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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A17-ST13 (FusionGDB2 ID:82584)

Fusion Gene Summary for SLC25A17-ST13

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A17-ST13
Fusion gene ID: 82584
HgeneTgene
Gene symbol

SLC25A17

ST13

Gene ID

10478

6767

Gene namesolute carrier family 25 member 17ST13 Hsp70 interacting protein
SynonymsPMP34AAG2|FAM10A1|FAM10A4|HIP|HOP|HSPABP|HSPABP1|P48|PRO0786|SNC6
Cytomap

22q13.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal membrane protein PMP34solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17hsc70-interacting proteinHsp70-interacting proteinaging-associated protein 2heat shock 70kD protein binding proteinprogesterone receptor-associated p48 proteinputative tumor suppressor ST13renal carcinoma antigen NY-REN-33suppression of tumorigenic
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000491545, ENST00000544408, 
ENST00000435456, ENST00000542412, 
ENST00000402844, 		ENST00000216218, 
Fusion gene scores* DoF score7 X 6 X 6=2529 X 8 X 6=432
# samples 913
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/432*10)=-1.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A17 [Title/Abstract] AND ST13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A17(41215199)-ST13(41240913), # samples:2
SLC25A17(41169941)-ST13(41246884), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC25A17-ST13 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC25A17-ST13 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC25A17-ST13 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC25A17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ST13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07L-01ASLC25A17chr22

41215199

-ST13chr22

41240913

-
ChimerDB4BRCATCGA-A8-A07LSLC25A17chr22

41215198

-ST13chr22

41244373

-
ChimerDB4LUADTCGA-55-7911-01ASLC25A17chr22

41169941

-ST13chr22

41246884

-


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Fusion Gene ORF analysis for SLC25A17-ST13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000491545ENST00000216218SLC25A17chr22

41215199

-ST13chr22

41240913

-
5UTR-3CDSENST00000491545ENST00000216218SLC25A17chr22

41215198

-ST13chr22

41244373

-
5UTR-3CDSENST00000491545ENST00000216218SLC25A17chr22

41169941

-ST13chr22

41246884

-
5UTR-3CDSENST00000544408ENST00000216218SLC25A17chr22

41215199

-ST13chr22

41240913

-
5UTR-3CDSENST00000544408ENST00000216218SLC25A17chr22

41215198

-ST13chr22

41244373

-
Frame-shiftENST00000435456ENST00000216218SLC25A17chr22

41215199

-ST13chr22

41240913

-
Frame-shiftENST00000542412ENST00000216218SLC25A17chr22

41215199

-ST13chr22

41240913

-
Frame-shiftENST00000544408ENST00000216218SLC25A17chr22

41169941

-ST13chr22

41246884

-
In-frameENST00000402844ENST00000216218SLC25A17chr22

41169941

-ST13chr22

41246884

-
In-frameENST00000435456ENST00000216218SLC25A17chr22

41215198

-ST13chr22

41244373

-
In-frameENST00000435456ENST00000216218SLC25A17chr22

41169941

-ST13chr22

41246884

-
In-frameENST00000542412ENST00000216218SLC25A17chr22

41215198

-ST13chr22

41244373

-
In-frameENST00000542412ENST00000216218SLC25A17chr22

41169941

-ST13chr22

41246884

-
intron-3CDSENST00000402844ENST00000216218SLC25A17chr22

41215199

-ST13chr22

41240913

-
intron-3CDSENST00000402844ENST00000216218SLC25A17chr22

41215198

-ST13chr22

41244373

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC25A17-ST13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A17-ST13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41215199/chr22:41240913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-897_92258308.0RepeatNote=Solcar 1
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-8999_192258308.0RepeatNote=Solcar 2
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89126_160258308.0Topological domainLumenal
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89182_202258308.0Topological domainCytoplasmic
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-891_9258308.0Topological domainNote=Cytoplasmic
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-8931_66258308.0Topological domainLumenal
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-8988_104258308.0Topological domainCytoplasmic
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-191_918308.0Topological domainNote=Cytoplasmic
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89105_125258308.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-8910_30258308.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89161_181258308.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89203_223258308.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-8967_87258308.0TransmembraneHelical%3B Name%3D2
TgeneST13chr22:41169941chr22:41246884ENST00000216218012279_31236370.0Compositional biasNote=Gly/Met/Pro-rich
TgeneST13chr22:41215198chr22:41244373ENST00000216218112279_31256370.0Compositional biasNote=Gly/Met/Pro-rich
TgeneST13chr22:41169941chr22:41246884ENST00000216218012319_35836370.0DomainNote=STI1
TgeneST13chr22:41215198chr22:41244373ENST00000216218112319_35856370.0DomainNote=STI1
TgeneST13chr22:41169941chr22:41246884ENST00000216218012114_14736370.0RepeatNote=TPR 1
TgeneST13chr22:41169941chr22:41246884ENST00000216218012148_18136370.0RepeatNote=TPR 2
TgeneST13chr22:41169941chr22:41246884ENST00000216218012182_21536370.0RepeatNote=TPR 3
TgeneST13chr22:41215198chr22:41244373ENST00000216218112114_14756370.0RepeatNote=TPR 1
TgeneST13chr22:41215198chr22:41244373ENST00000216218112148_18156370.0RepeatNote=TPR 2
TgeneST13chr22:41215198chr22:41244373ENST00000216218112182_21556370.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89200_294258308.0RepeatNote=Solcar 3
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19200_29418308.0RepeatNote=Solcar 3
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-197_9218308.0RepeatNote=Solcar 1
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-1999_19218308.0RepeatNote=Solcar 2
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89224_280258308.0Topological domainLumenal
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89302_307258308.0Topological domainNote=Cytoplasmic
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19126_16018308.0Topological domainLumenal
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19182_20218308.0Topological domainCytoplasmic
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19224_28018308.0Topological domainLumenal
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19302_30718308.0Topological domainNote=Cytoplasmic
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-1931_6618308.0Topological domainLumenal
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-1988_10418308.0Topological domainCytoplasmic
HgeneSLC25A17chr22:41169941chr22:41246884ENST00000435456-89281_301258308.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19105_12518308.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-1910_3018308.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19161_18118308.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19203_22318308.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-19281_30118308.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A17chr22:41215198chr22:41244373ENST00000435456-1967_8718308.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for SLC25A17-ST13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC25A17-ST13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A17-ST13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A17-ST13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource