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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC7A5-NOS1AP (FusionGDB2 ID:83496)

Fusion Gene Summary for SLC7A5-NOS1AP

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC7A5-NOS1AP
Fusion gene ID: 83496
HgeneTgene
Gene symbol

SLC7A5

NOS1AP

Gene ID

8140

9722

Gene namesolute carrier family 7 member 5nitric oxide synthase 1 adaptor protein
Synonyms4F2LC|CD98|D16S469E|E16|LAT1|MPE166330408P19Rik|CAPON
Cytomap

16q24.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionlarge neutral amino acids transporter small subunit 14F2 light chainCD98 light chainL-type amino acid transporter 1integral membrane protein E16sodium-independent neutral amino acid transporter LAT1solute carrier family 7 (amino acid transporter ligcarboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car
Modification date2020031320200313
UniProtAcc.

O75052

Ensembl transtripts involved in fusion geneENST00000261622, ENST00000565644, 
ENST00000454693, ENST00000493151, 
ENST00000361897, ENST00000530878, 
Fusion gene scores* DoF score17 X 9 X 10=15309 X 10 X 7=630
# samples 2011
** MAII scorelog2(20/1530*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC7A5 [Title/Abstract] AND NOS1AP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC7A5(87902491)-NOS1AP(162124195), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC7A5

GO:1904556

L-tryptophan transmembrane transport

30867591

TgeneNOS1AP

GO:0098974

postsynaptic actin cytoskeleton organization

26869880


check buttonFusion gene breakpoints across SLC7A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOS1AP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QS-01ASLC7A5chr16

87902491

-NOS1APchr1

162124195

+
ChimerDB4SARCTCGA-FX-A2QSSLC7A5chr16

87902490

-NOS1APchr1

162124194

+


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Fusion Gene ORF analysis for SLC7A5-NOS1AP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261622ENST00000454693SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
5CDS-intronENST00000261622ENST00000454693SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
5CDS-intronENST00000261622ENST00000493151SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
5CDS-intronENST00000261622ENST00000493151SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
In-frameENST00000261622ENST00000361897SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
In-frameENST00000261622ENST00000361897SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
In-frameENST00000261622ENST00000530878SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
In-frameENST00000261622ENST00000530878SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
intron-3CDSENST00000565644ENST00000361897SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
intron-3CDSENST00000565644ENST00000361897SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
intron-3CDSENST00000565644ENST00000530878SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
intron-3CDSENST00000565644ENST00000530878SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
intron-intronENST00000565644ENST00000454693SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
intron-intronENST00000565644ENST00000454693SLC7A5chr16

87902490

-NOS1APchr1

162124194

+
intron-intronENST00000565644ENST00000493151SLC7A5chr16

87902491

-NOS1APchr1

162124195

+
intron-intronENST00000565644ENST00000493151SLC7A5chr16

87902490

-NOS1APchr1

162124194

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261622SLC7A5chr1687902491-ENST00000530878NOS1APchr1162124195+29896046162004462
ENST00000261622SLC7A5chr1687902491-ENST00000361897NOS1APchr1162124195+50286046162019467
ENST00000261622SLC7A5chr1687902490-ENST00000530878NOS1APchr1162124194+29896046162004462
ENST00000261622SLC7A5chr1687902490-ENST00000361897NOS1APchr1162124194+50286046162019467

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261622ENST00000530878SLC7A5chr1687902491-NOS1APchr1162124195+0.0151031420.9848969
ENST00000261622ENST00000361897SLC7A5chr1687902491-NOS1APchr1162124195+0.0028726470.99712735
ENST00000261622ENST00000530878SLC7A5chr1687902490-NOS1APchr1162124194+0.0151031420.9848969
ENST00000261622ENST00000361897SLC7A5chr1687902490-NOS1APchr1162124194+0.0028726470.99712735

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Fusion Genomic Features for SLC7A5-NOS1AP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC7A5chr1687902490-NOS1APchr1162124194+1.43E-060.99999857
SLC7A5chr1687902490-NOS1APchr1162124194+1.43E-060.99999857
SLC7A5chr1687902490-NOS1APchr1162124194+1.43E-060.99999857
SLC7A5chr1687902490-NOS1APchr1162124194+1.43E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for SLC7A5-NOS1AP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:87902491/chr1:162124195)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NOS1AP

O75052

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110105_126179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110148_169179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-1101_49179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-11071_83179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110105_126179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110148_169179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-1101_49179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-11071_83179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110127_147179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-11050_70179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-11084_104179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110127_147179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-11050_70179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-11084_104179508.0TransmembraneHelical
TgeneNOS1APchr16:87902490chr1:162124194ENST00000361897010322_36335507.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902490chr1:162124194ENST0000049315102322_3630212.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902490chr1:162124194ENST00000530878010322_36335502.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902491chr1:162124195ENST00000361897010322_36335507.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902491chr1:162124195ENST0000049315102322_3630212.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902491chr1:162124195ENST00000530878010322_36335502.0Coiled coilOntology_term=ECO:0000255
TgeneNOS1APchr16:87902490chr1:162124194ENST00000361897010301_30835507.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902490chr1:162124194ENST0000049315102301_3080212.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902490chr1:162124194ENST00000530878010301_30835502.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902491chr1:162124195ENST00000361897010301_30835507.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902491chr1:162124195ENST0000049315102301_3080212.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902491chr1:162124195ENST00000530878010301_30835502.0Compositional biasNote=Poly-Gln
TgeneNOS1APchr16:87902490chr1:162124194ENST000004931510226_1960212.0DomainPID
TgeneNOS1APchr16:87902491chr1:162124195ENST000004931510226_1960212.0DomainPID
TgeneNOS1APchr16:87902490chr1:162124194ENST00000361897010504_50635507.0MotifPDZ-binding
TgeneNOS1APchr16:87902490chr1:162124194ENST0000049315102504_5060212.0MotifPDZ-binding
TgeneNOS1APchr16:87902490chr1:162124194ENST00000530878010504_50635502.0MotifPDZ-binding
TgeneNOS1APchr16:87902491chr1:162124195ENST00000361897010504_50635507.0MotifPDZ-binding
TgeneNOS1APchr16:87902491chr1:162124195ENST0000049315102504_5060212.0MotifPDZ-binding
TgeneNOS1APchr16:87902491chr1:162124195ENST00000530878010504_50635502.0MotifPDZ-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110191_192179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110215_242179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110264_276179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110298_324179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110346_369179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110391_395179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110417_430179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110452_457179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110479_507179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110105_1260242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110148_1690242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110191_1920242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-1101_490242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110215_2420242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110264_2760242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110298_3240242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110346_3690242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110391_3950242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110417_4300242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110452_4570242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110479_5070242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-11071_830242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110191_192179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110215_242179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110264_276179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110298_324179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110346_369179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110391_395179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110417_430179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110452_457179508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110479_507179508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110105_1260242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110148_1690242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110191_1920242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-1101_490242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110215_2420242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110264_2760242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110298_3240242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110346_3690242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110391_3950242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110417_4300242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110452_4570242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110479_5070242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-11071_830242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110170_190179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110193_214179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110243_263179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110277_297179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110325_345179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110370_390179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110396_416179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110431_451179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000261622-110458_478179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110127_1470242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110170_1900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110193_2140242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110243_2630242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110277_2970242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110325_3450242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110370_3900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110396_4160242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110431_4510242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-110458_4780242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-11050_700242.0TransmembraneHelical
HgeneSLC7A5chr16:87902490chr1:162124194ENST00000565644-11084_1040242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110170_190179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110193_214179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110243_263179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110277_297179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110325_345179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110370_390179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110396_416179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110431_451179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000261622-110458_478179508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110127_1470242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110170_1900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110193_2140242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110243_2630242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110277_2970242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110325_3450242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110370_3900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110396_4160242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110431_4510242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-110458_4780242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-11050_700242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr1:162124195ENST00000565644-11084_1040242.0TransmembraneHelical
TgeneNOS1APchr16:87902490chr1:162124194ENST0000036189701026_19635507.0DomainPID
TgeneNOS1APchr16:87902490chr1:162124194ENST0000053087801026_19635502.0DomainPID
TgeneNOS1APchr16:87902491chr1:162124195ENST0000036189701026_19635507.0DomainPID
TgeneNOS1APchr16:87902491chr1:162124195ENST0000053087801026_19635502.0DomainPID


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Fusion Gene Sequence for SLC7A5-NOS1AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83496_83496_1_SLC7A5-NOS1AP_SLC7A5_chr16_87902490_ENST00000261622_NOS1AP_chr1_162124194_ENST00000361897_length(transcript)=5028nt_BP=604nt
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCGCAGAGCATGGCGGGTGCGGGCCCGAAGCGG
CGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA
GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTGGGGACCATTATCGGCTCGGGCATC
TTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG
GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATGCTGGAGGTCTACGGCTCGCTGCCC
GCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG
CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTACGTAGGAAGCCTGGACGTGCCAAG
GCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCAT
TATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGCTTCTTTTATTGCAGAAAAAGGAATGGACGTGGGATGAGAG
CAAGATGCTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCG
AGATGGTGCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGAGCCAAGCTATGAGAATCGTTCGGACGGTGGGGCAGGC
CTTTGAGGTCTGCCACAAGCTGAGCCTGCAGCACACGCAGCAGAATGCAGATGGCCAGGAAGATGGAGAGAGCGAGAGGAACAGCAACAG
CTCAGGAGACCCAGGCCGCCAGCTCACTGGAGCCGAGAGGGCCTCCACGGCCACTGCAGAGGAGACTGACATCGATGCGGTGGAGGTCCC
ACTTCCAGGGAATGATGTCCTGGAATTCAGCCGAGGTGTGACTGATCTAGATGCTGTAGGGAAGGAAGGAGGCTCTCACACAGGCTCCAA
GGTTTCGCACCCCCAGGAGCCCATGCTGACAGCCTCACCCAGGATGCTGCTCCCTTCTTCTTCCTCGAAGCCTCCAGGCCTGGGCACAGA
GACACCGCTGTCCACTCACCACCAGATGCAGCTCCTCCAGCAGCTCCTCCAGCAGCAGCAGCAGCAGACACAAGTGGCTGTGGCCCAGGT
ACACTTGCTGAAGGACCAGTTGGCTGCTGAGGCTGCGGCGCGGCTGGAGGCCCAGGCTCGCGTGCATCAGCTTTTGCTGCAGAACAAGGA
CATGCTCCAGCACATCTCCCTGCTGGTCAAGCAGGTGCAAGAGCTGGAACTGAAGCTGTCAGGACAGAACGCCATGGGCTCCCAGGACAG
CTTGCTGGAGATCACCTTCCGCTCCGGAGCCCTGCCCGTGCTCTGTGACCCCACGACCCCTAAGCCAGAGGACCTGCATTCGCCGCCGCT
GGGCGCGGGCTTGGCTGACTTTGCCCACCCTGCGGGCAGCCCCTTAGGTAGGCGCGACTGCTTGGTGAAGCTGGAGTGCTTTCGCTTTCT
TCCGCCCGAGGACACCCCGCCCCCAGCGCAGGGCGAGGCGCTCCTGGGCGGTCTGGAGCTCATCAAGTTCCGAGAGTCAGGCATCGCCTC
GGAGTACGAGTCCAACACGGACGAGAGCGAGGAGCGCGACTCGTGGTCCCAGGAGGAGCTGCCGCGCCTGCTGAATGTCCTGCAGAGGCA
GGAACTGGGCGACGGCCTGGATGATGAGATCGCCGTGTAGGTGCCGAGGGCGAGGAGATGGAGGCGGCGGCGTGGCTGGAGGGGCCGTGT
CTGGCTGCTGCCCGGGTAGGGGATGCCCAGTGAATGTGCACTGCCGAGGAGAATGCCAGCCAGGGCCCGGGAGAGTGTGAGGTTTCAGGA
AAGTATTGAGATTCTGCTTTGGAGGGTAAAGTGGGGAAGAAATCGGATTCCCAGAGGTGAATCAGCTCCTCTCCTACTTGTGACTAGAGG
GTGGTGGAGGTAAGGCCTTCCAGAGCCCATGGCTTCAGGAGAGGGTCTCTCTCCAGGACTGCCAGGCTGCTGGAGGACCTGCCCCTACCT
GCTGCATCGTCAGGCTCCCACGCTTTGTCCGTGATGCCCCCCTACCCCCTCACTCTCCCCGTCTCCATGGTCCCGACCAGGAAGGGAAGC
CATCGGTACCTTCTCAGGTACTTTGTTTCTGGATATCACGATGCTGCGAGTTGCCTAACCCTCCCCCTACCTTTATGAGAGGAATTCCTT
CTCCAGGCCCTTGCTGAGATTGTAGAGATTGAGTGCTCTGGACCGCAAAAGCCAGGCTAGTCCTTGTAGGGTGAGCATGGAATTGGAATG
TGTCACAGTGGATAAGCTTTTAGAGGAACTGAATCCAAACATTTTCTCCAGCCGGACATTGAATGTTGCTACAAAGGGAGCCTTGAAGCT
TTAACATGGTTCAGGCCCTTGGTGTGAGAGCCCAGGGGGAGGACAGCTTGTCTGCTGCTCCAAATCACTTAGATCTGATTCCTGTTTTGA
AAGTCCTGCCCTGCCTTCCTCCTGCCTGTAGCCCAGCCCATCTAAATGGAAGCTGGGAATTGCCCCTCACCTCCCCTGTGTCCTGTCCAG
CTGAAGCTTTTGCAGCACTTTACCTCTCTGAAAGCCCCAGAGGACCAGAGCCCCCAGCCTTACCTCTCAACCTGTCCCCTCCACTGGGCA
GTGGTGGTCAGTTTTTACTGCAAAAAAAAAAAAAGAAAAAAGAGAAAGAAAAAAAAGAATGAATGCAAGCTGATAGCTGAGACTGTGAGA
CTGTTTTTGTCCACTCTTCTGAATCACTGCCACTTGGGTCAGGGACCACAGCCATTGCCACCCTTGGCCCATCTCTCTGCGTGCGTGCCT
TGAGCACACATATAAAAAGTGCCATGTGCAATTGTCTTATCTTTTATGATCTAGGCTTTGCCTAGGGATCACTACTCCTTAACGGGCTGG
CTGGGGCAATGAGGAAAAGCTCCTTTGCTCCTGTAAGGCCATAAGTGGCTGTTAACAGATTTTCAAATGCCTGAAGAGATTGCTGAGACC
TGCTAGAGTCATATGTTCGGGGAATTAAGTCTTTATCCTAGACAACAAGGTACAGATGCAAACTGCAGTGTTATTGGAGGGTCAATCGGC
AAGGATATGATTATCCCAAAATGGAGTTCATCGACCCTAGCTTTCCTTTAGATTATATATAAATAAAAGTGCAGTCCTCTTCTAATGGCC
ACAGTTGGTTTTCTTGTAGCCCAGAAAGTCCAAATTAAAGGAAATAAATTCAGTTTTATGTTAGCCTTCCTTGGTGCATCAGGGTGTCAG
TGGAAATAGGATCAGGTGGTGTGTGTGTGTGTGTTTTGTGTGTGTGTGTACACATGTGTTTATATATACATGTGTGAGGGAAAGTGTGTA
CATATATGTAGGATTGTAACCAGACGGAAAAGAACGAGGATCTCCAGGGTGTTTGAATCAGCAACAGATTTGTGTTTTCTAACATGCATT
TAGTTGGAGAGGCATGGTTCTGTTTGTTTTGTTTTGATCTAATTTGCCATTGGAAATAGGTACAGTTACACAGAGAAGGAAGAACCAGGA
AAGTGAGATCCATGAAACTAAATGAGCAGCTGTCAGAATCCAGTGTGGCTGAGCCTACCTAGCTTATGAAATCTAACCCAGGGTTCCCTG
AGTCCAAGACCACTTAGATTATTAAGATTTTGAACGTCCAGAGGAGTGAAAAGTCTGTTTTCTGACGTAAGCCGGAGCTGAGGATAAAGC
CAGAGGCCAGTGGATTAGGTGTATGGAATGTGGATGGAGAGGGCTTGTGTGGGATGTGGCCAGGGAGTGGGTGAGGAAGGCCGCTTCTAA
ATGGCCTGTAAAAACTTGAGATTGGATAGACGAAAGGAAATGGAGAAATTAAAGAATTGGAGAAACTAGTTATCTGTGTTGCTGACTTTG
GGACCCATCCAAGACTCCTGCCCTTGGGGTGTTCCATGGTGGTTTCTTCCTGCCTGGGCGCCACCCTTTCCCCAGTTCAGGCCCTCCCTG
GAGGACTAGTTTGTGTATTGGTATCCTCCCCAGTGGACCCAAACCAGCGCATACTTGGTGTGTGGAGATGGGAGACAAAGGACAGATCTA
GGAGCCTTGAAGGATCACCAGCCACCGACCCTCCATCAGGGCCAACTGGGCAGGAAAGGGAACATTGCAGACCTGATTTCCCGACGATGT
CACCCTGTCCTCCCTCCTTGCTTCTTGCTCTGCTAACTCAACTCTGCCTTCCTCTTTTTCATTCTTCTACTCTGCCCTATATGGAGGACA
AATGGACACCAGGGGTGCTAACCTTATTGGTGCCTGCCCCAGCCTACCCCAGGTGCCAGCAGACTCTCGTGCACAGGAGGCTCCCACAGT
TATGGAGCCAGGAAAGAATTTCTCTGCACTGGATGGACTGTATATTGAGATTAAAAATTATATTCCTTATATTCCTGCTTATATCAATGC
TCTCTCTGTAAAACCTCTTCCTAGCCTCATTTCTCTCAACTGATCTTGTTTAGGCGTTGTATTCCTTTTATTTACTCTTTGCTTGACTGC
TTCCTCCTAACCCTCTACCCACTAGCACTCTACTTCCTAAAGCTGTTGTGTCATTAACTCTGTTGGATCAACTCTCTGGGAAAAGATTCT

>83496_83496_1_SLC7A5-NOS1AP_SLC7A5_chr16_87902490_ENST00000261622_NOS1AP_chr1_162124194_ENST00000361897_length(amino acids)=467AA_BP=
MDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIF
SYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDID
AVEVPLPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLLQQQQQQTQV
AVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDL
HSPPLGAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLN

--------------------------------------------------------------
>83496_83496_2_SLC7A5-NOS1AP_SLC7A5_chr16_87902490_ENST00000261622_NOS1AP_chr1_162124194_ENST00000530878_length(transcript)=2989nt_BP=604nt
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCGCAGAGCATGGCGGGTGCGGGCCCGAAGCGG
CGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA
GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTGGGGACCATTATCGGCTCGGGCATC
TTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG
GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATGCTGGAGGTCTACGGCTCGCTGCCC
GCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG
CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTACGTAGGAAGCCTGGACGTGCCAAG
GCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCAT
TATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGAT
GCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAA
TATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGAGCCAAGCTATGAGAATCGTTCGGACGGTGGGGCAGGCCTTTGAGGTCTGCCA
CAAGCTGAGCCTGCAGCACACGCAGCAGAATGCAGATGGCCAGGAAGATGGAGAGAGCGAGAGGAACAGCAACAGCTCAGGAGACCCAGG
CCGCCAGCTCACTGGAGCCGAGAGGGCCTCCACGGCCACTGCAGAGGAGACTGACATCGATGCGGTGGAGGTCCCACTTCCAGGGAATGA
TGTCCTGGAATTCAGCCGAGGTGTGACTGATCTAGATGCTGTAGGGAAGGAAGGAGGCTCTCACACAGGCTCCAAGGTTTCGCACCCCCA
GGAGCCCATGCTGACAGCCTCACCCAGGATGCTGCTCCCTTCTTCTTCCTCGAAGCCTCCAGGCCTGGGCACAGAGACACCGCTGTCCAC
TCACCACCAGATGCAGCTCCTCCAGCAGCTCCTCCAGCAGCAGCAGCAGCAGACACAAGTGGCTGTGGCCCAGGTACACTTGCTGAAGGA
CCAGTTGGCTGCTGAGGCTGCGGCGCGGCTGGAGGCCCAGGCTCGCGTGCATCAGCTTTTGCTGCAGAACAAGGACATGCTCCAGCACAT
CTCCCTGCTGGTCAAGCAGGTGCAAGAGCTGGAACTGAAGCTGTCAGGACAGAACGCCATGGGCTCCCAGGACAGCTTGCTGGAGATCAC
CTTCCGCTCCGGAGCCCTGCCCGTGCTCTGTGACCCCACGACCCCTAAGCCAGAGGACCTGCATTCGCCGCCGCTGGGCGCGGGCTTGGC
TGACTTTGCCCACCCTGCGGGCAGCCCCTTAGGTAGGCGCGACTGCTTGGTGAAGCTGGAGTGCTTTCGCTTTCTTCCGCCCGAGGACAC
CCCGCCCCCAGCGCAGGGCGAGGCGCTCCTGGGCGGTCTGGAGCTCATCAAGTTCCGAGAGTCAGGCATCGCCTCGGAGTACGAGTCCAA
CACGGACGAGAGCGAGGAGCGCGACTCGTGGTCCCAGGAGGAGCTGCCGCGCCTGCTGAATGTCCTGCAGAGGCAGGAACTGGGCGACGG
CCTGGATGATGAGATCGCCGTGTAGGTGCCGAGGGCGAGGAGATGGAGGCGGCGGCGTGGCTGGAGGGGCCGTGTCTGGCTGCTGCCCGG
GTAGGGGATGCCCAGTGAATGTGCACTGCCGAGGAGAATGCCAGCCAGGGCCCGGGAGAGTGTGAGGTTTCAGGAAAGTATTGAGATTCT
GCTTTGGAGGGTAAAGTGGGGAAGAAATCGGATTCCCAGAGGTGAATCAGCTCCTCTCCTACTTGTGACTAGAGGGTGGTGGAGGTAAGG
CCTTCCAGAGCCCATGGCTTCAGGAGAGGGTCTCTCTCCAGGACTGCCAGGCTGCTGGAGGACCTGCCCCTACCTGCTGCATCGTCAGGC
TCCCACGCTTTGTCCGTGATGCCCCCCTACCCCCTCACTCTCCCCGTCTCCATGGTCCCGACCAGGAAGGGAAGCCATCGGTACCTTCTC
AGGTACTTTGTTTCTGGATATCACGATGCTGCGAGTTGCCTAACCCTCCCCCTACCTTTATGAGAGGAATTCCTTCTCCAGGCCCTTGCT
GAGATTGTAGAGATTGAGTGCTCTGGACCGCAAAAGCCAGGCTAGTCCTTGTAGGGTGAGCATGGAATTGGAATGTGTCACAGTGGATAA
GCTTTTAGAGGAACTGAATCCAAACATTTTCTCCAGCCGGACATTGAATGTTGCTACAAAGGGAGCCTTGAAGCTTTAACATGGTTCAGG
CCCTTGGTGTGAGAGCCCAGGGGGAGGACAGCTTGTCTGCTGCTCCAAATCACTTAGATCTGATTCCTGTTTTGAAAGTCCTGCCCTGCC
TTCCTCCTGCCTGTAGCCCAGCCCATCTAAATGGAAGCTGGGAATTGCCCCTCACCTCCCCTGTGTCCTGTCCAGCTGAAGCTTTTGCAG
CACTTTACCTCTCTGAAAGCCCCAGAGGACCAGAGCCCCCAGCCTTACCTCTCAACCTGTCCCCTCCACTGGGCAGTGGTGGTCAGTTTT

>83496_83496_2_SLC7A5-NOS1AP_SLC7A5_chr16_87902490_ENST00000261622_NOS1AP_chr1_162124194_ENST00000530878_length(amino acids)=462AA_BP=
MDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIAR
DGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDIDAVEVP
LPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLLQQQQQQTQVAVAQV
HLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPL
GAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQ

--------------------------------------------------------------
>83496_83496_3_SLC7A5-NOS1AP_SLC7A5_chr16_87902491_ENST00000261622_NOS1AP_chr1_162124195_ENST00000361897_length(transcript)=5028nt_BP=604nt
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCGCAGAGCATGGCGGGTGCGGGCCCGAAGCGG
CGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA
GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTGGGGACCATTATCGGCTCGGGCATC
TTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG
GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATGCTGGAGGTCTACGGCTCGCTGCCC
GCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG
CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTACGTAGGAAGCCTGGACGTGCCAAG
GCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCAT
TATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGCTTCTTTTATTGCAGAAAAAGGAATGGACGTGGGATGAGAG
CAAGATGCTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCG
AGATGGTGCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGAGCCAAGCTATGAGAATCGTTCGGACGGTGGGGCAGGC
CTTTGAGGTCTGCCACAAGCTGAGCCTGCAGCACACGCAGCAGAATGCAGATGGCCAGGAAGATGGAGAGAGCGAGAGGAACAGCAACAG
CTCAGGAGACCCAGGCCGCCAGCTCACTGGAGCCGAGAGGGCCTCCACGGCCACTGCAGAGGAGACTGACATCGATGCGGTGGAGGTCCC
ACTTCCAGGGAATGATGTCCTGGAATTCAGCCGAGGTGTGACTGATCTAGATGCTGTAGGGAAGGAAGGAGGCTCTCACACAGGCTCCAA
GGTTTCGCACCCCCAGGAGCCCATGCTGACAGCCTCACCCAGGATGCTGCTCCCTTCTTCTTCCTCGAAGCCTCCAGGCCTGGGCACAGA
GACACCGCTGTCCACTCACCACCAGATGCAGCTCCTCCAGCAGCTCCTCCAGCAGCAGCAGCAGCAGACACAAGTGGCTGTGGCCCAGGT
ACACTTGCTGAAGGACCAGTTGGCTGCTGAGGCTGCGGCGCGGCTGGAGGCCCAGGCTCGCGTGCATCAGCTTTTGCTGCAGAACAAGGA
CATGCTCCAGCACATCTCCCTGCTGGTCAAGCAGGTGCAAGAGCTGGAACTGAAGCTGTCAGGACAGAACGCCATGGGCTCCCAGGACAG
CTTGCTGGAGATCACCTTCCGCTCCGGAGCCCTGCCCGTGCTCTGTGACCCCACGACCCCTAAGCCAGAGGACCTGCATTCGCCGCCGCT
GGGCGCGGGCTTGGCTGACTTTGCCCACCCTGCGGGCAGCCCCTTAGGTAGGCGCGACTGCTTGGTGAAGCTGGAGTGCTTTCGCTTTCT
TCCGCCCGAGGACACCCCGCCCCCAGCGCAGGGCGAGGCGCTCCTGGGCGGTCTGGAGCTCATCAAGTTCCGAGAGTCAGGCATCGCCTC
GGAGTACGAGTCCAACACGGACGAGAGCGAGGAGCGCGACTCGTGGTCCCAGGAGGAGCTGCCGCGCCTGCTGAATGTCCTGCAGAGGCA
GGAACTGGGCGACGGCCTGGATGATGAGATCGCCGTGTAGGTGCCGAGGGCGAGGAGATGGAGGCGGCGGCGTGGCTGGAGGGGCCGTGT
CTGGCTGCTGCCCGGGTAGGGGATGCCCAGTGAATGTGCACTGCCGAGGAGAATGCCAGCCAGGGCCCGGGAGAGTGTGAGGTTTCAGGA
AAGTATTGAGATTCTGCTTTGGAGGGTAAAGTGGGGAAGAAATCGGATTCCCAGAGGTGAATCAGCTCCTCTCCTACTTGTGACTAGAGG
GTGGTGGAGGTAAGGCCTTCCAGAGCCCATGGCTTCAGGAGAGGGTCTCTCTCCAGGACTGCCAGGCTGCTGGAGGACCTGCCCCTACCT
GCTGCATCGTCAGGCTCCCACGCTTTGTCCGTGATGCCCCCCTACCCCCTCACTCTCCCCGTCTCCATGGTCCCGACCAGGAAGGGAAGC
CATCGGTACCTTCTCAGGTACTTTGTTTCTGGATATCACGATGCTGCGAGTTGCCTAACCCTCCCCCTACCTTTATGAGAGGAATTCCTT
CTCCAGGCCCTTGCTGAGATTGTAGAGATTGAGTGCTCTGGACCGCAAAAGCCAGGCTAGTCCTTGTAGGGTGAGCATGGAATTGGAATG
TGTCACAGTGGATAAGCTTTTAGAGGAACTGAATCCAAACATTTTCTCCAGCCGGACATTGAATGTTGCTACAAAGGGAGCCTTGAAGCT
TTAACATGGTTCAGGCCCTTGGTGTGAGAGCCCAGGGGGAGGACAGCTTGTCTGCTGCTCCAAATCACTTAGATCTGATTCCTGTTTTGA
AAGTCCTGCCCTGCCTTCCTCCTGCCTGTAGCCCAGCCCATCTAAATGGAAGCTGGGAATTGCCCCTCACCTCCCCTGTGTCCTGTCCAG
CTGAAGCTTTTGCAGCACTTTACCTCTCTGAAAGCCCCAGAGGACCAGAGCCCCCAGCCTTACCTCTCAACCTGTCCCCTCCACTGGGCA
GTGGTGGTCAGTTTTTACTGCAAAAAAAAAAAAAGAAAAAAGAGAAAGAAAAAAAAGAATGAATGCAAGCTGATAGCTGAGACTGTGAGA
CTGTTTTTGTCCACTCTTCTGAATCACTGCCACTTGGGTCAGGGACCACAGCCATTGCCACCCTTGGCCCATCTCTCTGCGTGCGTGCCT
TGAGCACACATATAAAAAGTGCCATGTGCAATTGTCTTATCTTTTATGATCTAGGCTTTGCCTAGGGATCACTACTCCTTAACGGGCTGG
CTGGGGCAATGAGGAAAAGCTCCTTTGCTCCTGTAAGGCCATAAGTGGCTGTTAACAGATTTTCAAATGCCTGAAGAGATTGCTGAGACC
TGCTAGAGTCATATGTTCGGGGAATTAAGTCTTTATCCTAGACAACAAGGTACAGATGCAAACTGCAGTGTTATTGGAGGGTCAATCGGC
AAGGATATGATTATCCCAAAATGGAGTTCATCGACCCTAGCTTTCCTTTAGATTATATATAAATAAAAGTGCAGTCCTCTTCTAATGGCC
ACAGTTGGTTTTCTTGTAGCCCAGAAAGTCCAAATTAAAGGAAATAAATTCAGTTTTATGTTAGCCTTCCTTGGTGCATCAGGGTGTCAG
TGGAAATAGGATCAGGTGGTGTGTGTGTGTGTGTTTTGTGTGTGTGTGTACACATGTGTTTATATATACATGTGTGAGGGAAAGTGTGTA
CATATATGTAGGATTGTAACCAGACGGAAAAGAACGAGGATCTCCAGGGTGTTTGAATCAGCAACAGATTTGTGTTTTCTAACATGCATT
TAGTTGGAGAGGCATGGTTCTGTTTGTTTTGTTTTGATCTAATTTGCCATTGGAAATAGGTACAGTTACACAGAGAAGGAAGAACCAGGA
AAGTGAGATCCATGAAACTAAATGAGCAGCTGTCAGAATCCAGTGTGGCTGAGCCTACCTAGCTTATGAAATCTAACCCAGGGTTCCCTG
AGTCCAAGACCACTTAGATTATTAAGATTTTGAACGTCCAGAGGAGTGAAAAGTCTGTTTTCTGACGTAAGCCGGAGCTGAGGATAAAGC
CAGAGGCCAGTGGATTAGGTGTATGGAATGTGGATGGAGAGGGCTTGTGTGGGATGTGGCCAGGGAGTGGGTGAGGAAGGCCGCTTCTAA
ATGGCCTGTAAAAACTTGAGATTGGATAGACGAAAGGAAATGGAGAAATTAAAGAATTGGAGAAACTAGTTATCTGTGTTGCTGACTTTG
GGACCCATCCAAGACTCCTGCCCTTGGGGTGTTCCATGGTGGTTTCTTCCTGCCTGGGCGCCACCCTTTCCCCAGTTCAGGCCCTCCCTG
GAGGACTAGTTTGTGTATTGGTATCCTCCCCAGTGGACCCAAACCAGCGCATACTTGGTGTGTGGAGATGGGAGACAAAGGACAGATCTA
GGAGCCTTGAAGGATCACCAGCCACCGACCCTCCATCAGGGCCAACTGGGCAGGAAAGGGAACATTGCAGACCTGATTTCCCGACGATGT
CACCCTGTCCTCCCTCCTTGCTTCTTGCTCTGCTAACTCAACTCTGCCTTCCTCTTTTTCATTCTTCTACTCTGCCCTATATGGAGGACA
AATGGACACCAGGGGTGCTAACCTTATTGGTGCCTGCCCCAGCCTACCCCAGGTGCCAGCAGACTCTCGTGCACAGGAGGCTCCCACAGT
TATGGAGCCAGGAAAGAATTTCTCTGCACTGGATGGACTGTATATTGAGATTAAAAATTATATTCCTTATATTCCTGCTTATATCAATGC
TCTCTCTGTAAAACCTCTTCCTAGCCTCATTTCTCTCAACTGATCTTGTTTAGGCGTTGTATTCCTTTTATTTACTCTTTGCTTGACTGC
TTCCTCCTAACCCTCTACCCACTAGCACTCTACTTCCTAAAGCTGTTGTGTCATTAACTCTGTTGGATCAACTCTCTGGGAAAAGATTCT

>83496_83496_3_SLC7A5-NOS1AP_SLC7A5_chr16_87902491_ENST00000261622_NOS1AP_chr1_162124195_ENST00000361897_length(amino acids)=467AA_BP=
MDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIF
SYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDID
AVEVPLPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLLQQQQQQTQV
AVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDL
HSPPLGAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLN

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>83496_83496_4_SLC7A5-NOS1AP_SLC7A5_chr16_87902491_ENST00000261622_NOS1AP_chr1_162124195_ENST00000530878_length(transcript)=2989nt_BP=604nt
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCGCAGAGCATGGCGGGTGCGGGCCCGAAGCGG
CGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA
GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTGGGGACCATTATCGGCTCGGGCATC
TTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG
GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATGCTGGAGGTCTACGGCTCGCTGCCC
GCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG
CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTACGTAGGAAGCCTGGACGTGCCAAG
GCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCAT
TATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGAT
GCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAA
TATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGAGCCAAGCTATGAGAATCGTTCGGACGGTGGGGCAGGCCTTTGAGGTCTGCCA
CAAGCTGAGCCTGCAGCACACGCAGCAGAATGCAGATGGCCAGGAAGATGGAGAGAGCGAGAGGAACAGCAACAGCTCAGGAGACCCAGG
CCGCCAGCTCACTGGAGCCGAGAGGGCCTCCACGGCCACTGCAGAGGAGACTGACATCGATGCGGTGGAGGTCCCACTTCCAGGGAATGA
TGTCCTGGAATTCAGCCGAGGTGTGACTGATCTAGATGCTGTAGGGAAGGAAGGAGGCTCTCACACAGGCTCCAAGGTTTCGCACCCCCA
GGAGCCCATGCTGACAGCCTCACCCAGGATGCTGCTCCCTTCTTCTTCCTCGAAGCCTCCAGGCCTGGGCACAGAGACACCGCTGTCCAC
TCACCACCAGATGCAGCTCCTCCAGCAGCTCCTCCAGCAGCAGCAGCAGCAGACACAAGTGGCTGTGGCCCAGGTACACTTGCTGAAGGA
CCAGTTGGCTGCTGAGGCTGCGGCGCGGCTGGAGGCCCAGGCTCGCGTGCATCAGCTTTTGCTGCAGAACAAGGACATGCTCCAGCACAT
CTCCCTGCTGGTCAAGCAGGTGCAAGAGCTGGAACTGAAGCTGTCAGGACAGAACGCCATGGGCTCCCAGGACAGCTTGCTGGAGATCAC
CTTCCGCTCCGGAGCCCTGCCCGTGCTCTGTGACCCCACGACCCCTAAGCCAGAGGACCTGCATTCGCCGCCGCTGGGCGCGGGCTTGGC
TGACTTTGCCCACCCTGCGGGCAGCCCCTTAGGTAGGCGCGACTGCTTGGTGAAGCTGGAGTGCTTTCGCTTTCTTCCGCCCGAGGACAC
CCCGCCCCCAGCGCAGGGCGAGGCGCTCCTGGGCGGTCTGGAGCTCATCAAGTTCCGAGAGTCAGGCATCGCCTCGGAGTACGAGTCCAA
CACGGACGAGAGCGAGGAGCGCGACTCGTGGTCCCAGGAGGAGCTGCCGCGCCTGCTGAATGTCCTGCAGAGGCAGGAACTGGGCGACGG
CCTGGATGATGAGATCGCCGTGTAGGTGCCGAGGGCGAGGAGATGGAGGCGGCGGCGTGGCTGGAGGGGCCGTGTCTGGCTGCTGCCCGG
GTAGGGGATGCCCAGTGAATGTGCACTGCCGAGGAGAATGCCAGCCAGGGCCCGGGAGAGTGTGAGGTTTCAGGAAAGTATTGAGATTCT
GCTTTGGAGGGTAAAGTGGGGAAGAAATCGGATTCCCAGAGGTGAATCAGCTCCTCTCCTACTTGTGACTAGAGGGTGGTGGAGGTAAGG
CCTTCCAGAGCCCATGGCTTCAGGAGAGGGTCTCTCTCCAGGACTGCCAGGCTGCTGGAGGACCTGCCCCTACCTGCTGCATCGTCAGGC
TCCCACGCTTTGTCCGTGATGCCCCCCTACCCCCTCACTCTCCCCGTCTCCATGGTCCCGACCAGGAAGGGAAGCCATCGGTACCTTCTC
AGGTACTTTGTTTCTGGATATCACGATGCTGCGAGTTGCCTAACCCTCCCCCTACCTTTATGAGAGGAATTCCTTCTCCAGGCCCTTGCT
GAGATTGTAGAGATTGAGTGCTCTGGACCGCAAAAGCCAGGCTAGTCCTTGTAGGGTGAGCATGGAATTGGAATGTGTCACAGTGGATAA
GCTTTTAGAGGAACTGAATCCAAACATTTTCTCCAGCCGGACATTGAATGTTGCTACAAAGGGAGCCTTGAAGCTTTAACATGGTTCAGG
CCCTTGGTGTGAGAGCCCAGGGGGAGGACAGCTTGTCTGCTGCTCCAAATCACTTAGATCTGATTCCTGTTTTGAAAGTCCTGCCCTGCC
TTCCTCCTGCCTGTAGCCCAGCCCATCTAAATGGAAGCTGGGAATTGCCCCTCACCTCCCCTGTGTCCTGTCCAGCTGAAGCTTTTGCAG
CACTTTACCTCTCTGAAAGCCCCAGAGGACCAGAGCCCCCAGCCTTACCTCTCAACCTGTCCCCTCCACTGGGCAGTGGTGGTCAGTTTT

>83496_83496_4_SLC7A5-NOS1AP_SLC7A5_chr16_87902491_ENST00000261622_NOS1AP_chr1_162124195_ENST00000530878_length(amino acids)=462AA_BP=
MDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIAR
DGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDIDAVEVP
LPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLLQQQQQQTQVAVAQV
HLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPL
GAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQ

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Fusion Gene PPI Analysis for SLC7A5-NOS1AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNOS1APchr16:87902490chr1:162124194ENST00000361897010494_50635.0507.0NOS1
TgeneNOS1APchr16:87902490chr1:162124194ENST0000049315102494_5060212.0NOS1
TgeneNOS1APchr16:87902490chr1:162124194ENST00000530878010494_50635.0502.0NOS1
TgeneNOS1APchr16:87902491chr1:162124195ENST00000361897010494_50635.0507.0NOS1
TgeneNOS1APchr16:87902491chr1:162124195ENST0000049315102494_5060212.0NOS1
TgeneNOS1APchr16:87902491chr1:162124195ENST00000530878010494_50635.0502.0NOS1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC7A5-NOS1AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC7A5-NOS1AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource