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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLCO2A1-SLC25A36 (FusionGDB2 ID:83596)

Fusion Gene Summary for SLCO2A1-SLC25A36

check button Fusion gene summary
Fusion gene informationFusion gene name: SLCO2A1-SLC25A36
Fusion gene ID: 83596
HgeneTgene
Gene symbol

SLCO2A1

SLC25A36

Gene ID

6578

55186

Gene namesolute carrier organic anion transporter family member 2A1solute carrier family 25 member 36
SynonymsMATR1|OATP2A1|PGT|PHOAR2|SLC21A2PNC2
Cytomap

3q22.1-q22.2

3q23

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier organic anion transporter family member 2A1matrin F/G 1solute carrier family 21 (prostaglandin transporter), member 2solute carrier family 25 member 36epididymis secretory sperm binding proteinsolute carrier family 25 (pyrimidine nucleotide carrier ), member 36
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310926, ENST00000493729, 
ENST00000478651, 		ENST00000324194, 
ENST00000393015, ENST00000453248, 
ENST00000507429, ENST00000446041, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 6 X 3=90
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLCO2A1 [Title/Abstract] AND SLC25A36 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLCO2A1(133692507)-SLC25A36(140689769), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC25A36

GO:0000002

mitochondrial genome maintenance

25320081

TgeneSLC25A36

GO:0006864

pyrimidine nucleotide transport

25320081

TgeneSLC25A36

GO:0007005

mitochondrion organization

25320081

TgeneSLC25A36

GO:0051881

regulation of mitochondrial membrane potential

25320081


check buttonFusion gene breakpoints across SLCO2A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC25A36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-7338-01ASLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+


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Fusion Gene ORF analysis for SLCO2A1-SLC25A36

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310926ENST00000324194SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000310926ENST00000393015SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000310926ENST00000453248SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000310926ENST00000507429SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000493729ENST00000324194SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000493729ENST00000393015SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000493729ENST00000453248SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5CDS-intronENST00000493729ENST00000507429SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5UTR-3CDSENST00000478651ENST00000446041SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5UTR-intronENST00000478651ENST00000324194SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5UTR-intronENST00000478651ENST00000393015SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5UTR-intronENST00000478651ENST00000453248SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
5UTR-intronENST00000478651ENST00000507429SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
In-frameENST00000310926ENST00000446041SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+
In-frameENST00000493729ENST00000446041SLCO2A1chr3

133692507

-SLC25A36chr3

140689769

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310926SLCO2A1chr3133692507-ENST00000446041SLC25A36chr3140689769+46996711811218345
ENST00000493729SLCO2A1chr3133692507-ENST00000446041SLC25A36chr3140689769+4537509191056345

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310926ENST00000446041SLCO2A1chr3133692507-SLC25A36chr3140689769+0.0006173020.99938273
ENST00000493729ENST00000446041SLCO2A1chr3133692507-SLC25A36chr3140689769+0.000594250.99940574

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Fusion Genomic Features for SLCO2A1-SLC25A36


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLCO2A1chr3133692506-SLC25A36chr3140689768+0.0047006580.99529934
SLCO2A1chr3133692506-SLC25A36chr3140689768+0.0047006580.99529934

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLCO2A1-SLC25A36


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:133692507/chr3:140689769)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-3141_32132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-31453_71132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-31493_98132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-31433_52132644.0TransmembraneHelical%3B Name%3D1
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-31472_92132644.0TransmembraneHelical%3B Name%3D2
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-31499_123132644.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437224_308128312.0RepeatSolcar 3
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137224_308128311.0RepeatSolcar 3
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437180_200128312.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437226_246128312.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437291_311128312.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137180_200128311.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137226_246128311.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137291_311128311.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314438_496132644.0DomainKazal-like
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314124_167132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314197_215132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314237_254132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314280_321132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314344_363132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314388_391132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314416_518132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314542_550132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314577_610132644.0Topological domainExtracellular
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314630_643132644.0Topological domainCytoplasmic
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314168_196132644.0TransmembraneHelical%3B Name%3D4
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314216_236132644.0TransmembraneHelical%3B Name%3D5
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314255_279132644.0TransmembraneHelical%3B Name%3D6
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314322_343132644.0TransmembraneHelical%3B Name%3D7
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314364_387132644.0TransmembraneHelical%3B Name%3D8
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314392_415132644.0TransmembraneHelical%3B Name%3D9
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314519_541132644.0TransmembraneHelical%3B Name%3D10
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314551_576132644.0TransmembraneHelical%3B Name%3D11
HgeneSLCO2A1chr3:133692507chr3:140689769ENST00000310926-314611_629132644.0TransmembraneHelical%3B Name%3D12
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437116_203128312.0RepeatSolcar 2
TgeneSLC25A36chr3:133692507chr3:140689769ENST00000324194374_108128312.0RepeatSolcar 1
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137116_203128311.0RepeatSolcar 2
TgeneSLC25A36chr3:133692507chr3:140689769ENST00000446041374_108128311.0RepeatSolcar 1
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000032419437111_131128312.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A36chr3:133692507chr3:140689769ENST000003241943741_57128312.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A36chr3:133692507chr3:140689769ENST00000324194377_27128312.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A36chr3:133692507chr3:140689769ENST0000044604137111_131128311.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A36chr3:133692507chr3:140689769ENST000004460413741_57128311.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A36chr3:133692507chr3:140689769ENST00000446041377_27128311.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for SLCO2A1-SLC25A36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83596_83596_1_SLCO2A1-SLC25A36_SLCO2A1_chr3_133692507_ENST00000310926_SLC25A36_chr3_140689769_ENST00000446041_length(transcript)=4699nt_BP=671nt
ACACCTGTCTGAGGGGGCGGCGGCGGCGGCGGCGGCGGGGCGGGGGCTCGTAGCGCCTTTGACACCCGAGGAAAAGAGGGAGGAGGGAGA
GCGCGTTTCATCATCGGCGGCGGCCACTTATAAAAACTTCTAGGCGCGCACTCGCTGGCTCAGTCTCCGCTCCGCGAATCTCCTCCGGCC
ACTGCCGCCGCGGTCGCCTCTCACCCGCCCGGCCGCTCCAGCCCGAGGCGCCCCGACCCCGCGCCACTCCGCGCCCGGCCAGCCGCCCGC
AGCCATGGGGCTCCTGCCCAAGCTCGGCGCGTCCCAGGGCAGCGACACCTCTACTAGCCGAGCCGGCCGCTGTGCCCGCTCGGTCTTCGG
CAACATTAAGGTGTTTGTGCTCTGCCAAGGCCTCCTGCAGCTCTGCCAACTCCTGTACAGCGCCTACTTCAAGAGCAGCCTCACCACCAT
TGAGAAGCGCTTTGGGCTCTCCAGTTCTTCATCGGGTCTCATTTCCAGCTTGAATGAGATCAGCAATGCCATCCTCATCATCTTTGTCAG
CTACTTTGGCAGCCGGGTGCACCGTCCACGTCTGATTGGCATCGGAGGTCTCTTCCTGGCTGCAGGTGCCTTCATCCTCACCCTCCCACA
CTTCCTCTCCGAGCCCTACCAGTACACCTTGGCCAGCACTGGTTTTACTGCAATCACAGCAACCAACCCCATTTGGCTTATAAAGACTCG
GTTACAGCTTGATGCAAGGAACCGCGGGGAAAGGCGAATGGGTGCTTTTGAATGTGTTCGTAAAGTGTATCAGACAGATGGACTAAAAGG
ATTTTATAGGGGCATGTCTGCTTCATATGCTGGTATATCAGAGACTGTTATCCATTTTGTTATTTATGAAAGTATAAAACAAAAACTACT
GGAATATAAGACTGCTTCTACAATGGAAAATGATGAAGAGTCTGTGAAAGAAGCATCAGATTTTGTGGGAATGATGCTAGCTGCTGCCAC
CTCAAAAACTTGTGCCACAACTATAGCATATCCACATGTTGTAAGAACAAGACTACGTGAAGAGGGAACAAAATACAGATCTTTTTTTCA
GACTCTATCTTTGCTTGTTCAAGAAGAAGGTTATGGGTCTCTTTATCGTGGTCTGACAACTCATCTAGTGAGACAGATTCCAAACACAGC
CATTATGATGGCCACCTATGAATTGGTGGTTTACCTACTCAATGGATAGCAGCACGAGGACTGCTGTACTGCAAAAAAAGAAGACCAAAA
GATTACAGTGGACCATGGGATACAGAAGCCAGCATGGCAGACAGAAGAAAAATAGTTTGGGAACATGTAACTATTCTAAGTGGAAGTTTT
GTTGTAGGAATTATAGTAATCACACCACATTACTTGGCCTTTCGGTAATGTGAAAAAAAAAAAAAACCTCAGAGCCTCCAAGGAAATGCC
TTTAGAAGCACTCCTCTCTCAAAATTGCCATTTTCTCTACCATGTCCCCCAGACACAGTTGGGTTTTGTTGATTTATGGCAGTCTTCTAA
ACAAAGCCATCCTTAATTTTACATACTGTATTGTAACTATCCAAAGATAGTATTGGCAGTCATAAATTTATAACTTCTGGCCTTTGTTTA
ATTCCAGTAAAATAACAGCAATGACAATGAGATCGTCAGTATTATTTTCACATTTCCCTGAGAGGACCTGGCACAATATTTTAAATTTAA
TTATTTGGCAGTAGTCACTGTTTTTGACAACCAATGAAATAGCGTCTAAATATCTTGTATATTTTTTAGCATCAAAATGTTTTGGTTTCC
ACTGCTGACAGGTGCTTGTTGTTTAGCCTAATGTGGATATTTAAATTGTTAACATACCAAACACACATGGTAATAGTTTGGGACAAAATA
ACTAGTAAAATGTTGATTTCTCGGCTTTTTCACTGACTGCGGCATGTCCTCGTGTCTTCTCTGATTTTGTGGTACATGAATGAATGCATT
TATCTTTTTAGTGACTTACTAGTTACGAACTTGAATTATCACCTCTTTGTCATACTTAAGTATCATTTACATAAAGTGTAAAAGATTTTT
TCACTTTTGAATCTTTACCTACTTGCTTTCACATTAAGAATTTGAACTTTTGAGTTTTTTCCAGGTCTATATATAATAGATTACATTTAT
TTTGTAAAGAAAATAGTAATTTAAAGTTTTGCCATTTTAAGGTGACAATATTTGGGACAGTATAAATATTATAGACAAGGGCCCCCTTGC
TGTCTGCTTTAGCAGGTAGTGACATTAATTGACTTATAGTTTTGTGTAAATGAACAAACTGCTTTTGACAAGAAATTTATTCTGTCCTAG
TTTCCTGCGTGGTAAATCATAGAAAGATTCAAGTTCATTTGGGTTAAATGTGCTAATAGGATGTAGCTTTTAAATTCTGCTATTGAGTCA
GCTGTACCTTTTAATACTTTAAATGTGTTATTTGTATGGCCCTTATAAAGGTGTTTGCTGTAATTCTGTTAAAAGACTTCGCCTATGCCA
TACTGGTGTATAAAAACTGCCGCAATTGGACGCCGGTGTGGTACTCATTTCAGTATACCTGAACTGTACATTTTGTGCAATGGCTTTATC
TAAAAGAATGACGCTTCGTGAAAGCACTTTGTGGCCTTTTTTGGGGGGGAGGGTGAGAGAGTAGGAGAGAATACCATGTTAAGATTAAAA
AAAAAAACAAAAACATTGGTCACGTATTAGGCAGAAACAGTGTTCATAACATTTTTCTGGGTTTTAAATATGTTGTTTCGGATATCCTTA
ATATAAATGTTTTAGGTATTCTGTGTACCCTGTCGTACCCCCAACATTATAGAATATTGCAGCGTGTCATTGCAAGCTTTCTCTGCTGTC
ACCAGTGAAACATAGTGCCCTGTTAAATTCCCCCACTTTAACTTCCTTGTGATCAACAGTAACTGGATGTTTTTGAGGTGCTCAATTGGA
ATAAAAATATTCCAATCTATTTGGAGACCAAAGGCAAAATCAGTTTTCTTACCTTTGGAATTATTCGTACCTTTTATGGTAAATTTCAGC
TTTGACATGTATTATGAGGAACGTACCAAAAACCGGTTTGTAACAAATCTGTAGAGAAGGTCTGAATCTATCGTGTTTGCCTTTTCAGGT
GCCATTTCTACTGCCTAATACAGTGCCATTTGCCTTGTGAAGACCCATAAACATTCATTGTGTTGAATGTAAGATAGAGACTCTCCCTAG
TCTTACTGATCTCAGTACCCCACAAATGATTAAGAATGATATGAAAACCAGCAGCTAAGGAACATCTTATTATTTAGTTGTAGCATATTC
ATAACAAGTGTCCTTCAAGGATAAACATATATTCTCTATTTGTATTTAGCAAGTAAAACTTGTGTTGACCTTTAGTGCATTATATTCAGC
TTTTAACAGTATTATGTATGTACTGGAAAGCAAAGAAATCTTAGAGTCTTGGACATTGTTTATTTGTGCAACAACTAGAAAGGAGCAATG
AAGTTTATTTCAGTTGTATTTTTCCCTAAGCACAATCTGCAATAGTTTATGTATGACAGAGATAATTCAAAAAGGAAAACTATATATAAA
AGTTGTATATAAAGTTTGTCTCTGAAATATTTCTTTGAAGTTTTTAAAAAATCGACTCATGTTTAAAAACAAAAACACATATTCAGAGCA
TTGGACTTTTTTAACTTGTTTTCATCTGTTTATCATGACTTTTTTATTTCTGGTGTAGAGTCCACATTATTTAGTTTGTTGTACTTTTAA
ATTTCAAAGTTCAAATCTGAAGAATTAGCGTTTGTGATTTCGGGATACCATGCAGTGGTTTTAATCCCAGGAAAAAAACTATCACCAAAA
GTTCGTTTGATTCTCATTATGTAACTTTGTAGAACCATCCTTTCTAGATGGGTCCACCACAGTGAATTTGTAACTTTGAAGTCAGGATAG
AATATCATTAGATTATCTGTGAGATAGCATTACTATGTTAGGACCAGCAGAGTTTGGGTTGGTAAAAATAATGTTTGCTCTATTACTGGG
TTACAGACATTTCAGCATTTTTAGGTTGGTTTTAAATCACTAAAAATATTTATTCGGATTTGAAGGATTTAAGTGCTAAAAATCAATCCA
TTTCTTGCCCTTCAATAATTGTCCATGCCTGCCTTTTGTTGTTTACATGCTCTTCTGCCCAGACTGTTAGTAATCTAGGGACCCCCTTTG
GAGCTGATAAGTACAGTTCAGCCTTTTCTCCTCAAATATATAATGACTTTAACATTCCTAAGAATATAGGTATTTCTGAATGATTTAAAT
TTGAGGAATTTTAATACATAAAATACAATGTACAAACTTTCTGCCCACTCAGATCTCTTCTCCATCATGTACTTAGTATTTCCCATTAAC
CTACACACTGATTTTTATGCTACTCCTTGTAGAAACAAAATTCTGGTTTGACTCAGTTTTTGTGTTTATAAACTTTTGGAATGTGTACCC
CGTTTATGTGAAGAATTATGACCTATCAGTCATAGCTAAATAGTGAACCTCAAAAGTGTTAACTTTTGACTATTCATGTGAGGTTTGGTA
TCTTGCATTTATGTACATGGCTGTAAATTATGTGCATTTACTCTGTATTTATGTTATCTAGCTGACTTTTACTTGAATTGTTCAAATTTT

>83596_83596_1_SLCO2A1-SLC25A36_SLCO2A1_chr3_133692507_ENST00000310926_SLC25A36_chr3_140689769_ENST00000446041_length(amino acids)=345AA_BP=163
MPPRSPLTRPAAPARGAPTPRHSAPGQPPAAMGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTI
EKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGFTAITATNPIWLIKTR
LQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAAT

--------------------------------------------------------------
>83596_83596_2_SLCO2A1-SLC25A36_SLCO2A1_chr3_133692507_ENST00000493729_SLC25A36_chr3_140689769_ENST00000446041_length(transcript)=4537nt_BP=509nt
CGCGAATCTCCTCCGGCCACTGCCGCCGCGGTCGCCTCTCACCCGCCCGGCCGCTCCAGCCCGAGGCGCCCCGACCCCGCGCCACTCCGC
GCCCGGCCAGCCGCCCGCAGCCATGGGGCTCCTGCCCAAGCTCGGCGCGTCCCAGGGCAGCGACACCTCTACTAGCCGAGCCGGCCGCTG
TGCCCGCTCGGTCTTCGGCAACATTAAGGTGTTTGTGCTCTGCCAAGGCCTCCTGCAGCTCTGCCAACTCCTGTACAGCGCCTACTTCAA
GAGCAGCCTCACCACCATTGAGAAGCGCTTTGGGCTCTCCAGTTCTTCATCGGGTCTCATTTCCAGCTTGAATGAGATCAGCAATGCCAT
CCTCATCATCTTTGTCAGCTACTTTGGCAGCCGGGTGCACCGTCCACGTCTGATTGGCATCGGAGGTCTCTTCCTGGCTGCAGGTGCCTT
CATCCTCACCCTCCCACACTTCCTCTCCGAGCCCTACCAGTACACCTTGGCCAGCACTGGTTTTACTGCAATCACAGCAACCAACCCCAT
TTGGCTTATAAAGACTCGGTTACAGCTTGATGCAAGGAACCGCGGGGAAAGGCGAATGGGTGCTTTTGAATGTGTTCGTAAAGTGTATCA
GACAGATGGACTAAAAGGATTTTATAGGGGCATGTCTGCTTCATATGCTGGTATATCAGAGACTGTTATCCATTTTGTTATTTATGAAAG
TATAAAACAAAAACTACTGGAATATAAGACTGCTTCTACAATGGAAAATGATGAAGAGTCTGTGAAAGAAGCATCAGATTTTGTGGGAAT
GATGCTAGCTGCTGCCACCTCAAAAACTTGTGCCACAACTATAGCATATCCACATGTTGTAAGAACAAGACTACGTGAAGAGGGAACAAA
ATACAGATCTTTTTTTCAGACTCTATCTTTGCTTGTTCAAGAAGAAGGTTATGGGTCTCTTTATCGTGGTCTGACAACTCATCTAGTGAG
ACAGATTCCAAACACAGCCATTATGATGGCCACCTATGAATTGGTGGTTTACCTACTCAATGGATAGCAGCACGAGGACTGCTGTACTGC
AAAAAAAGAAGACCAAAAGATTACAGTGGACCATGGGATACAGAAGCCAGCATGGCAGACAGAAGAAAAATAGTTTGGGAACATGTAACT
ATTCTAAGTGGAAGTTTTGTTGTAGGAATTATAGTAATCACACCACATTACTTGGCCTTTCGGTAATGTGAAAAAAAAAAAAAACCTCAG
AGCCTCCAAGGAAATGCCTTTAGAAGCACTCCTCTCTCAAAATTGCCATTTTCTCTACCATGTCCCCCAGACACAGTTGGGTTTTGTTGA
TTTATGGCAGTCTTCTAAACAAAGCCATCCTTAATTTTACATACTGTATTGTAACTATCCAAAGATAGTATTGGCAGTCATAAATTTATA
ACTTCTGGCCTTTGTTTAATTCCAGTAAAATAACAGCAATGACAATGAGATCGTCAGTATTATTTTCACATTTCCCTGAGAGGACCTGGC
ACAATATTTTAAATTTAATTATTTGGCAGTAGTCACTGTTTTTGACAACCAATGAAATAGCGTCTAAATATCTTGTATATTTTTTAGCAT
CAAAATGTTTTGGTTTCCACTGCTGACAGGTGCTTGTTGTTTAGCCTAATGTGGATATTTAAATTGTTAACATACCAAACACACATGGTA
ATAGTTTGGGACAAAATAACTAGTAAAATGTTGATTTCTCGGCTTTTTCACTGACTGCGGCATGTCCTCGTGTCTTCTCTGATTTTGTGG
TACATGAATGAATGCATTTATCTTTTTAGTGACTTACTAGTTACGAACTTGAATTATCACCTCTTTGTCATACTTAAGTATCATTTACAT
AAAGTGTAAAAGATTTTTTCACTTTTGAATCTTTACCTACTTGCTTTCACATTAAGAATTTGAACTTTTGAGTTTTTTCCAGGTCTATAT
ATAATAGATTACATTTATTTTGTAAAGAAAATAGTAATTTAAAGTTTTGCCATTTTAAGGTGACAATATTTGGGACAGTATAAATATTAT
AGACAAGGGCCCCCTTGCTGTCTGCTTTAGCAGGTAGTGACATTAATTGACTTATAGTTTTGTGTAAATGAACAAACTGCTTTTGACAAG
AAATTTATTCTGTCCTAGTTTCCTGCGTGGTAAATCATAGAAAGATTCAAGTTCATTTGGGTTAAATGTGCTAATAGGATGTAGCTTTTA
AATTCTGCTATTGAGTCAGCTGTACCTTTTAATACTTTAAATGTGTTATTTGTATGGCCCTTATAAAGGTGTTTGCTGTAATTCTGTTAA
AAGACTTCGCCTATGCCATACTGGTGTATAAAAACTGCCGCAATTGGACGCCGGTGTGGTACTCATTTCAGTATACCTGAACTGTACATT
TTGTGCAATGGCTTTATCTAAAAGAATGACGCTTCGTGAAAGCACTTTGTGGCCTTTTTTGGGGGGGAGGGTGAGAGAGTAGGAGAGAAT
ACCATGTTAAGATTAAAAAAAAAAACAAAAACATTGGTCACGTATTAGGCAGAAACAGTGTTCATAACATTTTTCTGGGTTTTAAATATG
TTGTTTCGGATATCCTTAATATAAATGTTTTAGGTATTCTGTGTACCCTGTCGTACCCCCAACATTATAGAATATTGCAGCGTGTCATTG
CAAGCTTTCTCTGCTGTCACCAGTGAAACATAGTGCCCTGTTAAATTCCCCCACTTTAACTTCCTTGTGATCAACAGTAACTGGATGTTT
TTGAGGTGCTCAATTGGAATAAAAATATTCCAATCTATTTGGAGACCAAAGGCAAAATCAGTTTTCTTACCTTTGGAATTATTCGTACCT
TTTATGGTAAATTTCAGCTTTGACATGTATTATGAGGAACGTACCAAAAACCGGTTTGTAACAAATCTGTAGAGAAGGTCTGAATCTATC
GTGTTTGCCTTTTCAGGTGCCATTTCTACTGCCTAATACAGTGCCATTTGCCTTGTGAAGACCCATAAACATTCATTGTGTTGAATGTAA
GATAGAGACTCTCCCTAGTCTTACTGATCTCAGTACCCCACAAATGATTAAGAATGATATGAAAACCAGCAGCTAAGGAACATCTTATTA
TTTAGTTGTAGCATATTCATAACAAGTGTCCTTCAAGGATAAACATATATTCTCTATTTGTATTTAGCAAGTAAAACTTGTGTTGACCTT
TAGTGCATTATATTCAGCTTTTAACAGTATTATGTATGTACTGGAAAGCAAAGAAATCTTAGAGTCTTGGACATTGTTTATTTGTGCAAC
AACTAGAAAGGAGCAATGAAGTTTATTTCAGTTGTATTTTTCCCTAAGCACAATCTGCAATAGTTTATGTATGACAGAGATAATTCAAAA
AGGAAAACTATATATAAAAGTTGTATATAAAGTTTGTCTCTGAAATATTTCTTTGAAGTTTTTAAAAAATCGACTCATGTTTAAAAACAA
AAACACATATTCAGAGCATTGGACTTTTTTAACTTGTTTTCATCTGTTTATCATGACTTTTTTATTTCTGGTGTAGAGTCCACATTATTT
AGTTTGTTGTACTTTTAAATTTCAAAGTTCAAATCTGAAGAATTAGCGTTTGTGATTTCGGGATACCATGCAGTGGTTTTAATCCCAGGA
AAAAAACTATCACCAAAAGTTCGTTTGATTCTCATTATGTAACTTTGTAGAACCATCCTTTCTAGATGGGTCCACCACAGTGAATTTGTA
ACTTTGAAGTCAGGATAGAATATCATTAGATTATCTGTGAGATAGCATTACTATGTTAGGACCAGCAGAGTTTGGGTTGGTAAAAATAAT
GTTTGCTCTATTACTGGGTTACAGACATTTCAGCATTTTTAGGTTGGTTTTAAATCACTAAAAATATTTATTCGGATTTGAAGGATTTAA
GTGCTAAAAATCAATCCATTTCTTGCCCTTCAATAATTGTCCATGCCTGCCTTTTGTTGTTTACATGCTCTTCTGCCCAGACTGTTAGTA
ATCTAGGGACCCCCTTTGGAGCTGATAAGTACAGTTCAGCCTTTTCTCCTCAAATATATAATGACTTTAACATTCCTAAGAATATAGGTA
TTTCTGAATGATTTAAATTTGAGGAATTTTAATACATAAAATACAATGTACAAACTTTCTGCCCACTCAGATCTCTTCTCCATCATGTAC
TTAGTATTTCCCATTAACCTACACACTGATTTTTATGCTACTCCTTGTAGAAACAAAATTCTGGTTTGACTCAGTTTTTGTGTTTATAAA
CTTTTGGAATGTGTACCCCGTTTATGTGAAGAATTATGACCTATCAGTCATAGCTAAATAGTGAACCTCAAAAGTGTTAACTTTTGACTA
TTCATGTGAGGTTTGGTATCTTGCATTTATGTACATGGCTGTAAATTATGTGCATTTACTCTGTATTTATGTTATCTAGCTGACTTTTAC

>83596_83596_2_SLCO2A1-SLC25A36_SLCO2A1_chr3_133692507_ENST00000493729_SLC25A36_chr3_140689769_ENST00000446041_length(amino acids)=345AA_BP=163
MPPRSPLTRPAAPARGAPTPRHSAPGQPPAAMGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTI
EKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGFTAITATNPIWLIKTR
LQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAAT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLCO2A1-SLC25A36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLCO2A1-SLC25A36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLCO2A1-SLC25A36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource