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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A51-DCN (FusionGDB2 ID:82725)

Fusion Gene Summary for SLC25A51-DCN

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A51-DCN
Fusion gene ID: 82725
HgeneTgene
Gene symbol

SLC25A51

DCN

Gene ID

92014

1634

Gene namesolute carrier family 25 member 51decorin
SynonymsCG7943|MCART1CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
Cytomap

9p13.2-p13.1

12q21.33

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 25 member 51mitochondrial carrier triple repeat 1mitochondrial carrier triple repeat protein 1decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
Modification date2020031320200313
UniProtAcc

Q9H1U9

P07585

Ensembl transtripts involved in fusion geneENST00000242275, ENST00000377716, 
ENST00000496760, ENST00000380590, 
ENST00000052754, ENST00000228329, 
ENST00000303320, ENST00000393155, 
ENST00000420120, ENST00000425043, 
ENST00000441303, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000547568, ENST00000548768, 
ENST00000550099, ENST00000551354, 
ENST00000552962, 
Fusion gene scores* DoF score6 X 5 X 5=15012 X 9 X 6=648
# samples 612
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A51 [Title/Abstract] AND DCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A51(37899826)-DCN(91558494), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDCN

GO:0010508

positive regulation of autophagy

23798385

TgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

TgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

TgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

TgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

TgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across SLC25A51 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7477-01BSLC25A51chr9

37899826

-DCNchr12

91558494

-


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Fusion Gene ORF analysis for SLC25A51-DCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000242275ENST00000052754SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-3CDSENST00000377716ENST00000052754SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-3CDSENST00000496760ENST00000052754SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000228329SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000303320SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000393155SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000420120SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000425043SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000441303SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000456569SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000546370SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000546745SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000547568SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000548768SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000550099SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000551354SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000242275ENST00000552962SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000228329SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000303320SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000393155SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000420120SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000425043SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000441303SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000456569SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000546370SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000546745SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000547568SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000548768SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000550099SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000551354SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000377716ENST00000552962SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000228329SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000303320SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000393155SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000420120SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000425043SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000441303SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000456569SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000546370SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000546745SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000547568SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000548768SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000550099SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000551354SLC25A51chr9

37899826

-DCNchr12

91558494

-
5UTR-intronENST00000496760ENST00000552962SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-3CDSENST00000380590ENST00000052754SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000228329SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000303320SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000393155SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000420120SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000425043SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000441303SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000456569SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000546370SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000546745SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000547568SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000548768SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000550099SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000551354SLC25A51chr9

37899826

-DCNchr12

91558494

-
intron-intronENST00000380590ENST00000552962SLC25A51chr9

37899826

-DCNchr12

91558494

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC25A51-DCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A51-DCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37899826/:91558494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A51

Q9H1U9

DCN

P07585

FUNCTION: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). {ECO:0000269|PubMed:32906142}.FUNCTION: May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC25A51-DCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC25A51-DCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A51-DCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A51-DCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource