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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A36-PEX5L (FusionGDB2 ID:82658)

Fusion Gene Summary for SLC25A36-PEX5L

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A36-PEX5L
Fusion gene ID: 82658
HgeneTgene
Gene symbol

SLC25A36

PEX5L

Gene ID

55186

51555

Gene namesolute carrier family 25 member 36peroxisomal biogenesis factor 5 like
SynonymsPNC2PEX5R|PEX5RP|PXR2|PXR2B|TRIP8b
Cytomap

3q23

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 25 member 36epididymis secretory sperm binding proteinsolute carrier family 25 (pyrimidine nucleotide carrier ), member 36PEX5-related proteinHCN channel auxiliary subunitPEX2-related proteinPEX5-like proteinPex5p-related proteinperoxin-5-related proteinperoxisome biogenesis factor 5-liketetratricopeptide repeat-containing Rab8b-interacting protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000393015, ENST00000324194, 
ENST00000446041, ENST00000453248, 
ENST00000507429, 		ENST00000263962, 
ENST00000392649, ENST00000467460, 
ENST00000468741, ENST00000476138, 
ENST00000485199, ENST00000464614, 
ENST00000465751, ENST00000467440, 
ENST00000472994, 
Fusion gene scores* DoF score9 X 9 X 5=40511 X 12 X 6=792
# samples 1011
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/792*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A36 [Title/Abstract] AND PEX5L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A36(140660937)-PEX5L(179533792), # samples:4
Anticipated loss of major functional domain due to fusion event.SLC25A36-PEX5L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC25A36

GO:0000002

mitochondrial genome maintenance

25320081

HgeneSLC25A36

GO:0006864

pyrimidine nucleotide transport

25320081

HgeneSLC25A36

GO:0007005

mitochondrion organization

25320081

HgeneSLC25A36

GO:0051881

regulation of mitochondrial membrane potential

25320081


check buttonFusion gene breakpoints across SLC25A36 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PEX5L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-6175-01ASLC25A36chr3

140660937

-PEX5Lchr3

179533792

-
ChimerDB4LUSCTCGA-85-6175-01ASLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
ChimerDB4LUSCTCGA-85-6175SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-


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Fusion Gene ORF analysis for SLC25A36-PEX5L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000393015ENST00000263962SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-3CDSENST00000393015ENST00000392649SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-3CDSENST00000393015ENST00000467460SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-3CDSENST00000393015ENST00000468741SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-3CDSENST00000393015ENST00000476138SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-3CDSENST00000393015ENST00000485199SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-5UTRENST00000393015ENST00000464614SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-5UTRENST00000393015ENST00000465751SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-5UTRENST00000393015ENST00000467440SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
3UTR-5UTRENST00000393015ENST00000472994SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000324194ENST00000464614SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000324194ENST00000465751SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000324194ENST00000467440SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000324194ENST00000472994SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000446041ENST00000464614SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000446041ENST00000465751SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000446041ENST00000467440SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000446041ENST00000472994SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000453248ENST00000464614SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000453248ENST00000465751SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000453248ENST00000467440SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000453248ENST00000472994SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000507429ENST00000464614SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000507429ENST00000465751SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000507429ENST00000467440SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
5CDS-5UTRENST00000507429ENST00000472994SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000263962SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000392649SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000467460SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000468741SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000476138SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000324194ENST00000485199SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000263962SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000392649SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000467460SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000468741SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000476138SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000446041ENST00000485199SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000263962SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000392649SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000467460SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000468741SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000476138SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000453248ENST00000485199SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000263962SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000392649SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000467460SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000468741SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000476138SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-
Frame-shiftENST00000507429ENST00000485199SLC25A36chr3

140660937

+PEX5Lchr3

179533792

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC25A36-PEX5L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A36-PEX5L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:140660937/:179533792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC25A36-PEX5L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC25A36-PEX5L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A36-PEX5L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A36-PEX5L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource