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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC5A1-DEPDC5 (FusionGDB2 ID:83412)

Fusion Gene Summary for SLC5A1-DEPDC5

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC5A1-DEPDC5
Fusion gene ID: 83412
HgeneTgene
Gene symbol

SLC5A1

DEPDC5

Gene ID

6523

9681

Gene namesolute carrier family 5 member 1DEP domain containing 5, GATOR1 subcomplex subunit
SynonymsD22S675|NAGT|SGLT1DEP.5|FFEVF|FFEVF1
Cytomap

22q12.3

22q12.2-q12.3

Type of geneprotein-codingprotein-coding
Descriptionsodium/glucose cotransporter 1Na+/glucose cotransporter 1high affinity sodium-glucose cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 1GATOR complex protein DEPDC5DEP domain containing 5DEP domain-containing protein 5
Modification date2020031320200315
UniProtAcc.

O75140

Ensembl transtripts involved in fusion geneENST00000266088, ENST00000543737, 
ENST00000494060, ENST00000539165, 
ENST00000400242, ENST00000536766, 
ENST00000266091, ENST00000382105, 
ENST00000382111, ENST00000382112, 
ENST00000400246, ENST00000400248, 
ENST00000400249, ENST00000535622, 
Fusion gene scores* DoF score6 X 8 X 3=14415 X 17 X 7=1785
# samples 917
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1785*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC5A1 [Title/Abstract] AND DEPDC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC5A1(32487749)-DEPDC5(32266576), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC5A1-DEPDC5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC5A1-DEPDC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC5A1-DEPDC5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC5A1-DEPDC5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC5A1

GO:1904659

glucose transmembrane transport

8836035


check buttonFusion gene breakpoints across SLC5A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DEPDC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1470-01ASLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
ChimerDB4OVTCGA-24-1470SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+


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Fusion Gene ORF analysis for SLC5A1-DEPDC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000266088ENST00000494060SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-3UTRENST00000266088ENST00000494060SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-3UTRENST00000543737ENST00000494060SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-3UTRENST00000543737ENST00000494060SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-5UTRENST00000266088ENST00000539165SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-5UTRENST00000266088ENST00000539165SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-5UTRENST00000543737ENST00000539165SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-5UTRENST00000543737ENST00000539165SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-intronENST00000266088ENST00000400242SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-intronENST00000266088ENST00000400242SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-intronENST00000266088ENST00000536766SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-intronENST00000266088ENST00000536766SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-intronENST00000543737ENST00000400242SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-intronENST00000543737ENST00000400242SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
5CDS-intronENST00000543737ENST00000536766SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
5CDS-intronENST00000543737ENST00000536766SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000266091SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000266091SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000382105SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000382105SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000382111SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000382111SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000382112SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000382112SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000400246SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000400246SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000400248SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000400248SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000400249SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000400249SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000266088ENST00000535622SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000266088ENST00000535622SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000266091SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000266091SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000382105SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000382105SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000382111SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000382111SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000382112SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000382112SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000400246SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000400246SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000400248SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000400248SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000400249SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000400249SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+
Frame-shiftENST00000543737ENST00000535622SLC5A1chr22

32487749

+DEPDC5chr22

32266576

+
Frame-shiftENST00000543737ENST00000535622SLC5A1chr22

32487749

+DEPDC5chr22

32266575

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC5A1-DEPDC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC5A1chr2232487749+DEPDC5chr2232266575+1.56E-121
SLC5A1chr2232487749+DEPDC5chr2232266575+1.56E-121
SLC5A1chr2232487749+DEPDC5chr2232266575+1.56E-121
SLC5A1chr2232487749+DEPDC5chr2232266575+1.56E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC5A1-DEPDC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32487749/:32266576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DEPDC5

O75140

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29769719}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC5A1-DEPDC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC5A1-DEPDC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC5A1-DEPDC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC5A1-DEPDC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource