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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC35E4-SEC14L2 (FusionGDB2 ID:83000)

Fusion Gene Summary for SLC35E4-SEC14L2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC35E4-SEC14L2
Fusion gene ID: 83000
HgeneTgene
Gene symbol

SLC35E4

SEC14L2

Gene ID

339665

23541

Gene namesolute carrier family 35 member E4SEC14 like lipid binding 2
Synonyms-C22orf6|SPF|TAP|TAP1
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 35 member E4SEC14-like protein 2alpha-tocopherol-associated proteinsqualene transfer proteinsupernatant protein factortocopherol-associated protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000300385, ENST00000343605, 
ENST00000406566, 		ENST00000459728, 
ENST00000402592, ENST00000403484, 
ENST00000405717, ENST00000312932, 
Fusion gene scores* DoF score4 X 3 X 3=366 X 6 X 4=144
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC35E4 [Title/Abstract] AND SEC14L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC35E4(31033056)-SEC14L2(30802331), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC35E4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC14L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-AARE-01ASLC35E4chr22

31033056

-SEC14L2chr22

30802331

+
ChimerDB4LUADTCGA-49-AARESLC35E4chr22

31033056

+SEC14L2chr22

30802331

+


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Fusion Gene ORF analysis for SLC35E4-SEC14L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000300385ENST00000459728SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-3UTRENST00000343605ENST00000459728SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-3UTRENST00000406566ENST00000459728SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000300385ENST00000402592SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000300385ENST00000403484SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000300385ENST00000405717SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000343605ENST00000402592SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000343605ENST00000403484SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000343605ENST00000405717SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000406566ENST00000402592SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000406566ENST00000403484SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
5CDS-5UTRENST00000406566ENST00000405717SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
In-frameENST00000300385ENST00000312932SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
In-frameENST00000343605ENST00000312932SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+
In-frameENST00000406566ENST00000312932SLC35E4chr22

31033056

+SEC14L2chr22

30802331

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343605SLC35E4chr2231033056+ENST00000312932SEC14L2chr2230802331+540914187392499586
ENST00000300385SLC35E4chr2231033056+ENST00000312932SEC14L2chr2230802331+525512645852345586
ENST00000406566SLC35E4chr2231033056+ENST00000312932SEC14L2chr2230802331+4738747681828586

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343605ENST00000312932SLC35E4chr2231033056+SEC14L2chr2230802331+0.0356192920.96438074
ENST00000300385ENST00000312932SLC35E4chr2231033056+SEC14L2chr2230802331+0.0341610830.96583885
ENST00000406566ENST00000312932SLC35E4chr2231033056+SEC14L2chr2230802331+0.0297316740.9702683

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Fusion Genomic Features for SLC35E4-SEC14L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC35E4chr2231033056+SEC14L2chr2230802330+2.44E-060.9999976
SLC35E4chr2231033056+SEC14L2chr2230802330+2.44E-060.9999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC35E4-SEC14L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31033056/chr22:30802331)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12125_179206235.0DomainNote=EamA
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12125_179206351.0DomainNote=EamA
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13125_179206399.3333333333333DomainNote=EamA
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12110_132206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12135_155206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+1251_71206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+1273_93206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12110_132206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12135_155206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+1251_71206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+1273_93206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13110_132206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13135_155206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+1351_71206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+1373_93206399.3333333333333TransmembraneHelical
TgeneSEC14L2chr22:31033056chr22:30802331ENST00000312932112275_38343404.0DomainGOLD
TgeneSEC14L2chr22:31033056chr22:30802331ENST0000031293211276_24943404.0DomainCRAL-TRIO
TgeneSEC14L2chr22:31033056chr22:30802331ENST00000402592110275_38343321.0DomainGOLD
TgeneSEC14L2chr22:31033056chr22:30802331ENST0000040259211076_24943321.0DomainCRAL-TRIO
TgeneSEC14L2chr22:31033056chr22:30802331ENST00000405717111275_38343393.0DomainGOLD
TgeneSEC14L2chr22:31033056chr22:30802331ENST0000040571711176_24943393.0DomainCRAL-TRIO

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12111_319206235.0Compositional biasNote=Leu-rich
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12111_319206351.0Compositional biasNote=Leu-rich
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13111_319206399.3333333333333Compositional biasNote=Leu-rich
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12218_238206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12258_278206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12279_299206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000300385+12312_332206235.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12218_238206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12258_278206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12279_299206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000343605+12312_332206351.0TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13218_238206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13258_278206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13279_299206399.3333333333333TransmembraneHelical
HgeneSLC35E4chr22:31033056chr22:30802331ENST00000406566+13312_332206399.3333333333333TransmembraneHelical


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Fusion Gene Sequence for SLC35E4-SEC14L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83000_83000_1_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000300385_SEC14L2_chr22_30802331_ENST00000312932_length(transcript)=5255nt_BP=1264nt
GGAGTCACAGCCGCAGCCAGAGCCGCAGCCAAAGCCTCAGAGAGCAGGAGTTGGAGCGCAGGCCCTGCTGGATCCGCGCCTAGCTCGCCG
CCAGGCACCGGCCGGAGGACGGGCCGTGGTGTCAGCTCACTGCCCGGGCGCTGTGGGAGGCAGCGAGCCCGCGACCCCCCGGGCCGGGCA
CCGCCAGGCGCGGAGCCCAGATCGCCCCCCTGCCAGGCCTGGTCACGGCCAGAGCACGCAGGAGTTCCCAGGGTCTGGATCTGCGCGCAC
CCTAATGACCTGGGGACTGAAGAGAAAAAAGGAACGAGGATTTCATCTAAAAGCATAACGTGGGCACTAGGCGAGGAGGAAAGTGGAGAC
CACCTGGCACGGGGCAGAGGTGCCTGGAGCCCACGCTTGAGCATCGGAGACCCTGGCATCCTAGCAGCCGCGACCTTGGCTCTGCCCTGT
CTGAGCTGGAAACACAGCTTAGCTTCTAGACATCGCTGGCACAGGCCTGGCACAAGTAAGCAGTGTCCTCACCTGTCTGAAACGGGACAC
GGGGTCGGAGGAACCAGGATCTAGCCTGGCCCCAAGCGGAACTCTCTGGTGGCCCAGAGGTCGTCACTGGGGAGCCCGCCTCCTGCCCTA
GCCTCACTGGTGCGGATGTGCCGCTGCCCGCCGGAGCACCATGATGGCAGGATGACCTCAGCCGAAGTAGGAGCAGCAGCTGGTGGTGCT
CAGGCGGCTGGGCCCCCCGAGTGGCCCCCTGGCAGCCCTCAGGCCCTCCGGCAGCCTGGCCGGGCCCGAGTGGCCATGGCAGCACTGGTG
TGGCTGCTGGCGGGAGCCAGCATGTCAAGCCTCAACAAGTGGATCTTCACAGTGCACGGCTTTGGGCGGCCCCTGCTGCTGTCGGCCCTG
CACATGCTGGTGGCAGCCCTGGCATGCCACCGGGGGGCACGGCGCCCCATGCCAGGCGGCACTCGCTGCCGAGTCCTACTGCTCAGTCTC
ACCTTTGGCACGTCCATGGCCTGCGGCAACGTGGGCCTAAGGGCTGTGCCCCTGGACCTGGCACAACTGGTTACTACCACCACACCTCTG
TTCACCCTGGCCCTGTCGGCGCTGCTGCTGGGCCGCCGCCACCACCCACTTCAGTTGGCCGCCATGGGTCCGCTCTGCCTGGGGGCCGCC
TGCAGCCTGGCTGGAGAGTTCCGGACACCCCCTACCGGCTGTGGCTTCCTGCTCGCAGCCACCTGCCTCCGCGGACTCAAGTCGGTTCAG
CAAACCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGCATGTGGAGTTCCGAAAGCAAAAGGACATTGACAACATCATT
AGCTGGCAGCCTCCAGAGGTGATCCAACAGTATCTGTCAGGGGGTATGTGTGGCTATGACCTGGATGGCTGCCCAGTCTGGTACGACATA
ATTGGACCTCTGGATGCCAAGGGTCTGCTGTTCTCAGCCTCCAAACAGGACCTGCTGAGGACCAAGATGCGGGAGTGTGAGCTGCTTCTG
CAAGAGTGTGCCCACCAGACCACAAAGTTGGGGAGGAAGGTGGAGACCATCACCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCAT
CTCTGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAGGAAAATTATCCCGAAACACTGAAGCGTCTTTTTGTTGTT
AAAGCCCCCAAACTGTTTCCTGTGGCCTATAACCTCATCAAACCCTTCCTGAGTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCA
AATTGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTGGAGTATGGGGGCACCATGACTGACCCTGATGGAAACCCC
AAGTGCAAATCCAAGATCAACTACGGGGGTGACATCCCCAGGAAGTATTATGTGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTG
CAGATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCTGGCTGTGTCCTCAGGTGGCAGTTTATGTCAGATGGAGCG
GATGTTGGTTTTGGGATTTTCCTGAAGACCAAGATGGGAGAGAGGCAGCGGGCAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTAC
AACTCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGCATCTATGTCCTGCGGTTTGACAACACCTACAGCTTCATT
CATGCCAAGAAGGTCAATTTCACTGTGGAGGTCCTGCTTCCAGACAAAGCCTCAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCG
AAATAACACCTTCTCCTATAGCAGGCCTGGCCCCCTCAGTGTCTCCCTGTCAATTTCTACCCCTTGTAGCAGTCATTTTCGCACAACCCT
GAAGCCCAAAGAAACTGGGCTGGAGGACAGACCTCAGGAGCTTTCATTTCAGTTAGGCAGAGGAAGAGCGACTGCAGTGGGTCTCCGTGT
CTATCAAATACCTAAGGAGTCCCCAGGAGCTGGCTGGCCATCGTGATAGGATCTGTCTGTCCTGTAAACTGTGCCAACTTCACCTGTCCA
GGGACAGCGAAGCTGGGGGTGGCGGGGGGCATGTACCACAGGGTGGCAGCAGGGAAAAAAATTAGAAAAGGGTGAAAGATTGGGACTTAA
CACTTCAGGGAAGTCAGCTGCCGGGGAGAAACTTGCTCCTAAATGAACACATAAGTTTAGATCGCAATGAGGAGTAGCAGGGTAGCTGGT
TGCTAGAGTTACGGTGGGGATCAGAAACTCTTCCAAACATTTTAGCACTGAGGCTGGGGTAGCTTTTGGCTTTTCCCAGGTCTCAGGAGG
TGGCCTGAGTCAGCACACATCTTCCCACTCGGTAGACAGGCTGGCCTCTCCCTCACTTTGAGACTTTGGCAACTCCTGGGCCACACGGCC
TGCCTCTTTGATTACTAATGATTGTCAGTGACTCAGAGCTTCCTGGGACTTCGGGTACCCACCCGCTGTTCTCCATGCAAACAAAGCGCC
AGGGAAATGACCCACAGGGATCGCAGCTGCAGGGAGGGCCAGGGAGGTTGGGGGTGGGAGTGAATGCTAAAAGCAGATCGTCCAGTGCCC
TTTTCAGTGCTACCGGCCTCTCACCAAGCAGTCCTCCATGTGAGCAACCCCGAGACAAAAATGCTAAGTGGGATCAAGAGAGCAGCACTC
GGAGAGGGTGTTTGCCAGTCTGAGTGTCCCGCGGTGCCCGCCAACCCGCTTCCTGACTGACCTGAGCAAGGTCTTACTAAGCAGTCCCAT
CTCTGTGGGAGGCATGCAACGCGTGCAGGGAGTTCAGGTGCCGGTCGGCGTAGCCAGGCCTGGAGGCCCCCCAGGCAGGAGGCCGCCCAA
AGGCGGGGCCGGCGTCTCGCAGACTAGGGGCTGGGGGCGGCCACAGACGGCCTCGAAACCACAGCCCTTACCCCAATCCCACGAGCCCCG
CCAACGAACCACAGGTGCTGGGCTTTAGAGAACATGGGAAGGCGGCCCCAGACCTGCGGGAACGCCTTTCCCTCAGAGCCAGGCCCCGGC
CCCGTCTGGGAAGCTCATCTTGCGAAGCTGAGGGAGCTCAGGGCAAAGGCCAGGCTAGCGCGGACCGGAAGGGGCCGAGGCTGCACGGGC
CTCTGCCAGAACGCTCAGGACATCCCGGCCTGGGTTTACAACGCTGTTAGGAAAATTAACCAATGAATAAAGCAACGTTCAGTGCGCAGG
GAGTGAAATTCAATGCCCACCGCTAGGCTCCTCGCTGCCTCTCACTCAAGAGGCCCAAACTCAGACGGCGTCAGGGACCCGGACCCAGCA
GCCGTTTCACGCCAATAGATAGGGCGCATGCGCAGAAATCCTCCTCGGCTCTCTAGCGTGAGCTTTCCCAAGGGGCCACGCCCAGCTTGC
CTTCTGATTGGTCCAGCTGGTGGGTTGTCTTCCGCCATCTTTGATCAGGGCACTAAGGATGCTCCCCACGGCCTTCACAGTGACGGCGGA
GACCCTGCCCCGCCAGCTGCTCAGTACGTGCCGCGTAGCCCGTGCGAGCCAAGTGTGAGTCCGGGCGAGCGCCTGCGGAGCTAGCACTGG
GCCCAGAATGAGAGGGAGGCGGAGGAGCAGCGATCACGTGGTTTTAGGGACTGTCTAATAATTCCACGCCAGCATTGCCGGTGTTTCAGG
GGGTGGGAACCGCTGCGTTCCCCATCAACTTTTCTCCCACCCACCACCCTCCCCAACCTACAAGCCCAGCTCAGCTTGAGGTAACTGCTG
ACCGGACTGTCCTATACAGCCCTACAAGACAGAGGCGCCTAGGGCTGAAAGCGGGGGCCTCCGTAGGGAGCCAGCGGGGGCCTCAATAGT
TACTCATTTTCTCTACCTTTGATGAAAATAAGAGCTAATTCTTAATAAGGCCTACCGGGTATCACGCAAAAACCCTGTGCTTACTATTAC
ACTTTGGGTTGTTGCAAAGATTAAAGGAAATAAGCCGTGCAAAGCGCTTAAGAGCTTGGTATAAGTAAGTGCTCGTCAATGTTGGCTACT
CTCATTTTTTTTGCAGACGTGGGAACTGGGGCTCAGGGAGGCTAACAGCCAGTAGGCGGCACAGCTAGGATTTGAACCCAGGATTGTCTC
CAACGCCGCTCAATTATACCCGCCAAGGAGTCACAGAGACTTAGTGAAGTGCACACATTGCTCACCTGGGTGAACTGAGGTCCAGCGGGG
GAAGGCTTCCTCCTGTTGTAATCACTAACCCCAACTCTGTCTCCCTTGCCCGATTCATTCATTCGTTAATTAATTCATCCAACATCCTGT
CCCCAAGAAGCTCAGTCTGGGGACATACTGATCCAGTTAAATGCGAGTGCTTCCTAGTTATACATGGCGACTGCTGAGAAGGGACTCCAG
AGTCCAGGCACCTACCTCCCAGGGGCTCACCGTTCACTCCTCTAGCCTCATTTAGAGCTCGCATTAAGAGCACGGGATCTGGATCCACAC
TGTTTGGATTCAAATCACAACTTCACCACTTAGCAGCTGTGTGTTCTGGGAAAATGACCCACCTTCTCTGTGCCTCCATTTTCTCACCTG
TAAAACGGGCTCCCAGGCTGGTGGGAGGGTTTCAGGTGTAAGACATGGAGAGTCCTTTAGCGAACATGTAGACTGGCAATAAACTCAATA

>83000_83000_1_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000300385_SEC14L2_chr22_30802331_ENST00000312932_length(amino acids)=586AA_BP=34
MVAQRSSLGSPPPALASLVRMCRCPPEHHDGRMTSAEVGAAAGGAQAAGPPEWPPGSPQALRQPGRARVAMAALVWLLAGASMSSLNKWI
FTVHGFGRPLLLSALHMLVAALACHRGARRPMPGGTRCRVLLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLGRRHH
PLQLAAMGPLCLGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQTRSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGG
MCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCM
FEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRK
YYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSD

--------------------------------------------------------------
>83000_83000_2_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000343605_SEC14L2_chr22_30802331_ENST00000312932_length(transcript)=5409nt_BP=1418nt
GGGCTTGGCTGGGGTGCTCAGCCCAATTTTCCGTGTAGGGAGCGGGCGGCGGCGGGGGAGGCAGAGGCGGAGGCGGAGTCAAGAGCGCAC
CGCCGCGCCCGCCGTGCCGGGCCTGAGCTGGAGCCGGGCGTGAGTCGCAGCAGGAGCCGCAGCCGGAGTCACAGCCGCAGCCAGAGCCGC
AGCCAAAGCCTCAGAGAGCAGGAGTTGGAGCGCAGGCCCTGCTGGATCCGCGCCTAGCTCGCCGCCAGGCACCGGCCGGAGGACGGGCCG
TGGTGTCAGCTCACTGCCCGGGCGCTGTGGGAGGCAGCGAGCCCGCGACCCCCCGGGCCGGGCACCGCCAGGCGCGGAGCCCAGATCGCC
CCCCTGCCAGGCCTGGTCACGGCCAGAGCACGCAGGAGTTCCCAGGGTCTGGATCTGCGCGCACCCTAATGACCTGGGGACTGAAGAGAA
AAAAGGAACGAGGATTTCATCTAAAAGCATAACGTGGGCACTAGGCGAGGAGGAAAGTGGAGACCACCTGGCACGGGGCAGAGGTGCCTG
GAGCCCACGCTTGAGCATCGGAGACCCTGGCATCCTAGCAGCCGCGACCTTGGCTCTGCCCTGTCTGAGCTGGAAACACAGCTTAGCTTC
TAGACATCGCTGGCACAGGCCTGGCACAAGTAAGCAGTGTCCTCACCTGTCTGAAACGGGACACGGGGTCGGAGGAACCAGGATCTAGCC
TGGCCCCAAGCGGAACTCTCTGGTGGCCCAGAGGTCGTCACTGGGGAGCCCGCCTCCTGCCCTAGCCTCACTGGTGCGGATGTGCCGCTG
CCCGCCGGAGCACCATGATGGCAGGATGACCTCAGCCGAAGTAGGAGCAGCAGCTGGTGGTGCTCAGGCGGCTGGGCCCCCCGAGTGGCC
CCCTGGCAGCCCTCAGGCCCTCCGGCAGCCTGGCCGGGCCCGAGTGGCCATGGCAGCACTGGTGTGGCTGCTGGCGGGAGCCAGCATGTC
AAGCCTCAACAAGTGGATCTTCACAGTGCACGGCTTTGGGCGGCCCCTGCTGCTGTCGGCCCTGCACATGCTGGTGGCAGCCCTGGCATG
CCACCGGGGGGCACGGCGCCCCATGCCAGGCGGCACTCGCTGCCGAGTCCTACTGCTCAGTCTCACCTTTGGCACGTCCATGGCCTGCGG
CAACGTGGGCCTAAGGGCTGTGCCCCTGGACCTGGCACAACTGGTTACTACCACCACACCTCTGTTCACCCTGGCCCTGTCGGCGCTGCT
GCTGGGCCGCCGCCACCACCCACTTCAGTTGGCCGCCATGGGTCCGCTCTGCCTGGGGGCCGCCTGCAGCCTGGCTGGAGAGTTCCGGAC
ACCCCCTACCGGCTGTGGCTTCCTGCTCGCAGCCACCTGCCTCCGCGGACTCAAGTCGGTTCAGCAAACCAGAAGCTTCGACCTGCAGAA
GTCGGAGGCCATGCTCCGGAAGCATGTGGAGTTCCGAAAGCAAAAGGACATTGACAACATCATTAGCTGGCAGCCTCCAGAGGTGATCCA
ACAGTATCTGTCAGGGGGTATGTGTGGCTATGACCTGGATGGCTGCCCAGTCTGGTACGACATAATTGGACCTCTGGATGCCAAGGGTCT
GCTGTTCTCAGCCTCCAAACAGGACCTGCTGAGGACCAAGATGCGGGAGTGTGAGCTGCTTCTGCAAGAGTGTGCCCACCAGACCACAAA
GTTGGGGAGGAAGGTGGAGACCATCACCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCATCTCTGGAAGCCTGCTGTGGAGGCCTA
TGGAGAGTTTCTCTGCATGTTTGAGGAAAATTATCCCGAAACACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGC
CTATAACCTCATCAAACCCTTCCTGAGTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCAAATTGGAAGGAGGTTTTACTGAAACA
TATCAGCCCTGACCAGGTGCCTGTGGAGTATGGGGGCACCATGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGG
GGGTGACATCCCCAGGAAGTATTATGTGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTGCAGATTTCCCGTGGCTCCTCCCACCA
AGTGGAGTATGAGATCCTCTTCCCTGGCTGTGTCCTCAGGTGGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAA
GACCAAGATGGGAGAGAGGCAGCGGGCAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTACAACTCCCACCTGGTCCCTGAAGATGG
GACCCTCACCTGCAGTGATCCTGGCATCTATGTCCTGCGGTTTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGT
GGAGGTCCTGCTTCCAGACAAAGCCTCAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCGAAATAACACCTTCTCCTATAGCAGGC
CTGGCCCCCTCAGTGTCTCCCTGTCAATTTCTACCCCTTGTAGCAGTCATTTTCGCACAACCCTGAAGCCCAAAGAAACTGGGCTGGAGG
ACAGACCTCAGGAGCTTTCATTTCAGTTAGGCAGAGGAAGAGCGACTGCAGTGGGTCTCCGTGTCTATCAAATACCTAAGGAGTCCCCAG
GAGCTGGCTGGCCATCGTGATAGGATCTGTCTGTCCTGTAAACTGTGCCAACTTCACCTGTCCAGGGACAGCGAAGCTGGGGGTGGCGGG
GGGCATGTACCACAGGGTGGCAGCAGGGAAAAAAATTAGAAAAGGGTGAAAGATTGGGACTTAACACTTCAGGGAAGTCAGCTGCCGGGG
AGAAACTTGCTCCTAAATGAACACATAAGTTTAGATCGCAATGAGGAGTAGCAGGGTAGCTGGTTGCTAGAGTTACGGTGGGGATCAGAA
ACTCTTCCAAACATTTTAGCACTGAGGCTGGGGTAGCTTTTGGCTTTTCCCAGGTCTCAGGAGGTGGCCTGAGTCAGCACACATCTTCCC
ACTCGGTAGACAGGCTGGCCTCTCCCTCACTTTGAGACTTTGGCAACTCCTGGGCCACACGGCCTGCCTCTTTGATTACTAATGATTGTC
AGTGACTCAGAGCTTCCTGGGACTTCGGGTACCCACCCGCTGTTCTCCATGCAAACAAAGCGCCAGGGAAATGACCCACAGGGATCGCAG
CTGCAGGGAGGGCCAGGGAGGTTGGGGGTGGGAGTGAATGCTAAAAGCAGATCGTCCAGTGCCCTTTTCAGTGCTACCGGCCTCTCACCA
AGCAGTCCTCCATGTGAGCAACCCCGAGACAAAAATGCTAAGTGGGATCAAGAGAGCAGCACTCGGAGAGGGTGTTTGCCAGTCTGAGTG
TCCCGCGGTGCCCGCCAACCCGCTTCCTGACTGACCTGAGCAAGGTCTTACTAAGCAGTCCCATCTCTGTGGGAGGCATGCAACGCGTGC
AGGGAGTTCAGGTGCCGGTCGGCGTAGCCAGGCCTGGAGGCCCCCCAGGCAGGAGGCCGCCCAAAGGCGGGGCCGGCGTCTCGCAGACTA
GGGGCTGGGGGCGGCCACAGACGGCCTCGAAACCACAGCCCTTACCCCAATCCCACGAGCCCCGCCAACGAACCACAGGTGCTGGGCTTT
AGAGAACATGGGAAGGCGGCCCCAGACCTGCGGGAACGCCTTTCCCTCAGAGCCAGGCCCCGGCCCCGTCTGGGAAGCTCATCTTGCGAA
GCTGAGGGAGCTCAGGGCAAAGGCCAGGCTAGCGCGGACCGGAAGGGGCCGAGGCTGCACGGGCCTCTGCCAGAACGCTCAGGACATCCC
GGCCTGGGTTTACAACGCTGTTAGGAAAATTAACCAATGAATAAAGCAACGTTCAGTGCGCAGGGAGTGAAATTCAATGCCCACCGCTAG
GCTCCTCGCTGCCTCTCACTCAAGAGGCCCAAACTCAGACGGCGTCAGGGACCCGGACCCAGCAGCCGTTTCACGCCAATAGATAGGGCG
CATGCGCAGAAATCCTCCTCGGCTCTCTAGCGTGAGCTTTCCCAAGGGGCCACGCCCAGCTTGCCTTCTGATTGGTCCAGCTGGTGGGTT
GTCTTCCGCCATCTTTGATCAGGGCACTAAGGATGCTCCCCACGGCCTTCACAGTGACGGCGGAGACCCTGCCCCGCCAGCTGCTCAGTA
CGTGCCGCGTAGCCCGTGCGAGCCAAGTGTGAGTCCGGGCGAGCGCCTGCGGAGCTAGCACTGGGCCCAGAATGAGAGGGAGGCGGAGGA
GCAGCGATCACGTGGTTTTAGGGACTGTCTAATAATTCCACGCCAGCATTGCCGGTGTTTCAGGGGGTGGGAACCGCTGCGTTCCCCATC
AACTTTTCTCCCACCCACCACCCTCCCCAACCTACAAGCCCAGCTCAGCTTGAGGTAACTGCTGACCGGACTGTCCTATACAGCCCTACA
AGACAGAGGCGCCTAGGGCTGAAAGCGGGGGCCTCCGTAGGGAGCCAGCGGGGGCCTCAATAGTTACTCATTTTCTCTACCTTTGATGAA
AATAAGAGCTAATTCTTAATAAGGCCTACCGGGTATCACGCAAAAACCCTGTGCTTACTATTACACTTTGGGTTGTTGCAAAGATTAAAG
GAAATAAGCCGTGCAAAGCGCTTAAGAGCTTGGTATAAGTAAGTGCTCGTCAATGTTGGCTACTCTCATTTTTTTTGCAGACGTGGGAAC
TGGGGCTCAGGGAGGCTAACAGCCAGTAGGCGGCACAGCTAGGATTTGAACCCAGGATTGTCTCCAACGCCGCTCAATTATACCCGCCAA
GGAGTCACAGAGACTTAGTGAAGTGCACACATTGCTCACCTGGGTGAACTGAGGTCCAGCGGGGGAAGGCTTCCTCCTGTTGTAATCACT
AACCCCAACTCTGTCTCCCTTGCCCGATTCATTCATTCGTTAATTAATTCATCCAACATCCTGTCCCCAAGAAGCTCAGTCTGGGGACAT
ACTGATCCAGTTAAATGCGAGTGCTTCCTAGTTATACATGGCGACTGCTGAGAAGGGACTCCAGAGTCCAGGCACCTACCTCCCAGGGGC
TCACCGTTCACTCCTCTAGCCTCATTTAGAGCTCGCATTAAGAGCACGGGATCTGGATCCACACTGTTTGGATTCAAATCACAACTTCAC
CACTTAGCAGCTGTGTGTTCTGGGAAAATGACCCACCTTCTCTGTGCCTCCATTTTCTCACCTGTAAAACGGGCTCCCAGGCTGGTGGGA
GGGTTTCAGGTGTAAGACATGGAGAGTCCTTTAGCGAACATGTAGACTGGCAATAAACTCAATAAATGGTGACTGTTATAATTAATCCTC

>83000_83000_2_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000343605_SEC14L2_chr22_30802331_ENST00000312932_length(amino acids)=586AA_BP=34
MVAQRSSLGSPPPALASLVRMCRCPPEHHDGRMTSAEVGAAAGGAQAAGPPEWPPGSPQALRQPGRARVAMAALVWLLAGASMSSLNKWI
FTVHGFGRPLLLSALHMLVAALACHRGARRPMPGGTRCRVLLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLGRRHH
PLQLAAMGPLCLGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQTRSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGG
MCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCM
FEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRK
YYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSD

--------------------------------------------------------------
>83000_83000_3_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000406566_SEC14L2_chr22_30802331_ENST00000312932_length(transcript)=4738nt_BP=747nt
CTCACCTGTCTGAAACGGGACACGGGGTCGGAGGAACCAGGATCTAGCCTGGCCCCAAGCGGAACTCTCTGGTGGCCCAGAGGTCGTCAC
TGGGGAGCCCGCCTCCTGCCCTAGCCTCACTGGTGCGGATGTGCCGCTGCCCGCCGGAGCACCATGATGGCAGGATGACCTCAGCCGAAG
TAGGAGCAGCAGCTGGTGGTGCTCAGGCGGCTGGGCCCCCCGAGTGGCCCCCTGGCAGCCCTCAGGCCCTCCGGCAGCCTGGCCGGGCCC
GAGTGGCCATGGCAGCACTGGTGTGGCTGCTGGCGGGAGCCAGCATGTCAAGCCTCAACAAGTGGATCTTCACAGTGCACGGCTTTGGGC
GGCCCCTGCTGCTGTCGGCCCTGCACATGCTGGTGGCAGCCCTGGCATGCCACCGGGGGGCACGGCGCCCCATGCCAGGCGGCACTCGCT
GCCGAGTCCTACTGCTCAGTCTCACCTTTGGCACGTCCATGGCCTGCGGCAACGTGGGCCTAAGGGCTGTGCCCCTGGACCTGGCACAAC
TGGTTACTACCACCACACCTCTGTTCACCCTGGCCCTGTCGGCGCTGCTGCTGGGCCGCCGCCACCACCCACTTCAGTTGGCCGCCATGG
GTCCGCTCTGCCTGGGGGCCGCCTGCAGCCTGGCTGGAGAGTTCCGGACACCCCCTACCGGCTGTGGCTTCCTGCTCGCAGCCACCTGCC
TCCGCGGACTCAAGTCGGTTCAGCAAACCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGCATGTGGAGTTCCGAAAGC
AAAAGGACATTGACAACATCATTAGCTGGCAGCCTCCAGAGGTGATCCAACAGTATCTGTCAGGGGGTATGTGTGGCTATGACCTGGATG
GCTGCCCAGTCTGGTACGACATAATTGGACCTCTGGATGCCAAGGGTCTGCTGTTCTCAGCCTCCAAACAGGACCTGCTGAGGACCAAGA
TGCGGGAGTGTGAGCTGCTTCTGCAAGAGTGTGCCCACCAGACCACAAAGTTGGGGAGGAAGGTGGAGACCATCACCATAATTTATGACT
GCGAGGGGCTTGGCCTCAAGCATCTCTGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAGGAAAATTATCCCGAAA
CACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGCCTATAACCTCATCAAACCCTTCCTGAGTGAGGACACTCGTA
AGAAGATCATGGTCCTGGGAGCAAATTGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTGGAGTATGGGGGCACCA
TGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGGGGGTGACATCCCCAGGAAGTATTATGTGCGAGACCAGGTGA
AACAGCAGTATGAACACAGCGTGCAGATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCTGGCTGTGTCCTCAGGT
GGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAAGACCAAGATGGGAGAGAGGCAGCGGGCAGGGGAGATGACAG
AGGTGCTGCCCAACCAGAGGTACAACTCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGCATCTATGTCCTGCGGT
TTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGTGGAGGTCCTGCTTCCAGACAAAGCCTCAGAAGAGAAGATGA
AACAGCTGGGGGCAGGCACCCCGAAATAACACCTTCTCCTATAGCAGGCCTGGCCCCCTCAGTGTCTCCCTGTCAATTTCTACCCCTTGT
AGCAGTCATTTTCGCACAACCCTGAAGCCCAAAGAAACTGGGCTGGAGGACAGACCTCAGGAGCTTTCATTTCAGTTAGGCAGAGGAAGA
GCGACTGCAGTGGGTCTCCGTGTCTATCAAATACCTAAGGAGTCCCCAGGAGCTGGCTGGCCATCGTGATAGGATCTGTCTGTCCTGTAA
ACTGTGCCAACTTCACCTGTCCAGGGACAGCGAAGCTGGGGGTGGCGGGGGGCATGTACCACAGGGTGGCAGCAGGGAAAAAAATTAGAA
AAGGGTGAAAGATTGGGACTTAACACTTCAGGGAAGTCAGCTGCCGGGGAGAAACTTGCTCCTAAATGAACACATAAGTTTAGATCGCAA
TGAGGAGTAGCAGGGTAGCTGGTTGCTAGAGTTACGGTGGGGATCAGAAACTCTTCCAAACATTTTAGCACTGAGGCTGGGGTAGCTTTT
GGCTTTTCCCAGGTCTCAGGAGGTGGCCTGAGTCAGCACACATCTTCCCACTCGGTAGACAGGCTGGCCTCTCCCTCACTTTGAGACTTT
GGCAACTCCTGGGCCACACGGCCTGCCTCTTTGATTACTAATGATTGTCAGTGACTCAGAGCTTCCTGGGACTTCGGGTACCCACCCGCT
GTTCTCCATGCAAACAAAGCGCCAGGGAAATGACCCACAGGGATCGCAGCTGCAGGGAGGGCCAGGGAGGTTGGGGGTGGGAGTGAATGC
TAAAAGCAGATCGTCCAGTGCCCTTTTCAGTGCTACCGGCCTCTCACCAAGCAGTCCTCCATGTGAGCAACCCCGAGACAAAAATGCTAA
GTGGGATCAAGAGAGCAGCACTCGGAGAGGGTGTTTGCCAGTCTGAGTGTCCCGCGGTGCCCGCCAACCCGCTTCCTGACTGACCTGAGC
AAGGTCTTACTAAGCAGTCCCATCTCTGTGGGAGGCATGCAACGCGTGCAGGGAGTTCAGGTGCCGGTCGGCGTAGCCAGGCCTGGAGGC
CCCCCAGGCAGGAGGCCGCCCAAAGGCGGGGCCGGCGTCTCGCAGACTAGGGGCTGGGGGCGGCCACAGACGGCCTCGAAACCACAGCCC
TTACCCCAATCCCACGAGCCCCGCCAACGAACCACAGGTGCTGGGCTTTAGAGAACATGGGAAGGCGGCCCCAGACCTGCGGGAACGCCT
TTCCCTCAGAGCCAGGCCCCGGCCCCGTCTGGGAAGCTCATCTTGCGAAGCTGAGGGAGCTCAGGGCAAAGGCCAGGCTAGCGCGGACCG
GAAGGGGCCGAGGCTGCACGGGCCTCTGCCAGAACGCTCAGGACATCCCGGCCTGGGTTTACAACGCTGTTAGGAAAATTAACCAATGAA
TAAAGCAACGTTCAGTGCGCAGGGAGTGAAATTCAATGCCCACCGCTAGGCTCCTCGCTGCCTCTCACTCAAGAGGCCCAAACTCAGACG
GCGTCAGGGACCCGGACCCAGCAGCCGTTTCACGCCAATAGATAGGGCGCATGCGCAGAAATCCTCCTCGGCTCTCTAGCGTGAGCTTTC
CCAAGGGGCCACGCCCAGCTTGCCTTCTGATTGGTCCAGCTGGTGGGTTGTCTTCCGCCATCTTTGATCAGGGCACTAAGGATGCTCCCC
ACGGCCTTCACAGTGACGGCGGAGACCCTGCCCCGCCAGCTGCTCAGTACGTGCCGCGTAGCCCGTGCGAGCCAAGTGTGAGTCCGGGCG
AGCGCCTGCGGAGCTAGCACTGGGCCCAGAATGAGAGGGAGGCGGAGGAGCAGCGATCACGTGGTTTTAGGGACTGTCTAATAATTCCAC
GCCAGCATTGCCGGTGTTTCAGGGGGTGGGAACCGCTGCGTTCCCCATCAACTTTTCTCCCACCCACCACCCTCCCCAACCTACAAGCCC
AGCTCAGCTTGAGGTAACTGCTGACCGGACTGTCCTATACAGCCCTACAAGACAGAGGCGCCTAGGGCTGAAAGCGGGGGCCTCCGTAGG
GAGCCAGCGGGGGCCTCAATAGTTACTCATTTTCTCTACCTTTGATGAAAATAAGAGCTAATTCTTAATAAGGCCTACCGGGTATCACGC
AAAAACCCTGTGCTTACTATTACACTTTGGGTTGTTGCAAAGATTAAAGGAAATAAGCCGTGCAAAGCGCTTAAGAGCTTGGTATAAGTA
AGTGCTCGTCAATGTTGGCTACTCTCATTTTTTTTGCAGACGTGGGAACTGGGGCTCAGGGAGGCTAACAGCCAGTAGGCGGCACAGCTA
GGATTTGAACCCAGGATTGTCTCCAACGCCGCTCAATTATACCCGCCAAGGAGTCACAGAGACTTAGTGAAGTGCACACATTGCTCACCT
GGGTGAACTGAGGTCCAGCGGGGGAAGGCTTCCTCCTGTTGTAATCACTAACCCCAACTCTGTCTCCCTTGCCCGATTCATTCATTCGTT
AATTAATTCATCCAACATCCTGTCCCCAAGAAGCTCAGTCTGGGGACATACTGATCCAGTTAAATGCGAGTGCTTCCTAGTTATACATGG
CGACTGCTGAGAAGGGACTCCAGAGTCCAGGCACCTACCTCCCAGGGGCTCACCGTTCACTCCTCTAGCCTCATTTAGAGCTCGCATTAA
GAGCACGGGATCTGGATCCACACTGTTTGGATTCAAATCACAACTTCACCACTTAGCAGCTGTGTGTTCTGGGAAAATGACCCACCTTCT
CTGTGCCTCCATTTTCTCACCTGTAAAACGGGCTCCCAGGCTGGTGGGAGGGTTTCAGGTGTAAGACATGGAGAGTCCTTTAGCGAACAT

>83000_83000_3_SLC35E4-SEC14L2_SLC35E4_chr22_31033056_ENST00000406566_SEC14L2_chr22_30802331_ENST00000312932_length(amino acids)=586AA_BP=34
MVAQRSSLGSPPPALASLVRMCRCPPEHHDGRMTSAEVGAAAGGAQAAGPPEWPPGSPQALRQPGRARVAMAALVWLLAGASMSSLNKWI
FTVHGFGRPLLLSALHMLVAALACHRGARRPMPGGTRCRVLLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLGRRHH
PLQLAAMGPLCLGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQTRSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGG
MCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCM
FEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRK
YYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC35E4-SEC14L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC35E4-SEC14L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC35E4-SEC14L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource