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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRN-TNKS2 (FusionGDB2 ID:8336)

Fusion Gene Summary for ATRN-TNKS2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRN-TNKS2
Fusion gene ID: 8336
HgeneTgene
Gene symbol

ATRN

TNKS2

Gene ID

8455

80351

Gene nameattractintankyrase 2
SynonymsDPPT-L|MGCAARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6
Cytomap

20p13

10q23.32

Type of geneprotein-codingprotein-coding
Descriptionattractinattractin-2mahogany homologmahogany proteinpoly [ADP-ribose] polymerase tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Bprotein poly-ADP-ribosyltransferase tankyrase-2tankyrase IItankyrase,
Modification date2020031320200313
UniProtAcc

O75882

.
Ensembl transtripts involved in fusion geneENST00000262919, ENST00000446916, 
ENST00000371627, 
Fusion gene scores* DoF score5 X 6 X 4=1202 X 2 X 2=8
# samples 52
** MAII scorelog2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ATRN [Title/Abstract] AND TNKS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRN(3565527)-TNKS2(93572740), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNKS2

GO:0000209

protein polyubiquitination

19759537|21478859

TgeneTNKS2

GO:0006471

protein ADP-ribosylation

11739745

TgeneTNKS2

GO:0070212

protein poly-ADP-ribosylation

25043379

TgeneTNKS2

GO:0070213

protein auto-ADP-ribosylation

19759537|21478859

TgeneTNKS2

GO:1904355

positive regulation of telomere capping

21531765


check buttonFusion gene breakpoints across ATRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNKS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8503-01AATRNchr20

3565527

-TNKS2chr10

93572740

+
ChimerDB4LUSCTCGA-56-8503-01AATRNchr20

3565527

+TNKS2chr10

93572740

+
ChimerDB4LUSCTCGA-56-8503ATRNchr20

3565527

+TNKS2chr10

93572740

+


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Fusion Gene ORF analysis for ATRN-TNKS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262919ENST00000371627ATRNchr20

3565527

+TNKS2chr10

93572740

+
In-frameENST00000446916ENST00000371627ATRNchr20

3565527

+TNKS2chr10

93572740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262919ATRNchr203565527+ENST00000371627TNKS2chr1093572740+883132526865532161
ENST00000446916ATRNchr203565527+ENST00000371627TNKS2chr1093572740+87633184064852161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262919ENST00000371627ATRNchr203565527+TNKS2chr1093572740+0.0001628870.99983704
ENST00000446916ENST00000371627ATRNchr203565527+TNKS2chr1093572740+0.000157580.9998424

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Fusion Genomic Features for ATRN-TNKS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATRNchr203565527+TNKS2chr1093572739+0.0004989660.999501
ATRNchr203565527+TNKS2chr1093572739+0.0004989660.999501
ATRNchr203565527+TNKS2chr1093572739+0.0004989660.999501
ATRNchr203565527+TNKS2chr1093572739+0.0004989660.999501

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATRN-TNKS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3565527/chr10:93572740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRN

O75882

.
FUNCTION: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:9736737}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+182943_7710611430.0Compositional biasNote=Leu-rich
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+182543_7710611273.0Compositional biasNote=Leu-rich
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829101_12910611430.0DomainEGF-like
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829132_24810611430.0DomainCUB
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829703_74810611430.0DomainNote=PSI 1
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829755_79410611430.0DomainNote=PSI 2
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829795_91910611430.0DomainC-type lectin
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829932_98310611430.0DomainNote=PSI 3
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829986_106110611430.0DomainNote=PSI 4
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825101_12910611273.0DomainEGF-like
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825132_24810611273.0DomainCUB
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825703_74810611273.0DomainNote=PSI 1
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825755_79410611273.0DomainNote=PSI 2
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825795_91910611273.0DomainC-type lectin
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825932_98310611273.0DomainNote=PSI 3
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825986_106110611273.0DomainNote=PSI 4
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829352_40210611430.0RepeatNote=Kelch 1
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829404_45110611430.0RepeatNote=Kelch 2
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829461_50810611430.0RepeatNote=Kelch 3
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829513_56410611430.0RepeatNote=Kelch 4
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829566_62410611430.0RepeatNote=Kelch 5
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+1829625_67110611430.0RepeatNote=Kelch 6
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825352_40210611273.0RepeatNote=Kelch 1
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825404_45110611273.0RepeatNote=Kelch 2
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825461_50810611273.0RepeatNote=Kelch 3
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825513_56410611273.0RepeatNote=Kelch 4
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825566_62410611273.0RepeatNote=Kelch 5
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+1825625_67110611273.0RepeatNote=Kelch 6
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027873_936661167.0DomainSAM
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027959_1164661167.0DomainPARP catalytic
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027545_553661167.0RegionHIF1AN-binding
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027123_155661167.0RepeatNote=ANK 3
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027210_242661167.0RepeatNote=ANK 4
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027243_275661167.0RepeatNote=ANK 5
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027276_308661167.0RepeatNote=ANK 6
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027363_398661167.0RepeatNote=ANK 7
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027399_431661167.0RepeatNote=ANK 8
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027432_464661167.0RepeatNote=ANK 9
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027525_557661167.0RepeatNote=ANK 10
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027558_590661167.0RepeatNote=ANK 11
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027591_623661167.0RepeatNote=ANK 12
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027678_710661167.0RepeatNote=ANK 13
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027711_743661167.0RepeatNote=ANK 14
TgeneTNKS2chr20:3565527chr10:93572740ENST00000371627027744_776661167.0RepeatNote=ANK 15
TgeneTNKS2chr20:3565527chr10:93572740ENST0000037162702790_122661167.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+18291063_110810611430.0DomainLaminin EGF-like 1
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+18291109_115710611430.0DomainLaminin EGF-like 2
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+18251063_110810611273.0DomainLaminin EGF-like 1
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+18251109_115710611273.0DomainLaminin EGF-like 2
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+18291301_142910611430.0Topological domainCytoplasmic
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+182984_127910611430.0Topological domainExtracellular
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+18251301_142910611273.0Topological domainCytoplasmic
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+182584_127910611273.0Topological domainExtracellular
HgeneATRNchr20:3565527chr10:93572740ENST00000262919+18291280_130010611430.0TransmembraneHelical
HgeneATRNchr20:3565527chr10:93572740ENST00000446916+18251280_130010611273.0TransmembraneHelical
TgeneTNKS2chr20:3565527chr10:93572740ENST0000037162702757_89661167.0RepeatNote=ANK 1


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Fusion Gene Sequence for ATRN-TNKS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8336_8336_1_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000262919_TNKS2_chr10_93572740_ENST00000371627_length(transcript)=8831nt_BP=3252nt
GGCGAAGCGGAGCCGGCCGTGCGGTGTGTGTGTATGTGTTCGCGGGGCGCCGTCTCAGCCCCGGGAAGATGGTGGCTGCAGCGGCGGCAA
CTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCACTGGGACTGGGACGTGACCAGGG
CTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGGCTGCTGCTGCTGCTGTTGTTGC
TCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTGTCGGGCTCAGCCGCAGCCGAGG
CCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGCCCCGCCGGCTGGGTGGGCGAGC
AATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGAAATTATAAATACAAAACGAAGT
GCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAGTGTAGTTGGGACCATTTATATG
TTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGAGATGGCAATGAGACTGTCCCTG
AGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGATTTAATATTACTTACAGTTTTG
ATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAATGTGAATGTTCTGAAAACTGGA
AAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAATTCAAGTGATGTCAGAGGATGCT
CCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACTCGAGAGGAATATTCTAACTTAA
AGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATGTTCAACCACTCAGATTATAACA
TGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTTGTTAGATATGGTCATTCTTTGG
CATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAGTTGAGAGTTTTTCACATTCATA
ATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACACATTGTTACACTGAAGAATGGCC
GAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATATGATTTGGATAAGAACACATGGA
GTATATTACACACCCAGGGTGCCCTTGTGCAAGGGGGTTACGGCCATAGCAGTGTTTACGACCATAGGACCAGGGCCCTATACGTTCATG
GTGGCTACAAGGCTTTCAGTGCCAATAAGTACCGGCTTGCAGATGATCTCTACCGATATGATGTGGATACCCAGATGTGGACCATTCTTA
AGGACAGCCGATTTTTCCGTTACTTGCACACAGCTGTGATAGTGAGTGGAACCATGCTGGTGTTTGGAGGAAACACACACAATGACACAT
CTATGAGCCATGGCGCCAAATGCTTCTCTTCAGATTTCATGGCCTATGACATTGCCTGTGACCGCTGGTCAGTGCTTCCCAGACCTGATC
TCCACCATGATGTCAACAGATTTGGCCATTCAGCAGTCTTACACAACAGCACCATGTATGTGTTCGGTGGTTTCAATAGTCTCCTCCTCA
GCGACATCCTGGTATTCACCTCGGAACAGTGTGATGCGCATCGGAGTGAAGCCGCTTGTTTAGCAGCAGGACCTGGTATTCGGTGTGTGT
GGAACACAGGGTCGTCTCAGTGTATCTCGTGGGCGCTGGCAACTGATGAACAAGAAGAAAAGTTAAAATCAGAATGTTTTTCCAAAAGAA
CTCTTGACCATGACAGATGTGACCAGCACACAGATTGTTACAGCTGCACAGCCAACACCAATGACTGCCACTGGTGCAATGACCATTGTG
TCCCCAGGAACCACAGCTGCTCAGAAGGCCAGATCTCCATTTTTAGGTATGAGAATTGCCCCAAGGATAACCCCATGTACTACTGTAACA
AGAAGACCAGCTGCAGGAGCTGTGCCCTGGACCAGAACTGCCAGTGGGAGCCCCGGAATCAGGAGTGCATTGCCCTGCCCGAAAATATCT
GTGGCATTGGCTGGCATTTGGTTGGAAACTCATGTTTGAAAATTACTACTGCCAAGGAGAATTATGACAATGCTAAATTGTTCTGTAGGA
ACCACAATGCCCTTTTGGCTTCTCTTACAACCCAGAAGAAGGTAGAATTTGTCCTTAAGCAGCTGCGAATAATGCAGTCATCTCAGAGCA
TGTCCAAGCTCACCTTAACCCCATGGGTCGGCCTTCGGAAGATCAATGTGTCCTACTGGTGCTGGGAAGATATGTCCCCATTTACAAATA
GTTTACTACAGTGGATGCCGTCTGAGCCCAGTGATGCTGGATTCTGTGGAATTTTATCAGAACCCAGTACTCGGGGACTGAAGGCTGCAA
CCTGCATCAACCCACTCAATGGTAGTGTCTGTGAAAGGCCTGCAAACCACAGTGCTAAGCAGTGCCGGACACCATGTGCCTTGAGGACAG
CATGTGGAGATTGCACCAGCGGCAGCTCTGAGTGCATGTGGTGCAGCAACATGAAGCAGTGTGTGGACTCCAATGCCTACGTGGCCTCCT
TCCCTTTTGGCCAGTGTATGGAATGGTATACGATGAGCACCTGCCCCCCTGAAAATTGTTCAGGCTACTGTACCTGTAGTCATTGCTTGG
AGCAACCAGGCTGTGGCTGGTGTACTGATCCCAGCAATACTGGCAAAGGGAAATGCATAGAGGGTTCCTATAAAGGACCAGTGAAGATGC
CTTCGCAAGCCCCTACAGGAAATTTCTATCCACAGCCCCTGCTCAATTCCAGCATGTGTCTAGAGGACAGCAGATACAACTGGTCTTTCA
TTCACTGTCCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGTCCAAGCACGTGATGATGGGGGCCTTA
TTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGGTGCAGACCCCAATGCTCGAGATAATT
GGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTTACAGCATGGAGCTGAGCCAACCATCC
GAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGGTGAATATAAGAAAGATGAACTCTTAG
AAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTGCCACGCAAGTGATGGCAGAAAGTCAA
CTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGGAGCTGATGTCCATGCTAAAGATAAAG
GTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGTCAAGCATGGTGCCTGTGTAAATGCAA
TGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTCTCTTCTCTTAAGTTATGGTGCAGACC
CAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGAAAGATTAGCATATGAATTTAAAGGCC
ACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGAAATGGTGAATTTCAAGCATCCTCAAA
CACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGAACTGTTGCTAAGAAAAGGAGCAAACA
TCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGATGTTGTTGAAGTAGTGGTGAAACATG
AAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGGTCATCTACAAACCTGCCGCCTACTCC
TGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAATGAAAATGTACAGCAACTCCTCCAAG
AGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGATGTCGAAACTGTAAAAAAACTGTGTA
CTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGCTGGGTATAACAGAGTGTCCGTGGTGG
AATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCACAATGCATGTTCTTATGGACATTATG
AAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTACACCTTTACATGAAGCAGCAGCAAAAG
GAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGATGGAAATACTCCTTTGGATCTTGTTA
AAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAAGAAGGGTTGTTTAGCCAGAGTGAAGA
AGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACATTTAGCAGCTGGTTATAATAATTTAG
AAGTTGCAGAGTATTTGTTACAACACGGAGCTGATGTGAATGCCCAAGACAAAGGAGGACTTATTCCTTTACATAATGCAGCATCTTACG
GGCATGTAGATGTAGCAGCTCTACTAATAAAGTATAATGCATGTGTCAATGCCACGGACAAATGGGCTTTCACACCTTTGCACGAAGCAG
CCCAAAAGGGACGAACACAGCTTTGTGCTTTGTTGCTAGCCCATGGAGCTGACCCGACTCTTAAAAATCAGGAAGGACAAACACCTTTAG
ATTTAGTTTCAGCGGATGATGTCAGCGCTCTTCTGACAGCAGCCATGCCCCCATCTGCTCTGCCCTCTTGTTACAAGCCTCAAGTGCTCA
ATGGTGTGAGAAGCCCAGGAGCCACTGCAGATGCTCTCTCTTCAGGTCCATCTAGCCCATCAAGCCTTTCTGCAGCCAGCAGTCTTGACA
ACTTATCTGGGAGTTTTTCAGAACTGTCTTCAGTAGTTAGTTCAAGTGGAACAGAGGGTGCTTCCAGTTTGGAGAAAAAGGAGGTTCCAG
GAGTAGATTTTAGCATAACTCAATTCGTAAGGAATCTTGGACTTGAGCACCTAATGGATATATTTGAGAGAGAACAGATCACTTTGGATG
TATTAGTTGAGATGGGGCACAAGGAGCTGAAGGAGATTGGAATCAATGCTTATGGACATAGGCACAAACTAATTAAAGGAGTCGAGAGAC
TTATCTCCGGACAACAAGGTCTTAACCCATATTTAACTTTGAACACCTCTGGTAGTGGAACAATTCTTATAGATCTGTCTCCTGATGATA
AAGAGTTTCAGTCTGTGGAGGAAGAGATGCAAAGTACAGTTCGAGAGCACAGAGATGGAGGTCATGCAGGTGGAATCTTCAACAGATACA
ATATTCTCAAGATTCAGAAGGTTTGTAACAAGAAACTATGGGAAAGATACACTCACCGGAGAAAAGAAGTTTCTGAAGAAAACCACAACC
ATGCCAATGAACGAATGCTATTTCATGGGTCTCCTTTTGTGAATGCAATTATCCACAAAGGCTTTGATGAAAGGCATGCGTACATAGGTG
GTATGTTTGGAGCTGGCATTTATTTTGCTGAAAACTCTTCCAAAAGCAATCAATATGTATATGGAATTGGAGGAGGTACTGGGTGTCCAG
TTCACAAAGACAGATCTTGTTACATTTGCCACAGGCAGCTGCTCTTTTGCCGGGTAACCTTGGGAAAGTCTTTCCTGCAGTTCAGTGCAA
TGAAAATGGCACATTCTCCTCCAGGTCATCACTCAGTCACTGGTAGGCCCAGTGTAAATGGCCTAGCATTAGCTGAATATGTTATTTACA
GAGGAGAACAGGCTTATCCTGAGTATTTAATTACTTACCAGATTATGAGGCCTGAAGGTATGGTCGATGGATAAATAGTTATTTTAAGAA
ACTAATTCCACTGAACCTAAAATCATCAAAGCAGCAGTGGCCTCTACGTTTTACTCCTTTGCTGAAAAAAAATCATCTTGCCCACAGGCC
TGTGGCAAAAGGATAAAAATGTGAACGAAGTTTAACATTCTGACTTGATAAAGCTTTAATAATGTACAGTGTTTTCTAAATATTTCCTGT
TTTTTCAGCACTTTAACAGATGCCATTCCAGGTTAAACTGGGTTGTCTGTACTAAATTATAAACAGAGTTAACTTGAACCTTTTATATGT
TATGCATTGATTCTAACAAACTGTAATGCCCTCAACAGAACTAATTTTACTAATACAATACTGTGTTCTTTAAAACACAGCATTTACACT
GAATACAATTTCATTTGTAAAACTGTAAATAAGAGCTTTTGTACTAGCCCAGTATTTATTTACATTGCTTTGTAATATAAATCTGTTTTA
GAACTGCAGCGGTTTACAAAATTTTTTCATATGTATTGTTCATCTATACTTCATCTTACATCGTCATGATTGAGTGATCTTTACATTTGA
TTCCAGAGGCTATGTTCAGTTGTTAGTTGGGAAAGATTGAGTTATCAGATTTAATTTGCCGATGGGAGCCTTTATCTGTCATTAGAAATC
TTTCTCATTTAAGAACTTATGAATATGCTGAAGATTTAATTTGTGATACCTTTGTATGTATGAGACACATTCCAAAGAGCTCTAACTATG
ATAGGTCCTGATTACTAAAGAAGCTTCTTTACTGGCCTCAATTTCTAGCTTTCATGTTGGAAAATTTTCTGCAGTCCTTCTGTGAAAATT
AGAGCAAAGTGCTCCTGTTTTTTAGAGAAACTAAATCTTGCTGTTGAACAATTATTGTGTTCTTTTCATGGAACATAAGTAGGATGTTAC
ATTTCCAGGGTGGGAAGGGTAATCCTAAATCATTTCCCAATCTATTCTAATTACCTTAAATCTAAAGGGGAAAAAAAAAATCACAAACAG
GACTGGGTAGTTTTTTATCCTAAGTATATTTTTTCCTGTTCTTTTTACTTGGTTTTATTGCTGTATTTATAGCCAATCTATACATCATGG
GTAAACTTAACCCAGAACTATAAAATGTAGTTGTCTCAGTCCCCTCCAGGCCTCCTGAATGGGCAAGTGCAGTGAAACAGGTGCTTCTTG
CTCCTGGGTTTTCTCTCCATGATGTTATGCCCAATTGGAAATATGCTGTCAGTTTGTGCACCATATGGTGACCACGCCTGTGCTCAGTTT
GGCAGCTATAGAAGGAAATGCTGTCCCATAAAATGCCATTCCTATTTTCTAATATAAAACTCTTTTCCAGGAAGCATGCTTAAGCATCTT
GTTACAGAGACATACATCCATTATGGCTTGGCAATCTCTTTTATTTGTTGACTCTAGCTCCCTTCAAAGTCGAGGAAAGATCTTTACTCA
CTTAATGAGGACATTCCCCATCACTGTCTGTACCAGTTCACCTTTATTTTACGTTTTATTCAGTCTGTAAATTAACTGGCCCTTTGCAGT
AACTTGTACATAAAGTGCTAGAAAATCATGTTCCTTGTCCTGAGTAAGAGTTAATCAGAGTAAATGCATTTCTGGAGTTGTTTCTGTGAT
GTAAATTATGATCATTATTTAAGAAGTCAAATCCTGATCTTGAAGTGCTTTTTATACAGCTCTCTAATAATTACAAATATCCGAAAGTCA
TTTCTTGGAACACAAGTGGAGTATGCCAAATTTTATATGAATTTTTCAGATTATCTAAGCTTCCAGGTTTTATAATTAGAAGATAATGAG
AGAATTAATGGGGTTTATATTTACATTATCTCTCAACTATGTAGCCCATATTACTCACCCTATGAGTGAATCTGGAATTGCTTTTCATGT
GAAATCATTGTGGTCTATGAGTTTACAATACTGCAAACTGTGTTATTTTATCTAATCCATTGCTTAATGAGTGTGTTTTTCCATGAATGA
ATATACCGTGGTTCATATGTTAGCATGGCAGCATTTTCAGATAGCTTTTTGTTTGTTGGGAAGTTGGGGTTTTGGGGGGAGGGGGAGTAT
TAGTACGTTGCATGAAATAGCTTACTTTATAATGATGGAATTGCTTTTTCTTTTGTCTTGTGATTTTTTTTTTTGAAGTGAAATTTAACT
TTTTGTGCAAGTAGTACTATTATACCCATCTTCAGTGTCTTACTTGTACTGTATCACATTCCATACCCTCATTTAATTCTTAATAAAACT

>8336_8336_1_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000262919_TNKS2_chr10_93572740_ENST00000371627_length(amino acids)=2161AA_BP=1486
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV
SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE
CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE
CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM
FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH
IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVD
TQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFG
GFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDC
HWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYD
NAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPS
TRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGY
CTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP
LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS
CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE
REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA
GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGI
GGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVD

--------------------------------------------------------------
>8336_8336_2_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000446916_TNKS2_chr10_93572740_ENST00000371627_length(transcript)=8763nt_BP=3184nt
ATGGTGGCTGCAGCGGCGGCAACTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCAC
TGGGACTGGGACGTGACCAGGGCTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGG
CTGCTGCTGCTGCTGTTGTTGCTCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTG
TCGGGCTCAGCCGCAGCCGAGGCCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGC
CCCGCCGGCTGGGTGGGCGAGCAATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGA
AATTATAAATACAAAACGAAGTGCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAG
TGTAGTTGGGACCATTTATATGTTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGA
GATGGCAATGAGACTGTCCCTGAGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGA
TTTAATATTACTTACAGTTTTGATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAA
TGTGAATGTTCTGAAAACTGGAAAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAAT
TCAAGTGATGTCAGAGGATGCTCCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACT
CGAGAGGAATATTCTAACTTAAAGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATG
TTCAACCACTCAGATTATAACATGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTT
GTTAGATATGGTCATTCTTTGGCATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAG
TTGAGAGTTTTTCACATTCATAATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACAC
ATTGTTACACTGAAGAATGGCCGAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATAT
GATTTGGATAAGAACACATGGAGTATATTACACACCCAGGGTGCCCTTGTGCAAGGGGGTTACGGCCATAGCAGTGTTTACGACCATAGG
ACCAGGGCCCTATACGTTCATGGTGGCTACAAGGCTTTCAGTGCCAATAAGTACCGGCTTGCAGATGATCTCTACCGATATGATGTGGAT
ACCCAGATGTGGACCATTCTTAAGGACAGCCGATTTTTCCGTTACTTGCACACAGCTGTGATAGTGAGTGGAACCATGCTGGTGTTTGGA
GGAAACACACACAATGACACATCTATGAGCCATGGCGCCAAATGCTTCTCTTCAGATTTCATGGCCTATGACATTGCCTGTGACCGCTGG
TCAGTGCTTCCCAGACCTGATCTCCACCATGATGTCAACAGATTTGGCCATTCAGCAGTCTTACACAACAGCACCATGTATGTGTTCGGT
GGTTTCAATAGTCTCCTCCTCAGCGACATCCTGGTATTCACCTCGGAACAGTGTGATGCGCATCGGAGTGAAGCCGCTTGTTTAGCAGCA
GGACCTGGTATTCGGTGTGTGTGGAACACAGGGTCGTCTCAGTGTATCTCGTGGGCGCTGGCAACTGATGAACAAGAAGAAAAGTTAAAA
TCAGAATGTTTTTCCAAAAGAACTCTTGACCATGACAGATGTGACCAGCACACAGATTGTTACAGCTGCACAGCCAACACCAATGACTGC
CACTGGTGCAATGACCATTGTGTCCCCAGGAACCACAGCTGCTCAGAAGGCCAGATCTCCATTTTTAGGTATGAGAATTGCCCCAAGGAT
AACCCCATGTACTACTGTAACAAGAAGACCAGCTGCAGGAGCTGTGCCCTGGACCAGAACTGCCAGTGGGAGCCCCGGAATCAGGAGTGC
ATTGCCCTGCCCGAAAATATCTGTGGCATTGGCTGGCATTTGGTTGGAAACTCATGTTTGAAAATTACTACTGCCAAGGAGAATTATGAC
AATGCTAAATTGTTCTGTAGGAACCACAATGCCCTTTTGGCTTCTCTTACAACCCAGAAGAAGGTAGAATTTGTCCTTAAGCAGCTGCGA
ATAATGCAGTCATCTCAGAGCATGTCCAAGCTCACCTTAACCCCATGGGTCGGCCTTCGGAAGATCAATGTGTCCTACTGGTGCTGGGAA
GATATGTCCCCATTTACAAATAGTTTACTACAGTGGATGCCGTCTGAGCCCAGTGATGCTGGATTCTGTGGAATTTTATCAGAACCCAGT
ACTCGGGGACTGAAGGCTGCAACCTGCATCAACCCACTCAATGGTAGTGTCTGTGAAAGGCCTGCAAACCACAGTGCTAAGCAGTGCCGG
ACACCATGTGCCTTGAGGACAGCATGTGGAGATTGCACCAGCGGCAGCTCTGAGTGCATGTGGTGCAGCAACATGAAGCAGTGTGTGGAC
TCCAATGCCTACGTGGCCTCCTTCCCTTTTGGCCAGTGTATGGAATGGTATACGATGAGCACCTGCCCCCCTGAAAATTGTTCAGGCTAC
TGTACCTGTAGTCATTGCTTGGAGCAACCAGGCTGTGGCTGGTGTACTGATCCCAGCAATACTGGCAAAGGGAAATGCATAGAGGGTTCC
TATAAAGGACCAGTGAAGATGCCTTCGCAAGCCCCTACAGGAAATTTCTATCCACAGCCCCTGCTCAATTCCAGCATGTGTCTAGAGGAC
AGCAGATACAACTGGTCTTTCATTCACTGTCCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGTCCAA
GCACGTGATGATGGGGGCCTTATTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGGTGCA
GACCCCAATGCTCGAGATAATTGGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTTACAG
CATGGAGCTGAGCCAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGGTGAA
TATAAGAAAGATGAACTCTTAGAAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTGCCAC
GCAAGTGATGGCAGAAAGTCAACTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGGAGCT
GATGTCCATGCTAAAGATAAAGGTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGTCAAG
CATGGTGCCTGTGTAAATGCAATGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTCTCTT
CTCTTAAGTTATGGTGCAGACCCAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGAAAGA
TTAGCATATGAATTTAAAGGCCACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGAAATG
GTGAATTTCAAGCATCCTCAAACACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGAACTG
TTGCTAAGAAAAGGAGCAAACATCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGATGTT
GTTGAAGTAGTGGTGAAACATGAAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGGTCAT
CTACAAACCTGCCGCCTACTCCTGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAATGAA
AATGTACAGCAACTCCTCCAAGAGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGATGTC
GAAACTGTAAAAAAACTGTGTACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGCTGGG
TATAACAGAGTGTCCGTGGTGGAATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCACAAT
GCATGTTCTTATGGACATTATGAAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTACACCT
TTACATGAAGCAGCAGCAAAAGGAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGATGGA
AATACTCCTTTGGATCTTGTTAAAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAAGAAG
GGTTGTTTAGCCAGAGTGAAGAAGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACATTTA
GCAGCTGGTTATAATAATTTAGAAGTTGCAGAGTATTTGTTACAACACGGAGCTGATGTGAATGCCCAAGACAAAGGAGGACTTATTCCT
TTACATAATGCAGCATCTTACGGGCATGTAGATGTAGCAGCTCTACTAATAAAGTATAATGCATGTGTCAATGCCACGGACAAATGGGCT
TTCACACCTTTGCACGAAGCAGCCCAAAAGGGACGAACACAGCTTTGTGCTTTGTTGCTAGCCCATGGAGCTGACCCGACTCTTAAAAAT
CAGGAAGGACAAACACCTTTAGATTTAGTTTCAGCGGATGATGTCAGCGCTCTTCTGACAGCAGCCATGCCCCCATCTGCTCTGCCCTCT
TGTTACAAGCCTCAAGTGCTCAATGGTGTGAGAAGCCCAGGAGCCACTGCAGATGCTCTCTCTTCAGGTCCATCTAGCCCATCAAGCCTT
TCTGCAGCCAGCAGTCTTGACAACTTATCTGGGAGTTTTTCAGAACTGTCTTCAGTAGTTAGTTCAAGTGGAACAGAGGGTGCTTCCAGT
TTGGAGAAAAAGGAGGTTCCAGGAGTAGATTTTAGCATAACTCAATTCGTAAGGAATCTTGGACTTGAGCACCTAATGGATATATTTGAG
AGAGAACAGATCACTTTGGATGTATTAGTTGAGATGGGGCACAAGGAGCTGAAGGAGATTGGAATCAATGCTTATGGACATAGGCACAAA
CTAATTAAAGGAGTCGAGAGACTTATCTCCGGACAACAAGGTCTTAACCCATATTTAACTTTGAACACCTCTGGTAGTGGAACAATTCTT
ATAGATCTGTCTCCTGATGATAAAGAGTTTCAGTCTGTGGAGGAAGAGATGCAAAGTACAGTTCGAGAGCACAGAGATGGAGGTCATGCA
GGTGGAATCTTCAACAGATACAATATTCTCAAGATTCAGAAGGTTTGTAACAAGAAACTATGGGAAAGATACACTCACCGGAGAAAAGAA
GTTTCTGAAGAAAACCACAACCATGCCAATGAACGAATGCTATTTCATGGGTCTCCTTTTGTGAATGCAATTATCCACAAAGGCTTTGAT
GAAAGGCATGCGTACATAGGTGGTATGTTTGGAGCTGGCATTTATTTTGCTGAAAACTCTTCCAAAAGCAATCAATATGTATATGGAATT
GGAGGAGGTACTGGGTGTCCAGTTCACAAAGACAGATCTTGTTACATTTGCCACAGGCAGCTGCTCTTTTGCCGGGTAACCTTGGGAAAG
TCTTTCCTGCAGTTCAGTGCAATGAAAATGGCACATTCTCCTCCAGGTCATCACTCAGTCACTGGTAGGCCCAGTGTAAATGGCCTAGCA
TTAGCTGAATATGTTATTTACAGAGGAGAACAGGCTTATCCTGAGTATTTAATTACTTACCAGATTATGAGGCCTGAAGGTATGGTCGAT
GGATAAATAGTTATTTTAAGAAACTAATTCCACTGAACCTAAAATCATCAAAGCAGCAGTGGCCTCTACGTTTTACTCCTTTGCTGAAAA
AAAATCATCTTGCCCACAGGCCTGTGGCAAAAGGATAAAAATGTGAACGAAGTTTAACATTCTGACTTGATAAAGCTTTAATAATGTACA
GTGTTTTCTAAATATTTCCTGTTTTTTCAGCACTTTAACAGATGCCATTCCAGGTTAAACTGGGTTGTCTGTACTAAATTATAAACAGAG
TTAACTTGAACCTTTTATATGTTATGCATTGATTCTAACAAACTGTAATGCCCTCAACAGAACTAATTTTACTAATACAATACTGTGTTC
TTTAAAACACAGCATTTACACTGAATACAATTTCATTTGTAAAACTGTAAATAAGAGCTTTTGTACTAGCCCAGTATTTATTTACATTGC
TTTGTAATATAAATCTGTTTTAGAACTGCAGCGGTTTACAAAATTTTTTCATATGTATTGTTCATCTATACTTCATCTTACATCGTCATG
ATTGAGTGATCTTTACATTTGATTCCAGAGGCTATGTTCAGTTGTTAGTTGGGAAAGATTGAGTTATCAGATTTAATTTGCCGATGGGAG
CCTTTATCTGTCATTAGAAATCTTTCTCATTTAAGAACTTATGAATATGCTGAAGATTTAATTTGTGATACCTTTGTATGTATGAGACAC
ATTCCAAAGAGCTCTAACTATGATAGGTCCTGATTACTAAAGAAGCTTCTTTACTGGCCTCAATTTCTAGCTTTCATGTTGGAAAATTTT
CTGCAGTCCTTCTGTGAAAATTAGAGCAAAGTGCTCCTGTTTTTTAGAGAAACTAAATCTTGCTGTTGAACAATTATTGTGTTCTTTTCA
TGGAACATAAGTAGGATGTTACATTTCCAGGGTGGGAAGGGTAATCCTAAATCATTTCCCAATCTATTCTAATTACCTTAAATCTAAAGG
GGAAAAAAAAAATCACAAACAGGACTGGGTAGTTTTTTATCCTAAGTATATTTTTTCCTGTTCTTTTTACTTGGTTTTATTGCTGTATTT
ATAGCCAATCTATACATCATGGGTAAACTTAACCCAGAACTATAAAATGTAGTTGTCTCAGTCCCCTCCAGGCCTCCTGAATGGGCAAGT
GCAGTGAAACAGGTGCTTCTTGCTCCTGGGTTTTCTCTCCATGATGTTATGCCCAATTGGAAATATGCTGTCAGTTTGTGCACCATATGG
TGACCACGCCTGTGCTCAGTTTGGCAGCTATAGAAGGAAATGCTGTCCCATAAAATGCCATTCCTATTTTCTAATATAAAACTCTTTTCC
AGGAAGCATGCTTAAGCATCTTGTTACAGAGACATACATCCATTATGGCTTGGCAATCTCTTTTATTTGTTGACTCTAGCTCCCTTCAAA
GTCGAGGAAAGATCTTTACTCACTTAATGAGGACATTCCCCATCACTGTCTGTACCAGTTCACCTTTATTTTACGTTTTATTCAGTCTGT
AAATTAACTGGCCCTTTGCAGTAACTTGTACATAAAGTGCTAGAAAATCATGTTCCTTGTCCTGAGTAAGAGTTAATCAGAGTAAATGCA
TTTCTGGAGTTGTTTCTGTGATGTAAATTATGATCATTATTTAAGAAGTCAAATCCTGATCTTGAAGTGCTTTTTATACAGCTCTCTAAT
AATTACAAATATCCGAAAGTCATTTCTTGGAACACAAGTGGAGTATGCCAAATTTTATATGAATTTTTCAGATTATCTAAGCTTCCAGGT
TTTATAATTAGAAGATAATGAGAGAATTAATGGGGTTTATATTTACATTATCTCTCAACTATGTAGCCCATATTACTCACCCTATGAGTG
AATCTGGAATTGCTTTTCATGTGAAATCATTGTGGTCTATGAGTTTACAATACTGCAAACTGTGTTATTTTATCTAATCCATTGCTTAAT
GAGTGTGTTTTTCCATGAATGAATATACCGTGGTTCATATGTTAGCATGGCAGCATTTTCAGATAGCTTTTTGTTTGTTGGGAAGTTGGG
GTTTTGGGGGGAGGGGGAGTATTAGTACGTTGCATGAAATAGCTTACTTTATAATGATGGAATTGCTTTTTCTTTTGTCTTGTGATTTTT
TTTTTTGAAGTGAAATTTAACTTTTTGTGCAAGTAGTACTATTATACCCATCTTCAGTGTCTTACTTGTACTGTATCACATTCCATACCC

>8336_8336_2_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000446916_TNKS2_chr10_93572740_ENST00000371627_length(amino acids)=2161AA_BP=1486
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV
SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE
CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE
CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM
FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH
IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVD
TQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFG
GFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDC
HWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYD
NAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPS
TRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGY
CTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP
LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS
CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE
REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA
GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGI
GGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVD

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Fusion Gene PPI Analysis for ATRN-TNKS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRN-TNKS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRN-TNKS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource