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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC3A1-CAMKMT (FusionGDB2 ID:83219)

Fusion Gene Summary for SLC3A1-CAMKMT

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC3A1-CAMKMT
Fusion gene ID: 83219
HgeneTgene
Gene symbol

SLC3A1

CAMKMT

Gene ID

6519

79823

Gene namesolute carrier family 3 member 1calmodulin-lysine N-methyltransferase
SynonymsATR1|CSNU1|D2H|NBAT|RBATC2orf34|CLNMT|CaM KMT|Cam|KMT
Cytomap

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionneutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acidcalmodulin-lysine N-methyltransferase
Modification date2020031320200313
UniProtAcc.

Q7Z624

Ensembl transtripts involved in fusion geneENST00000260649, ENST00000409229, 
ENST00000409380, ENST00000409387, 
ENST00000409741, ENST00000410056, 
ENST00000409294, ENST00000409740, 
ENST00000477623, ENST00000378494, 
ENST00000402247, ENST00000403853, 
ENST00000407131, 
Fusion gene scores* DoF score5 X 6 X 5=1506 X 7 X 5=210
# samples 66
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC3A1 [Title/Abstract] AND CAMKMT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC3A1(44513296)-CAMKMT(44617380), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC3A1-CAMKMT seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC3A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAMKMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-98-A53B-01ASLC3A1chr2

44513296

+CAMKMTchr2

44617380

+


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Fusion Gene ORF analysis for SLC3A1-CAMKMT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000260649ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
5CDS-3UTRENST00000409229ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
5CDS-3UTRENST00000409380ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
5CDS-3UTRENST00000409387ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
5CDS-3UTRENST00000409741ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
5CDS-3UTRENST00000410056ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000260649ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000260649ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000260649ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000260649ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409229ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409229ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409229ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409229ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409380ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409380ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409380ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409380ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409387ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409387ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409387ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409387ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409741ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409741ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409741ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000409741ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000410056ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000410056ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000410056ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
Frame-shiftENST00000410056ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409294ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409294ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409294ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409294ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409740ENST00000378494SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409740ENST00000402247SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409740ENST00000403853SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3CDSENST00000409740ENST00000407131SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3UTRENST00000409294ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+
intron-3UTRENST00000409740ENST00000477623SLC3A1chr2

44513296

+CAMKMTchr2

44617380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC3A1-CAMKMT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC3A1chr244513296+CAMKMTchr244617379+0.0064905750.99350935
SLC3A1chr244513296+CAMKMTchr244617379+0.0064905750.99350935

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC3A1-CAMKMT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44513296/:44617380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMKMT

Q7Z624

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the trimethylation of 'Lys-116' in calmodulin. {ECO:0000269|PubMed:20975703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC3A1-CAMKMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC3A1-CAMKMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC3A1-CAMKMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC3A1-CAMKMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource