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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC2A13-FAM120A (FusionGDB2 ID:82817)

Fusion Gene Summary for SLC2A13-FAM120A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A13-FAM120A
Fusion gene ID: 82817
HgeneTgene
Gene symbol

SLC2A13

FAM120A

Gene ID

114134

23196

Gene namesolute carrier family 2 member 13family with sequence similarity 120A
SynonymsHMITC9orf10|HBVPTPAP|OSSA
Cytomap

12q12

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionproton myo-inositol cotransporterH(+)-myo-inositol symporterh(+)-myo-inositol cotransporterproton (H+) myo-inositol symportersolute carrier family 2 (facilitated glucose transporter), member 13constitutive coactivator of PPAR-gamma-like protein 1oxidative stess-associated Src activatoroxidative stress-associated Src activator
Modification date2020031320200320
UniProtAcc.

Q5T036

Ensembl transtripts involved in fusion geneENST00000280871, ENST00000380858, 
ENST00000333936, ENST00000340893, 
ENST00000375389, ENST00000475933, 
ENST00000277165, 
Fusion gene scores* DoF score11 X 6 X 8=52817 X 12 X 5=1020
# samples 918
** MAII scorelog2(9/528*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1020*10)=-2.50250034052918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC2A13 [Title/Abstract] AND FAM120A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC2A13(40422103)-FAM120A(96323391), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC2A13

GO:0015798

myo-inositol transport

11500374


check buttonFusion gene breakpoints across SLC2A13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM120A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A0YN-01ASLC2A13chr12

40422103

-FAM120Achr9

96323391

+


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Fusion Gene ORF analysis for SLC2A13-FAM120A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000280871ENST00000333936SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000280871ENST00000340893SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000280871ENST00000375389SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000280871ENST00000475933SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000380858ENST00000333936SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000380858ENST00000340893SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000380858ENST00000375389SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
5CDS-intronENST00000380858ENST00000475933SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
In-frameENST00000280871ENST00000277165SLC2A13chr12

40422103

-FAM120Achr9

96323391

+
In-frameENST00000380858ENST00000277165SLC2A13chr12

40422103

-FAM120Achr9

96323391

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280871SLC2A13chr1240422103-ENST00000277165FAM120Achr996323391+309497601526508
ENST00000380858SLC2A13chr1240422103-ENST00000277165FAM120Achr996323391+332412062121756514

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280871ENST00000277165SLC2A13chr1240422103-FAM120Achr996323391+0.0006330770.99936694
ENST00000380858ENST00000277165SLC2A13chr1240422103-FAM120Achr996323391+0.0009011820.9990989

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Fusion Genomic Features for SLC2A13-FAM120A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC2A13chr1240422102-FAM120Achr996323390+2.42E-060.9999976
SLC2A13chr1240422102-FAM120Achr996323390+2.42E-060.9999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC2A13-FAM120A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:40422103/chr9:96323391)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM120A

Q5T036

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310147_148308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310170_178308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-3101_76308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310200_212308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310234_239308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-31098_125308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310126_146308649.0TransmembraneHelical%3B Name%3D2
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310149_169308649.0TransmembraneHelical%3B Name%3D3
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310179_199308649.0TransmembraneHelical%3B Name%3D4
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310213_233308649.0TransmembraneHelical%3B Name%3D5
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310240_260308649.0TransmembraneHelical%3B Name%3D6
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-31077_97308649.0TransmembraneHelical%3B Name%3D1
TgeneFAM120Achr12:40422103chr9:96323391ENST0000037538909829_11180629.0RegionNote=RNA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310261_324308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310346_363308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310385_393308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310415_508308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310530_549308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310571_573308649.0Topological domainExtracellular
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310595_648308649.0Topological domainCytoplasmic
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310325_345308649.0TransmembraneHelical%3B Name%3D7
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310364_384308649.0TransmembraneHelical%3B Name%3D8
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310394_414308649.0TransmembraneHelical%3B Name%3D9
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310509_529308649.0TransmembraneHelical%3B Name%3D10
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310550_570308649.0TransmembraneHelical%3B Name%3D11
HgeneSLC2A13chr12:40422103chr9:96323391ENST00000280871-310574_594308649.0TransmembraneHelical%3B Name%3D12
TgeneFAM120Achr12:40422103chr9:96323391ENST000002771651418829_11189351119.0RegionNote=RNA binding
TgeneFAM120Achr12:40422103chr9:96323391ENST000003339361519829_11189631147.0RegionNote=RNA binding
TgeneFAM120Achr12:40422103chr9:96323391ENST000003408931317829_11188891073.0RegionNote=RNA binding


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Fusion Gene Sequence for SLC2A13-FAM120A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82817_82817_1_SLC2A13-FAM120A_SLC2A13_chr12_40422103_ENST00000280871_FAM120A_chr9_96323391_ENST00000277165_length(transcript)=3094nt_BP=976nt
CTGCCGGCCCGCGGAGCCGCGTCCCCCCGGGCAGCCCCGGGCCCCTGCCCTATGTCCCGCAAGGCAAGCGAGAATGTGGAGTACACGCTG
CGGAGCCTGAGCAGCCTGATGGGCGAGCGGCGCAGGAAGCAGCCGGAGCCGGACGCGGCGAGCGCGGCCGGGGAGTGCAGCCTCCTGGCT
GCCGCCGAATCGAGCACCAGCCTGCAGAGCGCGGGCGCGGGCGGCGGCGGCGTCGGGGACCTGGAGCGCGCGGCGCGGCGGCAGTTCCAG
CAGGACGAGACCCCCGCCTTCGTGTACGTGGTGGCCGTCTTCTCCGCGCTGGGCGGCTTCCTGTTTGGCTATGACACCGGGGTGGTGTCA
GGGGCCATGCTGCTGCTCAAGCGGCAGCTCAGTCTGGACGCGCTGTGGCAGGAGCTGCTGGTGTCCAGCACGGTGGGGGCGGCTGCCGTC
TCGGCGCTGGCCGGAGGCGCCCTCAACGGCGTCTTCGGCCGCCGCGCTGCCATCCTCCTGGCCAGTGCCCTCTTCACCGCCGGCTCCGCG
GTGCTGGCTGCGGCCAACAACAAGGAGACACTGCTCGCCGGCCGCCTGGTCGTGGGACTCGGCATCGGCATTGCTTCTATGACAGTGCCA
GTGTACATTGCGGAGGTCTCACCACCCAATTTAAGAGGCCGATTAGTCACCATTAATACCCTCTTCATCACAGGAGGGCAGTTCTTTGCA
AGTGTTGTTGATGGAGCCTTCAGTTATCTCCAGAAGGATGGATGGAGGTACATGTTGGGACTTGCAGCAGTTCCGGCGGTTATACAGTTT
TTTGGCTTTCTCTTTTTGCCTGAAAGCCCTCGATGGCTTATTCAGAAAGGACAGACTCAGAAGGCCCGTAGAATTTTATCTCAGATGCGT
GGTAACCAGACCATTGATGAGGAATATGATAGCATCAAAAACAACATTGAAGAGGAGGAAAAAGAGGTTGGCTCAGGAGTCCAACCTATA
CCTTCTCAGGGAGGCAAACTAGAAATAGCTGGCACTGTGGTTGGCCATTGGGCTGGGAGCAGGCGGGGCCGTGGGGGCCGGGGGCCTTTC
CCCCTGCAGGTGGTTTCTGTCGGAGGACCAGCTAGAGGGCGTCCAAGAGGAGTTATTTCCACCCCAGTGATTAGAACATTTGGAAGAGGT
GGAAGGTACTATGGCAGAGGTTACAAAAACCAGGCAGCAATTCAGGGCAGACCTCCTTATGCTGCTTCAGCAGAAGAAGTGGCCAAAGAA
CTTAAGTCAAAATCTGGGGAATCGAAGTCCTCTGCTATGTCTTCAGACGGGTCCCTGGCTGAAAACGGAGTGATGGCCGAGGAGAAGCCG
GCTCCCCAGATGAACGGGAGCACGGGTGACGCCAGGGCCCCCAGCCACTCTGAAAGTGCCTTGAATAATGACTCTAAAACGTGCAATACA
AATCCTCATTTAAATGCACTAAGTACAGACAGCGCTTGCCGCAGAGAAGCTGCTCTGGAGGCAGCTGTCTTAAATAAAGAAGAGTAAACT
TATTTTTTATAGAGGGTGAAGGATGCTGGAAGGGTAAGGATTTAGGAATATCTGGAGAGAAAGAGAGCCTGCAGTTATGTACATTTTGTC
CTTTCCGTAAGAGAAAAATGAGGACTTTGGAAATTCAGATCCCTCTTTGATATCAGAGATTTAAACAACACATTTTTAGTTTTAACCAGT
TGTAGTCAAAATGCTACAATAAAACAAAAAAGAGAAAGAAAATGAAGAGCATTTGACTCCCGCACTTAAAATGAAGTACACATAAAGTTT
AAACTGGTTATGACAAAAGCCTTTAGTTGTGTTTCTTGAACTATAAAGAAAACAAATTTTGGCAGTCTTTAAGTATATATAGCTTAAAAT
ATAATTTTTAGCATTTGGCACCATATGTATGCCATTATATTTGATTTTGCATTACTGTTTCACAATGAAGCTTTCTTTAAGGCTTTGATT
TTTATGATTATGAAAGAAATAAGGCACAACCACAGTTTTTCTTTCTTAAATTTCATCACTGTTGATGTGGTTCTTTTGTGTTAAAAAAAA
AAAGTGCAACTATCAAAACTAAAAAATTATAGAGTAATATTGCCGTTCTGCTGATTTTAAATATACAATACATCATACATACTTTACAAG
CAAGTTAAATGGAGATAAAGTTGAAATCATAGAAGATGCAAATGACCTTTCAAAATCAACACAATGTGTTCTGAAACTTTCGTGACTAAT
ACCATGCATCTGTGATCAATGAACTATGTGGTTTTGAATCGGATGTAGACCATTAGTACTACTACTTGAGCTAAACTTCTGCATGGTTCA
TAATTTTTAAAGTGTGTAGTTAATATGCATGTTATCGTCCTTTCTTCCATTCTTAACAGTATGTGCCCATTTGCAAAACAAAAATGCTAA
TAATCAGTAATAGTCCTATAAAAGATGTTAACTCTGTTTAGTCATTGACTGATCTTGCTCTAACCTTAAAATTTTGTGATTATTGACCTC
TGTTGCATTTATTCTAAAGCCCCCCAAAAATTATCTAGCCGTTTCGAATATCAACATTACCCTGGTGTATTCACTGCTGTATGCATTATT
GTTCTTTGTTGCTGTTTTATGCCTTCATATTAGCAAATATGAAATTCTGTGAAAAAAAACCCTTTGATCTTAAAAAAAAAAAAACCACCC
CCCCCTTCTGTAGCAGGAAACAAATTGCTTGTTCTTGAGAACTTTCCCATCAAGAATTTAGTAGAAGCAGGTATACTTCTATCATTTTGA
TGTTTTTGTTAATGTTTCCAAACAATGTACTTTGAAATCAGAATCACTTCTTATCGTTTTCATATACTTCTGATGCTCTTCATCACATTA
GTGATCAGAAATGAGGTGTAATTCCCCAACCCCTGCCCGCAAGAGCTAAGTAGGATCTTACTGTAAGTTGAAGGGAGTTTTGCCCTAACT
CATGGATTGTGCAAGAATGAACTGCTGTTGGGTTTGATTGACTGTCGATGGATTGTGGTGTGGTGTATCTGAAGGCTATTGAATGCAACT

>82817_82817_1_SLC2A13-FAM120A_SLC2A13_chr12_40422103_ENST00000280871_FAM120A_chr9_96323391_ENST00000277165_length(amino acids)=508AA_BP=325
LPARGAASPRAAPGPCPMSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARRQFQ
QDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA
VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQF
FGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPF
PLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKP

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>82817_82817_2_SLC2A13-FAM120A_SLC2A13_chr12_40422103_ENST00000380858_FAM120A_chr9_96323391_ENST00000277165_length(transcript)=3324nt_BP=1206nt
CGCCTCCCGCCCGCTCCGCAGCGCCAGCTCGGCAGGCGCGGGGCGTGAGTGTGGAGTGAGACCCGCCGGGCTCCAACTCCGCAGCGTCGG
AGCGCGGCGGGCAGCAACTTTCTCCCCGGAGCGGCCGTGGCGGCGGCTGCTGCCGTGGCAGCCGGAGCGGAAGCCGGGAGGAAGAAAGCG
GCGGCAGCGGCGGTTGCTCCCGCCGGCTCGGGCTGTCTAGCTCGCCGAGACTGCCGGCCCGCGGAGCCGCGTCCCCCCGGGCAGCCCCGG
GCCCCTGCCCTATGTCCCGCAAGGCAAGCGAGAATGTGGAGTACACGCTGCGGAGCCTGAGCAGCCTGATGGGCGAGCGGCGCAGGAAGC
AGCCGGAGCCGGACGCGGCGAGCGCGGCCGGGGAGTGCAGCCTCCTGGCTGCCGCCGAATCGAGCACCAGCCTGCAGAGCGCGGGCGCGG
GCGGCGGCGGCGTCGGGGACCTGGAGCGCGCGGCGCGGCGGCAGTTCCAGCAGGACGAGACCCCCGCCTTCGTGTACGTGGTGGCCGTCT
TCTCCGCGCTGGGCGGCTTCCTGTTTGGCTATGACACCGGGGTGGTGTCAGGGGCCATGCTGCTGCTCAAGCGGCAGCTCAGTCTGGACG
CGCTGTGGCAGGAGCTGCTGGTGTCCAGCACGGTGGGGGCGGCTGCCGTCTCGGCGCTGGCCGGAGGCGCCCTCAACGGCGTCTTCGGCC
GCCGCGCTGCCATCCTCCTGGCCAGTGCCCTCTTCACCGCCGGCTCCGCGGTGCTGGCTGCGGCCAACAACAAGGAGACACTGCTCGCCG
GCCGCCTGGTCGTGGGACTCGGCATCGGCATTGCTTCTATGACAGTGCCAGTGTACATTGCGGAGGTCTCACCACCCAATTTAAGAGGCC
GATTAGTCACCATTAATACCCTCTTCATCACAGGAGGGCAGTTCTTTGCAAGTGTTGTTGATGGAGCCTTCAGTTATCTCCAGAAGGATG
GATGGAGGTACATGTTGGGACTTGCAGCAGTTCCGGCGGTTATACAGTTTTTTGGCTTTCTCTTTTTGCCTGAAAGCCCTCGATGGCTTA
TTCAGAAAGGACAGACTCAGAAGGCCCGTAGAATTTTATCTCAGATGCGTGGTAACCAGACCATTGATGAGGAATATGATAGCATCAAAA
ACAACATTGAAGAGGAGGAAAAAGAGGTTGGCTCAGGAGTCCAACCTATACCTTCTCAGGGAGGCAAACTAGAAATAGCTGGCACTGTGG
TTGGCCATTGGGCTGGGAGCAGGCGGGGCCGTGGGGGCCGGGGGCCTTTCCCCCTGCAGGTGGTTTCTGTCGGAGGACCAGCTAGAGGGC
GTCCAAGAGGAGTTATTTCCACCCCAGTGATTAGAACATTTGGAAGAGGTGGAAGGTACTATGGCAGAGGTTACAAAAACCAGGCAGCAA
TTCAGGGCAGACCTCCTTATGCTGCTTCAGCAGAAGAAGTGGCCAAAGAACTTAAGTCAAAATCTGGGGAATCGAAGTCCTCTGCTATGT
CTTCAGACGGGTCCCTGGCTGAAAACGGAGTGATGGCCGAGGAGAAGCCGGCTCCCCAGATGAACGGGAGCACGGGTGACGCCAGGGCCC
CCAGCCACTCTGAAAGTGCCTTGAATAATGACTCTAAAACGTGCAATACAAATCCTCATTTAAATGCACTAAGTACAGACAGCGCTTGCC
GCAGAGAAGCTGCTCTGGAGGCAGCTGTCTTAAATAAAGAAGAGTAAACTTATTTTTTATAGAGGGTGAAGGATGCTGGAAGGGTAAGGA
TTTAGGAATATCTGGAGAGAAAGAGAGCCTGCAGTTATGTACATTTTGTCCTTTCCGTAAGAGAAAAATGAGGACTTTGGAAATTCAGAT
CCCTCTTTGATATCAGAGATTTAAACAACACATTTTTAGTTTTAACCAGTTGTAGTCAAAATGCTACAATAAAACAAAAAAGAGAAAGAA
AATGAAGAGCATTTGACTCCCGCACTTAAAATGAAGTACACATAAAGTTTAAACTGGTTATGACAAAAGCCTTTAGTTGTGTTTCTTGAA
CTATAAAGAAAACAAATTTTGGCAGTCTTTAAGTATATATAGCTTAAAATATAATTTTTAGCATTTGGCACCATATGTATGCCATTATAT
TTGATTTTGCATTACTGTTTCACAATGAAGCTTTCTTTAAGGCTTTGATTTTTATGATTATGAAAGAAATAAGGCACAACCACAGTTTTT
CTTTCTTAAATTTCATCACTGTTGATGTGGTTCTTTTGTGTTAAAAAAAAAAAGTGCAACTATCAAAACTAAAAAATTATAGAGTAATAT
TGCCGTTCTGCTGATTTTAAATATACAATACATCATACATACTTTACAAGCAAGTTAAATGGAGATAAAGTTGAAATCATAGAAGATGCA
AATGACCTTTCAAAATCAACACAATGTGTTCTGAAACTTTCGTGACTAATACCATGCATCTGTGATCAATGAACTATGTGGTTTTGAATC
GGATGTAGACCATTAGTACTACTACTTGAGCTAAACTTCTGCATGGTTCATAATTTTTAAAGTGTGTAGTTAATATGCATGTTATCGTCC
TTTCTTCCATTCTTAACAGTATGTGCCCATTTGCAAAACAAAAATGCTAATAATCAGTAATAGTCCTATAAAAGATGTTAACTCTGTTTA
GTCATTGACTGATCTTGCTCTAACCTTAAAATTTTGTGATTATTGACCTCTGTTGCATTTATTCTAAAGCCCCCCAAAAATTATCTAGCC
GTTTCGAATATCAACATTACCCTGGTGTATTCACTGCTGTATGCATTATTGTTCTTTGTTGCTGTTTTATGCCTTCATATTAGCAAATAT
GAAATTCTGTGAAAAAAAACCCTTTGATCTTAAAAAAAAAAAAACCACCCCCCCCTTCTGTAGCAGGAAACAAATTGCTTGTTCTTGAGA
ACTTTCCCATCAAGAATTTAGTAGAAGCAGGTATACTTCTATCATTTTGATGTTTTTGTTAATGTTTCCAAACAATGTACTTTGAAATCA
GAATCACTTCTTATCGTTTTCATATACTTCTGATGCTCTTCATCACATTAGTGATCAGAAATGAGGTGTAATTCCCCAACCCCTGCCCGC
AAGAGCTAAGTAGGATCTTACTGTAAGTTGAAGGGAGTTTTGCCCTAACTCATGGATTGTGCAAGAATGAACTGCTGTTGGGTTTGATTG

>82817_82817_2_SLC2A13-FAM120A_SLC2A13_chr12_40422103_ENST00000380858_FAM120A_chr9_96323391_ENST00000277165_length(amino acids)=514AA_BP=331
MSSSPRLPARGAASPRAAPGPCPMSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERA
ARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASAL
FTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAV
PAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSGVQPIPSQGGKLEIAGTVVGHWAGSRRGR
GGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGV

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Fusion Gene PPI Analysis for SLC2A13-FAM120A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneFAM120Achr12:40422103chr9:96323391ENST0000037538909339_4050629.0YES1%2C SRC and FYN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFAM120Achr12:40422103chr9:96323391ENST000002771651418339_405935.33333333333341119.0YES1%2C SRC and FYN
TgeneFAM120Achr12:40422103chr9:96323391ENST000003339361519339_405963.33333333333341147.0YES1%2C SRC and FYN
TgeneFAM120Achr12:40422103chr9:96323391ENST000003408931317339_405889.33333333333341073.0YES1%2C SRC and FYN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC2A13-FAM120A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC2A13-FAM120A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource