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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRN-UQCRB (FusionGDB2 ID:8337)

Fusion Gene Summary for ATRN-UQCRB

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRN-UQCRB
Fusion gene ID: 8337
HgeneTgene
Gene symbol

ATRN

UQCRB

Gene ID

8455

7381

Gene nameattractinubiquinol-cytochrome c reductase binding protein
SynonymsDPPT-L|MGCAMC3DN3|QCR7|QP-C|QPC|UQBC|UQBP|UQCR6|UQPC
Cytomap

20p13

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionattractinattractin-2mahogany homologmahogany proteincytochrome b-c1 complex subunit 7complex III subunit 7complex III subunit VIImitochondrial ubiquinone-binding proteinubiquinol-cytochrome c reductase complex 14 kDa proteinubiquinol-cytochrome c reductase, complex III subunit VI
Modification date2020031320200313
UniProtAcc

O75882

.
Ensembl transtripts involved in fusion geneENST00000262919, ENST00000446916, 
ENST00000517523, ENST00000518406, 
ENST00000523920, ENST00000287022, 
Fusion gene scores* DoF score5 X 6 X 4=1204 X 3 X 3=36
# samples 54
** MAII scorelog2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATRN [Title/Abstract] AND UQCRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRN(3541552)-UQCRB(97245455), # samples:6
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UQCRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A42X-01AATRNchr20

3541552

-UQCRBchr8

97245455

-
ChimerDB4SARCTCGA-K1-A42X-01AATRNchr20

3541552

+UQCRBchr8

97245455

-
ChimerDB4SARCTCGA-K1-A42X-02AATRNchr20

3541552

-UQCRBchr8

97245455

-
ChimerDB4SARCTCGA-K1-A42X-02AATRNchr20

3541552

+UQCRBchr8

97245455

-
ChimerDB4SARCTCGA-K1-A42XATRNchr20

3541552

+UQCRBchr8

97245455

-


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Fusion Gene ORF analysis for ATRN-UQCRB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262919ENST00000517523ATRNchr20

3541552

+UQCRBchr8

97245455

-
5CDS-intronENST00000262919ENST00000518406ATRNchr20

3541552

+UQCRBchr8

97245455

-
5CDS-intronENST00000262919ENST00000523920ATRNchr20

3541552

+UQCRBchr8

97245455

-
5CDS-intronENST00000446916ENST00000517523ATRNchr20

3541552

+UQCRBchr8

97245455

-
5CDS-intronENST00000446916ENST00000518406ATRNchr20

3541552

+UQCRBchr8

97245455

-
5CDS-intronENST00000446916ENST00000523920ATRNchr20

3541552

+UQCRBchr8

97245455

-
In-frameENST00000262919ENST00000287022ATRNchr20

3541552

+UQCRBchr8

97245455

-
In-frameENST00000446916ENST00000287022ATRNchr20

3541552

+UQCRBchr8

97245455

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262919ATRNchr203541552+ENST00000287022UQCRBchr897245455-69671515681831587
ENST00000446916ATRNchr203541552+ENST00000287022UQCRBchr897245455-6899144701763587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262919ENST00000287022ATRNchr203541552+UQCRBchr897245455-0.0006392840.99936074
ENST00000446916ENST00000287022ATRNchr203541552+UQCRBchr897245455-0.0006661450.9993338

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Fusion Genomic Features for ATRN-UQCRB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATRN-UQCRB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3541552/chr8:97245455)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRN

O75882

.
FUNCTION: Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:9736737}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+82943_774821430.0Compositional biasNote=Leu-rich
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+82543_774821273.0Compositional biasNote=Leu-rich
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829101_1294821430.0DomainEGF-like
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829132_2484821430.0DomainCUB
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825101_1294821273.0DomainEGF-like
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825132_2484821273.0DomainCUB
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829352_4024821430.0RepeatNote=Kelch 1
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829404_4514821430.0RepeatNote=Kelch 2
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825352_4024821273.0RepeatNote=Kelch 1
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825404_4514821273.0RepeatNote=Kelch 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+8291063_11084821430.0DomainLaminin EGF-like 1
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+8291109_11574821430.0DomainLaminin EGF-like 2
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829703_7484821430.0DomainNote=PSI 1
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829755_7944821430.0DomainNote=PSI 2
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829795_9194821430.0DomainC-type lectin
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829932_9834821430.0DomainNote=PSI 3
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829986_10614821430.0DomainNote=PSI 4
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+8251063_11084821273.0DomainLaminin EGF-like 1
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+8251109_11574821273.0DomainLaminin EGF-like 2
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825703_7484821273.0DomainNote=PSI 1
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825755_7944821273.0DomainNote=PSI 2
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825795_9194821273.0DomainC-type lectin
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825932_9834821273.0DomainNote=PSI 3
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825986_10614821273.0DomainNote=PSI 4
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829461_5084821430.0RepeatNote=Kelch 3
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829513_5644821430.0RepeatNote=Kelch 4
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829566_6244821430.0RepeatNote=Kelch 5
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+829625_6714821430.0RepeatNote=Kelch 6
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825461_5084821273.0RepeatNote=Kelch 3
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825513_5644821273.0RepeatNote=Kelch 4
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825566_6244821273.0RepeatNote=Kelch 5
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+825625_6714821273.0RepeatNote=Kelch 6
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+8291301_14294821430.0Topological domainCytoplasmic
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+82984_12794821430.0Topological domainExtracellular
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+8251301_14294821273.0Topological domainCytoplasmic
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+82584_12794821273.0Topological domainExtracellular
HgeneATRNchr20:3541552chr8:97245455ENST00000262919+8291280_13004821430.0TransmembraneHelical
HgeneATRNchr20:3541552chr8:97245455ENST00000446916+8251280_13004821273.0TransmembraneHelical


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Fusion Gene Sequence for ATRN-UQCRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8337_8337_1_ATRN-UQCRB_ATRN_chr20_3541552_ENST00000262919_UQCRB_chr8_97245455_ENST00000287022_length(transcript)=6967nt_BP=1515nt
GGCGAAGCGGAGCCGGCCGTGCGGTGTGTGTGTATGTGTTCGCGGGGCGCCGTCTCAGCCCCGGGAAGATGGTGGCTGCAGCGGCGGCAA
CTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCACTGGGACTGGGACGTGACCAGGG
CTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGGCTGCTGCTGCTGCTGTTGTTGC
TCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTGTCGGGCTCAGCCGCAGCCGAGG
CCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGCCCCGCCGGCTGGGTGGGCGAGC
AATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGAAATTATAAATACAAAACGAAGT
GCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAGTGTAGTTGGGACCATTTATATG
TTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGAGATGGCAATGAGACTGTCCCTG
AGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGATTTAATATTACTTACAGTTTTG
ATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAATGTGAATGTTCTGAAAACTGGA
AAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAATTCAAGTGATGTCAGAGGATGCT
CCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACTCGAGAGGAATATTCTAACTTAA
AGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATGTTCAACCACTCAGATTATAACA
TGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTTGTTAGATATGGTCATTCTTTGG
CATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAGTTGAGAGTTTTTCACATTCATA
ATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACACATTGTTACACTGAAGAATGGCC
GAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATATGATTTGGTTTCAGCATCAGGCA
AGTGGCTGGATGGTATTCGAAAATGGTATTACAATGCTGCAGGATTCAATAAACTGGGGTTAATGCGAGATGATACAATATACGAGGATG
AAGATGTAAAAGAAGCCATAAGAAGACTTCCTGAGAACCTTTATAATGACAGGATGTTTCGCATTAAGAGGGCACTGGACCTGAACTTGA
AGCATCAGATCTTGCCTAAAGAGCAGTGGACCAAATATGAAGAGGAAAATTTCTACCTTGAACCGTATCTGAAAGAGGTTATTCGGGAAA
GAAAAGAAAGAGAAGAATGGGCAAAGAAGTAATCATGTAGTTGAAGTCTGTGGATGCAGCTGTTATGAAGATGGTTAAACTTGAAACAAA
CAATTTTAAGAATTATTTGGTCTGAAGATGTTTTACTTTAAATAAATGTCTATTGTAATGGCTGGAGTTTTTGAATTCCAAACCTTATAC
TGAATAACTACTGAATCCCTTTACTGTTAAATTTTTTTCCAAACTTTCAAGATATATTTAGTTGTGTTTAACTGCTACTTGGAGCTCAGA
AGCCACTTTATCAGTTTTCCTCACTGGTTGGATAGCCTATCAGTTTATGGAAGGATATAACTTCCGTAAGTTACATCCTTATGGAAGCTA
CTGAATAAAAGAAGGGGGTATGCACCCCCTAGTTTGCCAAGATTGAGAAATAGCCTCTTCACTGGTATGCAAACAGATTTGATTTTGCAT
CCTATCATTTAAAAAGAAATTATGTCTGCACCCCAACATAGGCATACTTAAGTAATATACATACTCCTGTGCTAACATGTATACTAGAAA
ACAAAAAGATGTTAGAAAAATAAAAGTATAAAGACAAATCATACTGTCCCCATATCCCAGTGACTTTTCCACTTTGGAAATGATTGTTAT
GAAGTTTAAGGGTTGGATACTAGTCAGTTAAAAGTTTTAAGATTATAGGGTAATTTTTAAAAATATAAATTAGAATCATTGGCAAGGCAT
GGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGGTCACCTGAAGTCAGGAATTTGAGACCAGCCTGGCCAACAT
GGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTAGGCGTGATGGTAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGGA
GGAGAATTGCTTGACCCCAGGAGGTGGAGGTTGCAGTGAGCCTAGATCACACCACTGCACTTCAGCCTGAGCGACATTGACTGTCTCAAA
AAAAAAATTAGGATTATTCAATGTTGTCATCATTTCCACTCCTAAATTCTGAAATGCTTTCTTTGGTAGAGGTGAGAGTGTGGAGCCACA
GCTAGTAGAGAAGGAACAGTAGGACCTGCAGCCTCCCTGGTTTTCCAGGACAAGTCATTGCTGTGTGTGGCAGGAATGCCTTACCTCAAA
TAACAAAACAGTGTGAAAAACGAATTTGTGTTACATTTAAAGTTTGTAAAGCAATGAGAAATGTGTGTATCATAAAGAGCATCTTTAAAT
TTTTGCTAAAATATTAGCCTCTTAAATTCTCTAGGAACCCCCTCCCCCGCTTTTTTTTTTCCTTTCGCTGGTCGTTATTTTTCTAAACCT
ATCCTGAAATCATGTCAATTTTCTTTTGTATGGTTGAAGACAACTAGATCACTTGATAATGGTTTTGCTCAGGTCACATTGTGACAAGGT
TTTAATGTAGTCCTACTTTGCAGAAGGAGGCCAAGAAGATGGGCTGTCTAGAACCCCCTTTAAAAGCATTTGTCTATTCAGAAAATTTTC
CTGAGTAGATCTCTGCAAAGGCTCTTTTAATAGTGATTTCAAGATCACGTTTGCAGGACTCTGGTCTATTCGTTCAGACGTCTACTGTGC
ACAATTACAAGGAGACTACAACTGAGGCATCTCAAAGAGCACTGTCAAGGTGTGTAGGGAGCCGGGTGGGTGGAGGGAGGCTGGGCTCTG
ACCCTAGAAACCATGCTTATGAATGCTGTTAATGTTTAAAGCAAGCCTAAGGGCACTGCTGAAGGACAGGGGAACAAATAGAACTGACCA
AGACTGAGGTATAACAGGAACCCCCAGGCTATCCACCTGCTCAAGGTAAAGTGTGGTATTACATAAGGCAACCTCTGATTTTGTAAGAGT
TCTTCCTAAAGCCAAAGTGTATGCCTATTCTATGTTTCCAGATTACTTCATTCTTCTAAATGAGAACAAGTGTGCAAAAGTTCTTTGAAC
ACTAGATCAATGTTTTGTGTTCATTATAAATTATGGTTATCGTCCTGCTTGTTATGAAGACTAAGAAAGTAGATCTAGTATTTGGCTCAC
ACAGGTGAATGGGTGAGAATTTGTTAATCCATCAGTGAAGTCCTTTCATTTGAAAGAGAGGGCCTTTCTATTATCAAAAGCCGTCCTGTG
TGGAAAATCACCATGAGAGTGCCTGAAACACAGGCACTCTGCATTGTCCTGTAGACCAAATCTACATTGTCCTGTAGTCTGGTCTACATT
GTCCTGTAGACCGAATGGTAGAGTGATTCAGAGCTAATTCTGGGTTAGACTGCACAGGTCTGAATCTATTTGCTCACTGTGTAGTGCTTT
AGGAATACAATTTAACCTCTCCGTGCTTCAGTTTGTTTGTCCCTAAGATAGAGCTAATGATAGAAACCTACTTCACCCAGTTGTGAAAAT
TAACTGACTGCATGTCAAGCACTAACAGTTTCTGGCATATAGTATGCATAATGTAAATTATGTGCTGAGAAGCGAGAAAGAATAACTTGG
GAAAACGCTGAATATCATCAATGTCGAATAGCTAACCAGTAGCTAAGGTCCAAGGTCTCCTCTCTTCCTTCTATGTGGCACTCTTGTTTC
TGGTTCATCTACTCCCCTTGGGTGTCACCTCCTTGAGTGAAGTACCTGCTGGAGATGAGAAGAGTGGAACTGGATCTGCATGACAGCTTT
GATTAGGATGGAGCTAAGACTTGGCTATCTCCCTGTTTTGTGTTTTGGATGGGTGACATTTTAAAACTGCCAATATTCAAATCCTGCTAA
TTTGCTTTGTACAGTTTAAAATGTTTGATATCTTTTGTTGTTTAAAGTTTGAGATTGGTTTTGAATATACAGTTTTCCTACATCTTGAAG
AAAGTTATGTTTGTTTACTCTGAAGTGGTCTATGTTCTGTTTGTTTGTTTTACTATACTTTGCAAAAAAACAGATGGCTGGCTTATGTTC
ACTGTTGTAGTGCACTACCTAGTATCACTTGGCCTTCCTGTTGTCAAGATGTAGGAAGCAGCGTAAGGGATGTCGGGCCTTCAGACCCCC
AATTGCCAGCTGTGGTCCTAGTTCCAGATTGCATGGAAATATTTGATAACATTCCTGCACTGAGTTATCATGGTCTGAATATTTATGTGA
CGCTCTACGAGTGGTACCAAAATGTTAGTGATGGAGTTTTTACTAATGGCACCTTTTCCTGTTTTTAAATTCTAGAATCTTAATAAATCC
AAAGTGTACATTTTGGTAGTGATTTCATTTAGTTATTTACTTTAAGGACTCCCTTTTCAAGCATTAACTCTGCACTAATTTTGACTTATG
AAAAGATTCAGCAGTAAGAATAAAAACTGGGCCAAAGCCCAAAGTAATAATCCTTCACAAATAGGATGGAGTTTTAAAAATATGGGCATC
CTGTGTGTAGCTTTGAAAATAACCAAACTACTTGGAATTAAAAAGTTAGGTGAACATGAAGATTGTCATAACCAAATCCTTGACAGCTTG
ATGGATGAAGAGCAGATGGGTTTATGGTGTATGGGAGGAAGCATGGATTTTAGGAGGGACAGTATCAGAGAGGGATGGTTAGAAAGTGAG
TAAGACAGGTTGCTCTTTGGAAAACAAGGAAAATCCCTTTATTAGAACAAGGCATGAAATTCTGCCACTAGGTGGCGATGCCCTATAACT
TTACAACTTAGTGTACATCACACGAGCACTATGGAAGATTTCTCCATTCTGCGCCCCACCAACTCCCTCCCCTCCTTCATTTTTCAGGAT
GACAACACCTTAGAGGTTTATGGCCATCAGGAGAATTTACTACTAAGCTATATACTGATGTAATGAAATCTAATATATGTTGTGCAATGA
ATTATGAGATGTTATTTAGTTTCAGGATTTTATTACTTCAATCAGTTATGACCATATTTCCTTTTATATGATTGCTCACTCTTTAAACAT
ACCAGATGACTGTATAAGGAACACCTAATAAAGTCTATAGATGTTAAAATATTTTAAATGTTTTAATTTATATGCCATAATTTGTTTACA
TTCTGGTTATACTGGCGTTCATATTAAAAGCCATAACATGTTAGAATCTGAGATCTCAGGTCGGATAGTGCCTCTAAGTTATATTTTGCT
AAGAAATTTTATTGTATTAGCAATTGAGCAAGAAAGAAGAACTGAATCATTATACGGTGGTTAATTTTTAGCATAGATGTCAGAAAGCCT
GTTAATATTCCAGAGGCTTATGATAAACTATTTAAATTGTCATTCTGGATTCTGATTATATCTCCTACAAAGAAAGAGTGTATTATTTAT
TGAACTTTTTGTTTGAATACATGTGCCTATTTTTGCATAAATGTAAAAATGTAATTTTAAAATAAACCCCTGAAAACTTCTGGTAACATT
ATCCAGTTGAATAATTGTTCTGTTAGTATTCTAAATATTTTAAGAAAATTGTATACATATCTGTGACAATTGTATTCACAAGCCAAACCA
AAAAAAGATAATTATTTGTTTTACAAAGGAGTCAGCTTACAATTTTTCTCTTATGCATGCATTTAAAATGTGGTTTGCCATTAAACTGGA
AACACTGATCTGAGGCCAATGATTTAGGCAAGTCATTAGTCTAAAGATTGGCTTCCTCAGCTAGAAAATGAAGGGCTTTGACTAAAAAGT
CTTTTTCATTTCAGTACCAAAACATTCTGGGTCTGTGATTTAACTTACGCTCTTTATTGTTGGGATGAACTAATACTGATGGAATACTAG
CTTTGTACTAGGCACTGTTCGTATGTTGTCTCTTTTAATCCTCCCTGCAACCTTCTGGCATGGCTATTATAATGCCCATTGTATGGAAGA
AGAAATTAGGCTTCGAAAGTCCATTTTATGCTTGTTCATTACATAATTTTCTGGATTTTTTAAATTGATGTATGTGTTTATGTTCCAGGC
TAGGCAGAAGCTAGGAAGAATATAGCAGCCTCGTCACTGTTGAAATCTGGGGCTAGATAATTCTTTGTTGTGGGGGCCTCCTCTGTGTGT
TACAGGATATTTAGCAGCATCCTGGCTTCTACACGATAGGTACCAGTAGCGCCTCCTGCCTCCAACTGTAACAACCAAAAATGTTTTGAG

>8337_8337_1_ATRN-UQCRB_ATRN_chr20_3541552_ENST00000262919_UQCRB_chr8_97245455_ENST00000287022_length(amino acids)=587AA_BP=482
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV
SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE
CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE
CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM
FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH
IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIK

--------------------------------------------------------------
>8337_8337_2_ATRN-UQCRB_ATRN_chr20_3541552_ENST00000446916_UQCRB_chr8_97245455_ENST00000287022_length(transcript)=6899nt_BP=1447nt
ATGGTGGCTGCAGCGGCGGCAACTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCAC
TGGGACTGGGACGTGACCAGGGCTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGG
CTGCTGCTGCTGCTGTTGTTGCTCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTG
TCGGGCTCAGCCGCAGCCGAGGCCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGC
CCCGCCGGCTGGGTGGGCGAGCAATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGA
AATTATAAATACAAAACGAAGTGCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAG
TGTAGTTGGGACCATTTATATGTTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGA
GATGGCAATGAGACTGTCCCTGAGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGA
TTTAATATTACTTACAGTTTTGATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAA
TGTGAATGTTCTGAAAACTGGAAAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAAT
TCAAGTGATGTCAGAGGATGCTCCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACT
CGAGAGGAATATTCTAACTTAAAGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATG
TTCAACCACTCAGATTATAACATGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTT
GTTAGATATGGTCATTCTTTGGCATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAG
TTGAGAGTTTTTCACATTCATAATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACAC
ATTGTTACACTGAAGAATGGCCGAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATAT
GATTTGGTTTCAGCATCAGGCAAGTGGCTGGATGGTATTCGAAAATGGTATTACAATGCTGCAGGATTCAATAAACTGGGGTTAATGCGA
GATGATACAATATACGAGGATGAAGATGTAAAAGAAGCCATAAGAAGACTTCCTGAGAACCTTTATAATGACAGGATGTTTCGCATTAAG
AGGGCACTGGACCTGAACTTGAAGCATCAGATCTTGCCTAAAGAGCAGTGGACCAAATATGAAGAGGAAAATTTCTACCTTGAACCGTAT
CTGAAAGAGGTTATTCGGGAAAGAAAAGAAAGAGAAGAATGGGCAAAGAAGTAATCATGTAGTTGAAGTCTGTGGATGCAGCTGTTATGA
AGATGGTTAAACTTGAAACAAACAATTTTAAGAATTATTTGGTCTGAAGATGTTTTACTTTAAATAAATGTCTATTGTAATGGCTGGAGT
TTTTGAATTCCAAACCTTATACTGAATAACTACTGAATCCCTTTACTGTTAAATTTTTTTCCAAACTTTCAAGATATATTTAGTTGTGTT
TAACTGCTACTTGGAGCTCAGAAGCCACTTTATCAGTTTTCCTCACTGGTTGGATAGCCTATCAGTTTATGGAAGGATATAACTTCCGTA
AGTTACATCCTTATGGAAGCTACTGAATAAAAGAAGGGGGTATGCACCCCCTAGTTTGCCAAGATTGAGAAATAGCCTCTTCACTGGTAT
GCAAACAGATTTGATTTTGCATCCTATCATTTAAAAAGAAATTATGTCTGCACCCCAACATAGGCATACTTAAGTAATATACATACTCCT
GTGCTAACATGTATACTAGAAAACAAAAAGATGTTAGAAAAATAAAAGTATAAAGACAAATCATACTGTCCCCATATCCCAGTGACTTTT
CCACTTTGGAAATGATTGTTATGAAGTTTAAGGGTTGGATACTAGTCAGTTAAAAGTTTTAAGATTATAGGGTAATTTTTAAAAATATAA
ATTAGAATCATTGGCAAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGGTCACCTGAAGTCAGGAAT
TTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTAGGCGTGATGGTAGGCACCTGTAATCCC
AGCTACTCGGGAGGCTGAGGGAGGAGAATTGCTTGACCCCAGGAGGTGGAGGTTGCAGTGAGCCTAGATCACACCACTGCACTTCAGCCT
GAGCGACATTGACTGTCTCAAAAAAAAAATTAGGATTATTCAATGTTGTCATCATTTCCACTCCTAAATTCTGAAATGCTTTCTTTGGTA
GAGGTGAGAGTGTGGAGCCACAGCTAGTAGAGAAGGAACAGTAGGACCTGCAGCCTCCCTGGTTTTCCAGGACAAGTCATTGCTGTGTGT
GGCAGGAATGCCTTACCTCAAATAACAAAACAGTGTGAAAAACGAATTTGTGTTACATTTAAAGTTTGTAAAGCAATGAGAAATGTGTGT
ATCATAAAGAGCATCTTTAAATTTTTGCTAAAATATTAGCCTCTTAAATTCTCTAGGAACCCCCTCCCCCGCTTTTTTTTTTCCTTTCGC
TGGTCGTTATTTTTCTAAACCTATCCTGAAATCATGTCAATTTTCTTTTGTATGGTTGAAGACAACTAGATCACTTGATAATGGTTTTGC
TCAGGTCACATTGTGACAAGGTTTTAATGTAGTCCTACTTTGCAGAAGGAGGCCAAGAAGATGGGCTGTCTAGAACCCCCTTTAAAAGCA
TTTGTCTATTCAGAAAATTTTCCTGAGTAGATCTCTGCAAAGGCTCTTTTAATAGTGATTTCAAGATCACGTTTGCAGGACTCTGGTCTA
TTCGTTCAGACGTCTACTGTGCACAATTACAAGGAGACTACAACTGAGGCATCTCAAAGAGCACTGTCAAGGTGTGTAGGGAGCCGGGTG
GGTGGAGGGAGGCTGGGCTCTGACCCTAGAAACCATGCTTATGAATGCTGTTAATGTTTAAAGCAAGCCTAAGGGCACTGCTGAAGGACA
GGGGAACAAATAGAACTGACCAAGACTGAGGTATAACAGGAACCCCCAGGCTATCCACCTGCTCAAGGTAAAGTGTGGTATTACATAAGG
CAACCTCTGATTTTGTAAGAGTTCTTCCTAAAGCCAAAGTGTATGCCTATTCTATGTTTCCAGATTACTTCATTCTTCTAAATGAGAACA
AGTGTGCAAAAGTTCTTTGAACACTAGATCAATGTTTTGTGTTCATTATAAATTATGGTTATCGTCCTGCTTGTTATGAAGACTAAGAAA
GTAGATCTAGTATTTGGCTCACACAGGTGAATGGGTGAGAATTTGTTAATCCATCAGTGAAGTCCTTTCATTTGAAAGAGAGGGCCTTTC
TATTATCAAAAGCCGTCCTGTGTGGAAAATCACCATGAGAGTGCCTGAAACACAGGCACTCTGCATTGTCCTGTAGACCAAATCTACATT
GTCCTGTAGTCTGGTCTACATTGTCCTGTAGACCGAATGGTAGAGTGATTCAGAGCTAATTCTGGGTTAGACTGCACAGGTCTGAATCTA
TTTGCTCACTGTGTAGTGCTTTAGGAATACAATTTAACCTCTCCGTGCTTCAGTTTGTTTGTCCCTAAGATAGAGCTAATGATAGAAACC
TACTTCACCCAGTTGTGAAAATTAACTGACTGCATGTCAAGCACTAACAGTTTCTGGCATATAGTATGCATAATGTAAATTATGTGCTGA
GAAGCGAGAAAGAATAACTTGGGAAAACGCTGAATATCATCAATGTCGAATAGCTAACCAGTAGCTAAGGTCCAAGGTCTCCTCTCTTCC
TTCTATGTGGCACTCTTGTTTCTGGTTCATCTACTCCCCTTGGGTGTCACCTCCTTGAGTGAAGTACCTGCTGGAGATGAGAAGAGTGGA
ACTGGATCTGCATGACAGCTTTGATTAGGATGGAGCTAAGACTTGGCTATCTCCCTGTTTTGTGTTTTGGATGGGTGACATTTTAAAACT
GCCAATATTCAAATCCTGCTAATTTGCTTTGTACAGTTTAAAATGTTTGATATCTTTTGTTGTTTAAAGTTTGAGATTGGTTTTGAATAT
ACAGTTTTCCTACATCTTGAAGAAAGTTATGTTTGTTTACTCTGAAGTGGTCTATGTTCTGTTTGTTTGTTTTACTATACTTTGCAAAAA
AACAGATGGCTGGCTTATGTTCACTGTTGTAGTGCACTACCTAGTATCACTTGGCCTTCCTGTTGTCAAGATGTAGGAAGCAGCGTAAGG
GATGTCGGGCCTTCAGACCCCCAATTGCCAGCTGTGGTCCTAGTTCCAGATTGCATGGAAATATTTGATAACATTCCTGCACTGAGTTAT
CATGGTCTGAATATTTATGTGACGCTCTACGAGTGGTACCAAAATGTTAGTGATGGAGTTTTTACTAATGGCACCTTTTCCTGTTTTTAA
ATTCTAGAATCTTAATAAATCCAAAGTGTACATTTTGGTAGTGATTTCATTTAGTTATTTACTTTAAGGACTCCCTTTTCAAGCATTAAC
TCTGCACTAATTTTGACTTATGAAAAGATTCAGCAGTAAGAATAAAAACTGGGCCAAAGCCCAAAGTAATAATCCTTCACAAATAGGATG
GAGTTTTAAAAATATGGGCATCCTGTGTGTAGCTTTGAAAATAACCAAACTACTTGGAATTAAAAAGTTAGGTGAACATGAAGATTGTCA
TAACCAAATCCTTGACAGCTTGATGGATGAAGAGCAGATGGGTTTATGGTGTATGGGAGGAAGCATGGATTTTAGGAGGGACAGTATCAG
AGAGGGATGGTTAGAAAGTGAGTAAGACAGGTTGCTCTTTGGAAAACAAGGAAAATCCCTTTATTAGAACAAGGCATGAAATTCTGCCAC
TAGGTGGCGATGCCCTATAACTTTACAACTTAGTGTACATCACACGAGCACTATGGAAGATTTCTCCATTCTGCGCCCCACCAACTCCCT
CCCCTCCTTCATTTTTCAGGATGACAACACCTTAGAGGTTTATGGCCATCAGGAGAATTTACTACTAAGCTATATACTGATGTAATGAAA
TCTAATATATGTTGTGCAATGAATTATGAGATGTTATTTAGTTTCAGGATTTTATTACTTCAATCAGTTATGACCATATTTCCTTTTATA
TGATTGCTCACTCTTTAAACATACCAGATGACTGTATAAGGAACACCTAATAAAGTCTATAGATGTTAAAATATTTTAAATGTTTTAATT
TATATGCCATAATTTGTTTACATTCTGGTTATACTGGCGTTCATATTAAAAGCCATAACATGTTAGAATCTGAGATCTCAGGTCGGATAG
TGCCTCTAAGTTATATTTTGCTAAGAAATTTTATTGTATTAGCAATTGAGCAAGAAAGAAGAACTGAATCATTATACGGTGGTTAATTTT
TAGCATAGATGTCAGAAAGCCTGTTAATATTCCAGAGGCTTATGATAAACTATTTAAATTGTCATTCTGGATTCTGATTATATCTCCTAC
AAAGAAAGAGTGTATTATTTATTGAACTTTTTGTTTGAATACATGTGCCTATTTTTGCATAAATGTAAAAATGTAATTTTAAAATAAACC
CCTGAAAACTTCTGGTAACATTATCCAGTTGAATAATTGTTCTGTTAGTATTCTAAATATTTTAAGAAAATTGTATACATATCTGTGACA
ATTGTATTCACAAGCCAAACCAAAAAAAGATAATTATTTGTTTTACAAAGGAGTCAGCTTACAATTTTTCTCTTATGCATGCATTTAAAA
TGTGGTTTGCCATTAAACTGGAAACACTGATCTGAGGCCAATGATTTAGGCAAGTCATTAGTCTAAAGATTGGCTTCCTCAGCTAGAAAA
TGAAGGGCTTTGACTAAAAAGTCTTTTTCATTTCAGTACCAAAACATTCTGGGTCTGTGATTTAACTTACGCTCTTTATTGTTGGGATGA
ACTAATACTGATGGAATACTAGCTTTGTACTAGGCACTGTTCGTATGTTGTCTCTTTTAATCCTCCCTGCAACCTTCTGGCATGGCTATT
ATAATGCCCATTGTATGGAAGAAGAAATTAGGCTTCGAAAGTCCATTTTATGCTTGTTCATTACATAATTTTCTGGATTTTTTAAATTGA
TGTATGTGTTTATGTTCCAGGCTAGGCAGAAGCTAGGAAGAATATAGCAGCCTCGTCACTGTTGAAATCTGGGGCTAGATAATTCTTTGT
TGTGGGGGCCTCCTCTGTGTGTTACAGGATATTTAGCAGCATCCTGGCTTCTACACGATAGGTACCAGTAGCGCCTCCTGCCTCCAACTG

>8337_8337_2_ATRN-UQCRB_ATRN_chr20_3541552_ENST00000446916_UQCRB_chr8_97245455_ENST00000287022_length(amino acids)=587AA_BP=482
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV
SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE
CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE
CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM
FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH
IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATRN-UQCRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRN-UQCRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRN-UQCRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource