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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC9A8-B4GALT5 (FusionGDB2 ID:83558)

Fusion Gene Summary for SLC9A8-B4GALT5

Fusion gene summary

Fusion gene information	Fusion gene name: SLC9A8-B4GALT5
	Fusion gene ID: 83558
		Hgene	Tgene
	Gene symbol	SLC9A8	B4GALT5
	Gene ID	23315	9334
	Gene name	solute carrier family 9 member A8	beta-1,4-galactosyltransferase 5
	Synonyms	NHE-8\|NHE8	B4Gal-T5\|BETA4-GALT-IV\|beta4Gal-T5\|beta4GalT-V\|gt-V
	Cytomap	20q13.13	20q13.13
	Type of gene	protein-coding	protein-coding
	Description	sodium/hydrogen exchanger 8Na(+)/H(+) exchanger 8solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9 (sodium/hydrogen exchanger), member 8solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	beta-1,4-galactosyltransferase 5UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5beta-1,4-GalT IIbeta-1,4-GalT I
	Modification date	20200313	20200313
	UniProtAcc	.	O43286
	Ensembl transtripts involved in fusion gene	ENST00000539601, ENST00000541138, ENST00000361573, ENST00000417961, ENST00000490250,	ENST00000371711,
Fusion gene scores	* DoF score	9 X 7 X 6=378	12 X 9 X 5=540
	# samples	9	13
	** MAII score	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/540*10)=-2.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC9A8 [Title/Abstract] AND B4GALT5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC9A8(48431726)-B4GALT5(48273239), # samples:2 B4GALT5(48273104)-SLC9A8(48430005), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLC9A8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across B4GALT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A1L0-01A	SLC9A8	chr20	48431726	-	B4GALT5	chr20	48273239	-
ChimerDB4	SARC	TCGA-DX-A1L0-01A	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-

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Fusion Gene ORF analysis for SLC9A8-B4GALT5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000539601	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-
5UTR-3CDS	ENST00000541138	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-
In-frame	ENST00000361573	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-
In-frame	ENST00000417961	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-
intron-3CDS	ENST00000490250	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000417961

SLC9A8

chr20

48431726

ENST00000371711

B4GALT5

chr20

48273239

4837

418

1469

468

ENST00000361573

SLC9A8

chr20

48431726

ENST00000371711

B4GALT5

chr20

48273239

4669

250

1301

419

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000417961	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-	0.000629505	0.9993705
ENST00000361573	ENST00000371711	SLC9A8	chr20	48431726	+	B4GALT5	chr20	48273239	-	0.000611568	0.99938846

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Fusion Genomic Features for SLC9A8-B4GALT5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC9A8-B4GALT5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:48431726/chr20:48273239)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	B4GALT5 O43286
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). {ECO:0000250\|UniProtKB:Q9JMK0, ECO:0000269\|PubMed:24498430}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

169_173

389.0

Region

UDP-alpha-D-galactose binding

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

208_210

389.0

Region

UDP-alpha-D-galactose binding

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

235_236

389.0

Region

UDP-alpha-D-galactose binding

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

298_301

389.0

Region

N-acetyl-D-glucosamine binding

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

329_330

389.0

Region

UDP-alpha-D-galactose binding

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

36_388

389.0

Topological domain

Lumenal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

123_143

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

156_176

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

191_211

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

264_284

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

311_331

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

354_374

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

379_399

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

417_437

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

451_471

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

60_80

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000361573

84_104

582.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

123_143

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

156_176

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

191_211

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

264_284

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

311_331

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

354_374

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

379_399

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

417_437

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

451_471

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

60_80

598.0

Transmembrane

Helical

Hgene

SLC9A8

chr20:48431726

chr20:48273239

ENST00000417961

84_104

598.0

Transmembrane

Helical

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

1_14

389.0

Topological domain

Cytoplasmic

Tgene

B4GALT5

chr20:48431726

chr20:48273239

ENST00000371711

15_35

389.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for SLC9A8-B4GALT5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>83558_83558_1_SLC9A8-B4GALT5_SLC9A8_chr20_48431726_ENST00000361573_B4GALT5_chr20_48273239_ENST00000371711_length(transcript)=4669nt_BP=250nt
GCCCCGCGGCTCCGAACTCGGTGGTCCTGGAAGCTCCGCAGGATGGGGGAGAAGATGGCGGAAGAGGAGAGGTTCCCCAATACAACTCAT
GAGGGTTTCAATGTCACCCTCCACACCACCCTGGTTGTCACGACGAAACTGGTGCTCCCGACCCCTGGCAAGCCCATCCTCCCCGTGCAG
ACAGGGGAGCAGGCCCAGCAAGAGGAGCAGTCCAGCGGCATGACCATTTTCTTCAGCCTCCTTGTCCTAGTGAACACCTACCTCTTCATG
ATGCAAGCCCAAGGCATTCTGATCCGGGACAACGTGAGAACAATCGGTGCTCAGGTTTATGAGCAGGTGCTTCGGAGTGCTTATGCCAAG
AGGAACAGCAGTGTAAATGACTCAGATTATCCTCTTGACTTGAACCACAGTGAAACCTTCCTGCAAACTACAACATTTCTTCCTGAAGAC
TTCACCTACTTTGCAAACCATACCTGCCCTGAAAGACTCCCTTCCATGAAGGGCCCAATAGACATAAACATGAGTGAAATTGGAATGGAT
TACATTCATGAACTCTTCTCCAAAGACCCAACCATCAAGCTCGGAGGTCACTGGAAGCCTTCTGATTGCATGCCTCGGTGGAAGGTGGCG
ATCCTTATCCCCTTCCGGAACCGCCACGAGCACCTCCCAGTCCTGTTCAGACACCTGCTTCCCATGCTCCAGCGCCAGCGCTTGCAGTTT
GCATTTTATGTGGTTGAACAAGTTGGTACCCAACCCTTTAATCGAGCCATGCTTTTCAACGTTGGCTTTCAAGAGGCAATGAAAGACTTG
GATTGGGACTGTTTGATTTTTCATGATGTAGATCACATACCGGAAAGTGATCGCAACTATTATGGATGTGGACAGATGCCGAGGCATTTT
GCAACCAAATTGGATAAGTATATGTATCTGCTTCCTTATACCGAGTTCTTTGGCGGAGTGAGTGGCTTAACAGTGGAACAATTTCGGAAA
ATCAATGGCTTTCCTAATGCTTTCTGGGGTTGGGGTGGAGAAGATGACGACCTCTGGAACAGAGTACAGAATGCAGGCTATTCTGTGAGC
CGGCCAGAGGGTGACACAGGAAAGTACAAGTCCATTCCTCATCACCATCGAGGAGAAGTCCAGTTTCTTGGAAGGTATGCTCTGCTGAGG
AAGTCAAAAGAACGGCAAGGGCTGGATGGCCTCAACAACCTGAACTACTTTGCAAACATCACATACGACGCCTTGTATAAAAACATAACT
GTCAACCTGACACCCGAGCTGGCTCAGGTGAACGAGTACTGAGAGGAGAGAATGTACGTTTGCTTTACCCACCGCCACCAAGAAAGCAGT
CCGATGAGATTTTTTTTTGGAGGGGGGAGGGTCTACACAGCAAGAGAACAGAAATACTGTGTCTCATGAAGGATCACAGAGTTCAGGGGG
AAAATGTGACAGCACACGCACAAACGCCTTCACTGGATCAGCCGCTGGAACTGAGGGAGTGAGCTTGGGGACTTCCTTCGTCAGCACTGG
CTTTCTGTTTTCACAAGACAGACGTCTGTCCCGCTGCTCTCTCCCCATCTCCTACCCCACATCCTGTCTTAGCCGCAGTCTCCAGAACCC
ATGATGAACTGTGATCTGCCGTGGTCCTGCCGTGGTCCTGCCGTGGAGCCTGTCCCTACACATGACCTTGGAGCCTCTTGGCCTTCAGAG
CAGAGGCAAACCCACCACAGGGCAGCTGCGTTTTAGGAAGAGCAAATGAAACTCCACACCATTCTTCTAGATCTCTGGTGTTCTCTTTGG
TTTCATTTTTTTAAAAAATTACCTTCTTTGGGTGGGGATTGAGGGTGGAGGGGAGGGTGTTTGGGAAAGATAAATAGACATAAATATATA
ACAATCACTTCTTGAAGAAGTATAATTGTAAATAAGCCATGTAAAATGCCTTTTTAAAATTTAATTTTCTAGCTGGCTCCAATTCAAATT
GAGGATTTATGTATTAGGCCACTTACTTGGTTGGCAAGTGCAGGAACTCAGTTAAAATGCAGTTGAAGAATGTCATCTCCCGAATTGCTG
TCACTTTGGCGAGGGAGTGGATATAGGGCATGTCACAAAAGAACAAAATAACCCGACCTTTATTGCTGGGAGCTGGCTTCTGTCCCTTTC
TTCCCCCCCCCACGAGTCTTGCCCTTGACTTCTGCTCTGGATTCACTCTTCCCTGTCGGCCGCGCATGTGCTCATCCCACTCTCCGCTAA
GCGGGAGGCTGCTGTTAGAGCAGGCTGCTTCCTGCCTAAAGCAGGCCCTTCGGGGCTCGCTGCACACACATCTCTGGCTCTCCAGGCTTC
GTGTTCTGTCTTTTCATCAGCATGGCGGGGCGGGGGGCGGGGGGCGGGGGTGTGTATGGGAATCCCTCCCCCTCTTACTTTTTCTCTTGT
GGAACTTGGCCACAGTTTCTGAACAATGTGCCTACATTACCAGCTGGCTTCAGTGATTCCTCTGTGTCCCTTTTTGGTTTCTGGAAAGAT
TCTTTGTCAACATTAGTAACTGATACATAGAACCAAGGAGCACTCAAATAGGGAGCCAGGAGCCAGGGAGCTGGTGACACTTGTGTGCTG
TGGGGCAGCTGGGATCCAGGTAAGACCGGATTGAAGCTTTGAAATTAGACTAACAAAGCTCCAGACAGCAAGAGCCCAGGTGCACTGCTC
ACACCCCCACCTGCATTTTGAAGTCATATTATTTTTTGTTTTGTTTTTTAAGACGGTCTGGCTCTGTCGCCTAAGCTGGAGTGTGGTGGC
ACGATCACAGCTCACTGCAGCCTCCATCTCCTAGGCTCAAGCCATTTTCCCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCACAC
CACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGGTTTCTTCCATGTTGCCCAGGCTGGTCTCGAACTCCTGGACTCAAGC
AATCCGCCCACCTTGACTTCCCAAAGTGCTGGGATTATGGGCGGGTGTGAGCCATTGCGCCCAGCCTTGAAGTCATGTTCTAAATTGTAT
TTGAATTTGTGCCTCTTTGTTTTTCCCCAAACCAAAGCCCTCAAATTGTAGTCTCTGTCGGCTTCTGCAGAATTCTGGAAAATGCCAGTT
TTCCTCCCCCGCCCTTGTTTTCCATAAAACATATTTATATATTGTGATGAGGAGTACTTTCTGAAGAGTACTTCGTATTTTTTTTTAATT
GCCTTGTTTGCCTTCAACTTCCTTGATTTTCATAGTTTACATGGGTGTGTGTAGGGGTGTGTGTGTGTATGTGTGTGGGTTAGGGCTTTT
TTCGTTGCATGTGATGGTTCTGTGGACATATGATCCCCACAAACTGTGGGAGTGATTGGCCAGGCCTTGTTTTGTTTGTTTGTTTGTTTG
TGTTTTTGTTCTTTTGAAGAATAGAGTGGTATTTAGAAAATAAATTGCATTGCAAAGCTCTTATCGGCTCATATGAGAGAGCAGGTTCCT
GCCCTTGAAAATGCCGGTAAGCTATAGCATATGTTTTTTAAGACTTAAGCATTTCATGCTTTAAAATACCTTCACAAGTGAACATTACAC
ACAGAAGTTCATTTGGTTTTCCTTTGTTTTATGGTGCATATAGCAATAAAGACCCCCCTCCACCCTGCAACCCCCATCCCCCACCGGGCC
TTTGTCCCTGCCTTGGCTTTTCTCCCCTTCTCATTCTCCTCTCCCCTTTCCTCACTGAAGGCTGTGAGTTGCTTTCAATGTGACAACACT
ATGATGTCATTTGGAAGGATTTGCCAGGACAGACTGATTCTGAGTCCTGGGTGCCGTATGTGTATGCGGCAGTGTTGTCAGGCGATCTTG
TTTGAAGCTCTATGTTGCCATAATTACCATCAAGTACACACTGTTGGCAAAAGGCTAACACCTGACTTTAGAAAATGCTGATTTGAGAAC
AAAAGGAAAGGTCTTTTTTCACTGCTTAAAGTGGGGTCACTTTGATACCTTTGCGGTCATGTCTGTGTCTGATGAGTGTAGAATCTCTGG
ATGTGCACTGTCAGTCATGTGTCCACCAGGCCTCGAATATCATATGGGAAATGTCATAGTTAAAAACGTACAGCCAGGCCCGTGTGCTGT
TAATAGTGTGAAATTGTCATGTTAAAAAAAAAAACAGGAACCAAATGTGACCTTGTGCATATATTGGTAGCTGAAAATCTTCAAGGCTAC
TGATGGGTGGCCCCTTAATCTTGTCTTTGATTGCTGTGTGCAGGGAAAGGTGTCCCCGTTTGTTCATGCTGTTTTGGGGGGTGGGGGGGT
ATTTGCAAGAATACTCATTTTGACATAATAGGTCCTCTTGTCAGAGATCCTCTACCACAGACATTAATAGCTGAGCAGGAGCCACATGGA
TTGATTGTATCCACTCACCATTGACGATGGCATTGAGCGTAGCTAGCTTATTTCCATCACTACGTGTTTTTGAGCTTGCTCTTACGTTTT
AAGAGGTGCCAGGGGTACATTTTTGCACTGAAATCTAAAGATGTTTTAAAAAACACTTTTCACAAAAATAGTCCTTTGTCATTACATTAT

>83558_83558_1_SLC9A8-B4GALT5_SLC9A8_chr20_48431726_ENST00000361573_B4GALT5_chr20_48273239_ENST00000371711_length(amino acids)=419AA_BP=65
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLVNTYLFMMQAQGILIRDNVRT
IGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKL
GGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIP
ESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPH

--------------------------------------------------------------
>83558_83558_2_SLC9A8-B4GALT5_SLC9A8_chr20_48431726_ENST00000417961_B4GALT5_chr20_48273239_ENST00000371711_length(transcript)=4837nt_BP=418nt
CCGAAAGCCCCGGGAGAGACTAAGAAGCAATCCTCCCACGCGCTTTCTCCCACCCTCGGGCCACTGAGACGGAGGGACAGAGGGCCGCCC
TCGCGCGGCCGAGGCCCCGCCTCCCGCTCGCCCGCCCGCGCCTCCAGCGGAAGCCGGAAGCAAAAGCGGGTCCTGCTAGCCCCGCGGCTC
CGAACTCGGTGGTCCTGGAAGCTCCGCAGGATGGGGGAGAAGATGGCGGAAGAGGAGAGGTTCCCCAATACAACTCATGAGGGTTTCAAT
GTCACCCTCCACACCACCCTGGTTGTCACGACGAAACTGGTGCTCCCGACCCCTGGCAAGCCCATCCTCCCCGTGCAGACAGGGGAGCAG
GCCCAGCAAGAGGAGCAGTCCAGCGGCATGACCATTTTCTTCAGCCTCCTTGTCCTAGTGAACACCTACCTCTTCATGATGCAAGCCCAA
GGCATTCTGATCCGGGACAACGTGAGAACAATCGGTGCTCAGGTTTATGAGCAGGTGCTTCGGAGTGCTTATGCCAAGAGGAACAGCAGT
GTAAATGACTCAGATTATCCTCTTGACTTGAACCACAGTGAAACCTTCCTGCAAACTACAACATTTCTTCCTGAAGACTTCACCTACTTT
GCAAACCATACCTGCCCTGAAAGACTCCCTTCCATGAAGGGCCCAATAGACATAAACATGAGTGAAATTGGAATGGATTACATTCATGAA
CTCTTCTCCAAAGACCCAACCATCAAGCTCGGAGGTCACTGGAAGCCTTCTGATTGCATGCCTCGGTGGAAGGTGGCGATCCTTATCCCC
TTCCGGAACCGCCACGAGCACCTCCCAGTCCTGTTCAGACACCTGCTTCCCATGCTCCAGCGCCAGCGCTTGCAGTTTGCATTTTATGTG
GTTGAACAAGTTGGTACCCAACCCTTTAATCGAGCCATGCTTTTCAACGTTGGCTTTCAAGAGGCAATGAAAGACTTGGATTGGGACTGT
TTGATTTTTCATGATGTAGATCACATACCGGAAAGTGATCGCAACTATTATGGATGTGGACAGATGCCGAGGCATTTTGCAACCAAATTG
GATAAGTATATGTATCTGCTTCCTTATACCGAGTTCTTTGGCGGAGTGAGTGGCTTAACAGTGGAACAATTTCGGAAAATCAATGGCTTT
CCTAATGCTTTCTGGGGTTGGGGTGGAGAAGATGACGACCTCTGGAACAGAGTACAGAATGCAGGCTATTCTGTGAGCCGGCCAGAGGGT
GACACAGGAAAGTACAAGTCCATTCCTCATCACCATCGAGGAGAAGTCCAGTTTCTTGGAAGGTATGCTCTGCTGAGGAAGTCAAAAGAA
CGGCAAGGGCTGGATGGCCTCAACAACCTGAACTACTTTGCAAACATCACATACGACGCCTTGTATAAAAACATAACTGTCAACCTGACA
CCCGAGCTGGCTCAGGTGAACGAGTACTGAGAGGAGAGAATGTACGTTTGCTTTACCCACCGCCACCAAGAAAGCAGTCCGATGAGATTT
TTTTTTGGAGGGGGGAGGGTCTACACAGCAAGAGAACAGAAATACTGTGTCTCATGAAGGATCACAGAGTTCAGGGGGAAAATGTGACAG
CACACGCACAAACGCCTTCACTGGATCAGCCGCTGGAACTGAGGGAGTGAGCTTGGGGACTTCCTTCGTCAGCACTGGCTTTCTGTTTTC
ACAAGACAGACGTCTGTCCCGCTGCTCTCTCCCCATCTCCTACCCCACATCCTGTCTTAGCCGCAGTCTCCAGAACCCATGATGAACTGT
GATCTGCCGTGGTCCTGCCGTGGTCCTGCCGTGGAGCCTGTCCCTACACATGACCTTGGAGCCTCTTGGCCTTCAGAGCAGAGGCAAACC
CACCACAGGGCAGCTGCGTTTTAGGAAGAGCAAATGAAACTCCACACCATTCTTCTAGATCTCTGGTGTTCTCTTTGGTTTCATTTTTTT
AAAAAATTACCTTCTTTGGGTGGGGATTGAGGGTGGAGGGGAGGGTGTTTGGGAAAGATAAATAGACATAAATATATAACAATCACTTCT
TGAAGAAGTATAATTGTAAATAAGCCATGTAAAATGCCTTTTTAAAATTTAATTTTCTAGCTGGCTCCAATTCAAATTGAGGATTTATGT
ATTAGGCCACTTACTTGGTTGGCAAGTGCAGGAACTCAGTTAAAATGCAGTTGAAGAATGTCATCTCCCGAATTGCTGTCACTTTGGCGA
GGGAGTGGATATAGGGCATGTCACAAAAGAACAAAATAACCCGACCTTTATTGCTGGGAGCTGGCTTCTGTCCCTTTCTTCCCCCCCCCA
CGAGTCTTGCCCTTGACTTCTGCTCTGGATTCACTCTTCCCTGTCGGCCGCGCATGTGCTCATCCCACTCTCCGCTAAGCGGGAGGCTGC
TGTTAGAGCAGGCTGCTTCCTGCCTAAAGCAGGCCCTTCGGGGCTCGCTGCACACACATCTCTGGCTCTCCAGGCTTCGTGTTCTGTCTT
TTCATCAGCATGGCGGGGCGGGGGGCGGGGGGCGGGGGTGTGTATGGGAATCCCTCCCCCTCTTACTTTTTCTCTTGTGGAACTTGGCCA
CAGTTTCTGAACAATGTGCCTACATTACCAGCTGGCTTCAGTGATTCCTCTGTGTCCCTTTTTGGTTTCTGGAAAGATTCTTTGTCAACA
TTAGTAACTGATACATAGAACCAAGGAGCACTCAAATAGGGAGCCAGGAGCCAGGGAGCTGGTGACACTTGTGTGCTGTGGGGCAGCTGG
GATCCAGGTAAGACCGGATTGAAGCTTTGAAATTAGACTAACAAAGCTCCAGACAGCAAGAGCCCAGGTGCACTGCTCACACCCCCACCT
GCATTTTGAAGTCATATTATTTTTTGTTTTGTTTTTTAAGACGGTCTGGCTCTGTCGCCTAAGCTGGAGTGTGGTGGCACGATCACAGCT
CACTGCAGCCTCCATCTCCTAGGCTCAAGCCATTTTCCCACCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCACACCACCACACCTGG
CTAATTTTTTGTATTTTTAGTAGAGACAGGGGTTTCTTCCATGTTGCCCAGGCTGGTCTCGAACTCCTGGACTCAAGCAATCCGCCCACC
TTGACTTCCCAAAGTGCTGGGATTATGGGCGGGTGTGAGCCATTGCGCCCAGCCTTGAAGTCATGTTCTAAATTGTATTTGAATTTGTGC
CTCTTTGTTTTTCCCCAAACCAAAGCCCTCAAATTGTAGTCTCTGTCGGCTTCTGCAGAATTCTGGAAAATGCCAGTTTTCCTCCCCCGC
CCTTGTTTTCCATAAAACATATTTATATATTGTGATGAGGAGTACTTTCTGAAGAGTACTTCGTATTTTTTTTTAATTGCCTTGTTTGCC
TTCAACTTCCTTGATTTTCATAGTTTACATGGGTGTGTGTAGGGGTGTGTGTGTGTATGTGTGTGGGTTAGGGCTTTTTTCGTTGCATGT
GATGGTTCTGTGGACATATGATCCCCACAAACTGTGGGAGTGATTGGCCAGGCCTTGTTTTGTTTGTTTGTTTGTTTGTGTTTTTGTTCT
TTTGAAGAATAGAGTGGTATTTAGAAAATAAATTGCATTGCAAAGCTCTTATCGGCTCATATGAGAGAGCAGGTTCCTGCCCTTGAAAAT
GCCGGTAAGCTATAGCATATGTTTTTTAAGACTTAAGCATTTCATGCTTTAAAATACCTTCACAAGTGAACATTACACACAGAAGTTCAT
TTGGTTTTCCTTTGTTTTATGGTGCATATAGCAATAAAGACCCCCCTCCACCCTGCAACCCCCATCCCCCACCGGGCCTTTGTCCCTGCC
TTGGCTTTTCTCCCCTTCTCATTCTCCTCTCCCCTTTCCTCACTGAAGGCTGTGAGTTGCTTTCAATGTGACAACACTATGATGTCATTT
GGAAGGATTTGCCAGGACAGACTGATTCTGAGTCCTGGGTGCCGTATGTGTATGCGGCAGTGTTGTCAGGCGATCTTGTTTGAAGCTCTA
TGTTGCCATAATTACCATCAAGTACACACTGTTGGCAAAAGGCTAACACCTGACTTTAGAAAATGCTGATTTGAGAACAAAAGGAAAGGT
CTTTTTTCACTGCTTAAAGTGGGGTCACTTTGATACCTTTGCGGTCATGTCTGTGTCTGATGAGTGTAGAATCTCTGGATGTGCACTGTC
AGTCATGTGTCCACCAGGCCTCGAATATCATATGGGAAATGTCATAGTTAAAAACGTACAGCCAGGCCCGTGTGCTGTTAATAGTGTGAA
ATTGTCATGTTAAAAAAAAAAACAGGAACCAAATGTGACCTTGTGCATATATTGGTAGCTGAAAATCTTCAAGGCTACTGATGGGTGGCC
CCTTAATCTTGTCTTTGATTGCTGTGTGCAGGGAAAGGTGTCCCCGTTTGTTCATGCTGTTTTGGGGGGTGGGGGGGTATTTGCAAGAAT
ACTCATTTTGACATAATAGGTCCTCTTGTCAGAGATCCTCTACCACAGACATTAATAGCTGAGCAGGAGCCACATGGATTGATTGTATCC
ACTCACCATTGACGATGGCATTGAGCGTAGCTAGCTTATTTCCATCACTACGTGTTTTTGAGCTTGCTCTTACGTTTTAAGAGGTGCCAG
GGGTACATTTTTGCACTGAAATCTAAAGATGTTTTAAAAAACACTTTTCACAAAAATAGTCCTTTGTCATTACATTATTTACTCATGTGT

>83558_83558_2_SLC9A8-B4GALT5_SLC9A8_chr20_48431726_ENST00000417961_B4GALT5_chr20_48273239_ENST00000371711_length(amino acids)=468AA_BP=114
MRRRDRGPPSRGRGPASRSPARASSGSRKQKRVLLAPRLRTRWSWKLRRMGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKP
ILPVQTGEQAQQEEQSSGMTIFFSLLVLVNTYLFMMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTT
FLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQR
QRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTV
EQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYFANITYDAL

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Fusion Gene PPI Analysis for SLC9A8-B4GALT5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SLC9A8-B4GALT5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC9A8-B4GALT5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source