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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP9B-BRD8 (FusionGDB2 ID:8295)

Fusion Gene Summary for ATP9B-BRD8

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP9B-BRD8
Fusion gene ID: 8295
HgeneTgene
Gene symbol

ATP9B

BRD8

Gene ID

374868

10902

Gene nameATPase phospholipid transporting 9B (putative)bromodomain containing 8
SynonymsATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1SMAP|SMAP2|p120
Cytomap

18q23

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1bromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120
Modification date2020031320200313
UniProtAcc

O43861

Q9H0E9

Ensembl transtripts involved in fusion geneENST00000307671, ENST00000426216, 
ENST00000458297, ENST00000543761, 
ENST00000586722, ENST00000591464, 
ENST00000230901, ENST00000254900, 
ENST00000402931, ENST00000411594, 
ENST00000455658, ENST00000515014, 
Fusion gene scores* DoF score15 X 16 X 5=12006 X 6 X 3=108
# samples 157
** MAII scorelog2(15/1200*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP9B [Title/Abstract] AND BRD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP9B(76876920)-BRD8(137492576), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD8

GO:0043967

histone H4 acetylation

14966270

TgeneBRD8

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across ATP9B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BRD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI491545ATP9Bchr18

76876920

-BRD8chr5

137492576

+


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Fusion Gene ORF analysis for ATP9B-BRD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000307671ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000307671ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000307671ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000307671ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000307671ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000307671ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000426216ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000458297ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000543761ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000586722ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000230901ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000254900ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000402931ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000411594ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000455658ATP9Bchr18

76876920

-BRD8chr5

137492576

+
intron-intronENST00000591464ENST00000515014ATP9Bchr18

76876920

-BRD8chr5

137492576

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATP9B-BRD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP9B-BRD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76876920/:137492576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP9B

O43861

BRD8

Q9H0E9

FUNCTION: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATP9B-BRD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP9B-BRD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP9B-BRD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP9B-BRD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource