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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRX-ABCB7 (FusionGDB2 ID:8343)

Fusion Gene Summary for ATRX-ABCB7

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX-ABCB7
Fusion gene ID: 8343
HgeneTgene
Gene symbol

ATRX

ABCB7

Gene ID

546

22

Gene nameATRX chromatin remodelerATP binding cassette subfamily B member 7
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HXABC7|ASAT|Atm1p|EST140535
Cytomap

Xq21.1

Xq13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)ATP-binding cassette sub-family B member 7, mitochondrialABC transporter 7 proteinATP-binding cassette transporter 7ATP-binding cassette, sub-family B (MDR/TAP), member 7
Modification date2020031320200320
UniProtAcc

P46100

O75027

Ensembl transtripts involved in fusion geneENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
ENST00000534570, ENST00000253577, 
ENST00000339447, ENST00000373394, 
Fusion gene scores* DoF score17 X 13 X 9=19894 X 5 X 4=80
# samples 234
** MAII scorelog2(23/1989*10)=-3.11233750988937
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATRX [Title/Abstract] AND ABCB7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRX(77041332)-ABCB7(74318897), # samples:1
ATRX(77041468)-ABCB7(74334669), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253


check buttonFusion gene breakpoints across ATRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YV-01AATRXchrX

77041332

-ABCB7chrX

74318897

-
ChimerDB4SARCTCGA-HB-A3YV-01AATRXchrX

77041468

-ABCB7chrX

74334669

-


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Fusion Gene ORF analysis for ATRX-ABCB7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373344ENST00000534570ATRXchrX

77041468

-ABCB7chrX

74334669

-
5CDS-intronENST00000395603ENST00000534570ATRXchrX

77041468

-ABCB7chrX

74334669

-
5UTR-3CDSENST00000480283ENST00000253577ATRXchrX

77041468

-ABCB7chrX

74334669

-
5UTR-3CDSENST00000480283ENST00000339447ATRXchrX

77041468

-ABCB7chrX

74334669

-
5UTR-3CDSENST00000480283ENST00000373394ATRXchrX

77041468

-ABCB7chrX

74334669

-
5UTR-intronENST00000480283ENST00000534570ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000373344ENST00000253577ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000373344ENST00000339447ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000373344ENST00000373394ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000395603ENST00000253577ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000395603ENST00000339447ATRXchrX

77041468

-ABCB7chrX

74334669

-
In-frameENST00000395603ENST00000373394ATRXchrX

77041468

-ABCB7chrX

74334669

-
intron-3CDSENST00000373341ENST00000253577ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-3CDSENST00000373341ENST00000253577ATRXchrX

77041468

-ABCB7chrX

74334669

-
intron-3CDSENST00000373341ENST00000339447ATRXchrX

77041468

-ABCB7chrX

74334669

-
intron-3CDSENST00000373341ENST00000373394ATRXchrX

77041468

-ABCB7chrX

74334669

-
intron-3CDSENST00000373344ENST00000253577ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-3CDSENST00000395603ENST00000253577ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-3CDSENST00000480283ENST00000253577ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373341ENST00000339447ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373341ENST00000373394ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373341ENST00000534570ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373341ENST00000534570ATRXchrX

77041468

-ABCB7chrX

74334669

-
intron-intronENST00000373344ENST00000339447ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373344ENST00000373394ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000373344ENST00000534570ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000395603ENST00000339447ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000395603ENST00000373394ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000395603ENST00000534570ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000480283ENST00000339447ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000480283ENST00000373394ATRXchrX

77041332

-ABCB7chrX

74318897

-
intron-intronENST00000480283ENST00000534570ATRXchrX

77041332

-ABCB7chrX

74318897

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373344ATRXchrX77041468-ENST00000253577ABCB7chrX74334669-24192352742328684
ENST00000373344ATRXchrX77041468-ENST00000339447ABCB7chrX74334669-22942352712205644
ENST00000373344ATRXchrX77041468-ENST00000373394ABCB7chrX74334669-24122352712325684
ENST00000395603ATRXchrX77041468-ENST00000253577ABCB7chrX74334669-24192352742328684
ENST00000395603ATRXchrX77041468-ENST00000339447ABCB7chrX74334669-22942352712205644
ENST00000395603ATRXchrX77041468-ENST00000373394ABCB7chrX74334669-24122352712325684

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373344ENST00000253577ATRXchrX77041468-ABCB7chrX74334669-0.0019241310.99807584
ENST00000373344ENST00000339447ATRXchrX77041468-ABCB7chrX74334669-0.0015171860.9984829
ENST00000373344ENST00000373394ATRXchrX77041468-ABCB7chrX74334669-0.0018799350.99812
ENST00000395603ENST00000253577ATRXchrX77041468-ABCB7chrX74334669-0.0019241310.99807584
ENST00000395603ENST00000339447ATRXchrX77041468-ABCB7chrX74334669-0.0015171860.9984829
ENST00000395603ENST00000373394ATRXchrX77041468-ABCB7chrX74334669-0.0018799350.99812

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Fusion Genomic Features for ATRX-ABCB7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATRX-ABCB7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:77041332/chrX:74318897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRX

P46100

ABCB7

O75027

FUNCTION: Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.FUNCTION: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. {ECO:0000269|PubMed:10196363}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016140_43656754.0DomainABC transmembrane type-1
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016472_70656754.0DomainABC transporter
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016140_43656753.0DomainABC transmembrane type-1
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016472_70656753.0DomainABC transporter
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016505_51656754.0Nucleotide bindingATP
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016505_51656753.0Nucleotide bindingATP
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016141_16156754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016186_20656754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016260_28056754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016291_31156754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016383_40356754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000253577016410_43056754.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016141_16156753.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016186_20656753.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016260_28056753.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016291_31156753.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016383_40356753.0TransmembraneHelical
TgeneABCB7chrX:77041468chrX:74334669ENST00000373394016410_43056753.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351151_115662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351166_116962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351202_120662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351259_126662493.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351443_146662493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351499_150262493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351929_193962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351941_194862493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1352222_222562493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1352262_226562493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1352420_242562493.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-135745_75062493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341151_115662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341166_116962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341202_120662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341259_126662455.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341443_146662455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341499_150262455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341929_193962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341941_194862455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1342222_222562455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1342262_226562455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1342420_242562455.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-134745_75062455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351581_176862493.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-135159_29662493.0DomainADD
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1352025_220562493.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341581_176862455.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-134159_29662455.0DomainADD
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1342025_220562455.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351719_172262493.0MotifNote=DEGH box
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-135581_59462493.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341719_172262455.0MotifNote=DEGH box
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-134581_59462455.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351594_160162493.0Nucleotide bindingATP
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341594_160162455.0Nucleotide bindingATP
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-135170_20662493.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-135217_27262493.0Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-134170_20662455.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-134217_27262455.0Zinc fingerPHD-type%3B atypical


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Fusion Gene Sequence for ATRX-ABCB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8343_8343_1_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000253577_length(transcript)=2419nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGCAGATTCCAGAGTCATTAAAAAGTATCACATGGCA
GAGATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCA
TGGTCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAAATCATAAAAGCAATGCTTTCTTA
TGTGTGGCCCAAAGACAGGCCAGATCTACGAGCTAGAGTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGT
TCCCTTCATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAAC
CATGGCAACAGCAGTTCTGATTGGCTATGGTGTATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGT
AGCCCAGAATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGG
AGCTTTATCTAAGGCTATTGACAGAGGAACAAGGGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGA
AGTGATGCTTGTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATT
CACAGTTGCAGTCACACGGTGGAGAACTAGATTTAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACT
GCTGAATTATGAAACTGTGAAGTATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTC
ATTGAAAAGTACCTCTACTCTGGCTATGCTGAACTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAG
TCAGGGAATTGTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCT
GGGAACTGTATATAGAGAGACTAGACAAGCACTCATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAA
AGTGATGGCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGT
CCTTAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCT
ATTATTTCGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGC
AGTGGGAGTGGTACCTCAGGATGCTGTCCTCTTCCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGA
AGTGTATGCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACT
CAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTC
ATCGTTAGATTCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATT
GTCAACAGTGGTTGATGCAGATGAAATCATTGTCTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCC
TCATAGTATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATAT
ATCCAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGA

>8343_8343_1_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000253577_length(amino acids)=684AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVP
FMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGA
LSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL
NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLG
TVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLL
FRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLK
LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPH

--------------------------------------------------------------
>8343_8343_2_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000339447_length(transcript)=2294nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGATTCCAGAGTCATTAAAAAGTATCACATGGCAGAG
ATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGG
TCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGGCCATGAATATTGTGGTTCCCTTCATGTTTAAATATGCTGTAGACAGCCT
CAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAACCATGGCAACAGCAGTTCTGATTGGCTATGGTGT
ATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGCCCAGAATTCAATCCGAAGAATAGCCAAAAA
TGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGGAGCTTTATCTAAGGCTATTGACAGAGGAACAAG
GGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGTGATGCTTGTCAGTGGTGTTTTGTATTACAA
ATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATTCACAGTTGCAGTCACACGGTGGAGAACTAGATT
TAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCTGAATTATGAAACTGTGAAGTATTTTAATAA
TGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTCATTGAAAAGTACCTCTACTCTGGCTATGCTGAA
CTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCAGGGAATTGTGGCAGGTACCCTTACTGTTGG
AGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCTGGGAACTGTATATAGAGAGACTAGACAAGCACT
CATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGTGATGGCATCTCCCCTTCAGATCACACCACA
GACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGTCCTTAGTGGAATATCCTTTGAAGTCCCTGCAGG
AAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATTATTTCGCTTCTATGAGCCTCAAAAGGGTAG
CATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGCAGTGGGAGTGGTACCTCAGGATGCTGTCCTCTT
CCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGTGTATGCAGTGGCAAAATTAGCTGGACTTCA
TGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACTCAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGC
AATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATCGTTAGATTCGATTACTGAAGAGACTATTCT
TGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATTGTCAACAGTGGTTGATGCAGATGAAATCATTGT
CTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCATAGTATCTATTCAGAAATGTGGCATACACA
GAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATATATCCAAAGAGGAGGAAAGAAAGAAACTACAAGA
AGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGACATTTTCTTTTTTTGTTGTTTTGGACTACATAT

>8343_8343_2_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000339447_length(amino acids)=644AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGV
SRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYK
CGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLN
FGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQ
TATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLF
HNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL
GAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQE

--------------------------------------------------------------
>8343_8343_3_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000373394_length(transcript)=2412nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGATTCCAGAGTCATTAAAAAGTATCACATGGCAGAG
ATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGG
TCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAAATCATAAAAGCAATGCTTTCTTATGT
GTGGCCCAAAGACAGGCCAGATCTACGAGCTAGAGTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGTTCC
CTTCATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAACCAT
GGCAACAGCAGTTCTGATTGGCTATGGTGTATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGC
CCAGAATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGGAGC
TTTATCTAAGGCTATTGACAGAGGAACAAGGGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGT
GATGCTTGTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATTCAC
AGTTGCAGTCACACGGTGGAGAACTAGATTTAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCT
GAATTATGAAACTGTGAAGTATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTCATT
GAAAAGTACCTCTACTCTGGCTATGCTGAACTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCA
GGGAATTGTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCTGGG
AACTGTATATAGAGAGACTAGACAAGCACTCATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGT
GATGGCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGTCCT
TAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATT
ATTTCGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGCAGT
GGGAGTGGTACCTCAGGATGCTGTCCTCTTCCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGT
GTATGCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACTCAA
GCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATC
GTTAGATTCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATTGTC
AACAGTGGTTGATGCAGATGAAATCATTGTCTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCA
TAGTATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATATATC
CAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGACAT

>8343_8343_3_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000373344_ABCB7_chrX_74334669_ENST00000373394_length(amino acids)=684AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVP
FMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGA
LSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL
NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLG
TVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLL
FRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLK
LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPH

--------------------------------------------------------------
>8343_8343_4_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000253577_length(transcript)=2419nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGCAGATTCCAGAGTCATTAAAAAGTATCACATGGCA
GAGATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCA
TGGTCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAAATCATAAAAGCAATGCTTTCTTA
TGTGTGGCCCAAAGACAGGCCAGATCTACGAGCTAGAGTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGT
TCCCTTCATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAAC
CATGGCAACAGCAGTTCTGATTGGCTATGGTGTATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGT
AGCCCAGAATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGG
AGCTTTATCTAAGGCTATTGACAGAGGAACAAGGGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGA
AGTGATGCTTGTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATT
CACAGTTGCAGTCACACGGTGGAGAACTAGATTTAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACT
GCTGAATTATGAAACTGTGAAGTATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTC
ATTGAAAAGTACCTCTACTCTGGCTATGCTGAACTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAG
TCAGGGAATTGTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCT
GGGAACTGTATATAGAGAGACTAGACAAGCACTCATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAA
AGTGATGGCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGT
CCTTAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCT
ATTATTTCGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGC
AGTGGGAGTGGTACCTCAGGATGCTGTCCTCTTCCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGA
AGTGTATGCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACT
CAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTC
ATCGTTAGATTCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATT
GTCAACAGTGGTTGATGCAGATGAAATCATTGTCTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCC
TCATAGTATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATAT
ATCCAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGA

>8343_8343_4_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000253577_length(amino acids)=684AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVP
FMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGA
LSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL
NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLG
TVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLL
FRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLK
LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPH

--------------------------------------------------------------
>8343_8343_5_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000339447_length(transcript)=2294nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGATTCCAGAGTCATTAAAAAGTATCACATGGCAGAG
ATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGG
TCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGGCCATGAATATTGTGGTTCCCTTCATGTTTAAATATGCTGTAGACAGCCT
CAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAACCATGGCAACAGCAGTTCTGATTGGCTATGGTGT
ATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGCCCAGAATTCAATCCGAAGAATAGCCAAAAA
TGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGGAGCTTTATCTAAGGCTATTGACAGAGGAACAAG
GGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGTGATGCTTGTCAGTGGTGTTTTGTATTACAA
ATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATTCACAGTTGCAGTCACACGGTGGAGAACTAGATT
TAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCTGAATTATGAAACTGTGAAGTATTTTAATAA
TGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTCATTGAAAAGTACCTCTACTCTGGCTATGCTGAA
CTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCAGGGAATTGTGGCAGGTACCCTTACTGTTGG
AGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCTGGGAACTGTATATAGAGAGACTAGACAAGCACT
CATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGTGATGGCATCTCCCCTTCAGATCACACCACA
GACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGTCCTTAGTGGAATATCCTTTGAAGTCCCTGCAGG
AAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATTATTTCGCTTCTATGAGCCTCAAAAGGGTAG
CATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGCAGTGGGAGTGGTACCTCAGGATGCTGTCCTCTT
CCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGTGTATGCAGTGGCAAAATTAGCTGGACTTCA
TGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACTCAAGCTTTCAGGAGGAGAAAAGCAAAGAGTAGC
AATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATCGTTAGATTCGATTACTGAAGAGACTATTCT
TGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATTGTCAACAGTGGTTGATGCAGATGAAATCATTGT
CTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCATAGTATCTATTCAGAAATGTGGCATACACA
GAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATATATCCAAAGAGGAGGAAAGAAAGAAACTACAAGA
AGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGACATTTTCTTTTTTTGTTGTTTTGGACTACATAT

>8343_8343_5_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000339447_length(amino acids)=644AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGV
SRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYK
CGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLN
FGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQ
TATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLF
HNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL
GAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQE

--------------------------------------------------------------
>8343_8343_6_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000373394_length(transcript)=2412nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGATTCCAGAGTCATTAAAAAGTATCACATGGCAGAG
ATTGGGAAAAGGCAATTCAGGACAGTTCTTAGATGCTGCAAAGGCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGG
TCATGCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGGTTAAAAGATGTTGATACTCGGAAAATCATAAAAGCAATGCTTTCTTATGT
GTGGCCCAAAGACAGGCCAGATCTACGAGCTAGAGTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAGGCCATGAATATTGTGGTTCC
CTTCATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGTGATGCACCAAATACAGTTGCAACCAT
GGCAACAGCAGTTCTGATTGGCTATGGTGTATCAAGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGC
CCAGAATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGTTTTCACCTGAGCAGACAGACGGGAGC
TTTATCTAAGGCTATTGACAGAGGAACAAGGGGTATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGT
GATGCTTGTCAGTGGTGTTTTGTATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGAACACTTGGTACATACACAGCATTCAC
AGTTGCAGTCACACGGTGGAGAACTAGATTTAGAATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCT
GAATTATGAAACTGTGAAGTATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTTTTGAAGACGTATGAGACTGCTTCATT
GAAAAGTACCTCTACTCTGGCTATGCTGAACTTTGGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCA
GGGAATTGTGGCAGGTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAGCTTTCATTACCCCTGAACTTTCTGGG
AACTGTATATAGAGAGACTAGACAAGCACTCATAGATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAAGACAAAGT
GATGGCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTTGAATACATTGAGGGCCAGAAAGTCCT
TAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAGAAAGTGGCCATTGTAGGAGGTAGTGGGTCAGGGAAAAGCACAATAGTGAGGCTATT
ATTTCGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTGAGCCTGGAAAGCCTTCGGAGGGCAGT
GGGAGTGGTACCTCAGGATGCTGTCCTCTTCCATAATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGT
GTATGCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGACACCCAAGTAGGGGAACGAGGACTCAA
GCTTTCAGGAGGAGAAAAGCAAAGAGTAGCAATTGCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATC
GTTAGATTCGATTACTGAAGAGACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACTTCTATTTTCATTGCACACAGATTGTC
AACAGTGGTTGATGCAGATGAAATCATTGTCTTGGATCAGGGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCA
TAGTATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAATGGGAAGCAAAGAAAGAAAATATATC
CAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAAATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAAGTCACATAAGACAT

>8343_8343_6_ATRX-ABCB7_ATRX_chrX_77041468_ENST00000395603_ABCB7_chrX_74334669_ENST00000373394_length(amino acids)=684AA_BP=
MGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVP
FMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGA
LSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL
NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLG
TVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLL
FRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLK
LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPH

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Fusion Gene PPI Analysis for ATRX-ABCB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1351189_13266.6666666666666672493.0DAXX
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1341189_13266.6666666666666672455.0DAXX
HgeneATRXchrX:77041468chrX:74334669ENST00000373344-1352010_22806.6666666666666672493.0MECP2
HgeneATRXchrX:77041468chrX:74334669ENST00000395603-1342010_22806.6666666666666672455.0MECP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRX-ABCB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRX-ABCB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource