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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC30A4-AMACR (FusionGDB2 ID:82873)

Fusion Gene Summary for SLC30A4-AMACR

Fusion gene summary

Fusion gene information	Fusion gene name: SLC30A4-AMACR
	Fusion gene ID: 82873
		Hgene	Tgene
	Gene symbol	SLC30A4	AMACR
	Gene ID	7782	23600
	Gene name	solute carrier family 30 member 4	alpha-methylacyl-CoA racemase
	Synonyms	ZNT4\|znT-4	AMACRD\|CBAS4\|P504S\|RACE\|RM
	Cytomap	15q21.1\|15q21.1	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc transporter 4solute carrier family 30 (zinc transporter), member 4	alpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UHK6
	Ensembl transtripts involved in fusion gene	ENST00000261867, ENST00000559667,	ENST00000382068, ENST00000382085, ENST00000426255, ENST00000441713, ENST00000502637, ENST00000512079, ENST00000514195, ENST00000335606, ENST00000382072,
Fusion gene scores	* DoF score	8 X 3 X 1=24	28 X 3 X 4=336
	# samples	9	23
	** MAII score	log2(9/24*10)=1.90689059560852 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(23/336*10)=-0.546827371834385 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC30A4 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC30A4(45814161)-AMACR(34006004), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC30A4	GO:0009636	response to toxic substance	17575980
Hgene	SLC30A4	GO:0061088	regulation of sequestering of zinc ion	17349999
Tgene	AMACR	GO:0008206	bile acid metabolic process	10655068

Fusion gene breakpoints across SLC30A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AMACR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-YL-A8SC	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-

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Fusion Gene ORF analysis for SLC30A4-AMACR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000261867	ENST00000382068	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000382085	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000426255	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000441713	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000502637	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000512079	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000261867	ENST00000514195	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-3CDS	ENST00000559667	ENST00000335606	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-3CDS	ENST00000559667	ENST00000382072	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000382068	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000382085	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000426255	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000441713	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000502637	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000512079	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
5UTR-5UTR	ENST00000559667	ENST00000514195	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
In-frame	ENST00000261867	ENST00000335606	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-
In-frame	ENST00000261867	ENST00000382072	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261867	SLC30A4	chr15	45814161	-	ENST00000335606	AMACR	chr5	34006004	-	4523	706	315	1607	430
ENST00000261867	SLC30A4	chr15	45814161	-	ENST00000382072	AMACR	chr5	34006004	-	3366	706	315	1055	246

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261867	ENST00000335606	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-	0.000260243	0.9997397
ENST00000261867	ENST00000382072	SLC30A4	chr15	45814161	-	AMACR	chr5	34006004	-	0.002077024	0.99792296

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Fusion Genomic Features for SLC30A4-AMACR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC30A4-AMACR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:45814161/chr5:34006004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AMACR Q9UHK6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269\|PubMed:10655068, ECO:0000269\|PubMed:11060359, ECO:0000269\|PubMed:7649182}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

17_96

130

430.0

Compositional bias

Note=Asp-rich (acidic)

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

1_113

130

430.0

Topological domain

Cytoplasmic

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000335606

380_382

383.0

Motif

Microbody targeting signal

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382072

380_382

199.0

Motif

Microbody targeting signal

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382085

380_382

395.0

Motif

Microbody targeting signal

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000441713

380_382

230.0

Motif

Microbody targeting signal

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000335606

121_126

383.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382072

121_126

199.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382085

121_126

395.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000441713

121_126

230.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

241_247

130

430.0

Compositional bias

Note=His-rich

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

135_143

130

430.0

Topological domain

Vacuolar

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

165_178

130

430.0

Topological domain

Cytoplasmic

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

200_216

130

430.0

Topological domain

Vacuolar

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

238_274

130

430.0

Topological domain

Cytoplasmic

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

296_310

130

430.0

Topological domain

Vacuolar

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

332_429

130

430.0

Topological domain

Cytoplasmic

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

114_134

130

430.0

Transmembrane

Helical

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

144_164

130

430.0

Transmembrane

Helical

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

179_199

130

430.0

Transmembrane

Helical

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

217_237

130

430.0

Transmembrane

Helical

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

275_295

130

430.0

Transmembrane

Helical

Hgene

SLC30A4

chr15:45814161

chr5:34006004

ENST00000261867

311_331

130

430.0

Transmembrane

Helical

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000335606

55_58

383.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382072

55_58

199.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000382085

55_58

395.0

Region

Substrate binding

Tgene

AMACR

chr15:45814161

chr5:34006004

ENST00000441713

55_58

230.0

Region

Substrate binding

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Fusion Gene Sequence for SLC30A4-AMACR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82873_82873_1_SLC30A4-AMACR_SLC30A4_chr15_45814161_ENST00000261867_AMACR_chr5_34006004_ENST00000335606_length(transcript)=4523nt_BP=706nt
CGCGCAGGGCGGGGAGAGGCGGTGGCTGTGGGCGTCCGGCCCCGAACCTGTCAGACCTGGGGAGCCGGCCTCCAGCAGCGGGCGCGGCGG
GCGCGAGCACGACCCCACTCTCCTGCGGCCGCGGGTGGAGCAGCGCGAGCCCGCCTCGCTGAGCCGGCCGGGGGCGGGGAGATGAGTTGC
GGCCCCGCGGCAGCGCCCCAGGATGGGGAGGGACGCGCGGCACTGCCCTCGAGAACTGGCGCTCCGGTGAAGTAGGCGCCGCCGGCCGTC
CGCCTCCCCCAAGCCGTTCCGCACCGCGGCCGCTCAGCCTCTGCCATGGCCGGCTCTGGCGCGTGGAAGCGCCTCAAATCTATGCTAAGG
AAGGATGATGCGCCGCTGTTTTTAAATGACACCAGCGCCTTTGACTTCTCGGATGAGGCGGGGGACGAGGGGCTTTCTCGGTTCAACAAA
CTTCGAGTTGTGGTGGCCGATGACGGTTCCGAAGCCCCGGAAAGGCCTGTTAACGGGGCGCACCCGACCCTCCAGGCCGACGATGATTCC
TTACTGGACCAAGACTTACCTTTGACCAACAGTCAGCTGAGTTTGAAGGTGGACTCCTGTGACAACTGCAGCAAACAGAGAGAGATACTG
AAGCAGAGAAAGGTGAAAGCCAGGTTGACCATTGCTGCCGTTCTGTACTTGCTTTTCATGATTGGAGAACTTGTAGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATG
AAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTT
CTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCT
GCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTT
GGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCA
CGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTG
TCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGAT
TTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGAC
TTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGT
AGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTT
CATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAG
AATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGG
TTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGG
CTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTC
CTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGG
AGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGA
GAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGT
TTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGC
TTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGC
TTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCA
CCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACT
TGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAAT
GAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATAC
TCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGA
AGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTT
TCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAA
TAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGA
GGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCTAAATAAATAAATAAAAATAATAAT
AATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACA
GAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAG
GAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAG
ACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTC
CTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAA
AGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGA
TCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACA
AACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAAATATCAGGGCGATCTGACACAGCT
AATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGTGTGTGGAAAACTTGTAGTAAAAAA

>82873_82873_1_SLC30A4-AMACR_SLC30A4_chr15_45814161_ENST00000261867_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=430AA_BP=130
MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSL
KVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGV
LSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTT
YRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKER

--------------------------------------------------------------
>82873_82873_2_SLC30A4-AMACR_SLC30A4_chr15_45814161_ENST00000261867_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3366nt_BP=706nt
CGCGCAGGGCGGGGAGAGGCGGTGGCTGTGGGCGTCCGGCCCCGAACCTGTCAGACCTGGGGAGCCGGCCTCCAGCAGCGGGCGCGGCGG
GCGCGAGCACGACCCCACTCTCCTGCGGCCGCGGGTGGAGCAGCGCGAGCCCGCCTCGCTGAGCCGGCCGGGGGCGGGGAGATGAGTTGC
GGCCCCGCGGCAGCGCCCCAGGATGGGGAGGGACGCGCGGCACTGCCCTCGAGAACTGGCGCTCCGGTGAAGTAGGCGCCGCCGGCCGTC
CGCCTCCCCCAAGCCGTTCCGCACCGCGGCCGCTCAGCCTCTGCCATGGCCGGCTCTGGCGCGTGGAAGCGCCTCAAATCTATGCTAAGG
AAGGATGATGCGCCGCTGTTTTTAAATGACACCAGCGCCTTTGACTTCTCGGATGAGGCGGGGGACGAGGGGCTTTCTCGGTTCAACAAA
CTTCGAGTTGTGGTGGCCGATGACGGTTCCGAAGCCCCGGAAAGGCCTGTTAACGGGGCGCACCCGACCCTCCAGGCCGACGATGATTCC
TTACTGGACCAAGACTTACCTTTGACCAACAGTCAGCTGAGTTTGAAGGTGGACTCCTGTGACAACTGCAGCAAACAGAGAGAGATACTG
AAGCAGAGAAAGGTGAAAGCCAGGTTGACCATTGCTGCCGTTCTGTACTTGCTTTTCATGATTGGAGAACTTGTAGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATT
GAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCAT
GGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCAT
GGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGA
TGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCA
GGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGA
GGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAG
TCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATG
GAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGT
TATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGT
TGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTAC
ACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCA
GGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGT
TTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGA
GGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATG
TGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCA
GCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACAT
AAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCA
TCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCA
AGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCA
GTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTC
CTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACT
TACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATG
TTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGC
AATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATT
TTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCT
CAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACT
TTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTC

>82873_82873_2_SLC30A4-AMACR_SLC30A4_chr15_45814161_ENST00000261867_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=246AA_BP=130
MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSL
KVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGG

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Fusion Gene PPI Analysis for SLC30A4-AMACR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SLC30A4-AMACR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC30A4-AMACR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source