FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SLC44A4-HSPA1L (FusionGDB2 ID:83301)

Fusion Gene Summary for SLC44A4-HSPA1L

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC44A4-HSPA1L
Fusion gene ID: 83301
HgeneTgene
Gene symbol

SLC44A4

HSPA1L

Gene ID

80736

3305

Gene namesolute carrier family 44 member 4heat shock protein family A (Hsp70) member 1 like
SynonymsC6orf29|CTL4|DFNA72|NG22|TPPT|hTPPT1HSP70-1L|HSP70-HOM|HSP70T|hum70t
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 4testicular tissue protein Li 48thiamine pyrophosphate transporterthiamine pyrophosphate transporter 1heat shock 70 kDa protein 1-likeepididymis secretory sperm binding proteinheat shock 10kDa protein 1-likeheat shock 70 kDa protein 1-Homheat shock 70 kDa protein 1Lheat shock 70kD protein-like 1heat shock 70kDa protein 1-like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000229729, ENST00000375562, 
ENST00000465707, ENST00000366281, 
ENST00000383379, ENST00000415517, 
ENST00000417894, ENST00000425238, 
ENST00000442152, ENST00000453831, 
ENST00000463111, ENST00000469478, 
ENST00000492911, ENST00000495181, 
ENST00000495620, ENST00000497745, 
ENST00000544672, ENST00000546461, 
ENST00000547288, ENST00000547493, 
ENST00000547684, ENST00000548188, 
ENST00000549663, ENST00000549677, 
ENST00000550401, ENST00000550821, 
ENST00000551168, ENST00000553121, 
ENST00000553147, 		ENST00000375654, 
ENST00000417199, ENST00000383390, 
ENST00000417601, ENST00000426095, 
ENST00000456772, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 2 X 3=24
# samples 85
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC44A4 [Title/Abstract] AND HSPA1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC44A4(31846717)-HSPA1L(31779762), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC44A4

GO:0030974

thiamine pyrophosphate transmembrane transport

24379411

TgeneHSPA1L

GO:0042026

protein refolding

21231916


check buttonFusion gene breakpoints across SLC44A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HSPA1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0YKSLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-


Top

Fusion Gene ORF analysis for SLC44A4-HSPA1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000229729ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-5UTRENST00000229729ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-5UTRENST00000375562ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-5UTRENST00000375562ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000229729ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000229729ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000229729ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000229729ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000375562ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000375562ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000375562ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5CDS-intronENST00000375562ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-5UTRENST00000465707ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-5UTRENST00000465707ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-intronENST00000465707ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-intronENST00000465707ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-intronENST00000465707ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
5UTR-intronENST00000465707ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000366281ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000366281ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000383379ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000383379ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000415517ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000415517ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000417894ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000417894ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000425238ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000425238ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000442152ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000442152ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000453831ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000453831ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000463111ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000463111ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000469478ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000469478ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000492911ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000492911ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000495181ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000495181ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000495620ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000495620ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000497745ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000497745ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000544672ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000544672ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000546461ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000546461ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547288ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547288ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547493ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547493ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547684ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000547684ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000548188ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000548188ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000549663ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000549663ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000549677ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000549677ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000550401ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000550401ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000550821ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000550821ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000551168ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000551168ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000553121ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000553121ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000553147ENST00000375654SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-5UTRENST00000553147ENST00000417199SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000366281ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000366281ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000366281ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000366281ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000383379ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000383379ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000383379ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000383379ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000415517ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000415517ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000415517ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000415517ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000417894ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000417894ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000417894ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000417894ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000425238ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000425238ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000425238ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000425238ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000442152ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000442152ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000442152ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000442152ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000453831ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000453831ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000453831ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000453831ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000463111ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000463111ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000463111ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000463111ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000469478ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000469478ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000469478ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000469478ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000492911ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000492911ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000492911ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000492911ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495181ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495181ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495181ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495181ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495620ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495620ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495620ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000495620ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000497745ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000497745ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000497745ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000497745ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000544672ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000544672ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000544672ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000544672ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000546461ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000546461ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000546461ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000546461ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547288ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547288ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547288ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547288ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547493ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547493ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547493ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547493ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547684ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547684ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547684ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000547684ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000548188ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000548188ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000548188ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000548188ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549663ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549663ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549663ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549663ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549677ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549677ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549677ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000549677ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550401ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550401ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550401ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550401ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550821ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550821ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550821ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000550821ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000551168ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000551168ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000551168ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000551168ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553121ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553121ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553121ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553121ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553147ENST00000383390SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553147ENST00000417601SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553147ENST00000426095SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-
intron-intronENST00000553147ENST00000456772SLC44A4chr6

31846717

-HSPA1Lchr6

31779762

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SLC44A4-HSPA1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC44A4-HSPA1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31846717/:31779762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SLC44A4-HSPA1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for SLC44A4-HSPA1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SLC44A4-HSPA1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SLC44A4-HSPA1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource