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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC38A10-UFD1L (FusionGDB2 ID:83084)

Fusion Gene Summary for SLC38A10-UFD1L

Fusion gene summary

Fusion gene information	Fusion gene name: SLC38A10-UFD1L
	Fusion gene ID: 83084
		Hgene	Tgene
	Gene symbol	SLC38A10	UFD1L
	Gene ID	124565	7353
	Gene name	solute carrier family 38 member 10	ubiquitin recognition factor in ER associated degradation 1
	Synonyms	PP1744	UFD1L
	Cytomap	17q25.3	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	putative sodium-coupled neutral amino acid transporter 10	ubiquitin recognition factor in ER-associated degradation protein 1UB fusion protein 1ubiquitin fusion degradation 1 likeubiquitin fusion degradation protein 1 homolog
	Modification date	20200313	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000288439, ENST00000374759, ENST00000546352,	ENST00000484101, ENST00000360834, ENST00000399523, ENST00000263202,
Fusion gene scores	* DoF score	17 X 12 X 10=2040	8 X 6 X 3=144
	# samples	20	8
	** MAII score	log2(20/2040*10)=-3.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC38A10 [Title/Abstract] AND UFD1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC38A10(79263491)-UFD1L(19462623), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLC38A10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UFD1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3956-01A	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-

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Fusion Gene ORF analysis for SLC38A10-UFD1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000288439	ENST00000484101	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
5CDS-5UTR	ENST00000374759	ENST00000484101	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
5CDS-intron	ENST00000288439	ENST00000360834	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
5CDS-intron	ENST00000288439	ENST00000399523	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
5CDS-intron	ENST00000374759	ENST00000360834	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
5CDS-intron	ENST00000374759	ENST00000399523	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
In-frame	ENST00000288439	ENST00000263202	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
In-frame	ENST00000374759	ENST00000263202	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
intron-3CDS	ENST00000546352	ENST00000263202	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
intron-5UTR	ENST00000546352	ENST00000484101	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
intron-intron	ENST00000546352	ENST00000360834	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-
intron-intron	ENST00000546352	ENST00000399523	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374759	SLC38A10	chr17	79263491	-	ENST00000263202	UFD1L	chr22	19462623	-	2149	601	312	1388	358
ENST00000288439	SLC38A10	chr17	79263491	-	ENST00000263202	UFD1L	chr22	19462623	-	2111	563	274	1350	358

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374759	ENST00000263202	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-	0.003050637	0.9969494
ENST00000288439	ENST00000263202	SLC38A10	chr17	79263491	-	UFD1L	chr22	19462623	-	0.00284353	0.9971565

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Fusion Genomic Features for SLC38A10-UFD1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC38A10-UFD1L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79263491/chr22:19462623)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

36_58

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

4_24

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

36_58

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

4_24

1120.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

120_140

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

153_173

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

229_249

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

272_292

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

323_343

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

345_365

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

378_398

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000288439

84_104

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

120_140

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

153_173

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

229_249

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

272_292

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

323_343

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

345_365

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

378_398

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79263491

chr22:19462623

ENST00000374759

84_104

1120.0

Transmembrane

Helical

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Fusion Gene Sequence for SLC38A10-UFD1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>83084_83084_1_SLC38A10-UFD1L_SLC38A10_chr17_79263491_ENST00000288439_UFD1L_chr22_19462623_ENST00000263202_length(transcript)=2111nt_BP=563nt
GTGTCCCTAGCTGGCTCTGCGGCTCTTCCGGGTCTGGGCTCGGAGATTCACAGGCGGCCCGCGAGGCCGAGCGAGGGACGCATGGCCCTG
AGGCGGCCGCAGGGCTTGGCGGGGTCCGGAGGTTGACCTCGCCCCCGCAGCCGGCCTTCGAGGCTGCCTCCTCCAGGCAGCCTCTGGGGC
CCGCGCCCGCGCCTGCTCAGGCTCCCGTGTTCAGGCTGCCCATCCCCTCCCCACCGGCGTCCCGGACGTTGGGACCTGTGACCGTGGCCT
CGGGCTGGGCTTCCAAAGCCGGCCGCAGCCCGGCGACCCCCGAGGCCTCTCGCCCCGGGCCCCTAGACCTCTCACTATGACCGCGGCCGC
CGCCTCCAACTGGGGGCTGATCACGAACATCGTGAACAGCATCGTAGGGGTCAGTGTCCTCACCATGCCCTTCTGCTTCAAACAGTGCGG
CATCGTCCTGGGGGCGCTGCTCTTGGTCTTCTGCTCATGGATGACGCACCAGTCGTGCATGTTCTTGGTGAAGTCGGCCAGCCTGAGCAA
GCGGAGGACCTACGCCGGCCTGGTAATTATGCCACCCTCGGCCCTGGACCAACTCAGCCGACTTAACATTACCTATCCCATGCTGTTCAA
ACTGACCAATAAGAATTCGGACCGCATGACGCATTGTGGCGTGCTGGAGTTTGTGGCTGATGAGGGCATCTGCTACCTCCCACACTGGAT
GATGCAGAACTTACTCTTGGAAGAAGGCGGCCTGGTCCAGGTGGAGAGCGTCAACCTTCAAGTGGCCACCTACTCCAAATTCCAACCTCA
GAGCCCTGACTTCCTGGACATCACCAACCCCAAAGCCGTATTAGAAAACGCACTTAGGAACTTTGCCTGTCTGACCACCGGGGATGTGAT
TGCCATCAACTATAATGAAAAGATCTACGAACTGCGTGTGATGGAGACCAAACCCGACAAGGCAGTGTCCATCATTGAGTGTGACATGAA
CGTGGACTTTGATGCTCCCCTGGGCTACAAAGAACCCGAAAGACAAGTCCAGCATGAGGAGTCGACAGAAGGTGAAGCCGACCACAGTGG
CTATGCTGGAGAGCTGGGCTTCCGCGCTTTCTCTGGATCTGGCAATAGACTGGATGGAAAGAAGAAAGGGGTAGAGCCCAGCCCCTCCCC
AATCAAGCCTGGAGATATTAAAAGAGGAATTCCCAATTATGAATTTAAACTTGGTAAGATAACTTTCATCAGAAATTCACGTCCCCTTGT
CAAAAAGGTTGAAGAGGATGAAGCTGGAGGCAGATTCGTCGCTTTCTCTGGAGAAGGACAGTCATTGCGTAAAAAGGGAAGAAAGCCCTA
AGTGAGGACTGTTGGCTGATTGGAAAATAATAAAAGAATCATTTGCAACATCTTGGCTTTTAGTTACTGGCACTGACAGGGACGAGCCTC
ATCAGAGAATACTCTGTTACTTAAGATTTATTTAGAGTTACCTAAGAATTATTAAGTTTGACTTGGAAGTGGAGCAGCAGGACTTTGTAG
TTGTATGCTTGATTTGGGGAAAGACAAAGAGCTGTCCCTGAGGGCCTGTAGATAGCTGCCTCCTCACCTCTTCACGCTTTCAGCTTGAGG
GGAGCTCCCACTGCCTCAGCAGGAGCAATTCTGCATCCCTAATTCTGTCAAAACCTATGAAGGTGACTAAATTGTCTAACATGAAGTGTT
CTTTCTTTTTCTTCATTTATCCTTTCTTTTCCTACATCAATTGCATAGGTGTCAGTCTTTGGCCTAAAAAAAGGCTTTAAATAGACATGT
GTTCTATAAGTAGTGGCTGTCCCACTACTGTGGCTGCAATTTAAGTATTTGACAAAGAATGTTTCTATTTTTATTTTACATATTTTTTTC
AAAAACACCACTCAGAAGAACCTGATCTGAATGAGTTTGCACTTTTATTCTCATTTCATATGGACATAACTGGCTCCTTAGTGAACCTGT
TCATAGTGAAACAACTCCATGGAGAAGCAAACATGTGAATGTTAGAATGAACAAATGCTAAAGAGATGTTCCTCTCCTTCTTCCCTACTC

>83084_83084_1_SLC38A10-UFD1L_SLC38A10_chr17_79263491_ENST00000288439_UFD1L_chr22_19462623_ENST00000263202_length(amino acids)=358AA_BP=96
MGFQSRPQPGDPRGLSPRAPRPLTMTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKR
RTYAGLVIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQS
PDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERQVQHEESTEGEADHSGY

--------------------------------------------------------------
>83084_83084_2_SLC38A10-UFD1L_SLC38A10_chr17_79263491_ENST00000374759_UFD1L_chr22_19462623_ENST00000263202_length(transcript)=2149nt_BP=601nt
AAGTGTGAGCGCCGCGGCGGCAGCTGAGTTGGGCTGAGGTGTCCCTAGCTGGCTCTGCGGCTCTTCCGGGTCTGGGCTCGGAGATTCACA
GGCGGCCCGCGAGGCCGAGCGAGGGACGCATGGCCCTGAGGCGGCCGCAGGGCTTGGCGGGGTCCGGAGGTTGACCTCGCCCCCGCAGCC
GGCCTTCGAGGCTGCCTCCTCCAGGCAGCCTCTGGGGCCCGCGCCCGCGCCTGCTCAGGCTCCCGTGTTCAGGCTGCCCATCCCCTCCCC
ACCGGCGTCCCGGACGTTGGGACCTGTGACCGTGGCCTCGGGCTGGGCTTCCAAAGCCGGCCGCAGCCCGGCGACCCCCGAGGCCTCTCG
CCCCGGGCCCCTAGACCTCTCACTATGACCGCGGCCGCCGCCTCCAACTGGGGGCTGATCACGAACATCGTGAACAGCATCGTAGGGGTC
AGTGTCCTCACCATGCCCTTCTGCTTCAAACAGTGCGGCATCGTCCTGGGGGCGCTGCTCTTGGTCTTCTGCTCATGGATGACGCACCAG
TCGTGCATGTTCTTGGTGAAGTCGGCCAGCCTGAGCAAGCGGAGGACCTACGCCGGCCTGGTAATTATGCCACCCTCGGCCCTGGACCAA
CTCAGCCGACTTAACATTACCTATCCCATGCTGTTCAAACTGACCAATAAGAATTCGGACCGCATGACGCATTGTGGCGTGCTGGAGTTT
GTGGCTGATGAGGGCATCTGCTACCTCCCACACTGGATGATGCAGAACTTACTCTTGGAAGAAGGCGGCCTGGTCCAGGTGGAGAGCGTC
AACCTTCAAGTGGCCACCTACTCCAAATTCCAACCTCAGAGCCCTGACTTCCTGGACATCACCAACCCCAAAGCCGTATTAGAAAACGCA
CTTAGGAACTTTGCCTGTCTGACCACCGGGGATGTGATTGCCATCAACTATAATGAAAAGATCTACGAACTGCGTGTGATGGAGACCAAA
CCCGACAAGGCAGTGTCCATCATTGAGTGTGACATGAACGTGGACTTTGATGCTCCCCTGGGCTACAAAGAACCCGAAAGACAAGTCCAG
CATGAGGAGTCGACAGAAGGTGAAGCCGACCACAGTGGCTATGCTGGAGAGCTGGGCTTCCGCGCTTTCTCTGGATCTGGCAATAGACTG
GATGGAAAGAAGAAAGGGGTAGAGCCCAGCCCCTCCCCAATCAAGCCTGGAGATATTAAAAGAGGAATTCCCAATTATGAATTTAAACTT
GGTAAGATAACTTTCATCAGAAATTCACGTCCCCTTGTCAAAAAGGTTGAAGAGGATGAAGCTGGAGGCAGATTCGTCGCTTTCTCTGGA
GAAGGACAGTCATTGCGTAAAAAGGGAAGAAAGCCCTAAGTGAGGACTGTTGGCTGATTGGAAAATAATAAAAGAATCATTTGCAACATC
TTGGCTTTTAGTTACTGGCACTGACAGGGACGAGCCTCATCAGAGAATACTCTGTTACTTAAGATTTATTTAGAGTTACCTAAGAATTAT
TAAGTTTGACTTGGAAGTGGAGCAGCAGGACTTTGTAGTTGTATGCTTGATTTGGGGAAAGACAAAGAGCTGTCCCTGAGGGCCTGTAGA
TAGCTGCCTCCTCACCTCTTCACGCTTTCAGCTTGAGGGGAGCTCCCACTGCCTCAGCAGGAGCAATTCTGCATCCCTAATTCTGTCAAA
ACCTATGAAGGTGACTAAATTGTCTAACATGAAGTGTTCTTTCTTTTTCTTCATTTATCCTTTCTTTTCCTACATCAATTGCATAGGTGT
CAGTCTTTGGCCTAAAAAAAGGCTTTAAATAGACATGTGTTCTATAAGTAGTGGCTGTCCCACTACTGTGGCTGCAATTTAAGTATTTGA
CAAAGAATGTTTCTATTTTTATTTTACATATTTTTTTCAAAAACACCACTCAGAAGAACCTGATCTGAATGAGTTTGCACTTTTATTCTC
ATTTCATATGGACATAACTGGCTCCTTAGTGAACCTGTTCATAGTGAAACAACTCCATGGAGAAGCAAACATGTGAATGTTAGAATGAAC

>83084_83084_2_SLC38A10-UFD1L_SLC38A10_chr17_79263491_ENST00000374759_UFD1L_chr22_19462623_ENST00000263202_length(amino acids)=358AA_BP=96
MGFQSRPQPGDPRGLSPRAPRPLTMTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKR
RTYAGLVIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQS
PDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERQVQHEESTEGEADHSGY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC38A10-UFD1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SLC38A10-UFD1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC38A10-UFD1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source