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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A42-GATAD2A (FusionGDB2 ID:82694)

Fusion Gene Summary for SLC25A42-GATAD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A42-GATAD2A
Fusion gene ID: 82694
HgeneTgene
Gene symbol

SLC25A42

GATAD2A

Gene ID

284439

54815

Gene namesolute carrier family 25 member 42GATA zinc finger domain containing 2A
SynonymsMECRENp66alpha
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial coenzyme A transporter SLC25A42transcriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A
Modification date2020031320200313
UniProtAcc.

Q86YP4

Ensembl transtripts involved in fusion geneENST00000600275, ENST00000318596, 
ENST00000252577, ENST00000358713, 
ENST00000360315, ENST00000404158, 
ENST00000429563, ENST00000537887, 
ENST00000473184, 
Fusion gene scores* DoF score6 X 4 X 5=12011 X 10 X 9=990
# samples 614
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/990*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A42 [Title/Abstract] AND GATAD2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A42(19217194)-GATAD2A(19616153), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC25A42-GATAD2A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC25A42-GATAD2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC25A42-GATAD2A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SLC25A42-GATAD2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SLC25A42-GATAD2A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC25A42

GO:0015866

ADP transport

19429682

HgeneSLC25A42

GO:0015867

ATP transport

19429682

HgeneSLC25A42

GO:0035349

coenzyme A transmembrane transport

19429682

HgeneSLC25A42

GO:0080121

AMP transport

19429682

TgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469


check buttonFusion gene breakpoints across SLC25A42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GATAD2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1364-01ASLC25A42chr19

19217194

+GATAD2Achr19

19616153

+


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Fusion Gene ORF analysis for SLC25A42-GATAD2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000600275ENST00000252577SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-3CDSENST00000600275ENST00000358713SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-3CDSENST00000600275ENST00000360315SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-3CDSENST00000600275ENST00000404158SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-3CDSENST00000600275ENST00000429563SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-3CDSENST00000600275ENST00000537887SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
3UTR-intronENST00000600275ENST00000473184SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
5CDS-intronENST00000318596ENST00000473184SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
Frame-shiftENST00000318596ENST00000358713SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
Frame-shiftENST00000318596ENST00000404158SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
Frame-shiftENST00000318596ENST00000429563SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
Frame-shiftENST00000318596ENST00000537887SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
In-frameENST00000318596ENST00000252577SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+
In-frameENST00000318596ENST00000360315SLC25A42chr19

19217194

+GATAD2Achr19

19616153

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318596SLC25A42chr1919217194+ENST00000252577GATAD2Achr1919616153+4236648112837241
ENST00000318596SLC25A42chr1919217194+ENST00000360315GATAD2Achr1919616153+4236648112837241

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318596ENST00000252577SLC25A42chr1919217194+GATAD2Achr1919616153+0.207938420.7920616
ENST00000318596ENST00000360315SLC25A42chr1919217194+GATAD2Achr1919616153+0.207938420.7920616

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Fusion Genomic Features for SLC25A42-GATAD2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC25A42chr1919217194+GATAD2Achr1919616152+0.0149910920.98500896
SLC25A42chr1919217194+GATAD2Achr1919616152+0.0149910920.98500896

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC25A42-GATAD2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19217194/chr19:19616153)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GATAD2A

Q86YP4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+6831_117165319.0RepeatNote=Solcar 1
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68135_155165319.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+6833_53165319.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+6889_109165319.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68129_214165319.0RepeatNote=Solcar 2
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68224_312165319.0RepeatNote=Solcar 3
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68186_206165319.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68230_250165319.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A42chr19:19217194chr19:19616153ENST00000318596+68293_313165319.0TransmembraneHelical%3B Name%3D6
TgeneGATAD2Achr19:19217194chr19:19616153ENST00000252577911139_174565609.0Coiled coilOntology_term=ECO:0000255
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003587131012139_174590634.0Coiled coilOntology_term=ECO:0000255
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003603151012139_174590634.0Coiled coilOntology_term=ECO:0000255
TgeneGATAD2Achr19:19217194chr19:19616153ENST000004041581214139_174591635.0Coiled coilOntology_term=ECO:0000255
TgeneGATAD2Achr19:19217194chr19:19616153ENST00000252577911340_480565609.0RegionCR2%3B histone tail-binding
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003587131012340_480590634.0RegionCR2%3B histone tail-binding
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003603151012340_480590634.0RegionCR2%3B histone tail-binding
TgeneGATAD2Achr19:19217194chr19:19616153ENST000004041581214340_480591635.0RegionCR2%3B histone tail-binding
TgeneGATAD2Achr19:19217194chr19:19616153ENST00000252577911411_464565609.0Zinc fingerGATA-type
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003587131012411_464590634.0Zinc fingerGATA-type
TgeneGATAD2Achr19:19217194chr19:19616153ENST000003603151012411_464590634.0Zinc fingerGATA-type
TgeneGATAD2Achr19:19217194chr19:19616153ENST000004041581214411_464591635.0Zinc fingerGATA-type


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Fusion Gene Sequence for SLC25A42-GATAD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82694_82694_1_SLC25A42-GATAD2A_SLC25A42_chr19_19217194_ENST00000318596_GATAD2A_chr19_19616153_ENST00000252577_length(transcript)=4236nt_BP=648nt
GGGGCCGTGGCGGCTGGAGGTAGCGGCGGCGGCGACGCGTCCGGGCCGGTGAGGGGGCGCGGGGGGCGCCGGGGGGGCCCAAGCGTCAGC
GGCCCGCGCCTGTCGGGCTGAACTGAGGACCGAGTCTCCTGCCATTCCGAGCAGGCCTGGTATGGGTAATGGTGTGAAGGAAGGCCCGGT
GCGATTGCATGAGGATGCTGAGGCTGTCCTGTCCTCGTCCGTCTCATCAAAGCGTGACCACAGGCAAGTGCTCAGCTCCCTGCTGTCTGG
GGCCCTGGCTGGTGCCCTTGCCAAAACAGCGGTAGCTCCCCTGGACCGAACCAAAATCATCTTCCAAGTGTCTTCAAAAAGATTTTCTGC
CAAGGAGGCCTTCCGGGTCCTCTACTACACCTACCTCAACGAGGGATTTCTCAGCTTGTGGCGCGGGAACTCGGCCACCATGGTGCGCGT
GGTGCCCTACGCCGCCATCCAGTTCAGCGCACACGAGGAGTACAAGCGCATCCTGGGCAGCTACTATGGCTTCCGTGGAGAAGCCCTGCC
CCCTTGGCCTCGCCTCTTCGCCGGCGCACTGGCTGGAACGACAGCCGCTTCACTGACCTACCCCCTGGACCTGGTCAGAGCGCGGATGGC
CGTAACCCCGAAGGAAATGCGGGACCCTTGCGTTTGTCAGCCCAAGCCTGGCGGTGCACAAGAGCTCCTCGGCCGTGGACCGCCAGCGAG
AGTACCTCCTGGACATGATCCCACCCCGCTCCATCCCCCAGTCAGCCACGTGGAAATAGTGCGAGCCAGGCCCCGTGGAAGACGGGCTCC
CTCCTCCCCCACCTGGCCCCTGGTCTAGAAGGACCCACTGCACCACCCTCCGCTGGCTCGGGAAGACACCGTGCCCGCCCCAAGAGCAAG
CACCGGCCATGCTGCAGAGGCAAGACCTCAATTCTTGGCTGCAAAGTTTCATCAGGGCTAGGGGGCTGGTGCCGCCTCATAGGCAGACGA
GGATCATCGCTGGGGGACCTTTCCCGTGGGCTTTCTTCCTTTCTCTCTTTGCCTTTAGTTTGCCCGACACCAGCAGAAAAGTGGACCTTG
GGGGCTGGTTCTGCTCCTGGCCCCCTTGTTCAGCCCCTGCCGGCACACGGGCGGCTCACCCTGGACACTGTGATGCGCATGGGCAAGGCC
AGCGCCCGGGGCTTCTGAACCGAGCGGGGTGTTTCATTTTTTTGCTTTTCCCTGTCTTAGGCTCCCAGTCTTTGACTGCCTTCCCATGGC
GATCTATAAGTTGAAAGATTTTTTTTTTTTTTAATCACCTCATGATGATGGAGTTAAAAGTAAACCGTGCAGACCCTGGGGTCCCTGTTG
TACGCTGCATCATCCCGCTGGCCCTGTGCCCTGGAGGGTGGGCGGCTCATGGTGCCACAGCCCCTGGCAGGGACGGCCGGCCCGCCCCCG
TGACTGACTGACAGATGCAGGGATGGCCGAGGCAGCCCTCGCTCCAGCTGAACGCCTCCATTGCTGCTTGTTCTGGAGACCCCCGCCCCC
GCACCTTCCAGACTTAGCAGAAGAACAAACTGAAGAACAGACCCAGCCAGAGAAGCAGGGATTCCAGAAGCTGCCCATTAAGGGAGAAGG
AGAGGATCCGGTCGGCAGCAGCCCTGAGCAGAAAGCTGGAGGGGGGACTGTCGCGGGGTTTTTCTGTTGTGGTTTATTTTATTAAATTTT
TTCCTTTTTTCTATTCATTTCGATGGACGCAATCTTAAGCCACCCTGGCCTTGCTCCTGGGAGGTGAGCGTGCACAGGTGTGTGCAGGTC
AGGAGGTGCCGTCCAGGTGTGCGGCGAGCCGCTGCGCACAGATGTCAGGATTTCCGTTTGGGTCTAGTTTAGAACCTGTCCTTAAACCTA
GGGGTTGCTGTCAGGATTTGCTTTCAGACTTTTTTTTTTTTTGTAATTCCCTTTAGAGTCTACAAAAATGTTTTTAAAAGGATCAGGTCT
GCTTTTAGTTTCATTTTTGTTTCTTTCCCGTCCCACTCTTTAAAAACTGGTTCCGTGAGGAAAGGCAGAAGCCGTTCCGTGTCTCTTGCA
GGCTGGGCCGGCTTCATGCCAGTGCGAGGGCGTCCCGTGCCCACGTACATACGTATGTCTCCATGAGTTCTGGGCTCCACTGGTTCCAAT
TGAGCTCCAGCCCTGGTTTTCCTACCCATGCAGTTAGGGACTTTAATTTAATTTTTTTTTTGTAGGGCCACCGCCTTCAAACACAACTGC
TACAACATTCTAATAAAGGCTCATTTAACCCCCAGGCTCCTGTCGTGTGAATATCCTCAGTCTGTAGGAAACTTTTTTTGACACAGCATA
GAAGACCTAGTTTTGGAAAACATTATCTAATTTTTTGTTGTGCAAATCCCCAAATTTCTCACTAATTTTTGTTTTTTTGTGCATAACTTG
GATGGGCTGAAGGAGGTGAGGACAGATTGGGGAAGGGTGGCTTTCATTCCAAGATCCAGGGATTTGGGGAAAAGGAAGGAATTTGATGTT
TTTTGGGGTGGGAGGGGAGGGTGTGTTTTTTACACCAAAAAAAAAAAAAAAAATCAAGAGTATGCAAGCATTTCTATTCCTCGCATTTTT
CTGTGTGCCTGGCAAATAAATACCTGTCTCCTACGACCCTGAGCTGTTAGCCCTCTCTGTTCCATGACAGGGGCCAGATCTTCCAGCTCC
TCCCAGAAGGAGCACCCAGGCTGGCTTCTTCCCACTGAAAGCCCTCCCCAGCGAACCAACCTCAGTTCTATGCAGTGGCTGGGGATCAGG
CATCCAGACCGAAGTCACCTCTGCCTGCTCCAGCTTGGGTCAGCTGGGTCTGACCAGGGGGCCAGATCCGAGCCGCACCTGCCGGCCCCC
AGCCCCAGCTCCAGCTCCTGACCTCTCCCAGCCTGGCCTGGCTGTTCCTCCAGGGCTGATGGCTGTCAACCCATCCTTGTGAGTTCATAT
GGACTGCTGCCCCTCGAAAGGGAGAGGGTCGGCCCCATGTCCCCAGGGAGCATTCCATCAGGGACAACGTACATACTGTGATGTAAACTT
TTTTTTTTTCCCCCCAGGGGGCAAAAGTGTGAGATGCCTTAATCTTTCCTTCATTTCTGCTGTCTCGAACACTCTAGCCCATTATTTCCT
TTCAGTTCCTTGCAGCATAACCTCTACGATAAGCCCCAAGCGGGTTGTTGTATTATGACGTTTATGATGTTCCAGGTGAAGGCATTATTA
AGTACCTCTCTGGGTGTGGGGTTTGGACGCACCAGGATAGCTATTGATTAATGTTAAGGGTGTTCTACCCACAGCAAAGCACACCCTCTT
AAACCAGGCACTGCCTGGGTCCTGGTCCCGAGAGCCCTACCAGGATCAGGTTCCTGCAAGCCGTCAGAATGTGGGAGCCCCCAGCCCAAC
TGATTGTAACTGTCCCCTGTTACCTGTGACATGAACCTCCAACAGCACCTGGAAACGGTTCCCTCTGTCAGCTGCTCTGTAGACAGGGCT
GGGGAGATCTCAGAGTTCACACCTCGCCTGTTGTAGGGGAGGTTGGGGGTAGGGTTTGGAATGGCCAAGTGCCCTTGGAACCTCCCACAG
CTATGGCCGTCCTGACCTCATCCCAGGAACTCTACGGTGACCAGGAACCACCCCTCTGACGAGGTCTGTAGCGGCCCTTCTCAGAGTGGA
ACAGCCCACAGTGCTAGTTGTGCCTGGTCTTACCTGTACTCCACGGACCTCGGTGAAGCAAAAGCTTCAGGGCAGAGGGAATGAGGCAAC
CCAGTGGCAGCCCCGCTGGGCCCCGTGGCTCCTGCTCTCCTATTGGACGTAGAGGCAGGGGAGAGACTTCTCTATACAAATATTCTCATC
ACAGAAGGGATGATCCTTGCTGCTCTGCCGTAGGGTTTTTGATGCTGAGCTATGCTGCACATGACGTTAACCTAAAGAACTTGGACTGAG
CTTTTAAAAAAGGACAGCAAACAATTTTATAATCCTTAAAGTGTAATAGACGGTTACACTAGTGCAGGGTATTGGGGAGGCTCTTTGGGT
GTGGAGGCTGTCACTTGTATTTATTGTGACTCTAAATCTTTGATAGTAAAACAAATGTAAAAAGAAATGTTTGCCACCAGATGGGAATAG
AAGTTCCAATAAGCAGGCTGGAATGGGTGGCTATACGTTGTATCACGAGGAAGTTTTAGACTCTGAAGGATAATAAATGGATGATGTGTC

>82694_82694_1_SLC25A42-GATAD2A_SLC25A42_chr19_19217194_ENST00000318596_GATAD2A_chr19_19616153_ENST00000252577_length(amino acids)=241AA_BP=1
MRTESPAIPSRPGMGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVL
YYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKEMR

--------------------------------------------------------------
>82694_82694_2_SLC25A42-GATAD2A_SLC25A42_chr19_19217194_ENST00000318596_GATAD2A_chr19_19616153_ENST00000360315_length(transcript)=4236nt_BP=648nt
GGGGCCGTGGCGGCTGGAGGTAGCGGCGGCGGCGACGCGTCCGGGCCGGTGAGGGGGCGCGGGGGGCGCCGGGGGGGCCCAAGCGTCAGC
GGCCCGCGCCTGTCGGGCTGAACTGAGGACCGAGTCTCCTGCCATTCCGAGCAGGCCTGGTATGGGTAATGGTGTGAAGGAAGGCCCGGT
GCGATTGCATGAGGATGCTGAGGCTGTCCTGTCCTCGTCCGTCTCATCAAAGCGTGACCACAGGCAAGTGCTCAGCTCCCTGCTGTCTGG
GGCCCTGGCTGGTGCCCTTGCCAAAACAGCGGTAGCTCCCCTGGACCGAACCAAAATCATCTTCCAAGTGTCTTCAAAAAGATTTTCTGC
CAAGGAGGCCTTCCGGGTCCTCTACTACACCTACCTCAACGAGGGATTTCTCAGCTTGTGGCGCGGGAACTCGGCCACCATGGTGCGCGT
GGTGCCCTACGCCGCCATCCAGTTCAGCGCACACGAGGAGTACAAGCGCATCCTGGGCAGCTACTATGGCTTCCGTGGAGAAGCCCTGCC
CCCTTGGCCTCGCCTCTTCGCCGGCGCACTGGCTGGAACGACAGCCGCTTCACTGACCTACCCCCTGGACCTGGTCAGAGCGCGGATGGC
CGTAACCCCGAAGGAAATGCGGGACCCTTGCGTTTGTCAGCCCAAGCCTGGCGGTGCACAAGAGCTCCTCGGCCGTGGACCGCCAGCGAG
AGTACCTCCTGGACATGATCCCACCCCGCTCCATCCCCCAGTCAGCCACGTGGAAATAGTGCGAGCCAGGCCCCGTGGAAGACGGGCTCC
CTCCTCCCCCACCTGGCCCCTGGTCTAGAAGGACCCACTGCACCACCCTCCGCTGGCTCGGGAAGACACCGTGCCCGCCCCAAGAGCAAG
CACCGGCCATGCTGCAGAGGCAAGACCTCAATTCTTGGCTGCAAAGTTTCATCAGGGCTAGGGGGCTGGTGCCGCCTCATAGGCAGACGA
GGATCATCGCTGGGGGACCTTTCCCGTGGGCTTTCTTCCTTTCTCTCTTTGCCTTTAGTTTGCCCGACACCAGCAGAAAAGTGGACCTTG
GGGGCTGGTTCTGCTCCTGGCCCCCTTGTTCAGCCCCTGCCGGCACACGGGCGGCTCACCCTGGACACTGTGATGCGCATGGGCAAGGCC
AGCGCCCGGGGCTTCTGAACCGAGCGGGGTGTTTCATTTTTTTGCTTTTCCCTGTCTTAGGCTCCCAGTCTTTGACTGCCTTCCCATGGC
GATCTATAAGTTGAAAGATTTTTTTTTTTTTTAATCACCTCATGATGATGGAGTTAAAAGTAAACCGTGCAGACCCTGGGGTCCCTGTTG
TACGCTGCATCATCCCGCTGGCCCTGTGCCCTGGAGGGTGGGCGGCTCATGGTGCCACAGCCCCTGGCAGGGACGGCCGGCCCGCCCCCG
TGACTGACTGACAGATGCAGGGATGGCCGAGGCAGCCCTCGCTCCAGCTGAACGCCTCCATTGCTGCTTGTTCTGGAGACCCCCGCCCCC
GCACCTTCCAGACTTAGCAGAAGAACAAACTGAAGAACAGACCCAGCCAGAGAAGCAGGGATTCCAGAAGCTGCCCATTAAGGGAGAAGG
AGAGGATCCGGTCGGCAGCAGCCCTGAGCAGAAAGCTGGAGGGGGGACTGTCGCGGGGTTTTTCTGTTGTGGTTTATTTTATTAAATTTT
TTCCTTTTTTCTATTCATTTCGATGGACGCAATCTTAAGCCACCCTGGCCTTGCTCCTGGGAGGTGAGCGTGCACAGGTGTGTGCAGGTC
AGGAGGTGCCGTCCAGGTGTGCGGCGAGCCGCTGCGCACAGATGTCAGGATTTCCGTTTGGGTCTAGTTTAGAACCTGTCCTTAAACCTA
GGGGTTGCTGTCAGGATTTGCTTTCAGACTTTTTTTTTTTTTGTAATTCCCTTTAGAGTCTACAAAAATGTTTTTAAAAGGATCAGGTCT
GCTTTTAGTTTCATTTTTGTTTCTTTCCCGTCCCACTCTTTAAAAACTGGTTCCGTGAGGAAAGGCAGAAGCCGTTCCGTGTCTCTTGCA
GGCTGGGCCGGCTTCATGCCAGTGCGAGGGCGTCCCGTGCCCACGTACATACGTATGTCTCCATGAGTTCTGGGCTCCACTGGTTCCAAT
TGAGCTCCAGCCCTGGTTTTCCTACCCATGCAGTTAGGGACTTTAATTTAATTTTTTTTTTGTAGGGCCACCGCCTTCAAACACAACTGC
TACAACATTCTAATAAAGGCTCATTTAACCCCCAGGCTCCTGTCGTGTGAATATCCTCAGTCTGTAGGAAACTTTTTTTGACACAGCATA
GAAGACCTAGTTTTGGAAAACATTATCTAATTTTTTGTTGTGCAAATCCCCAAATTTCTCACTAATTTTTGTTTTTTTGTGCATAACTTG
GATGGGCTGAAGGAGGTGAGGACAGATTGGGGAAGGGTGGCTTTCATTCCAAGATCCAGGGATTTGGGGAAAAGGAAGGAATTTGATGTT
TTTTGGGGTGGGAGGGGAGGGTGTGTTTTTTACACCAAAAAAAAAAAAAAAAATCAAGAGTATGCAAGCATTTCTATTCCTCGCATTTTT
CTGTGTGCCTGGCAAATAAATACCTGTCTCCTACGACCCTGAGCTGTTAGCCCTCTCTGTTCCATGACAGGGGCCAGATCTTCCAGCTCC
TCCCAGAAGGAGCACCCAGGCTGGCTTCTTCCCACTGAAAGCCCTCCCCAGCGAACCAACCTCAGTTCTATGCAGTGGCTGGGGATCAGG
CATCCAGACCGAAGTCACCTCTGCCTGCTCCAGCTTGGGTCAGCTGGGTCTGACCAGGGGGCCAGATCCGAGCCGCACCTGCCGGCCCCC
AGCCCCAGCTCCAGCTCCTGACCTCTCCCAGCCTGGCCTGGCTGTTCCTCCAGGGCTGATGGCTGTCAACCCATCCTTGTGAGTTCATAT
GGACTGCTGCCCCTCGAAAGGGAGAGGGTCGGCCCCATGTCCCCAGGGAGCATTCCATCAGGGACAACGTACATACTGTGATGTAAACTT
TTTTTTTTTCCCCCCAGGGGGCAAAAGTGTGAGATGCCTTAATCTTTCCTTCATTTCTGCTGTCTCGAACACTCTAGCCCATTATTTCCT
TTCAGTTCCTTGCAGCATAACCTCTACGATAAGCCCCAAGCGGGTTGTTGTATTATGACGTTTATGATGTTCCAGGTGAAGGCATTATTA
AGTACCTCTCTGGGTGTGGGGTTTGGACGCACCAGGATAGCTATTGATTAATGTTAAGGGTGTTCTACCCACAGCAAAGCACACCCTCTT
AAACCAGGCACTGCCTGGGTCCTGGTCCCGAGAGCCCTACCAGGATCAGGTTCCTGCAAGCCGTCAGAATGTGGGAGCCCCCAGCCCAAC
TGATTGTAACTGTCCCCTGTTACCTGTGACATGAACCTCCAACAGCACCTGGAAACGGTTCCCTCTGTCAGCTGCTCTGTAGACAGGGCT
GGGGAGATCTCAGAGTTCACACCTCGCCTGTTGTAGGGGAGGTTGGGGGTAGGGTTTGGAATGGCCAAGTGCCCTTGGAACCTCCCACAG
CTATGGCCGTCCTGACCTCATCCCAGGAACTCTACGGTGACCAGGAACCACCCCTCTGACGAGGTCTGTAGCGGCCCTTCTCAGAGTGGA
ACAGCCCACAGTGCTAGTTGTGCCTGGTCTTACCTGTACTCCACGGACCTCGGTGAAGCAAAAGCTTCAGGGCAGAGGGAATGAGGCAAC
CCAGTGGCAGCCCCGCTGGGCCCCGTGGCTCCTGCTCTCCTATTGGACGTAGAGGCAGGGGAGAGACTTCTCTATACAAATATTCTCATC
ACAGAAGGGATGATCCTTGCTGCTCTGCCGTAGGGTTTTTGATGCTGAGCTATGCTGCACATGACGTTAACCTAAAGAACTTGGACTGAG
CTTTTAAAAAAGGACAGCAAACAATTTTATAATCCTTAAAGTGTAATAGACGGTTACACTAGTGCAGGGTATTGGGGAGGCTCTTTGGGT
GTGGAGGCTGTCACTTGTATTTATTGTGACTCTAAATCTTTGATAGTAAAACAAATGTAAAAAGAAATGTTTGCCACCAGATGGGAATAG
AAGTTCCAATAAGCAGGCTGGAATGGGTGGCTATACGTTGTATCACGAGGAAGTTTTAGACTCTGAAGGATAATAAATGGATGATGTGTC

>82694_82694_2_SLC25A42-GATAD2A_SLC25A42_chr19_19217194_ENST00000318596_GATAD2A_chr19_19616153_ENST00000360315_length(amino acids)=241AA_BP=1
MRTESPAIPSRPGMGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVL
YYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKEMR

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Fusion Gene PPI Analysis for SLC25A42-GATAD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A42-GATAD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A42-GATAD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource