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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC38A1-GLIPR1L1 (FusionGDB2 ID:83091)

Fusion Gene Summary for SLC38A1-GLIPR1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC38A1-GLIPR1L1
Fusion gene ID: 83091
HgeneTgene
Gene symbol

SLC38A1

GLIPR1L1

Gene ID

81539

256710

Gene namesolute carrier family 38 member 1GLIPR1 like 1
SynonymsATA1|NAT2|SAT1|SNAT1ALKN2972|PRO7434
Cytomap

12q13.11

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionsodium-coupled neutral amino acid transporter 1N-system amino acid transporter 2amino acid transporter A1amino acid transporter system A1system A amino acid transporter 1system N amino acid transporter 1GLIPR1-like protein 1GLI pathogenesis related 1 like 1
Modification date2020031320200313
UniProtAcc

Q9H2H9

Q6UWM5

Ensembl transtripts involved in fusion geneENST00000398637, ENST00000439706, 
ENST00000546893, ENST00000549049, 
ENST00000552197, ENST00000549633, 
ENST00000548623, ENST00000312442, 
ENST00000378695, 
Fusion gene scores* DoF score12 X 8 X 9=8646 X 5 X 4=120
# samples 127
** MAII scorelog2(12/864*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC38A1 [Title/Abstract] AND GLIPR1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC38A1(46622936)-GLIPR1L1(75756882), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC38A1-GLIPR1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC38A1-GLIPR1L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC38A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLIPR1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0187-01ASLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+


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Fusion Gene ORF analysis for SLC38A1-GLIPR1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398637ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5CDS-intronENST00000439706ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5CDS-intronENST00000546893ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5CDS-intronENST00000549049ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5CDS-intronENST00000552197ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5UTR-3CDSENST00000549633ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5UTR-3CDSENST00000549633ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
5UTR-intronENST00000549633ENST00000548623SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000398637ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000398637ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000439706ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000439706ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000546893ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
Frame-shiftENST00000546893ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
In-frameENST00000549049ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
In-frameENST00000549049ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
In-frameENST00000552197ENST00000312442SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+
In-frameENST00000552197ENST00000378695SLC38A1chr12

46622936

-GLIPR1L1chr12

75756882

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000549049SLC38A1chr1246622936-ENST00000378695GLIPR1L1chr1275756882+11518775631084173
ENST00000549049SLC38A1chr1246622936-ENST00000312442GLIPR1L1chr1275756882+14428775631057164
ENST00000552197SLC38A1chr1246622936-ENST00000378695GLIPR1L1chr1275756882+12739996851206173
ENST00000552197SLC38A1chr1246622936-ENST00000312442GLIPR1L1chr1275756882+15649996851179164

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000549049ENST00000378695SLC38A1chr1246622936-GLIPR1L1chr1275756882+0.0032956960.9967043
ENST00000549049ENST00000312442SLC38A1chr1246622936-GLIPR1L1chr1275756882+0.0034297310.9965702
ENST00000552197ENST00000378695SLC38A1chr1246622936-GLIPR1L1chr1275756882+0.0042897850.99571025
ENST00000552197ENST00000312442SLC38A1chr1246622936-GLIPR1L1chr1275756882+0.0037005710.99629945

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Fusion Genomic Features for SLC38A1-GLIPR1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC38A1chr1246622935-GLIPR1L1chr1275756881+0.0003944810.9996056
SLC38A1chr1246622935-GLIPR1L1chr1275756881+0.0003944810.9996056

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC38A1-GLIPR1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:46622936/chr12:75756882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC38A1

Q9H2H9

GLIPR1L1

Q6UWM5

FUNCTION: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269|PubMed:10891391}.FUNCTION: Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-5171_74104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-6181_74104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-5171_74104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-4161_74104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-51775_97104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-61875_97104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-51775_97104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-41675_97104488.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517134_147104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517169_188104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517212_216104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517238_275104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517297_312104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517334_350104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517372_393104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517415_416104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517438_452104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517474_487104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-51798_112104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618134_147104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618169_188104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618212_216104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618238_275104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618297_312104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618334_350104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618372_393104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618415_416104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618438_452104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618474_487104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-61898_112104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517134_147104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517169_188104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517212_216104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517238_275104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517297_312104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517334_350104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517372_393104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517415_416104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517438_452104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517474_487104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-51798_112104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416134_147104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416169_188104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416212_216104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416238_275104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416297_312104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416334_350104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416372_393104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416415_416104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416438_452104488.0Topological domainCytoplasmic
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416474_487104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-41698_112104488.0Topological domainExtracellular
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517113_133104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517148_168104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517189_211104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517217_237104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517276_296104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517313_333104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517351_371104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517394_414104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517417_437104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000398637-517453_473104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618113_133104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618148_168104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618189_211104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618217_237104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618276_296104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618313_333104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618351_371104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618394_414104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618417_437104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000439706-618453_473104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517113_133104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517148_168104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517189_211104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517217_237104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517276_296104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517313_333104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517351_371104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517394_414104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517417_437104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000546893-517453_473104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416113_133104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416148_168104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416189_211104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416217_237104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416276_296104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416313_333104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416351_371104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416394_414104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416417_437104488.0TransmembraneHelical
HgeneSLC38A1chr12:46622936chr12:75756882ENST00000549049-416453_473104488.0TransmembraneHelical
TgeneGLIPR1L1chr12:46622936chr12:75756882ENST000003124422539_171173234.0DomainSCP
TgeneGLIPR1L1chr12:46622936chr12:75756882ENST000003786952639_171173243.0DomainSCP


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Fusion Gene Sequence for SLC38A1-GLIPR1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83091_83091_1_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000549049_GLIPR1L1_chr12_75756882_ENST00000312442_length(transcript)=1442nt_BP=877nt
ACCGCGCGCGGGACGGGGAGGAATGGCCTGTCCGCGTTAAACCATCACAAGCCATGGTTGCGGAAGGGCCACGCGTCCCCCAGTAGGAGA
ATGACTCCGATTCGTGACCCTCAGCGCCGGTGCATGTCGATGTAAGTGCGAGGCCGGCGAGCAGAGTGTGAGTGGGGGTTGGTGGTGAGG
GGAGATTCTGATGCAATCGGCCCGGAAAGGAGGAGAGCCAGGCGAGCGCGGACTGGGGCGGCCACGCCACTCCGCCAGAAGGTCGCCAGG
AGCCTCCGCCCTTCACCTTCCTCCGAAATCCGCCAGGCCACGCCAAGCTCCCTGCCCAACCCTTACTGACGGGGGCCACATTTTCCCGGC
CTCCGCAGCCAGACCTTGACACAAAGGACATCAAACTGCCGAGGGTAAAAACCCCGGAAGGGCGGACACCTCCACATCGCCTTTTGCCAC
CTTTCCCTTTATTTCCGGAGGGGTGTCAAGCTTCCATTTTGGTATCTACTTCTAAATACACTCAGAACAGGAGAAATTTGGACTAATTTT
CAAACTACAGACACTTTCTAATCATGATGCATTTCAAAAGTGGACTCGAATTAACTGAGTTGCAAAACATGACAGTGCCCGAGGATGATA
ACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAATAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTC
TCACAAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATATTCCAGGTACAACCTCCTTAGGCATGTCTGTTTTTAACCTAAGCAACG
CCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCTACTTTTTCTAGGAAATTTTGCAAATATGCCTC
CTTACGTAAGAGGAGAATCTTGCTCTCTCTGCTCAAAAGAAGAGAAATGTGTAAAGAACCTCTGCAAAAATCCATTTCTGAAGCCAACGG
GGAGAGCACCTCAGCAGACAGCCTTTAATCCATTCAGCTTAGGTTTTCTTCTTCTGAGAATCTTTTAATGTCATTTATATACAAAAGAAA
TTCTCAAATGTTAAAATAAAGGAATAGTTTATTGCTTAATATAACTTATCATCACTTTGCTTCTTTACTGAATCTTCTACACTCTTGCCT
GATACCTAAATTTAATGTTTGTTTTTAACTCAAAAAATGTACTGTAGTATGGAAAATGGATAGCAGTAGAATAAAGTCTTAAGATTATTT
TTTAATTACAAATCCATATGTGTATCAAAAGTGTTCCACTCTTTAATTTTCTAATGAGAATGGATTATCATTTTAGTTATAGTACATTTA
GAGAACTAAAGACTTTTCACATATCAAATAGTTTCCTTAGATACCAATAGTTTCCTTTATGAATACCATCAACATCATTCAGAAACAAAA

>83091_83091_1_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000549049_GLIPR1L1_chr12_75756882_ENST00000312442_length(amino acids)=164AA_BP=105
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGIL

--------------------------------------------------------------
>83091_83091_2_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000549049_GLIPR1L1_chr12_75756882_ENST00000378695_length(transcript)=1151nt_BP=877nt
ACCGCGCGCGGGACGGGGAGGAATGGCCTGTCCGCGTTAAACCATCACAAGCCATGGTTGCGGAAGGGCCACGCGTCCCCCAGTAGGAGA
ATGACTCCGATTCGTGACCCTCAGCGCCGGTGCATGTCGATGTAAGTGCGAGGCCGGCGAGCAGAGTGTGAGTGGGGGTTGGTGGTGAGG
GGAGATTCTGATGCAATCGGCCCGGAAAGGAGGAGAGCCAGGCGAGCGCGGACTGGGGCGGCCACGCCACTCCGCCAGAAGGTCGCCAGG
AGCCTCCGCCCTTCACCTTCCTCCGAAATCCGCCAGGCCACGCCAAGCTCCCTGCCCAACCCTTACTGACGGGGGCCACATTTTCCCGGC
CTCCGCAGCCAGACCTTGACACAAAGGACATCAAACTGCCGAGGGTAAAAACCCCGGAAGGGCGGACACCTCCACATCGCCTTTTGCCAC
CTTTCCCTTTATTTCCGGAGGGGTGTCAAGCTTCCATTTTGGTATCTACTTCTAAATACACTCAGAACAGGAGAAATTTGGACTAATTTT
CAAACTACAGACACTTTCTAATCATGATGCATTTCAAAAGTGGACTCGAATTAACTGAGTTGCAAAACATGACAGTGCCCGAGGATGATA
ACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAATAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTC
TCACAAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATATTCCAGGTACAACCTCCTTAGGCATGTCTGTTTTTAACCTAAGCAACG
CCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCTACTTTTTCTAGGAAATTTTGCAAATATGCCTC
CTTACGTAAGAGGAGAATCTTGCTCTCTCTGCTCAAAAGAAGAGAAATGTGTAAAGAACCTCTGCAGGACTCCACAACTTATTATACCTA
ACCAAAATCCATTTCTGAAGCCAACGGGGAGAGCACCTCAGCAGACAGCCTTTAATCCATTCAGCTTAGGTTTTCTTCTTCTGAGAATCT

>83091_83091_2_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000549049_GLIPR1L1_chr12_75756882_ENST00000378695_length(amino acids)=173AA_BP=105
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGIL

--------------------------------------------------------------
>83091_83091_3_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000552197_GLIPR1L1_chr12_75756882_ENST00000312442_length(transcript)=1564nt_BP=999nt
GTTGCCGCAGAGGCCTTTAAACGCGTGGGTCGGTGCCGGGAGGAGAGCGCATCTTCGCCCTTGTGCGAGCCCCTTGCCCCCTAAATTATC
CACCTCCTGGCGCATGGGGCTCCCCAGCACCCACTGGGACCCAGTAGGTTACCCGGCTGCCTGGGCACCGTTTGCCTGCCAAATCGCCCG
CCTGAGGTTTGTGCTGAACTGTAGTTAGAGAAGGCACAAGTGCATATGGCAGCAAAAGGAATTTCGCGGTACCCGCGTCACGCCGCTCCC
AGTGCCTTTCACAGGCTGCCTTGGGCTGGGGAAGGTGGTGCTACAATTCAGAGTCCTTTGTCTTGCTCTGCGGCGCGGACCCGGGGTTTG
TACAAACCCTCGTTCTCTGTTAGAAACCTAACTGCCGCCAGGATCACGTACTTTCTCGGACGAATCCGCGGTGATGTGTGTAGCAAAAGT
GAAAAAAGACGCCTCTGCTAGAAAACGATATTTATTGAGTGTCTACTGTGTGCCAGGCACTATATCTATGTGCATAGAAAAACCCTGGAA
GGCCATACAACAATATATATAGAGTGATCGTCTCTGCTTGCTGAGCTAACAGGGGTGTCAAGCTTCCATTTTGGTATCTACTTCTAAATA
CACTCAGAACAGGAGAAATTTGGACTAATTTTCAAACTACAGACACTTTCTAATCATGATGCATTTCAAAAGTGGACTCGAATTAACTGA
GTTGCAAAACATGACAGTGCCCGAGGATGATAACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAATAGCAA
GTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCACAAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATATTCCAGGTACAACCTC
CTTAGGCATGTCTGTTTTTAACCTAAGCAACGCCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCT
ACTTTTTCTAGGAAATTTTGCAAATATGCCTCCTTACGTAAGAGGAGAATCTTGCTCTCTCTGCTCAAAAGAAGAGAAATGTGTAAAGAA
CCTCTGCAAAAATCCATTTCTGAAGCCAACGGGGAGAGCACCTCAGCAGACAGCCTTTAATCCATTCAGCTTAGGTTTTCTTCTTCTGAG
AATCTTTTAATGTCATTTATATACAAAAGAAATTCTCAAATGTTAAAATAAAGGAATAGTTTATTGCTTAATATAACTTATCATCACTTT
GCTTCTTTACTGAATCTTCTACACTCTTGCCTGATACCTAAATTTAATGTTTGTTTTTAACTCAAAAAATGTACTGTAGTATGGAAAATG
GATAGCAGTAGAATAAAGTCTTAAGATTATTTTTTAATTACAAATCCATATGTGTATCAAAAGTGTTCCACTCTTTAATTTTCTAATGAG
AATGGATTATCATTTTAGTTATAGTACATTTAGAGAACTAAAGACTTTTCACATATCAAATAGTTTCCTTAGATACCAATAGTTTCCTTT

>83091_83091_3_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000552197_GLIPR1L1_chr12_75756882_ENST00000312442_length(amino acids)=164AA_BP=105
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGIL

--------------------------------------------------------------
>83091_83091_4_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000552197_GLIPR1L1_chr12_75756882_ENST00000378695_length(transcript)=1273nt_BP=999nt
GTTGCCGCAGAGGCCTTTAAACGCGTGGGTCGGTGCCGGGAGGAGAGCGCATCTTCGCCCTTGTGCGAGCCCCTTGCCCCCTAAATTATC
CACCTCCTGGCGCATGGGGCTCCCCAGCACCCACTGGGACCCAGTAGGTTACCCGGCTGCCTGGGCACCGTTTGCCTGCCAAATCGCCCG
CCTGAGGTTTGTGCTGAACTGTAGTTAGAGAAGGCACAAGTGCATATGGCAGCAAAAGGAATTTCGCGGTACCCGCGTCACGCCGCTCCC
AGTGCCTTTCACAGGCTGCCTTGGGCTGGGGAAGGTGGTGCTACAATTCAGAGTCCTTTGTCTTGCTCTGCGGCGCGGACCCGGGGTTTG
TACAAACCCTCGTTCTCTGTTAGAAACCTAACTGCCGCCAGGATCACGTACTTTCTCGGACGAATCCGCGGTGATGTGTGTAGCAAAAGT
GAAAAAAGACGCCTCTGCTAGAAAACGATATTTATTGAGTGTCTACTGTGTGCCAGGCACTATATCTATGTGCATAGAAAAACCCTGGAA
GGCCATACAACAATATATATAGAGTGATCGTCTCTGCTTGCTGAGCTAACAGGGGTGTCAAGCTTCCATTTTGGTATCTACTTCTAAATA
CACTCAGAACAGGAGAAATTTGGACTAATTTTCAAACTACAGACACTTTCTAATCATGATGCATTTCAAAAGTGGACTCGAATTAACTGA
GTTGCAAAACATGACAGTGCCCGAGGATGATAACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAATAGCAA
GTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCACAAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATATTCCAGGTACAACCTC
CTTAGGCATGTCTGTTTTTAACCTAAGCAACGCCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCT
ACTTTTTCTAGGAAATTTTGCAAATATGCCTCCTTACGTAAGAGGAGAATCTTGCTCTCTCTGCTCAAAAGAAGAGAAATGTGTAAAGAA
CCTCTGCAGGACTCCACAACTTATTATACCTAACCAAAATCCATTTCTGAAGCCAACGGGGAGAGCACCTCAGCAGACAGCCTTTAATCC
ATTCAGCTTAGGTTTTCTTCTTCTGAGAATCTTTTAATGTCATTTATATACAAAAGAAATTCTCAAATGTTAAAATAAAGGAATAGTTTA

>83091_83091_4_SLC38A1-GLIPR1L1_SLC38A1_chr12_46622936_ENST00000552197_GLIPR1L1_chr12_75756882_ENST00000378695_length(amino acids)=173AA_BP=105
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC38A1-GLIPR1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC38A1-GLIPR1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC38A1-GLIPR1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource