FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SLC25A3-LAMB1 (FusionGDB2 ID:82682)

Fusion Gene Summary for SLC25A3-LAMB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A3-LAMB1
Fusion gene ID: 82682
HgeneTgene
Gene symbol

SLC25A3

LAMB1

Gene ID

5250

3912

Gene namesolute carrier family 25 member 3laminin subunit beta 1
SynonymsOK/SW-cl.48|PHC|PTPCLM|LIS5
Cytomap

12q23.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionphosphate carrier protein, mitochondrialphosphate transport proteinsolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3laminin subunit beta-1laminin B1 chainlaminin, beta 1
Modification date2020031320200313
UniProtAcc.

P07942

Ensembl transtripts involved in fusion geneENST00000188376, ENST00000228318, 
ENST00000401722, ENST00000547534, 
ENST00000548847, ENST00000549338, 
ENST00000551917, ENST00000552981, 
ENST00000551265, 		ENST00000393560, 
ENST00000474380, ENST00000393561, 
ENST00000222399, 
Fusion gene scores* DoF score13 X 12 X 4=6249 X 9 X 2=162
# samples 139
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A3 [Title/Abstract] AND LAMB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A3(98991808)-LAMB1(107564415), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC25A3-LAMB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC25A3-LAMB1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLAMB1

GO:0030335

positive regulation of cell migration

16289578

TgeneLAMB1

GO:0031175

neuron projection development

15894315

TgeneLAMB1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneLAMB1

GO:0042476

odontogenesis

15894315


check buttonFusion gene breakpoints across SLC25A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAMB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN410000SLC25A3chr12

98991808

+LAMB1chr7

107564415

-


Top

Fusion Gene ORF analysis for SLC25A3-LAMB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000188376ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000188376ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000228318ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000228318ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000401722ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000401722ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000547534ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000547534ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000548847ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000548847ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000549338ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000549338ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000551917ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000551917ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000552981ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
5CDS-intronENST00000552981ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000188376ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000228318ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000401722ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000547534ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000547534ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000548847ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000549338ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000551917ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
Frame-shiftENST00000552981ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000188376ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000228318ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000401722ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000548847ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000549338ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000551917ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
In-frameENST00000552981ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
intron-3CDSENST00000551265ENST00000222399SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
intron-3CDSENST00000551265ENST00000393561SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
intron-intronENST00000551265ENST00000393560SLC25A3chr12

98991808

+LAMB1chr7

107564415

-
intron-intronENST00000551265ENST00000474380SLC25A3chr12

98991808

+LAMB1chr7

107564415

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401722SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-762609150641163
ENST00000228318SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-73558293614173
ENST00000188376SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-966813138845235
ENST00000551917SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-70655391585164
ENST00000552981SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-69754458576172
ENST00000549338SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-66551253544163
ENST00000548847SLC25A3chr1298991808+ENST00000222399LAMB1chr7107564415-86671338745235

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401722ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.0234344770.97656554
ENST00000228318ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.0171100050.98288995
ENST00000188376ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.0704074050.92959255
ENST00000551917ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.0175536680.9824463
ENST00000552981ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.0291658120.97083414
ENST00000549338ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.034996020.965004
ENST00000548847ENST00000222399SLC25A3chr1298991808+LAMB1chr7107564415-0.063546420.9364536

Top

Fusion Genomic Features for SLC25A3-LAMB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC25A3-LAMB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:98991808/chr7:107564415)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAMB1

P07942

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+3763_147153362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+4863_147154363.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+4863_147153362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+4863_147153362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+4863_147154363.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+4863_147153362.0RepeatNote=Solcar 1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+3750_63153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+3787_121153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+4850_63154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+4887_121154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+4850_63153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+4887_121153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+4850_63153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+4887_121153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+4850_63154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+4887_121154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+4850_63153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+4887_121153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37122_141153362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+3764_86153362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48122_141154363.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+4864_86154363.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48122_141153362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+4864_86153362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48122_141153362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+4864_86153362.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48122_141154363.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+4864_86154363.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48122_141153362.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+4864_86153362.0TransmembraneHelical%3B Name%3D1
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341216_131501787.0Coiled coilOntology_term=ECO:0000255
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341353_138801787.0Coiled coilOntology_term=ECO:0000255
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341442_178101787.0Coiled coilOntology_term=ECO:0000255
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341028_108301787.0DomainLaminin EGF-like 11
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341084_113101787.0DomainLaminin EGF-like 12
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341132_117801787.0DomainLaminin EGF-like 13
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034271_33401787.0DomainLaminin EGF-like 1
TgeneLAMB1chr12:98991808chr7:107564415ENST0000022239903431_27001787.0DomainLaminin N-terminal
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034335_39701787.0DomainLaminin EGF-like 2
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034398_45701787.0DomainLaminin EGF-like 3
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034458_50901787.0DomainLaminin EGF-like 4
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034510_54001787.0DomainLaminin EGF-like 5%3B truncated
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034549_76701787.0DomainLaminin IV type B
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034773_82001787.0DomainLaminin EGF-like 6
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034821_86601787.0DomainLaminin EGF-like 7
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034867_91601787.0DomainLaminin EGF-like 8
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034917_97501787.0DomainLaminin EGF-like 9
TgeneLAMB1chr12:98991808chr7:107564415ENST00000222399034976_102701787.0DomainLaminin EGF-like 10
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341179_139701787.0RegionNote=Domain II
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341398_143001787.0RegionNote=Domain alpha
TgeneLAMB1chr12:98991808chr7:107564415ENST000002223990341431_178601787.0RegionNote=Domain I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37160_244153362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37261_339153362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48160_244154363.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48261_339154363.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48160_244153362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48261_339153362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48160_244153362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48261_339153362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48160_244154363.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48261_339154363.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48160_244153362.0RepeatNote=Solcar 2
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48261_339153362.0RepeatNote=Solcar 3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37142_161153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37184_218153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37239_261153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37285_314153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37334_362153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48142_161154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48184_218154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48239_261154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48285_314154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48334_362154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48142_161153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48184_218153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48239_261153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48285_314153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48334_362153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48142_161153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48184_218153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48239_261153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48285_314153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48334_362153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48142_161154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48184_218154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48239_261154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48285_314154363.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48334_362154363.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48142_161153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48184_218153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48239_261153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48285_314153362.0Topological domainMitochondrial matrix
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48334_362153362.0Topological domainMitochondrial intermembrane
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37162_183153362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37219_238153362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37262_284153362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000188376+37315_333153362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48162_183154363.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48219_238154363.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48262_284154363.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000228318+48315_333154363.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48162_183153362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48219_238153362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48262_284153362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000401722+48315_333153362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48162_183153362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48219_238153362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48262_284153362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000549338+48315_333153362.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48162_183154363.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48219_238154363.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48262_284154363.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000551917+48315_333154363.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48162_183153362.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48219_238153362.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48262_284153362.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A3chr12:98991808chr7:107564415ENST00000552981+48315_333153362.0TransmembraneHelical%3B Name%3D6


Top

Fusion Gene Sequence for SLC25A3-LAMB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82682_82682_1_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000188376_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=966nt_BP=813nt
GTGTGCGTCACGCCGACGACGCGCGAAGGGCACACATCTTAGGACCCGGAGGACGTCCGGCCTCTGTGAGCCGCAACCTTTCCAAGGGAG
TGGTTGTGTGATCGCCATCTTAGGGAGTGAGTGTGGCCGGGCCTTCTCCTGTGGCGGGTGTGGGGAGCGGAGCCCAGAGCTCCTGTGGGG
CCGCTGCTTTGGCGGTGGGCCCAGCCGGGAGCAGCCTCTTTCGAAGGCCGCCGTGACCTCTTCAAGGGCGTGGAGACGGGAAGGAAAAGG
CCCCGGTTGGGGTTCCAGGGCGCCGGTAACGTTAACCGGCGCCTTGCCTGTCCTCTAACCGTCGCTCCCTCCTCCCCTAGAAAGATGTTC
TCGTCCGTGGCGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGC
TCCCCAGGGCCCACGGGCCAGCCCCGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGTACAGTTGTGAATTTGGCTCCGCGAAG
TATTATGCACTGTGTGGCTTTGGTGGGGTCTTAAGTTGTGGTCTGACACACACTGCTGTGGTTCCCCTGGATTTAGTGAAATGCCGTATG
CAGGTGGACCCCCAAAAGTACAAGGGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATGG
GCTCCGACTTTCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGA
GAGTGTATAGCACATGCTTGTAACAGAGGAGAATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAACTGACTTAAT

>82682_82682_1_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000188376_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=235AA_BP=
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSV

--------------------------------------------------------------
>82682_82682_2_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000228318_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=735nt_BP=582nt
GTGTGCGTCACGCCGACGACGCGCGAAGGGCACACATCTTAGGACCCGGAGGACGTCCGGCCTCTGTGAGCCGCAACCTTTCCAAGGGAG
TGGTTGTGTGATCGCCATCTTAGGGAAAAGATGTTCTCGTCCGTGGCGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAG
CTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGCTCCCCAGGGCCCACGGGCCAGCCCCGCCGCCCTCGCAACCTGGCAGCCGCCGCC
GTGGAAGAGCAGTATAGCTGTGACTATGGATCTGGCAGATTCTTTATCCTTTGTGGACTTGGAGGAATTATTAGCTGTGGCACAACACAT
ACAGCATTGGTTCCTCTAGATCTGGTTAAATGCAGAATGCAGGTGGACCCCCAAAAGTACAAGGGCATATTTAACGGATTCTCAGTTACA
CTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATGGGCTCCGACTTTCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTT
TATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGAGAGTGTATAGCACATGCTTGTAACAGAGGAGAATAAAAAATGGCTGAGGTG
AACAAGGTAAAACAACTACATTTTAAAAACTGACTTAATGCTCTTCAAAATAAAACATCACCTATTTAATGTTTTTAATCACATTTTGTA

>82682_82682_2_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000228318_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=173AA_BP=
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHT

--------------------------------------------------------------
>82682_82682_3_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000401722_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=762nt_BP=609nt
ACCAATGGGCGACGCGTACTTGCAGTGGCGCGCTGTGTGCGTCACGCCGACGACGCGCGAAGGGCACACATCTTAGGACCCGGAGGACGT
CCGGCCTCTGTGAGCCGCAACCTTTCCAAGGGAGTGGTTGTGTGATCGCCATCTTAGGGAATGTTCTCGTCCGTGGCGCACCTGGCGCGG
GCGAACCCCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGCTCCCCAGGGCCCACGGGCCAGCCC
CGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGTACAGTTGTGAATTTGGCTCCGCGAAGTATTATGCACTGTGTGGCTTTGGT
GGGGTCTTAAGTTGTGGTCTGACACACACTGCTGTGGTTCCCCTGGATTTAGTGAAATGCCGTATGCAGGTGGACCCCCAAAAGTACAAG
GGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATGGGCTCCGACTTTCCTTGGCTACTCC
ATGCAGGGACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGAGAGTGTATAGCACATGCTTGTAAC
AGAGGAGAATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAACTGACTTAATGCTCTTCAAAATAAAACATCACCT

>82682_82682_3_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000401722_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=163AA_BP=
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKC

--------------------------------------------------------------
>82682_82682_4_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000548847_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=866nt_BP=713nt
ATCGCCATCTTAGGGAGTGAGTGTGGCCGGGCCTTCTCCTGTGGCGGGTGTGGGGAGCGGAGCCCAGAGCTCCTGTGGGGCCGCTGCTTT
GGCGGTGGGCCCAGCCGGGAGCAGCCTCTTTCGAAGGCCGCCGTGACCTCTTCAAGGGCGTGGAGACGGGAAGGAAAAGGCCCCGGTTGG
GGTTCCAGGGCGCCGGTAACGTTAACCGGCGCCTTGCCTGTCCTCTAACCGTCGCTCCCTCCTCCCCTAGAAAGATGTTCTCGTCCGTGG
CGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGCTCCCCAGGGC
CCACGGGCCAGCCCCGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGTACAGTTGTGAATTTGGCTCCGCGAAGTATTATGCAC
TGTGTGGCTTTGGTGGGGTCTTAAGTTGTGGTCTGACACACACTGCTGTGGTTCCCCTGGATTTAGTGAAATGCCGTATGCAGGTGGACC
CCCAAAAGTACAAGGGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATGGGCTCCGACTT
TCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGAGAGTGTATAG
CACATGCTTGTAACAGAGGAGAATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAACTGACTTAATGCTCTTCAAA

>82682_82682_4_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000548847_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=235AA_BP=
MWRVWGAEPRAPVGPLLWRWAQPGAASFEGRRDLFKGVETGRKRPRLGFQGAGNVNRRLACPLTVAPSSPRKMFSSVAHLARANPFNTPH
LQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSV

--------------------------------------------------------------
>82682_82682_5_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000549338_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=665nt_BP=512nt
CGCAACCTTTCCAAGGGAGTGGTTGTGTGATCGCCATCTTAGGGAGTGAAAAGATGTTCTCGTCCGTGGCGCACCTGGCGCGGGCGAACC
CCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAGCTCCCCAGGGCCCACGGGCCAGCCCCGCCGCC
CTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGTACAGTTGTGAATTTGGCTCCGCGAAGTATTATGCACTGTGTGGCTTTGGTGGGGTCT
TAAGTTGTGGTCTGACACACACTGCTGTGGTTCCCCTGGATTTAGTGAAATGCCGTATGCAGGTGGACCCCCAAAAGTACAAGGGCATAT
TTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATGGGCTCCGACTTTCCTTGGCTACTCCATGCAGG
GACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGGAGAGTGTATAGCACATGCTTGTAACAGAGGAG
AATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAACTGACTTAATGCTCTTCAAAATAAAACATCACCTATTTAAT

>82682_82682_5_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000549338_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=163AA_BP=
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKC

--------------------------------------------------------------
>82682_82682_6_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000551917_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=706nt_BP=553nt
AAGGGCACACATCTTAGGACCCGGAGGACGTCCGGCCTCTGTGAGCCGCAACCTTTCCAAGGGAGTGGTTGTGTGATCGCCATCTTAGGG
AATGTTCTCGTCCGTGGCGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCG
CAGCAGCTCCCCAGGGCCCACGGGCCAGCCCCGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGCAGTATAGCTGTGACTATGG
ATCTGGCAGATTCTTTATCCTTTGTGGACTTGGAGGAATTATTAGCTGTGGCACAACACATACAGCATTGGTTCCTCTAGATCTGGTTAA
ATGCAGAATGCAGGTGGACCCCCAAAAGTACAAGGGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGC
TAAAGGATGGGCTCCGACTTTCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAA
TATGCTTGGAGAGTGTATAGCACATGCTTGTAACAGAGGAGAATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAA

>82682_82682_6_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000551917_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=164AA_BP=
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVK

--------------------------------------------------------------
>82682_82682_7_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000552981_LAMB1_chr7_107564415_ENST00000222399_length(transcript)=697nt_BP=544nt
ATCTTAGGACCCGGAGGACGTCCGGCCTCTGTGAGCCGCAACCTTTCCAAGGGAGTGGTTGTGTGATCGCCATCTTAGGGAAAAGATGTT
CTCGTCCGTGGCGCACCTGGCGCGGGCGAACCCCTTCAACACGCCACATCTGCAGCTGGTGCACGATGGTCTCGGGGACCTCCGCAGCAG
CTCCCCAGGGCCCACGGGCCAGCCCCGCCGCCCTCGCAACCTGGCAGCCGCCGCCGTGGAAGAGTACAGTTGTGAATTTGGCTCCGCGAA
GTATTATGCACTGTGTGGCTTTGGTGGGGTCTTAAGTTGTGGTCTGACACACACTGCTGTGGTTCCCCTGGATTTAGTGAAATGCCGTAT
GCAGGTGGACCCCCAAAAGTACAAGGGCATATTTAACGGATTCTCAGTTACACTTAAAGAGGATGGTGTTCGTGGTTTGGCTAAAGGATG
GGCTCCGACTTTCCTTGGCTACTCCATGCAGGGACTCTGCAAGTTTGGCTTTTATGAAGTCTTTAAAGTCTTGTATAGCAATATGCTTGG
AGAGTGTATAGCACATGCTTGTAACAGAGGAGAATAAAAAATGGCTGAGGTGAACAAGGTAAAACAACTACATTTTAAAAACTGACTTAA

>82682_82682_7_SLC25A3-LAMB1_SLC25A3_chr12_98991808_ENST00000552981_LAMB1_chr7_107564415_ENST00000222399_length(amino acids)=172AA_BP=
MCDRHLREKMFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SLC25A3-LAMB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SLC25A3-LAMB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SLC25A3-LAMB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource