCGCGAGGTGCCCCACAGCTGCAGCCGCTACCGGCTCGCCACCATCGCCAACTTC
TCGGCGCTCGGGCTGGAGCCGGGGCGCGACGTGGACCTGGGGCAGCTGGAGCAGGAGAGCTGCCTGGATGGCTGGGAGTTCAGCCAGGAC
GTCTACCTGTCCACCGTCGTGACCGAGAATGCAGAGCCAGAGCCCCGGAGCCTCTCCCTGGGCGGCCATGTGGGTTTCGACAGCCTCCCC
GACCAGCTGGTCAGCAAGTCGGTCACTCAGGGCTTCAGCTTCAACATCCTCTGTGTGGGGGAGACCGGCATTGGCAAATCCACACTGATG
AACACACTCTTCAACACGACCTTCGAGACTGAGGAAGCCAGTCACCATGAGGCATGCGTGCGCCTGCGGCCCCAGACCTATGACCTCCAG
GAGAGCAACGTGCAGCTCAAGCTGACCATTGTGGATGCCGTGGGCTTTGGGGATCAGATCAATAAGGATGAGAGTTACAGGCCCATAGTT
GACTACATCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGCTCTTCGACTACCATGACACAAGGATCCAC
GTTTGCCTCTACTTCATCACGCCCACAGGGCACTCCCTGAAGTCTCTAGATCTAGTGACCATGAAGAAACTAGACAGCAAGGTGAACATT
ATTCCCATCATCGCCAAGGCTGACACCATCTCCAAGAGCGAGCTCCACAAGTTCAAGATCAAGATCATGGGCGAGTTGGTCAGCAATGGG
GTCCAGATCTACCAGTTCCCCACGGATGATGAGGCTGTTGCAGAGATTAACGCAGTCATGAATGCACATCTGCCCTTTGCCGTGGTGGGC
AGCACCGAGGAGGTGAAGGTGGGGAACAAGCTGGTCCGAGCACGGCAGTACCCCTGGGGAGTGGTGCAGGTGGAGAATGAGAATCACTGC
GACTTCGTGAAGCTGCGGGAGATGTTGATCCGGGTGAACATGGAAGACCTCCGCGAGCAGACCCACAGCCGGCACTACGAGCTCTACCGG
CGCTGCAAGTTGGAGGAGATGGGCTTTCAGGACAGCGATGGTGACAGCCAGCCCTTCAGCCTACAAGAGACATACGAGGCCAAGAGGAAG
GAGTTCCTAAGTGAGCTGCAGAGGAAGGAGGAAGAGATGAGGCAGATGTTTGTCAACAAAGTGAAGGAGACAGAGCTGGAGCTGAAGGAG
AAGGAAAGGGAGCTCCATGAGAAGTTTGAGCACCTGAAGCGGGTCCACCAGGAGGAGAAGCGCAAGGTGGAGGAAAAGCGCCGGGAACTG
GAGGAGGAGACCAACGCCTTCAATCGCCGGAAGGCTGCGGTGGAGGCCCTGCAGTCGCAGGCCTTGCACGCCACCTCGCAGCAGCCCCTG
AGGAAGGACAAGGACAAGAAGAACAGATCAGATATAGGAGCACACCAGCCGGGCATGAGCCTCTCCAGCTCTAAGGTGATGATGACCAAG
GCCAGTGTGGAGCCCTTGAACTGCAGCAGCTGGTGGCCCGCCATACAGTGCTGCAGCTGCCTGGTCAGGGATGCGACGTGGAGGGAAGGA
TTCCTCTGAGGCAGCAGCTCCAACACATGGGGCCAGCTCAGGACCACCAGGGCATGGAACTGGAGACCATGGTTTTTAATGTTAGAACAG
AAAACGCCATACTTTTCCTATATCAATGATCAAAAGTGCAAACAATTTAAATTTCCATCAGGGAACATCAAATGTTGCCCAACCCTTTTC
ATTCCTATCCATGGCTCCGTAAGGGGCTTGAGGCTTAATGCCCATCCTGTGGCCAAGCTGAGCTTCCACTCCGGGACCAAAAAAAAAAAA
AAGTCTGCTTTGTGACATCATCGTTATGAGCGGAAAGTACCTAGATGACAATGTTTCCATTCTGAAAAATAGAAACATACTATTCAAGAC
CAAGGTAGCAGAAAAGTTACTTGTATCTGCTTATCATAAGACGAAACTCTGCAACTTGGCAACGGTGGCCAGTTTTCGTAATGAAACAGT
CTTTAGTAATTTAATCTTCATGCTTCATAACAAACCAAAACCCCATGAGATTTCCACATTGCATAATTTTGCCTTACTAACAGAATCATA
TCCTTAAGGATGACCATCATTCCCCCAACTAAAACAAATACAAACTAATGTATGATATTTTTTTAAGTGCCAGATCAATATGGTCTAAAG
CTTCAATAAGGATTGTGTGTAGGTGAATAAAGACAGCTAAGTGAATGTGTGTAAAGTGTAGCAAAAGCAGACAGATATTTATGTACAGTA
TTCATAGAATGGAAAGTTAAATATTTTTGCAGTGTGTATTTAAAAGAGAAACTCACCATAATAGTGCCGTCTAAAAATCTTTGTAAAGTT
AATTTAATGTCCTTTAGAAGTGGGAGTCTGGTGGAACTGTGTTGGATTTAAGATACCTTTTCACTCTTCCGTATGTCATGAGCCTTGTGC
GTCACCTCACTGTGGTGCATGTGCAAGGGCGTGTGCACGCCTGTGCTTTGCCATCCCATGTTGTAAACAGCTGTTCCAAAGGCACAAACG
AGTTTAGGGTAGACTCTGTAAACACCTCCTTACTCACTATAGTCAAGAAGTCCAGCGGCGTCCCAATATAGAGGTCCCAGTGCAGTCTGT
CCAGAATAGCCAGCTCCATCCTCAGCAGCTCATTCGGGGAATAGTCAGAGCCATAGTGCTTTGTGAAGTCTTTTACTTGTGGAATAAACT

>82482_82482_1_SLC22A4-SEPT8_SLC22A4_chr5_131630702_ENST00000200652_SEPT8_chr5_132101221_ENST00000378719_length(amino acids)=622AA_BP=149
MRTLSSPVVASFGAAVGSMRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLR
DGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTENAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQ
GFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENY
LQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDD
EAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQ
DSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELEEETNAFNRR

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Fusion Gene PPI Analysis for SLC22A4-SEPT8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC22A4-SEPT8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC22A4-SEPT8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource