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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC35E1-IFT46 (FusionGDB2 ID:82969)

Fusion Gene Summary for SLC35E1-IFT46

Fusion gene summary

Fusion gene information	Fusion gene name: SLC35E1-IFT46
	Fusion gene ID: 82969
		Hgene	Tgene
	Gene symbol	SLC35E1	IFT46
	Gene ID	79939	56912
	Gene name	solute carrier family 35 member E1	intraflagellar transport 46
	Synonyms	-	C11orf2\|C11orf60\|CFAP32
	Cytomap	19p13.11	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 35 member E1	intraflagellar transport protein 46 homologUPF0360cilia and flagella associated protein 32intraflagellar transport 46 homologintraflagellar transport protein IFT46
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NQC8
	Ensembl transtripts involved in fusion gene	ENST00000431408, ENST00000595753, ENST00000593812,	ENST00000527868, ENST00000264020, ENST00000264021, ENST00000530872,
Fusion gene scores	* DoF score	7 X 7 X 4=196	13 X 8 X 4=416
	# samples	8	14
	** MAII score	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/416*10)=-1.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC35E1 [Title/Abstract] AND IFT46 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC35E1(16677342)-IFT46(118416568), # samples:1
Anticipated loss of major functional domain due to fusion event.	SLC35E1-IFT46 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC35E1-IFT46 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLC35E1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IFT46 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-X8-AAAR	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-

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Fusion Gene ORF analysis for SLC35E1-IFT46

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000431408	ENST00000527868	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
5CDS-intron	ENST00000595753	ENST00000527868	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
Frame-shift	ENST00000431408	ENST00000264020	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
Frame-shift	ENST00000431408	ENST00000264021	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
Frame-shift	ENST00000431408	ENST00000530872	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
In-frame	ENST00000595753	ENST00000264020	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
In-frame	ENST00000595753	ENST00000264021	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
In-frame	ENST00000595753	ENST00000530872	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
intron-3CDS	ENST00000593812	ENST00000264020	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
intron-3CDS	ENST00000593812	ENST00000264021	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
intron-3CDS	ENST00000593812	ENST00000530872	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-
intron-intron	ENST00000593812	ENST00000527868	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000595753	SLC35E1	chr19	16677342	-	ENST00000264021	IFT46	chr11	118416568	-	1405	774	18	1016	332
ENST00000595753	SLC35E1	chr19	16677342	-	ENST00000264020	IFT46	chr11	118416568	-	1390	774	18	1016	332
ENST00000595753	SLC35E1	chr19	16677342	-	ENST00000530872	IFT46	chr11	118416568	-	1255	774	18	842	274

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000595753	ENST00000264021	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-	0.09358313	0.9064169
ENST00000595753	ENST00000264020	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-	0.09233726	0.90766275
ENST00000595753	ENST00000530872	SLC35E1	chr19	16677342	-	IFT46	chr11	118416568	-	0.17089833	0.8291017

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Fusion Genomic Features for SLC35E1-IFT46

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC35E1-IFT46

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16677342/chr11:118416568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IFT46 Q9NQC8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

50_70

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

111_131

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

133_153

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

165_184

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

188_207

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

222_242

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

50_70

252

411.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

111_131

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

133_153

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

165_184

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

188_207

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

222_242

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

252_274

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

282_303

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000431408

312_332

105.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

252_274

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

282_303

252

411.0

Transmembrane

Helical

Hgene

SLC35E1

chr19:16677342

chr11:118416568

ENST00000595753

312_332

252

411.0

Transmembrane

Helical

Tgene

IFT46

chr19:16677342

chr11:118416568

ENST00000264020

31_55

275

356.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

Tgene

IFT46

chr19:16677342

chr11:118416568

ENST00000264021

31_55

224

305.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

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Fusion Gene Sequence for SLC35E1-IFT46

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82969_82969_1_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000264020_length(transcript)=1390nt_BP=774nt
GGCGGCCGCTCGGGCAGGATGGCGGCGGCCGCGGTGGGCGCGGGCCACGGCGCGGGGGGCCCGGGCGCAGCGAGCAGCAGTGGTGGGGCG
CGCGAGGGCGCGCGGGTGGCGGCGCTGTGCCTGCTGTGGTACGCGCTGAGCGCGGGCGGCAACGTGGTCAACAAGGTGATCCTGAGCGCC
TTCCCGTTCCCGGTGACCGTGTCGCTGTGCCACATCCTGGCTCTGTGCGCTGGGCTCCCGCCGCTGCTGCGCGCCTGGCGCGTGCCCCCC
GCGCCGCCCGTCTCGGGCCCCGGACCCAGTCCGCATCCGTCGTCCGGCCCGCTGCTGCCGCCGCGCTTCTACCCGCGCTACGTGCTACCG
CTCGCCTTCGGCAAGTACTTCGCGTCCGTGTCAGCGCACGTCAGCATCTGGAAGGTGCCCGTGTCCTATGCACACACCGTCAAGGCCACC
ATGCCCATCTGGGTGGTCCTCCTGTCCCGGATCATTATGAAGGAGAAGCAGAGCACCAAGGTATACTTGTCACTCATCCCCATCATCAGC
GGTGTCCTGCTGGCCACCGTCACCGAGTTGTCTTTTGACATGTGGGGACTCGTCAGCGCCCTCGCCGCCACGCTGTGCTTCTCGCTTCAG
AACATTTTCTCCAAAAAGGTCTTGCGAGATTCACGGATCCACCATCTCCGGCTGCTCAACATCCTGGGCTGCCACGCCGTCTTCTTTATG
ATCCCCACCTGGGTTCTGGTGGACCTCTCGGCTTTCCTGGTCAGCAGCGACTTGGTAAGCCTGCCCACGGCAGAGATTGATTGCAGCCTG
GCAGAGTACATTGACATGATCTGTGCCATTCTAGACATCCCTGTCTACAAGAGTCGGATCCAGTCCCTCCATCTGCTCTTTTCCCTCTAC
TCAGAATTCAAGAACTCACAGCATTTTAAAGCTCTCGCTGAAGGCAAGAAAGCATTCACTCCTTCATCCAATTCCACCTCCCAAGCTGGA
GACATGGAGACATTAACCTTCAGCTGAGACACTTCCCAAGCTGCTGTTTCAAGGCTGAGCTGGCCCCTCTGCCCCAGCTGAGATGGACAG
ATCGTTGTCAGCTACTTGATGTCCTTGCCCATGCCACAGCTTGGCTCAGGGGCAGTGCATGTCCTGCTGCCCTCTCTGCCAGAGGGCACA
GAACATGTTTGTTTAATGAACCTGCCTGCCTCAGATTGCTGTCCCCGGGGAGTTAATGCATCTACACCACTGTGGGGATTTGAGTTATAA
GAATTGGAATTTCTGAGATCCCATGGAGGTTAGATTGGGAGGAAAGCTTAAAAGATGTCCTTTTTGTGAGAGGGATGGAATTGTTTTCTT

>82969_82969_1_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000264020_length(amino acids)=332AA_BP=252
MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSG
PGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLAT
VTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLVSLPTAEIDCSLAEYIDM

--------------------------------------------------------------
>82969_82969_2_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000264021_length(transcript)=1405nt_BP=774nt
GGCGGCCGCTCGGGCAGGATGGCGGCGGCCGCGGTGGGCGCGGGCCACGGCGCGGGGGGCCCGGGCGCAGCGAGCAGCAGTGGTGGGGCG
CGCGAGGGCGCGCGGGTGGCGGCGCTGTGCCTGCTGTGGTACGCGCTGAGCGCGGGCGGCAACGTGGTCAACAAGGTGATCCTGAGCGCC
TTCCCGTTCCCGGTGACCGTGTCGCTGTGCCACATCCTGGCTCTGTGCGCTGGGCTCCCGCCGCTGCTGCGCGCCTGGCGCGTGCCCCCC
GCGCCGCCCGTCTCGGGCCCCGGACCCAGTCCGCATCCGTCGTCCGGCCCGCTGCTGCCGCCGCGCTTCTACCCGCGCTACGTGCTACCG
CTCGCCTTCGGCAAGTACTTCGCGTCCGTGTCAGCGCACGTCAGCATCTGGAAGGTGCCCGTGTCCTATGCACACACCGTCAAGGCCACC
ATGCCCATCTGGGTGGTCCTCCTGTCCCGGATCATTATGAAGGAGAAGCAGAGCACCAAGGTATACTTGTCACTCATCCCCATCATCAGC
GGTGTCCTGCTGGCCACCGTCACCGAGTTGTCTTTTGACATGTGGGGACTCGTCAGCGCCCTCGCCGCCACGCTGTGCTTCTCGCTTCAG
AACATTTTCTCCAAAAAGGTCTTGCGAGATTCACGGATCCACCATCTCCGGCTGCTCAACATCCTGGGCTGCCACGCCGTCTTCTTTATG
ATCCCCACCTGGGTTCTGGTGGACCTCTCGGCTTTCCTGGTCAGCAGCGACTTGGTAAGCCTGCCCACGGCAGAGATTGATTGCAGCCTG
GCAGAGTACATTGACATGATCTGTGCCATTCTAGACATCCCTGTCTACAAGAGTCGGATCCAGTCCCTCCATCTGCTCTTTTCCCTCTAC
TCAGAATTCAAGAACTCACAGCATTTTAAAGCTCTCGCTGAAGGCAAGAAAGCATTCACTCCTTCATCCAATTCCACCTCCCAAGCTGGA
GACATGGAGACATTAACCTTCAGCTGAGACACTTCCCAAGCTGCTGTTTCAAGGCTGAGCTGGCCCCTCTGCCCCAGCTGAGATGGACAG
ATCGTTGTCAGCTACTTGATGTCCTTGCCCATGCCACAGCTTGGCTCAGGGGCAGTGCATGTCCTGCTGCCCTCTCTGCCAGAGGGCACA
GAACATGTTTGTTTAATGAACCTGCCTGCCTCAGATTGCTGTCCCCGGGGAGTTAATGCATCTACACCACTGTGGGGATTTGAGTTATAA
GAATTGGAATTTCTGAGATCCCATGGAGGTTAGATTGGGAGGAAAGCTTAAAAGATGTCCTTTTTGTGAGAGGGATGGAATTGTTTTCTT

>82969_82969_2_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000264021_length(amino acids)=332AA_BP=252
MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSG
PGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLAT
VTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLVSLPTAEIDCSLAEYIDM

--------------------------------------------------------------
>82969_82969_3_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000530872_length(transcript)=1255nt_BP=774nt
GGCGGCCGCTCGGGCAGGATGGCGGCGGCCGCGGTGGGCGCGGGCCACGGCGCGGGGGGCCCGGGCGCAGCGAGCAGCAGTGGTGGGGCG
CGCGAGGGCGCGCGGGTGGCGGCGCTGTGCCTGCTGTGGTACGCGCTGAGCGCGGGCGGCAACGTGGTCAACAAGGTGATCCTGAGCGCC
TTCCCGTTCCCGGTGACCGTGTCGCTGTGCCACATCCTGGCTCTGTGCGCTGGGCTCCCGCCGCTGCTGCGCGCCTGGCGCGTGCCCCCC
GCGCCGCCCGTCTCGGGCCCCGGACCCAGTCCGCATCCGTCGTCCGGCCCGCTGCTGCCGCCGCGCTTCTACCCGCGCTACGTGCTACCG
CTCGCCTTCGGCAAGTACTTCGCGTCCGTGTCAGCGCACGTCAGCATCTGGAAGGTGCCCGTGTCCTATGCACACACCGTCAAGGCCACC
ATGCCCATCTGGGTGGTCCTCCTGTCCCGGATCATTATGAAGGAGAAGCAGAGCACCAAGGTATACTTGTCACTCATCCCCATCATCAGC
GGTGTCCTGCTGGCCACCGTCACCGAGTTGTCTTTTGACATGTGGGGACTCGTCAGCGCCCTCGCCGCCACGCTGTGCTTCTCGCTTCAG
AACATTTTCTCCAAAAAGGTCTTGCGAGATTCACGGATCCACCATCTCCGGCTGCTCAACATCCTGGGCTGCCACGCCGTCTTCTTTATG
ATCCCCACCTGGGTTCTGGTGGACCTCTCGGCTTTCCTGGTCAGCAGCGACTTGGTAAGCCTGCCCACGGCAGAGATTGATTGCAGCCTG
GCAGAGTACATTGACATGATCTGTGCATTTTAAAGCTCTCGCTGAAGGCAAGAAAGCATTCACTCCTTCATCCAATTCCACCTCCCAAGC
TGGAGACATGGAGACATTAACCTTCAGCTGAGACACTTCCCAAGCTGCTGTTTCAAGGCTGAGCTGGCCCCTCTGCCCCAGCTGAGATGG
ACAGATCGTTGTCAGCTACTTGATGTCCTTGCCCATGCCACAGCTTGGCTCAGGGGCAGTGCATGTCCTGCTGCCCTCTCTGCCAGAGGG
CACAGAACATGTTTGTTTAATGAACCTGCCTGCCTCAGATTGCTGTCCCCGGGGAGTTAATGCATCTACACCACTGTGGGGATTTGAGTT

>82969_82969_3_SLC35E1-IFT46_SLC35E1_chr19_16677342_ENST00000595753_IFT46_chr11_118416568_ENST00000530872_length(amino acids)=274AA_BP=252
MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSG
PGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLAT
VTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLVSLPTAEIDCSLAEYIDM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC35E1-IFT46

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SLC35E1-IFT46

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC35E1-IFT46

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source