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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A13-MBD2 (FusionGDB2 ID:82559)

Fusion Gene Summary for SLC25A13-MBD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A13-MBD2
Fusion gene ID: 82559
HgeneTgene
Gene symbol

SLC25A13

MBD2

Gene ID

10165

64174

Gene namesolute carrier family 25 member 13dipeptidase 2
SynonymsARALAR2|CITRIN|CTLN2|NICCDMBD2
Cytomap

7q21.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding mitochondrial carrier protein Aralar2mitochondrial aspartate glutamate carrier 2solute carrier family 25 (aspartate/glutamate carrier), member 13dipeptidase 2
Modification date2020031320200313
UniProtAcc.

Q9UBB5

Ensembl transtripts involved in fusion geneENST00000265631, ENST00000416240, 
ENST00000542654, ENST00000494085, 
ENST00000398398, ENST00000579025, 
ENST00000583046, ENST00000256429, 
Fusion gene scores* DoF score17 X 13 X 11=243113 X 7 X 7=637
# samples 1715
** MAII scorelog2(17/2431*10)=-3.83794324189103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/637*10)=-2.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A13 [Title/Abstract] AND MBD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A13(95951254)-MBD2(51692536), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC25A13

GO:0006754

ATP biosynthetic process

12851387

HgeneSLC25A13

GO:0015810

aspartate transmembrane transport

11566871

HgeneSLC25A13

GO:0015813

L-glutamate transmembrane transport

11566871

HgeneSLC25A13

GO:0043490

malate-aspartate shuttle

11566871

HgeneSLC25A13

GO:0045333

cellular respiration

12851387

HgeneSLC25A13

GO:0051592

response to calcium ion

11566871


check buttonFusion gene breakpoints across SLC25A13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-1597-01BSLC25A13chr7

95951254

-MBD2chr18

51692536

-


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Fusion Gene ORF analysis for SLC25A13-MBD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265631ENST00000398398SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5CDS-intronENST00000265631ENST00000579025SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5CDS-intronENST00000265631ENST00000583046SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5CDS-intronENST00000416240ENST00000398398SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5CDS-intronENST00000416240ENST00000579025SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5CDS-intronENST00000416240ENST00000583046SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5UTR-3CDSENST00000542654ENST00000256429SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5UTR-intronENST00000542654ENST00000398398SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5UTR-intronENST00000542654ENST00000579025SLC25A13chr7

95951254

-MBD2chr18

51692536

-
5UTR-intronENST00000542654ENST00000583046SLC25A13chr7

95951254

-MBD2chr18

51692536

-
In-frameENST00000265631ENST00000256429SLC25A13chr7

95951254

-MBD2chr18

51692536

-
In-frameENST00000416240ENST00000256429SLC25A13chr7

95951254

-MBD2chr18

51692536

-
intron-3CDSENST00000494085ENST00000256429SLC25A13chr7

95951254

-MBD2chr18

51692536

-
intron-intronENST00000494085ENST00000398398SLC25A13chr7

95951254

-MBD2chr18

51692536

-
intron-intronENST00000494085ENST00000579025SLC25A13chr7

95951254

-MBD2chr18

51692536

-
intron-intronENST00000494085ENST00000583046SLC25A13chr7

95951254

-MBD2chr18

51692536

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265631SLC25A13chr795951254-ENST00000256429MBD2chr1851692536-3163152137547136
ENST00000416240SLC25A13chr795951254-ENST00000256429MBD2chr1851692536-3217206191601136

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265631ENST00000256429SLC25A13chr795951254-MBD2chr1851692536-0.0056628020.99433714
ENST00000416240ENST00000256429SLC25A13chr795951254-MBD2chr1851692536-0.0055726860.9944273

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Fusion Genomic Features for SLC25A13-MBD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A13-MBD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:95951254/chr18:51692536)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MBD2

Q9UBB5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMBD2chr7:95951254chr18:51692536ENST000005830460350_960303.0Compositional biasNote=Arg-rich
TgeneMBD2chr7:95951254chr18:51692536ENST00000583046036_1400303.0Compositional biasNote=Gly-rich
TgeneMBD2chr7:95951254chr18:51692536ENST0000058304603145_2130303.0DomainMBD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118100_1115676.0Calcium bindingNote=2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118171_1825676.0Calcium bindingNote=3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-11866_775676.0Calcium binding1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118100_1115677.0Calcium bindingNote=2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118171_1825677.0Calcium bindingNote=3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-11866_775677.0Calcium binding1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118125_1575676.0DomainEF-hand 3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118158_1935676.0DomainEF-hand 4
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-11851_865676.0DomainEF-hand 1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-11887_1225676.0DomainEF-hand 2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118125_1575677.0DomainEF-hand 3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118158_1935677.0DomainEF-hand 4
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-11851_865677.0DomainEF-hand 1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-11887_1225677.0DomainEF-hand 2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118296_3115676.0RegionLinker loop domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-1182_2955676.0RegionN-terminal domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118321_6125676.0RegionCarrier domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118613_6755676.0RegionC-terminal domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118296_3115677.0RegionLinker loop domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-1182_2955677.0RegionN-terminal domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118321_6125677.0RegionCarrier domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118613_6755677.0RegionC-terminal domain
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118326_4185676.0RepeatSolcar 1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118426_5105676.0RepeatSolcar 2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118518_6065676.0RepeatSolcar 3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118326_4185677.0RepeatSolcar 1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118426_5105677.0RepeatSolcar 2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118518_6065677.0RepeatSolcar 3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118332_3495676.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118393_4125676.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118436_4495676.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118485_5045676.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118524_5415676.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000265631-118581_6005676.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118332_3495677.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118393_4125677.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118436_4495677.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118485_5045677.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118524_5415677.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A13chr7:95951254chr18:51692536ENST00000416240-118581_6005677.0TransmembraneHelical%3B Name%3D6
TgeneMBD2chr7:95951254chr18:51692536ENST000002564292750_962801015.6666666666666Compositional biasNote=Arg-rich
TgeneMBD2chr7:95951254chr18:51692536ENST00000256429276_1402801015.6666666666666Compositional biasNote=Gly-rich
TgeneMBD2chr7:95951254chr18:51692536ENST0000025642927145_2132801015.6666666666666DomainMBD


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Fusion Gene Sequence for SLC25A13-MBD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82559_82559_1_SLC25A13-MBD2_SLC25A13_chr7_95951254_ENST00000265631_MBD2_chr18_51692536_ENST00000256429_length(transcript)=3163nt_BP=152nt
GGCCAGGAACGCACGCTGCCTGGCCGTATCGCCGCCCCCACCGCCGCCGCCGCCGGGACTAGAAGTGAGCCGCCCGGGTCCCAAACGCCA
GCCAGCCAGTCAGTGGGTCCCGCAGTCGCCCGCAACCGGGGCGAATCATGGCGGCCGCCAAGCTTTTCTGGGAGAAGAGGCTACAAGGAC
TTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGA
CCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTG
TTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTAC
GCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATG
AAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCCAAGAGAAAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTT
GCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTAATAGCACTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATC
TATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAAAATTAGTCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGC
TTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGTAAAACATTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATT
CTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTATATAAACATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTC
TTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAGACTGATTGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCC
CTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGGGCCTTAGGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGC
AGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTCACCAGAATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAA
TTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATAAGAATAAGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGA
CCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTTAAAGAATGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATC
AGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTAGACAGAGTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTA
CCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCTGTTGAAACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATA
TTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAAAATCAAAACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTA
TAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAAATCATTCTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTT
TTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAATTCCACATGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTT
CCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACTAGCTAGGTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTT
ATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGCTCAACTTTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAG
TCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAGCCAATTGGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTG
GGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGTATGACTAGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCG
AGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCACCTTGGTGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATAT
ATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTATACACATATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTC
AGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTGGGGACCATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACA
ACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCACCCTCTTCCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGT
TACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTTCCCTTGCTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCA
CCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAACTGCCTTTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCA
CCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACATAGTCATCAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTT
CCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAGCACACACTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTG
CCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTGTCCCTCCTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTG
TTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGCACAGTGCCTGGCACATAGTGGGTGCTCACATTGGAGCACACTATTGT

>82559_82559_1_SLC25A13-MBD2_SLC25A13_chr7_95951254_ENST00000265631_MBD2_chr18_51692536_ENST00000256429_length(amino acids)=136AA_BP=5
MAAAKLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVT

--------------------------------------------------------------
>82559_82559_2_SLC25A13-MBD2_SLC25A13_chr7_95951254_ENST00000416240_MBD2_chr18_51692536_ENST00000256429_length(transcript)=3217nt_BP=206nt
AATGGGCGGGCAGCATCCACATGACCCGCGCCGGCGGGAGGGCGTGGGGAGGCAGGCCAGGAACGCACGCTGCCTGGCCGTATCGCCGCC
CCCACCGCCGCCGCCGCCGGGACTAGAAGTGAGCCGCCCGGGTCCCAAACGCCAGCCAGCCAGTCAGTGGGTCCCGCAGTCGCCCGCAAC
CGGGGCGAATCATGGCGGCCGCCAAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAA
CCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAA
GCTCTGCGCCAATCACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTT
TTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCT
TGTCGCGAGCTGCTGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGAC
TTTCCCCAAGAGAAAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAG
CTTTTTAATAGCACTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAG
GACTTAAAATTAGTCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCA
CTTACGTAAAACATTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTT
CACTGTATATAAACATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATA
TTCACAGACTGATTGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGA
TCCCTGGGCCTTAGGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTG
TGCTTTCACCAGAATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAG
TTCTATAAGAATAAGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATT
GTTTTTTAAAGAATGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCA
GCTTCTAGACAGAGTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTC
TTTTTCTGTTGAAACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGA
TTTCTAAAATCAAAACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAA
AAGTAAAATCATTCTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTAT
GACCAATTCCACATGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAA
TATGACTAGCTAGGTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGA
TTTACGCTCAACTTTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCC
TGGGAAGCCAATTGGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAA
AGCTAGTATGACTAGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGT
AACTTCACCTTGGTGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACA
CAATGTATACACATATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTG
TCCCTTGGGGACCATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAAC
CTACCACCCTCTTCCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCT
GCCCTTTCCCTTGCTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTC
ATATGAACTGCCTTTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCC
TCCACATAGTCATCAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTT
TTAAGAGCACACACTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTT
GAGCCTGTCCCTCCTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGT

>82559_82559_2_SLC25A13-MBD2_SLC25A13_chr7_95951254_ENST00000416240_MBD2_chr18_51692536_ENST00000256429_length(amino acids)=136AA_BP=5
MAAAKLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVT

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Fusion Gene PPI Analysis for SLC25A13-MBD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A13-MBD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A13-MBD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource