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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A16-DRGX (FusionGDB2 ID:82571)

Fusion Gene Summary for SLC25A16-DRGX

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A16-DRGX
Fusion gene ID: 82571
HgeneTgene
Gene symbol

SLC25A16

DRGX

Gene ID

8034

644168

Gene namesolute carrier family 25 member 16dorsal root ganglia homeobox
SynonymsD10S105E|GDA|GDC|HGT.1|ML7|hML7DRG11|PRRXL1
Cytomap

10q21.3

10q11.23

Type of geneprotein-codingprotein-coding
Descriptiongraves disease carrier proteinmitochondrial solute carrier protein homologsolute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16dorsal root ganglia homeobox proteinpaired related homeobox-like 1paired-like homeodomain trancription factor DRG11
Modification date2020031320200313
UniProtAcc

P16260

.
Ensembl transtripts involved in fusion geneENST00000265870, ENST00000539557, 
ENST00000609923, 
ENST00000374139, 
ENST00000434016, 
Fusion gene scores* DoF score7 X 7 X 3=1472 X 2 X 2=8
# samples 72
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SLC25A16 [Title/Abstract] AND DRGX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A16(70248224)-DRGX(50574426), # samples:3
Anticipated loss of major functional domain due to fusion event.SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC25A16-DRGX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SLC25A16-DRGX seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC25A16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DRGX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-AA1V-06BSLC25A16chr10

70248224

-DRGXchr10

50574426

-


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Fusion Gene ORF analysis for SLC25A16-DRGX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265870ENST00000374139SLC25A16chr10

70248224

-DRGXchr10

50574426

-
5UTR-3CDSENST00000265870ENST00000434016SLC25A16chr10

70248224

-DRGXchr10

50574426

-
Frame-shiftENST00000539557ENST00000434016SLC25A16chr10

70248224

-DRGXchr10

50574426

-
Frame-shiftENST00000609923ENST00000374139SLC25A16chr10

70248224

-DRGXchr10

50574426

-
In-frameENST00000539557ENST00000374139SLC25A16chr10

70248224

-DRGXchr10

50574426

-
In-frameENST00000609923ENST00000434016SLC25A16chr10

70248224

-DRGXchr10

50574426

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000609923SLC25A16chr1070248224-ENST00000434016DRGXchr1050574426-113887290947285
ENST00000539557SLC25A16chr1070248224-ENST00000374139DRGXchr1050574426-31869963911071226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000609923ENST00000434016SLC25A16chr1070248224-DRGXchr1050574426-0.0090276940.9909723
ENST00000539557ENST00000374139SLC25A16chr1070248224-DRGXchr1050574426-0.0113014940.98869854

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Fusion Genomic Features for SLC25A16-DRGX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A16-DRGX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70248224/chr10:50574426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A16

P16260

.
FUNCTION: Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO:0000269|PubMed:11158296}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79128_216257333.0RepeatNote=Solcar 2
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-7934_120257333.0RepeatNote=Solcar 1
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79134_154257333.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79191_211257333.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-7937_57257333.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-7988_108257333.0TransmembraneHelical%3B Name%3D2
TgeneDRGXchr10:70248224chr10:50574426ENST0000037413946204_217175264.0MotifOAR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79238_328257333.0RepeatNote=Solcar 3
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79244_264257333.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A16chr10:70248224chr10:50574426ENST00000609923-79299_319257333.0TransmembraneHelical%3B Name%3D6
TgeneDRGXchr10:70248224chr10:50574426ENST000003741394633_92175264.0DNA bindingHomeobox


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Fusion Gene Sequence for SLC25A16-DRGX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82571_82571_1_SLC25A16-DRGX_SLC25A16_chr10_70248224_ENST00000539557_DRGX_chr10_50574426_ENST00000374139_length(transcript)=3186nt_BP=996nt
GTAAGTTGGCAACCTAGGCTCCTGACGCGACCCTGGTCCTGATGGCGGCGGCGACGGCCGCGGCAGCCCTGGCGGCGGCCGATCCCCCTC
CCGCAATGCCGCAGGCGGCAGGGGCCGGAGGGCCCACAACCCGCAGAGACTTCTACTGGCTGCGCTCCTTTCTGGCCGGAGAAGAAGAGG
AGTTTACTTCAAACAGAACCTGGCAATCGGATAAATACCTTCAAGTGTCTGTCTCCGTAAAAATGTTCCAGAAGAAGAGGAGGTTACTTC
AAACAGAACCTGGCAGTTGGATTAATACCTTGAAGTGTCTGTCTCCATAACCACATTTTAGCAAGATTCCCAGCCTTCCTCAGGTATTGC
TGGATGCTGTGCCAAAACAACAGTTGCTCCATTGGATCGAGTAAAGGTTTTATTACAAGCTCACAATCACCATTACAAGCATTTAGGAGT
ATTTTCTGCATTGCGTGCTGTTCCTCAAAAAGAAGGATTCCTTGGATTGTATAAAGGAAATGGTGCAATGATGATTCGAATCTTTCCCTA
TGGTGCAATCCAGTTTATGGCATTTGAGCATTATAAAACGTTAATTACTACGAAGCTGGGAATTTCAGGTCATGTGCACAGATTAATGGC
TGGATCCATGGCAGGTATGACAGCAGTTATCTGTACTTACCCTCTTGACATGGTTAGGGTCCGCCTAGCATTCCAGGTGAAAGGGGAACA
CAGCTATACAGGAATTATTCATGCTTTCAAAACAATTTATGCAAAGGAAGGTGGTTTCTTTGGATTTTACAGAGGTCTGATGCCTACTAT
TTTAGGAATGGCTCCATATGCAGGTGTTTCATTTTTTACTTTTGGTACCTTGAAGAGTGTTGGGCTTTCCCATGCTCCTACCCTTCTTGG
CAGACCTTCATCAGACAATCCTAATGTCTTAGTTTTGAAAACTCATGTAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCGCAGAC
AATATCGGGGCCCACTGTGCTCTTGCTGCGTCCCAGACCCCATGGGACTCTCCTTCCTTCCCACCTATGGCTGCCAGAGTAACCGCACGG
CCAGCGTGGCCACCCTGCGCATGAAGGCCCGCGAGCACTCAGAAGCTGTCCTGCAGTCAGCCAACCTCCTGCCTTCCACCAGCAGCAGCC
CCGGCCCTGTCGCCAAGCCGGCGCCCCCAGATGGCAGCCAGGAAAAGACCTCTCCCACCAAGGAACAGAGCGAGGCAGAGAAGAGTGTAT
GAGGGTCCACAGTGCCCCGCCCGGCCTGCCCTCCCCCGCCCCTCCTTCTCCCAGCCTCAGCCCCTACAGAAAACTCTCCAAATAGCAAGG
AGAAGCCTGCGGCCCCAGGGCCTCTGCATGGACCCAGGACGGGCAAGTGAGACCCACAGCTCCCTTGGCACCTGGAGCGTCCCTCTGGAG
TCCCACCAGTGCGGCAGTGTTGTCCTGGCTTCTTTGGCAACAGATCCCGATGGCACTTGGTGGCAGCAGAGCCCTCTCTGTGAGGAGCCT
CCCTGGGATTTCCATCCAGGCCCAGAGTCTCGGAGGGAGGTAGATTCCTCATCCGTCTCCCTTCCTATTTCCTCCCTGGGCTGCCTTTGA
AGGTCTTGTCAACCCCAGGAACTGTGGCATGGGCTGAAGTTTCATGAAAAGAAAAGGGCCTGTCCCGCTTACAGTGTTTAAGAACTGGGG
AACTGGTGGAACCCCAAGCGACTCTTGCTCCCCTGGACCAAGATGAGCAGTAATGCCCTTTCTCTTGTTGGAGAATATTGGTTGTGGGCT
TCATTACAAAGTGAGAAGATGCAGGGTAGGGAGGGGCCAACAGGACACAGCCTGTCCCAGAGGACCACGGTGGCTCTGACCCAGGAGATC
TCACTGGCACATCTGGCCGGGGGGCTGGGCTAATCACCCAGGCCACCTGCTCCATGAACTGGGGGCTGCTGTCTTGACACTGTGGGTGTG
GAACTAGTGTGGCCCCTGTACCTGAAGCACTCACCTGCAAGCCCTTCCTCTCTCCCAGATAGACCTGTGGATTGGTGGGAAGTTAAGCAA
CTGAAAAGCAGCTCTCTGGTCCAGGAGGGCCTGAGGGCCCTTGGAGAGGGAAGAAGCCCTTCAGGAATGCCTCTGAAGTAATTATGCATA
CAGATGAACTACCTTTCCCCACATGCCTGGCACGTAGAGGGGGCTCTTCAGTGGTGGTGGTTTTTTACTGGGGAAAAAAAAGTAGGAAAG
GAGACAGGAACGGCGTATGTGCAGATATGGAGCATGGGGAAGACAGCTTTCTCATGGTGTGGAGAGCATTAATTCCAAAGGGCCAAATTT
CACAGAGATTTCTGTTTTGGTCTAGTGTGGCTGTTTTCTCTGGTGAGGATGGTGACCTAGAGGAGATCCAAGGGGAACGTGCAATAGCAT
AAGCTCTGCCGCTTTCTGGCAGGGGCGCCCGGCATGGGAAAGGTTGCAGTCTTTGGTGGCTTTTGCTGATGGTGTTTCCATGCGGATGGT
TATTGCCTTCATGATGGTTATTTTGGTTTCAGTTATTATCGTCAAAATGTTTTACTTTCACATTTCCTGTCCCCTTTTTACCTTCCCCCA
CTCCATGACCCCCAAATAATACTCCTGAGTGTATCATGCCTTGTCTATGATCACTACGAAGCATTTGATAAAACCCACTGTCTCCTTTAA
AGAAAAAAATCAAATCCTTCTTCCTGCTGTATTTTGCTTGTTGAGTATAAAGATGAAACGATTTGCCAAAAAGCGGCAAAGTTGCTTCCG
TTTCCCTGTAATTACGAATGTTTGGTTGAAGGATGTAAGCTCAAGCCCTTATGTACACTAACTCTTCAATCTAATTGTTTGATTAAACTC
GTATTTCCTCCAGAAAGGTACATAAATAAGTGAACTGTTGAGCAAATTAAGAATACTTAACAGCATTGCATCTGAAAAGTAGTTATGCTG
ATTAAATTTTGTGTCCTTGAGGACTTTCAGGAAATTACTTTTGATCGTCAATAACACAATTAAGTAAACTACACACACATTAGCATGAAT
AATTGATAAGAAATTATGTATTACCACGAAGCACTGATTTAATAATTCATGATGCGACACTCTAGTGACTGTGCAAAACTGGATCATATC

>82571_82571_1_SLC25A16-DRGX_SLC25A16_chr10_70248224_ENST00000539557_DRGX_chr10_50574426_ENST00000374139_length(amino acids)=226AA_BP=202
MDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVI
CTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVL

--------------------------------------------------------------
>82571_82571_2_SLC25A16-DRGX_SLC25A16_chr10_70248224_ENST00000609923_DRGX_chr10_50574426_ENST00000434016_length(transcript)=1138nt_BP=872nt
GCGGGGCGGTCAGCCTCCTGTCACCGCCTGTTCCGGCTATGGTCCCGTCCGGTGTTCTGTAAGTTGGCAACCTAGGCTCCTGACGCGACC
CTGGTCCTGATGGCGGCGGCGACGGCCGCGGCAGCCCTGGCGGCGGCCGATCCCCCTCCCGCAATGCCGCAGGCGGCAGGGGCCGGAGGG
CCCACAACCCGCAGAGACTTCTACTGGCTGCGCTCCTTTCTGGCCGGAGGTATTGCTGGATGCTGTGCCAAAACAACAGTTGCTCCATTG
GATCGAGTAAAGGTTTTATTACAAGCTCACAATCACCATTACAAGCATTTAGGAGTATTTTCTGCATTGCGTGCTGTTCCTCAAAAAGAA
GGATTCCTTGGATTGTATAAAGGAAATGGTGCAATGATGATTCGAATCTTTCCCTATGGTGCAATCCAGTTTATGGCATTTGAGCATTAT
AAAACGTTAATTACTACGAAGCTGGGAATTTCAGGTCATGTGCACAGATTAATGGCTGGATCCATGGCAGGTATGACAGCAGTTATCTGT
ACTTACCCTCTTGACATGGTTAGGGTCCGCCTAGCATTCCAGGTGAAAGGGGAACACAGCTATACAGGAATTATTCATGCTTTCAAAACA
ATTTATGCAAAGGAAGGTGGTTTCTTTGGATTTTACAGAGGTCTGATGCCTACTATTTTAGGAATGGCTCCATATGCAGGTGTTTCATTT
TTTACTTTTGGTACCTTGAAGAGTGTTGGGCTTTCCCATGCTCCTACCCTTCTTGGCAGACCTTCATCAGACAATCCTAATGTCTTAGTT
TTGAAAACTCATGTAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCGCAGACAATATCGGGGCCCACTGTGCTCTTGCTGCGTCCC
AGACCCCATGGGACTCTCCTTCCTTCCCACCTATGGCTGCCAGAGTAACCGCACGGCCAGCGTGGCCACCCTGCGCATGAAGGCCCGCGA
GCACTCAGAAGCTGTCCTGCAGTCAGCCAACCTCCTGCCTTCCACCAGCAGCAGCCCCGGCCCTGTCGCCAAGCCGGCGCCCCCAGATGG

>82571_82571_2_SLC25A16-DRGX_SLC25A16_chr10_70248224_ENST00000609923_DRGX_chr10_50574426_ENST00000434016_length(amino acids)=285AA_BP=261
MVLMAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKE
GFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKT
IYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISGPTVLLLRP

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Fusion Gene PPI Analysis for SLC25A16-DRGX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A16-DRGX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A16-DRGX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource