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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC35E3-COPZ1 (FusionGDB2 ID:82988)

Fusion Gene Summary for SLC35E3-COPZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC35E3-COPZ1
Fusion gene ID: 82988
HgeneTgene
Gene symbol

SLC35E3

COPZ1

Gene ID

55508

22818

Gene namesolute carrier family 35 member E3COPI coat complex subunit zeta 1
SynonymsBLOV1CGI-120|COPZ|HSPC181|zeta-COP|zeta1-COP
Cytomap

12q15

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 35 member E3bladder cancer-overexpressed gene 1 proteinsolute carrier family 35, member E2coatomer subunit zeta-1coatomer protein complex subunit zeta 1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat protein
Modification date2020031320200313
UniProtAcc.

P61923

Ensembl transtripts involved in fusion geneENST00000538043, ENST00000398004, 
ENST00000262061, ENST00000416254, 
ENST00000455864, ENST00000549043, 
ENST00000552218, ENST00000552362, 
ENST00000553231, ENST00000548281, 
ENST00000548753, ENST00000549116, 
ENST00000551779, 
Fusion gene scores* DoF score11 X 6 X 4=2645 X 5 X 2=50
# samples 135
** MAII scorelog2(13/264*10)=-1.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: SLC35E3 [Title/Abstract] AND COPZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC35E3(69145970)-COPZ1(54735990), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC35E3-COPZ1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOPZ1

GO:0006891

intra-Golgi vesicle-mediated transport

11056392


check buttonFusion gene breakpoints across SLC35E3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COPZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23R-01ASLC35E3chr12

69145970

+COPZ1chr12

54735990

+


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Fusion Gene ORF analysis for SLC35E3-COPZ1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538043ENST00000262061SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000416254SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000455864SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000549043SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000552218SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000552362SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3CDSENST00000538043ENST00000553231SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-3UTRENST00000538043ENST00000548281SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-5UTRENST00000538043ENST00000548753SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-intronENST00000538043ENST00000549116SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
3UTR-intronENST00000538043ENST00000551779SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
5CDS-3UTRENST00000398004ENST00000548281SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
5CDS-5UTRENST00000398004ENST00000548753SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
5CDS-intronENST00000398004ENST00000549116SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
5CDS-intronENST00000398004ENST00000551779SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
Frame-shiftENST00000398004ENST00000416254SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000262061SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000455864SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000549043SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000552218SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000552362SLC35E3chr12

69145970

+COPZ1chr12

54735990

+
In-frameENST00000398004ENST00000553231SLC35E3chr12

69145970

+COPZ1chr12

54735990

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398004SLC35E3chr1269145970+ENST00000262061COPZ1chr1254735990+27179441821390402
ENST00000398004SLC35E3chr1269145970+ENST00000549043COPZ1chr1254735990+19709441821390402
ENST00000398004SLC35E3chr1269145970+ENST00000552218COPZ1chr1254735990+16219441821453423
ENST00000398004SLC35E3chr1269145970+ENST00000553231COPZ1chr1254735990+14529441821420412
ENST00000398004SLC35E3chr1269145970+ENST00000552362COPZ1chr1254735990+14079441821339385
ENST00000398004SLC35E3chr1269145970+ENST00000455864COPZ1chr1254735990+17819441821390402

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398004ENST00000262061SLC35E3chr1269145970+COPZ1chr1254735990+0.0029707050.9970293
ENST00000398004ENST00000549043SLC35E3chr1269145970+COPZ1chr1254735990+0.0047978140.9952022
ENST00000398004ENST00000552218SLC35E3chr1269145970+COPZ1chr1254735990+0.0031607350.9968393
ENST00000398004ENST00000553231SLC35E3chr1269145970+COPZ1chr1254735990+0.0047749370.9952251
ENST00000398004ENST00000552362SLC35E3chr1269145970+COPZ1chr1254735990+0.0031169150.9968831
ENST00000398004ENST00000455864SLC35E3chr1269145970+COPZ1chr1254735990+0.0043701140.9956299

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Fusion Genomic Features for SLC35E3-COPZ1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC35E3chr1269145970+COPZ1chr1254735989+0.0002095990.9997904
SLC35E3chr1269145970+COPZ1chr1254735989+0.0002095990.9997904

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC35E3-COPZ1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69145970/chr12:54735990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COPZ1

P61923

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250|UniProtKB:P53600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+3577_82224314.0Compositional biasNote=Poly-Leu
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35126_143224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35153_173224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+3517_37224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35187_206224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+3540_60224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+3577_97224314.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35225_245224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35252_272224314.0TransmembraneHelical
HgeneSLC35E3chr12:69145970chr12:54735990ENST00000398004+35275_295224314.0TransmembraneHelical


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Fusion Gene Sequence for SLC35E3-COPZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82988_82988_1_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000262061_length(transcript)=2717nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCC
TAGAGAGTGATCCCCAGCAGGTGGTACACCGGGTGGCATTAAGGGGTGAAGATGTCCCCCTTACGGAGCAGACCGTGTCTCAGGTGCTGC
AGTCAGCCAAAGAACAGATCAAGTGGTCACTCCTTCGGTGAAGACCTCACTGTTCCTGGCTCTTCATCCTCTTCAAAAAATTTGCATGTC
TGCTGTGAATTTTCATCTAGTTCCCCAATCGATGCTCTCAGGGTCATCTCGGGGATCACAGGGATCCTTAAATCTCCATTCTGTTTGTGG
TTGCCCCCTCAACCTCCCCTACACCCTTCCTATTCTTTTTCATTCTTCTTGCAGTTCTGGGAGTAAAGCTCCCAGCATATTTAGATAATA
GGGCAGGGGAAGCACCCTCTTTCTTTCTAGACTGGATTATGCTCACATGCTCCCTTGCCCTGACATTTTTGTAAATTCTGTGCCCTTTGC
TGTAGCTACACTTCAGATTAAAGTAGGAGAAAGAATGTGCTGAGTGTTTTCCTCCCTTTGCCTCTACCTGGCCCTCATCCCAACAGCCCA
GCAAGGGGAGAGAGAAAGAGAATTCTTTTCTATAGAACGAGTGGGGGCGGGGATGGGTAGGGATTTATCCAATCTAAGCCCTAACCCCAC
TTAGTGACCTCAGTGTTTTCTTCCATTCCTTCTTACTGCCCTGTCCTCTGCCTTGGAAGAGGCTTTGGGAATAGTTCATAGGGAAGGGAC
AACATGGAAGAAACAGCGATTTAAATTGTATTGAACAGGGCATATAAAATGCATTCTGTACCCTGATCTGGCATATAGCTTCAAAACTGC
AGTGGCGAGTGTCCATCTCTTAGTTAGCTACCTTAACTGTCCACCCTTACTACCTGTGGGATCGTTGCCTGGTTTGTCTTCTCTGTGTCC
TGGAGCAAAGCCAGTTCCTAAAACTAAAACTCCATTCTAGTCTTGGGAAGAAAAGTTTCTACTCAGAACTGGGGAAGGAGTGGAACTTAT
GACTTGGGCCTCTAGGCTGTCTCTGTCCCCTCAGCTCCCCGACATGCATTTACTCTCTGCCGTGGGTCTGCAGTCGCTGCAACCTACCCT
CTCTCTGCCTCAGCCTTACACCCAAGCAGTAGGTCTGTGCTCTCCCTGTCTCTAGGTCGCTGAGAGAGGTGCTTTTCTTCATAAAACCTT
TGGGGTTTGGATTTCCCCAGGAAGATGGAGAATGGAATACTCACTCTTGGGTCTAATCTTTCCCCTTGACCCAGAACTTCCTCCCCACAA
AAATGCCTTTAAAAACCTTCCTGAGACTTAAGCATTCTGCCCCACTTACTAACTGCCAGTTCTCCAGCACTGAGGTGGGGCAGATAACGG
GGCATATTTAAGGGGGCATCTTTGTGTAAAAGATGCATGGAGTCAGGAGAAAACCACCTTCATAAACTGCTCTGTGCAAAGAGGAATAAA

>82988_82988_1_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000262061_length(amino acids)=402AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVIL

--------------------------------------------------------------
>82988_82988_2_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000455864_length(transcript)=1781nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCC
TAGAGAGTGATCCCCAGCAGGTGGTACACCGGGTGGCATTAAGGGGTGAAGATGTCCCCCTTACGGAGCAGACCGTGTCTCAGGTGCTGC
AGTCAGCCAAAGAACAGATCAAGTGGTCACTCCTTCGGTGAAGACCTCACTGTTCCTGGCTCTTCATCCTCTTCAAAAAATTTGCATGTC
TGCTGTGAATTTTCATCTAGTTCCCCAATCGATGCTCTCAGGGTCATCTCGGGGATCACAGGGATCCTTAAATCTCCATTCTGTTTGTGG
TTGCCCCCTCAACCTCCCCTACACCCTTCCTATTCTTTTTCATTCTTCTTGCAGTTCTGGGAGTAAAGCTCCCAGCATATTTAGATAATA
GGGCAGGGGAAGCACCCTCTTTCTTTCTAGACTGGATTATGCTCACATGCTCCCTTGCCCTGACATTTTTGTAAATTCTGTGCCCTTTGC

>82988_82988_2_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000455864_length(amino acids)=402AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVIL

--------------------------------------------------------------
>82988_82988_3_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000549043_length(transcript)=1970nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCC
TAGAGAGTGATCCCCAGCAGGTGGTACACCGGGTGGCATTAAGGGGTGAAGATGTCCCCCTTACGGAGCAGACCGTGTCTCAGGTGCTGC
AGTCAGCCAAAGAACAGATCAAGTGGTCACTCCTTCGGTGAAGACCTCACTGTTCCTGGCTCTTCATCCTCTTCAAAAAATTTGCATGTC
TGCTGTGAATTTTCATCTAGTTCCCCAATCGATGCTCTCAGGGTCATCTCGGGGATCACAGGGATCCTTAAATCTCCATTCTGTTTGTGG
TTGCCCCCTCAACCTCCCCTACACCCTTCCTATTCTTTTTCATTCTTCTTGCAGTTCTGGGAGTAAAGCTCCCAGCATATTTAGATAATA
GGGCAGGGGAAGCACCCTCTTTCTTTCTAGACTGGATTATGCTCACATGCTCCCTTGCCCTGACATTTTTGTAAATTCTGTGCCCTTTGC
TGTAGCTACACTTCAGATTAAAGTAGGAGAAAGAATGTGCTGAGTGTTTTCCTCCCTTTGCCTCTACCTGGCCCTCATCCCAACAGCCCA
GCAAGGGGAGAGAGAAAGAGAATTCTTTTCTATAGAACGAGTGGGGGCGGGGATGGGTAGGGATTTATCCAATCTAAGCCCTAACCCCAC

>82988_82988_3_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000549043_length(amino acids)=402AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVIL

--------------------------------------------------------------
>82988_82988_4_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000552218_length(transcript)=1621nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGAACAGGAAGCACCCAGGCAGGAGGACTGCATGAGTCGAGTTCAAGACAAGCTTGGGCAACACAGAAAAATGTAGAAAAGCGAGCAC
TGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCCTAGAGAGTGATCCCCAGCAGGTGGTAC
ACCGGGTGGCATTAAGGGGTGAAGATGTCCCCCTTACGGAGCAGACCGTGTCTCAGGTGCTGCAGTCAGCCAAAGAACAGATCAAGTGGT
CACTCCTTCGGTGAAGACCTCACTGTTCCTGGCTCTTCATCCTCTTCAAAAAATTTGCATGTCTGCTGTGAATTTTCATCTAGTTCCCCA
ATCGATGCTCTCAGGGTCATCTCGGGGATCACAGGGATCCTTAAATCTCCATTCTGTTTGTGGTTGCCCCCTCAACCTCCCCTACACCCT

>82988_82988_4_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000552218_length(amino acids)=423AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRTGSTQAGGLHESSSRQAWATQKNVEKRAL

--------------------------------------------------------------
>82988_82988_5_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000552362_length(transcript)=1407nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCC
TAGAGAGTGATCCCCAGCAGGTGGTACACCGGGTGCTGCAGTCAGCCAAAGAACAGATCAAGTGGTCACTCCTTCGGTGAAGACCTCACT

>82988_82988_5_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000552362_length(amino acids)=385AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVIL

--------------------------------------------------------------
>82988_82988_6_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000553231_length(transcript)=1452nt_BP=944nt
GCGGAAGCACTGGAGCCCCGAGTCACGTGGCTGCGGGCGGAGATGAGCGGGGCGTGGGACGTGCTGCGGCGTCCTAGCTGGCTTACAGGG
CGGCGGCGGGGTGTGTGTCCTCTGTTAAGAGTGCTACTCGCCCGGGGTTGATCTGTGCATGCCACTCCTGGGTCAGACGGTGAGGTCGGC
GTCTGCGAGGACGCGGCGGTGGAGTAGAAGGGCAGCCGGAGACAGGCCCGGCGCCCCTTCCGAGGCTAGACGGCCCCAGCTTCGCGGGGA
TCATGGCATTGCTGGTGGACCGAGTGCGGGGCCACTGGCGAATCGCCGCCGGGCTCCTGTTCAACCTGCTGGTGTCCATCTGCATTGTGT
TCCTCAACAAATGGATTTATGTGTACCACGGCTTCCCCAACATGAGCCTGACCCTGGTGCACTTCGTGGTCACCTGGCTGGGCTTGTATA
TCTGCCAGAAGCTGGACATCTTTGCCCCCAAAAGTCTGCCGCCCTCCAGGCTCCTCCTCCTGGCCCTCAGCTTCTGTGGCTTTGTGGTCT
TCACTAACCTTTCTCTGCAGAACAACACCATAGGCACCTATCAGCTGGCCAAGGCCATGACCACGCCGGTGATCATAGCCATCCAGACCT
TCTGCTACCAGAAAACCTTCTCCACCAGAATCCAGCTCACGCTGATTCCTATAACTTTAGGTGTAATCCTAAATTCTTATTACGATGTGA
AGTTTAATTTCCTTGGAATGGTGTTTGCTGCTCTTGGTGTTTTAGTTACATCCCTTTATCAAGTGTGGGTAGGAGCCAAACAGCATGAAT
TACAAGTGAACTCAATGCAGCTGCTGTACTACCAGGCTCCGATGTCATCTGCCATGTTGCTGGTTGCTGTGCCCTTCTTTGAGCCAGTGT
TTGGAGAAGGAGGAATATTTGGTCCCTGGTCAGTTTCTGCTTTGTACTATGACGACACCTACCCCAGTGTCAAGGAGCAAAAGGCCTTTG
AGAAGAACATTTTCAACAAGACCCATCGGACTGACAGTGAAATTGCCCTCTTGGAAGGCCTGACAGTGGTATACAAAAGCAGTATAGATC
TCTATTTCTATGTGATTGGCAGCTCCTATGAAAATGAGCTGATGCTTATGGCTGTTCTGAACTGTCTCTTCGACTCATTGAGCCAGATGC
TGAGGAAAAATGTAGAAAAGCGAGCACTGCTGGAGAACATGGAGGGGCTGTTCTTGGCTGTGGATGAAATTGTAGATGGAGGGGTGATCC
TAGAGAGTGATCCCCAGCAGGTGGTACACCGGGTGGCATTAAGGGGTGAAGATGTCCCCCTTACGGAGCAGACCGTGTCTCAGGTATACC
TCTTCTCTCTTCATCCCCTCAGTGGGTTTGAATTTTTTTGGAATTTTCCAAACAATCTGCTAGGGCCTTAGAGAGCTTCTTCCCATCTCT

>82988_82988_6_SLC35E3-COPZ1_SLC35E3_chr12_69145970_ENST00000398004_COPZ1_chr12_54735990_ENST00000553231_length(amino acids)=412AA_BP=249
MRGRGGGVEGQPETGPAPLPRLDGPSFAGIMALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYI
CQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVK
FNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALYYDDTYPSVKEQKAFE
KNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC35E3-COPZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC35E3-COPZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC35E3-COPZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource