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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC2A9-RAD51 (FusionGDB2 ID:82863)

Fusion Gene Summary for SLC2A9-RAD51

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A9-RAD51
Fusion gene ID: 82863
HgeneTgene
Gene symbol

SLC2A9

RAD51

Gene ID

56606

5888

Gene namesolute carrier family 2 member 9RAD51 recombinase
SynonymsGLUT9|GLUTX|UAQTL2|URATv1BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA
Cytomap

4p16.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 2, facilitated glucose transporter member 9GLUT-9glucose transporter type 9human glucose transporter-like protein-9solute carrier family 2 (facilitated glucose transporter), member 9urate transporterurate voltage-driven efflux DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
Modification date2020031320200322
UniProtAcc.

O15315

Ensembl transtripts involved in fusion geneENST00000264784, ENST00000309065, 
ENST00000506583, ENST00000481042, 
ENST00000382643, ENST00000530766, 
ENST00000532743, ENST00000557850, 
ENST00000267868, ENST00000423169, 
Fusion gene scores* DoF score6 X 5 X 3=907 X 7 X 5=245
# samples 67
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC2A9 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC2A9(10020599)-RAD51(40998375), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC2A9-RAD51 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC2A9-RAD51 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC2A9-RAD51 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAD51

GO:0000724

double-strand break repair via homologous recombination

16428451

TgeneRAD51

GO:0006268

DNA unwinding involved in DNA replication

7988572

TgeneRAD51

GO:0006974

cellular response to DNA damage stimulus

23509288|25585578

TgeneRAD51

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneRAD51

GO:0031297

replication fork processing

25585578

TgeneRAD51

GO:0051106

positive regulation of DNA ligation

8929543

TgeneRAD51

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneRAD51

GO:0072757

cellular response to camptothecin

23509288


check buttonFusion gene breakpoints across SLC2A9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3X1-01ASLC2A9chr4

10020599

-RAD51chr15

40998375

+


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Fusion Gene ORF analysis for SLC2A9-RAD51

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264784ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000309065ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000309065ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000506583ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000506583ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
In-frameENST00000264784ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
In-frameENST00000264784ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-3CDSENST00000481042ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-3CDSENST00000481042ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264784SLC2A9chr410020599-ENST00000423169RAD51chr1540998375+139030345920291
ENST00000264784SLC2A9chr410020599-ENST00000267868RAD51chr1540998375+2076303451097350

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264784ENST00000423169SLC2A9chr410020599-RAD51chr1540998375+0.0037634080.9962366
ENST00000264784ENST00000267868SLC2A9chr410020599-RAD51chr1540998375+0.0014360480.99856395

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Fusion Genomic Features for SLC2A9-RAD51


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC2A9chr410020598-RAD51chr1540998374+4.09E-121
SLC2A9chr410020598-RAD51chr1540998374+4.09E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC2A9-RAD51


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:10020599/chr15:40998375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAD51

O15315

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-2121_5183541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-3131_5154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-4141_5154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-21252_7283541.0TransmembraneHelical%3B Name%3D1
TgeneRAD51chr4:10020599chr15:40998375ENST0000038264301048_770341.0DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST0000053274301048_770341.0DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST000005578500848_770243.0DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST00000267868210127_13475340.0Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000382643010127_1340341.0Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST0000042316929127_13475281.0Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000532743010127_1340341.0Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST0000055785008127_1340243.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212129_14083541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212162_17183541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212193_20083541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212222_23183541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212253_31683541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212338_35483541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212376_38183541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212403_41583541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212437_45183541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212473_47883541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212500_54083541.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-21273_10783541.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313129_14054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313162_17154512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313193_20054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313222_23154512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313253_31654512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313338_35454512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313376_38154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313403_41554512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313437_45154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313473_47854512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313500_54054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-31373_10754512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414129_14054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414162_17154512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414193_20054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414222_23154512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414253_31654512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414338_35454512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414376_38154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414403_41554512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414437_45154512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414473_47854512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414500_54054512.0Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-41473_10754512.0Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212108_12883541.0TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212141_16183541.0TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212172_19283541.0TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212201_22183541.0TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212232_25283541.0TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212317_33783541.0TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212355_37583541.0TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212382_40283541.0TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212416_43683541.0TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212452_47283541.0TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212479_49983541.0TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313108_12854512.0TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313141_16154512.0TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313172_19254512.0TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313201_22154512.0TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313232_25254512.0TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313317_33754512.0TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313355_37554512.0TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313382_40254512.0TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313416_43654512.0TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313452_47254512.0TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313479_49954512.0TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-31352_7254512.0TransmembraneHelical%3B Name%3D1
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414108_12854512.0TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414141_16154512.0TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414172_19254512.0TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414201_22154512.0TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414232_25254512.0TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414317_33754512.0TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414355_37554512.0TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414382_40254512.0TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414416_43654512.0TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414452_47254512.0TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414479_49954512.0TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-41452_7254512.0TransmembraneHelical%3B Name%3D1
TgeneRAD51chr4:10020599chr15:40998375ENST0000026786821048_7775340.0DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST000004231692948_7775281.0DomainNote=HhH


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Fusion Gene Sequence for SLC2A9-RAD51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82863_82863_1_SLC2A9-RAD51_SLC2A9_chr4_10020599_ENST00000264784_RAD51_chr15_40998375_ENST00000267868_length(transcript)=2076nt_BP=303nt
CTTGGCAGAGTCTGGGGTCCCTGGACTGAGCCATCAGCTGGGTCACTGAGACCCATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTG
GGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGGAGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGG
GTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCCCTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGC
TACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTTCCAATGGGTTTCACCACTGCAACTGAATTCCACCAA
AGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTACTTCAAGGTGGAATTGAGACTGGATCTATCACAGAA
ATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAA
GGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGAT
GTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCT
AGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCAC
TTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGAT
GGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAA
GGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTG
GGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTT
CTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAG
ACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGG
TATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAG
CTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGAT
TCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTG
CCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAG
CATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAG
TCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGC
TACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGG
TGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAATAAAGTAGTTATTA

>82863_82863_1_SLC2A9-RAD51_SLC2A9_chr4_10020599_ENST00000264784_RAD51_chr15_40998375_ENST00000267868_length(amino acids)=350AA_BP=86
MRPMARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPAEAA
KLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPE
RLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEF

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>82863_82863_2_SLC2A9-RAD51_SLC2A9_chr4_10020599_ENST00000264784_RAD51_chr15_40998375_ENST00000423169_length(transcript)=1390nt_BP=303nt
CTTGGCAGAGTCTGGGGTCCCTGGACTGAGCCATCAGCTGGGTCACTGAGACCCATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTG
GGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGGAGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGG
GTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCCCTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGC
TACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTTCCAATGGGTTTCACCACTGCAACTGAATTCCACCAA
AGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTACTTCAAGGTGGAATTGAGACTGGATCTATCACAGAA
ATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAA
GGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGAT
GTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCT
AGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCAC
TTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTA
CGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTT
CCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAG
GATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATG
TTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAA
TGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAA

>82863_82863_2_SLC2A9-RAD51_SLC2A9_chr4_10020599_ENST00000264784_RAD51_chr15_40998375_ENST00000423169_length(amino acids)=291AA_BP=86
MRPMARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPAEAA
KLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPE
RLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEI

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Fusion Gene PPI Analysis for SLC2A9-RAD51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAD51chr4:10020599chr15:40998375ENST00000267868210184_25775.0340.0PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000382643010184_2570341.0PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST0000042316929184_25775.0281.0PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000532743010184_2570341.0PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST0000055785008184_2570243.0PALB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC2A9-RAD51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC2A9-RAD51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource