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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC8A1-SNHG14 (FusionGDB2 ID:83530)

Fusion Gene Summary for SLC8A1-SNHG14

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC8A1-SNHG14
Fusion gene ID: 83530
HgeneTgene
Gene symbol

SLC8A1

SNHG14

Gene ID

6546

104472715

Gene namesolute carrier family 8 member A1small nucleolar RNA host gene 14
SynonymsNCX1115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3A-ATS|UBE3AATS
Cytomap

2p22.1

15q11.2

Type of geneprotein-codingncRNA
Descriptionsodium/calcium exchanger 1Na(+)/Ca(2+)-exchange protein 1Na+/Ca++ exchangerNa+/Ca2+ exchangersolute carrier family 8 (sodium/calcium exchanger), member 1solute carrier family 8 member 1UBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)
Modification date2020031320200303
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332839, ENST00000402441, 
ENST00000403092, ENST00000405269, 
ENST00000405901, ENST00000406391, 
ENST00000406785, ENST00000408028, 
ENST00000542024, ENST00000542756, 
ENST00000363358, ENST00000365067, 
ENST00000365306, ENST00000384430, 
ENST00000384733, ENST00000390982, 
ENST00000414175, ENST00000424208, 
ENST00000424333, ENST00000441592, 
ENST00000450809, ENST00000452731, 
ENST00000453082, ENST00000456576, 
ENST00000459433, ENST00000516123, 
ENST00000546682, ENST00000547292, 
ENST00000549804, ENST00000551077, 
ENST00000551361, ENST00000551631, 
ENST00000551938, ENST00000553108, 
ENST00000553134, ENST00000553149, 
ENST00000554726, ENST00000580438, 
Fusion gene scores* DoF score5 X 5 X 2=5016 X 19 X 4=1216
# samples 520
** MAII scorelog2(5/50*10)=0log2(20/1216*10)=-2.60407132366886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC8A1 [Title/Abstract] AND SNHG14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC8A1(40361267)-SNHG14(25242315), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC8A1

GO:0006883

cellular sodium ion homeostasis

1374913

HgeneSLC8A1

GO:0070509

calcium ion import

1374913

HgeneSLC8A1

GO:0098719

sodium ion import across plasma membrane

1374913


check buttonFusion gene breakpoints across SLC8A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SNHG14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA569749SLC8A1chr2

40361267

-SNHG14chr15

25242315

+


Top

Fusion Gene ORF analysis for SLC8A1-SNHG14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000332839ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000332839ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000402441ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000403092ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405269ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000405901ENST00000553149SLC8A1chr2

40361267

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intron-intronENST00000405901ENST00000554726SLC8A1chr2

40361267

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intron-intronENST00000405901ENST00000580438SLC8A1chr2

40361267

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40361267

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40361267

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intron-intronENST00000406391ENST00000365306SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000384430SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000390982SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000414175SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000424208SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000424333SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000441592SLC8A1chr2

40361267

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40361267

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40361267

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40361267

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40361267

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intron-intronENST00000406391ENST00000459433SLC8A1chr2

40361267

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40361267

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40361267

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40361267

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intron-intronENST00000406391ENST00000549804SLC8A1chr2

40361267

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intron-intronENST00000406391ENST00000551077SLC8A1chr2

40361267

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40361267

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40361267

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40361267

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40361267

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40361267

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intron-intronENST00000406391ENST00000553149SLC8A1chr2

40361267

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40361267

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intron-intronENST00000406785ENST00000363358SLC8A1chr2

40361267

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40361267

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intron-intronENST00000406785ENST00000365306SLC8A1chr2

40361267

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40361267

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40361267

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intron-intronENST00000406785ENST00000414175SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000424208SLC8A1chr2

40361267

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40361267

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40361267

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intron-intronENST00000406785ENST00000450809SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000452731SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000453082SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000456576SLC8A1chr2

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intron-intronENST00000406785ENST00000459433SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000516123SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000546682SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000547292SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000549804SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000551077SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000551361SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000551631SLC8A1chr2

40361267

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intron-intronENST00000406785ENST00000551938SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000553108SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000553134SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000553149SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000554726SLC8A1chr2

40361267

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25242315

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intron-intronENST00000406785ENST00000580438SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000363358SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000365067SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000365306SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000384430SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000384733SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000390982SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000414175SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000424208SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000424333SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000441592SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000450809SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000452731SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000453082SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000456576SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000459433SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000516123SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000546682SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000547292SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000549804SLC8A1chr2

40361267

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intron-intronENST00000408028ENST00000551077SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000551361SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000551631SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000551938SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000553108SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000553134SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000553149SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000554726SLC8A1chr2

40361267

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25242315

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intron-intronENST00000408028ENST00000580438SLC8A1chr2

40361267

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25242315

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intron-intronENST00000542024ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000365306SLC8A1chr2

40361267

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25242315

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intron-intronENST00000542024ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542024ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542024ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542024ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542024ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

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intron-intronENST00000542756ENST00000363358SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000365067SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000365306SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000384430SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000384733SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000390982SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000414175SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000424208SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000424333SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000441592SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000450809SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000452731SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000453082SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000456576SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000459433SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000516123SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000546682SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000547292SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000549804SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000551077SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000551361SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000551631SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000551938SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000553108SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000553134SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000553149SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000554726SLC8A1chr2

40361267

-SNHG14chr15

25242315

+
intron-intronENST00000542756ENST00000580438SLC8A1chr2

40361267

-SNHG14chr15

25242315

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SLC8A1-SNHG14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC8A1-SNHG14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40361267/:25242315)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC8A1-SNHG14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC8A1-SNHG14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC8A1-SNHG14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC8A1-SNHG14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource