FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATR-XRN1 (FusionGDB2 ID:8360)

Fusion Gene Summary for ATR-XRN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATR-XRN1
Fusion gene ID: 8360
HgeneTgene
Gene symbol

ATR

XRN1

Gene ID

390502

54464

Gene nameserpin family A member 2 (gene/pseudogene)5'-3' exoribonuclease 1
SynonymsARGS|ATR|PIL|SERPINA2P|psiATRSEP1
Cytomap

14q32.13

3q23

Type of geneprotein-codingprotein-coding
Descriptionputative alpha-1-antitrypsin-related proteinserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2serpin A2serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene5'-3' exoribonuclease 1strand-exchange protein 1 homolog
Modification date2020031320200329
UniProtAcc

Q13535

.
Ensembl transtripts involved in fusion geneENST00000350721, ENST00000383101, 
ENST00000463916, ENST00000465074, 
ENST00000544157, ENST00000264951, 
ENST00000392981, 
Fusion gene scores* DoF score8 X 6 X 6=2885 X 7 X 4=140
# samples 108
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATR [Title/Abstract] AND XRN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATR(142253922)-XRN1(142123918), # samples:1
XRN1(142116171)-ATR(142172075), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-96-A4JK-01AATRchr3

142253922

-XRN1chr3

142123918

-


Top

Fusion Gene ORF analysis for ATR-XRN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000350721ENST00000463916ATRchr3

142253922

-XRN1chr3

142123918

-
5CDS-intronENST00000350721ENST00000465074ATRchr3

142253922

-XRN1chr3

142123918

-
5CDS-intronENST00000350721ENST00000544157ATRchr3

142253922

-XRN1chr3

142123918

-
5CDS-intronENST00000383101ENST00000463916ATRchr3

142253922

-XRN1chr3

142123918

-
5CDS-intronENST00000383101ENST00000465074ATRchr3

142253922

-XRN1chr3

142123918

-
5CDS-intronENST00000383101ENST00000544157ATRchr3

142253922

-XRN1chr3

142123918

-
In-frameENST00000350721ENST00000264951ATRchr3

142253922

-XRN1chr3

142123918

-
In-frameENST00000350721ENST00000392981ATRchr3

142253922

-XRN1chr3

142123918

-
In-frameENST00000383101ENST00000264951ATRchr3

142253922

-XRN1chr3

142123918

-
In-frameENST00000383101ENST00000392981ATRchr3

142253922

-XRN1chr3

142123918

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350721ATRchr3142253922-ENST00000264951XRN1chr3142123918-12379406712274742450
ENST00000350721ATRchr3142253922-ENST00000392981XRN1chr3142123918-7689406712274382438
ENST00000383101ATRchr3142253922-ENST00000264951XRN1chr3142123918-12187387512272822386
ENST00000383101ATRchr3142253922-ENST00000392981XRN1chr3142123918-7497387512272462374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350721ENST00000264951ATRchr3142253922-XRN1chr3142123918-0.0001325830.99986744
ENST00000350721ENST00000392981ATRchr3142253922-XRN1chr3142123918-0.0001959850.9998041
ENST00000383101ENST00000264951ATRchr3142253922-XRN1chr3142123918-0.0001293780.99987066
ENST00000383101ENST00000392981ATRchr3142253922-XRN1chr3142123918-0.0001923080.99980766

Top

Fusion Genomic Features for ATR-XRN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ATR-XRN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:142253922/chr3:142123918)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATR

Q13535

.
FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRchr3:142253922chr3:142123918ENST00000350721-2147799_83513152645.0RepeatNote=HEAT 1
HgeneATRchr3:142253922chr3:142123918ENST00000383101-2046799_83512512581.0RepeatNote=HEAT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRchr3:142253922chr3:142123918ENST00000350721-21471640_218513152645.0DomainFAT
HgeneATRchr3:142253922chr3:142123918ENST00000350721-21472322_256713152645.0DomainPI3K/PI4K
HgeneATRchr3:142253922chr3:142123918ENST00000350721-21472612_264413152645.0DomainFATC
HgeneATRchr3:142253922chr3:142123918ENST00000383101-20461640_218512512581.0DomainFAT
HgeneATRchr3:142253922chr3:142123918ENST00000383101-20462322_256712512581.0DomainPI3K/PI4K
HgeneATRchr3:142253922chr3:142123918ENST00000383101-20462612_264412512581.0DomainFATC
HgeneATRchr3:142253922chr3:142123918ENST00000350721-21471329_136513152645.0RepeatNote=HEAT 2
HgeneATRchr3:142253922chr3:142123918ENST00000383101-20461329_136512512581.0RepeatNote=HEAT 2


Top

Fusion Gene Sequence for ATR-XRN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8360_8360_1_ATR-XRN1_ATR_chr3_142253922_ENST00000350721_XRN1_chr3_142123918_ENST00000264951_length(transcript)=12379nt_BP=4067nt
TTCCGGGAGGAGTTTTGGCCTCCACACGGCTCCGTCGGGCGCCGCGCTCTTCCGGCAGCGGTAGCTTTGGAGACGCCGGGAACCCGCGTT
GGCGTGGTTGACTAGTGCCTCGCAGCCTCAGCATGGGGGAACATGGCCTGGAGCTGGCTTCCATGATCCCCGCCCTGCGGGAGCTGGGCA
GTGCCACACCAGAGGAATATAATACAGTTGTACAGAAGCCAAGACAAATTCTGTGTCAATTCATTGACCGGATACTTACAGATGTAAATG
TTGTTGCTGTAGAACTTGTAAAGAAAACTGACTCTCAGCCAACCTCCGTGATGTTGCTTGATTTCATCCAGCATATCATGAAATCCTCCC
CACTTATGTTTGTAAATGTGAGTGGAAGCCATGAGGCCAAAGGCAGTTGTATTGAATTCAGTAATTGGATCATAACGAGACTTCTGCGGA
TTGCAGCAACTCCCTCCTGTCATTTGTTACACAAGAAAATCTGTGAAGTCATCTGTTCATTATTATTTCTTTTTAAAAGCAAGAGTCCTG
CTATTTTTGGGGTACTCACAAAAGAATTATTACAACTTTTTGAAGACTTGGTTTACCTCCATAGAAGAAATGTGATGGGTCATGCTGTGG
AATGGCCAGTGGTCATGAGCCGATTTTTAAGTCAATTAGATGAACACATGGGATATTTACAATCAGCTCCTTTGCAGTTGATGAGTATGC
AAAATTTAGAATTTATTGAAGTCACTTTATTAATGGTTCTTACTCGTATTATTGCAATTGTGTTTTTTAGAAGGCAAGAACTCTTACTTT
GGCAGATAGGTTGTGTTCTGCTAGAGTATGGTAGTCCAAAAATTAAATCCCTAGCAATTAGCTTTTTAACAGAACTTTTTCAGCTTGGAG
GACTACCAGCACAACCAGCTAGCACTTTTTTCAGCTCATTTTTGGAATTATTAAAACACCTTGTAGAAATGGATACTGACCAATTGAAAC
TCTATGAAGAGCCATTATCAAAGCTGATAAAGACACTATTTCCCTTTGAAGCAGAAGCTTATAGAAATATTGAACCTGTCTATTTAAATA
TGCTGCTGGAAAAACTCTGTGTCATGTTTGAAGACGGTGTGCTCATGCGGCTTAAGTCTGATTTGCTAAAAGCAGCTTTGTGCCATTTAC
TGCAGTATTTCCTTAAATTTGTGCCAGCTGGGTATGAATCTGCTTTACAAGTCAGGAAGGTCTATGTGAGAAATATTTGTAAAGCTCTTT
TGGATGTGCTTGGAATTGAGGTAGATGCAGAGTACTTGTTGGGCCCACTTTATGCAGCTTTGAAAATGGAAAGTATGGAAATCATTGAGG
AGATTCAATGCCAAACTCAACAGGAAAACCTCAGCAGTAATAGTGATGGAATATCACCCAAAAGGCGTCGTCTCAGCTCGTCTCTAAACC
CTTCTAAAAGAGCACCAAAACAGACTGAGGAAATTAAACATGTGGACATGAACCAAAAGAGCATATTATGGAGTGCACTGAAACAGAAAG
CTGAATCCCTTCAGATTTCCCTTGAATACAGTGGCCTAAAGAATCCTGTTATTGAGATGTTAGAAGGAATTGCTGTTGTCTTACAACTGA
CTGCTCTGTGTACTGTTCATTGTTCTCATCAAAACATGAACTGCCGTACTTTCAAGGACTGTCAACATAAATCCAAGAAGAAACCTTCTG
TAGTGATAACTTGGATGTCATTGGATTTTTACACAAAAGTGCTTAAGAGCTGTAGAAGTTTGTTAGAATCTGTTCAGAAACTGGACCTGG
AGGCAACCATTGATAAGGTGGTGAAAATTTATGATGCTTTGATTTATATGCAAGTAAACAGTTCATTTGAAGATCATATCCTGGAAGATT
TATGTGGTATGCTCTCACTTCCATGGATTTATTCCCATTCTGATGATGGCTGTTTAAAGTTGACCACATTTGCCGCTAATCTTCTAACAT
TAAGCTGTAGGATTTCAGATAGCTATTCACCACAGGCACAATCACGATGTGTGTTTCTTCTGACTCTGTTTCCAAGAAGAATATTCCTTG
AGTGGAGAACAGCAGTTTACAACTGGGCCCTGCAGAGCTCCCATGAAGTAATCCGGGCTAGTTGTGTTAGTGGATTTTTTATCTTATTGC
AGCAGCAGAATTCTTGTAACAGAGTTCCCAAGATTCTTATAGATAAAGTCAAAGATGATTCTGACATTGTCAAGAAAGAATTTGCTTCTA
TACTTGGTCAACTTGTCTGTACTCTTCACGGCATGTTTTATCTGACAAGTTCTTTAACAGAACCTTTCTCTGAACACGGACATGTGGACC
TCTTCTGTAGGAACTTGAAAGCCACTTCTCAACATGAATGTTCATCTTCTCAACTAAAAGCTTCTGTCTGCAAGCCATTCCTTTTCCTAC
TGAAAAAAAAAATACCTAGTCCAGTAAAACTTGCTTTCATAGATAATCTACATCATCTTTGTAAGCATCTTGATTTTAGAGAAGATGAAA
CAGATGTAAAAGCAGTTCTTGGAACTTTATTAAATTTAATGGAAGATCCAGACAAAGATGTTAGAGTGGCTTTTAGTGGAAATATCAAGC
ACATATTGGAATCCTTGGACTCTGAAGATGGATTTATAAAGGAGCTTTTTGTCTTAAGAATGAAGGAAGCATATACACATGCCCAAATAT
CAAGAAATAATGAGCTGAAGGATACCTTGATTCTTACAACAGGGGATATTGGAAGGGCCGCAAAAGGAGATTTGGTACCATTTGCACTCT
TACACTTATTGCATTGTTTGTTATCCAAGTCAGCATCTGTCTCTGGAGCAGCATACACAGAAATTAGAGCTCTGGTTGCAGCTAAAAGTG
TTAAACTGCAAAGTTTTTTCAGCCAGTATAAGAAACCCATCTGTCAGTTTTTGGTAGAATCCCTTCACTCTAGTCAGATGACAGCACTTC
CGAATACTCCATGCCAGAATGCTGACGTGCGAAAACAAGATGTGGCTCACCAGAGAGAAATGGCTTTAAATACGTTGTCTGAAATTGCCA
ACGTTTTCGACTTTCCTGATCTTAATCGTTTTCTTACTAGGACATTACAAGTTCTACTACCTGATCTTGCTGCCAAAGCAAGCCCTGCAG
CTTCTGCTCTCATTCGAACTTTAGGAAAACAATTAAATGTCAATCGTAGAGAGATTTTAATAAACAACTTCAAATATATTTTTTCTCATT
TGGTCTGTTCTTGTTCCAAAGATGAATTAGAACGTGCCCTTCATTATCTGAAGAATGAAACAGAAATTGAACTGGGGAGCCTGTTGAGAC
AAGATTTCCAAGGATTGCATAATGAATTATTGCTGCGTATTGGAGAACACTATCAACAGGTTTTTAATGGTTTGTCAATACTTGCCTCAT
TTGCATCCAGTGATGATCCATATCAGGGCCCGAGAGATATCATATCACCTGAACTGATGGCTGATTATTTACAACCCAAATTGTTGGGCA
TTTTGGCTTTTTTTAACATGCAGTTACTGAGCTCTAGTGTTGGCATTGAAGATAAGAAAATGGCCTTGAACAGTTTGATGTCTTTGATGA
AGTTAATGGGACCCAAACATGTCAGTTCTGTGAGGGTGAAGATGATGACCACACTGAGAACTGGCCTTCGATTCAAGGATGATTTTCCTG
AATTGTGTTGCAGAGCTTGGGACTGCTTTGTTCGCTGCCTGGATCATGCTTGTCTGGGCTCCCTTCTCAGTCATGTAATAGTAGCTTTGT
TACCTCTTATACACATCCAGCCTAAAGAAACTGCAGCTATCTTCCACTACCTCATAATTGAAAACAGGGATGCTGTGCAAGATTTTCTTC
ATGAAATATATTTTTTACCTGATCATCCAGAATTAAAAAAGATAAAAGCCGTTCTCCAGGAATACAGAAAGGAGACCTCTGAGAGCACTG
ATCTTCAGACAACTCTTCAGCTCTCTATGAAGGCCATTCAACATGAAAATGTCGATGTTCGTATTCATGCTCTTACAAGCTTGAAGGAAA
CCTTGTATAAAAATCAGAAGCGATTATTGGAAGCCATGGAGACATGTAACCACTCCCTCAAAAAGGAAGAGAGGAAAAGAAACCAACATA
GTGAGTGCCTAATGTGCTGGTATGATAGAGACACAGAGTTTATCTATCCTTCTCCATGGCCAGAAAAGTTCCCTGCCATAGAACGATGTT
GTACAAGGTATAAAATAATATCCTTAGATGCTTGGCGTGTAGACATAAACAAAAACAAAATAACCAGAATTGACCAGAAAGCATTATATT
TCTGTGGATTTCCTACTCTGAAACACATCAGACACAAATTTTTTTTGAAGAAAAGTGGTGTTCAAGTATTCCAGCAAAGCAGTCGTGGAG
AAAACATGATGTTGGAAATCTTAGTGGATGCAGAATCAGATGAACTTACCGTAGAAAATGTAGCTTCATCAGTGCTTGGAAAATCTGTCT
TTGTTAATTGGCCTCACCTTGAGGAAGCTAGAGTCGTGGCTGTATCAGATGGAGAAACTAAGTTTTACTTGGAAGAACCTCCAGGAACAC
AGAAGCTTTATTCAGGAAGAACTGCCCCACCATCTAAAGTGGTTCATCTTGGAGATAAAGAACAATCTAACTGGGCAAAAGAAGTACAAG
GAATTTCAGAACACTACCTGAGAAGAAAAGGAATAATAATAAATGAAACATCTGCAGTTGTGTATGCTCAGTTACTCACAGGTCGTAAAT
ATCAAATAAATCAAAATGGTGAAGTTCGTCTAGAGAAACAGTGGTCAAAACAAGTTGTTCCTTTTGTTTATCAAACTATTGTCAAGGACA
TCCGAGCTTTCGACTCCCGTTTCTCCAATATCAAAACATTGGATGATTTGTTTCCTCTGAGAAGTATGGTCTTTATGCTGGGAACTCCCT
ATTATGGCTGCACTGGAGAAGTTCAGGATTCAGGTGATGTGATTACAGAAGGTAGGATTCGTGTGATTTTCAGCATTCCATGTGAACCCA
ATCTTGATGCTTTAATACAGAACCAGCATAAATATTCTATAAAGTACAACCCAGGATATGTGTTGGCCAGTCGCCTTGGAGTGAGTGGAT
ACCTTGTTTCAAGGTTTACAGGAAGTATTTTTATTGGAAGAGGATCTAGGAGAAACCCTCATGGAGACCATAAAGCAAATGTGGGTTTAA
ATCTCAAATTCAACAAGAAAAATGAGGAGGTACCTGGATATACTAAGAAAGTTGGAAGTGAATGGATGTATTCATCTGCAGCAGAACAAC
TTCTGGCAGAGTACTTAGAGAGAGCTCCAGAACTATTTAGTTATATAGCCAAAAATAGCCAAGAGGATGTGTTCTATGAAGATGACATTT
GGCCTGGAGAAAATGAGAATGGTGCTGAAAAAGTTCAAGAAATTATTACTTGGCTAAAAGGACATCCTGTCAGTACTTTATCTCGTTCTT
CTTGTGATTTACAAATTCTGGATGCAGCTATTGTTGAGAAAATTGAGGAAGAAGTCGAAAAGTGCAAGCAAAGAAAGAATAATAAGAAGG
TGCGAGTAACAGTGAAACCCCATTTGCTATACAGACCTTTAGAACAGCAACATGGAGTCATTCCTGATCGGGATGCAGAATTTTGTCTTT
TTGACCGTGTTGTAAATGTGAGAGAAAACTTCTCAGTTCCAGTTGGCCTTCGAGGCACCATCATAGGAATAAAAGGAGCTAATAGAGAAG
CCGATGTACTATTTGAAGTATTATTTGATGAAGAATTTCCTGGAGGGTTAACAATAAGATGCTCACCTGGTAGAGGTTATCGACTGCCAA
CAAGTGCCTTGGTGAACCTTTCTCATGGGAGTCGCTCTGAAACTGGAAATCAGAAGTTGACAGCCATCGTAAAACCACAACCAGCTGTAC
ATCAACATAGCTCAAGTTCATCAGTTTCCTCTGGGCATTTGGGAGCCCTCAACCATTCCCCTCAATCACTTTTTGTTCCTACTCAAGTAC
CTACTAAAGATGATGATGAATTCTGCAACATTTGGCAGTCCTTACAGGGATCTGGAAAGATGCAATACTTTCAGCCAACTATACAAGAGA
AGGGTGCAGTTCTACCTCAAGAAATAAGCCAAGTAAATCAACATCATAAATCTGGCTTTAATGACAACAGTGTTAAATATCAGCAAAGAA
AACATGACCCTCACAGAAAATTTAAAGAAGAGTGTAAGAGTCCTAAAGCTGAGTGTTGGTCCCAAAAAATGTCCAATAAGCAGCCTAACT
CTGGAATTGAGAACTTTTTAGCATCTTTGAATATCTCCAAAGAAAATGAAGTACAGTCATCTCATCATGGGGAGCCTCCAAGTGAAGAGC
ATTTGTCACCACAGTCATTTGCCATGGGAACACGGATGCTTAAAGAAATTCTAAAAATTGATGGCTCTAACACTGTGGACCATAAGAATG
AAATCAAACAGATTGCTAATGAAATCCCTGTTTCCTCTAACAGAAGAGATGAATATGGATTACCCTCTCAGCCTAAACAAAATAAGAAAT
TAGCATCTTATATGAACAAGCCTCACAGTGCTAATGAGTACCATAATGTTCAGTCTATGGACAATATGTGTTGGCCTGCCCCCAGCCAGA
TCCCTCCTGTATCCACACCAGTAACTGAACTTTCTCGAATTTGTTCCCTTGTTGGAATGCCACAACCTGATTTCTCCTTTCTTAGGATGC
CACAGACAATGACCGTTTGCCAAGTAAAATTATCTAATGGCTTACTGGTACATGGGCCACAGTGCCACTCTGAAAATGAAGCCAAAGAGA
AAGCTGCACTTTTTGCTTTACAACAGTTGGGCTCCTTAGGCATGAATTTCCCTTTGCCTTCACAAGTATTTGCAAATTATCCTTCAGCTG
TACCACCTGGAACCATTCCTCCAGCCTTTCCCCCACCTACTGGCTGGGATCACTATGGAAGCAACTATGCATTGGGGGCAGCTAATATAA
TGCCTTCGTCGTCTCATCTCTTTGGCTCAATGCCATGGGGACCATCGGTGCCAGTTCCTGGGAAGCCCTTCCATCATACTTTATATTCTG
GGACCATGCCCATGGCTGGGGGAATACCAGGGGGTGTGCACAATCAGTTTATACCTCTGCAGGTTACTAAAAAAAGGGTTGCAAACAAAA
AGAACTTTGAGAATAAGGAAGCCCAGAGTTCTCAAGCCACTCCAGTTCAGACTAGCCAGCCAGATTCTTCCAACATTGTCAAAGTAAGTC
CACGGGAGAGCTCATCAGCTTCTTTGAAGTCCTCTCCGATTGCTCAACCTGCATCTTCTTTTCAAGTTGAAACTGCCTCTCAAGGCCATA
GTATATCTCACCATAAGTCAACACCAATCTCTTCTTCAAGAAGAAAATCAAGAAAACTGGCTGTTAATTTTGGTGTTTCTAAACCTTCTG
AGTAAATTTGGCTCTTAGAATTAAGTTAATTTCTTCTCTTTCCATCTACCTTTTTATAAATACATATCTATGTCTCATAAAAATTAGAAT
GTACTATTTTAAAATAATATGTGTAAATTGAAATTTTTTTCATTTTTAAGTTATCAGGCACTTTTCATGCTGTTTAAAAGACTGTGTATC
AAATTGTGCACTTTAAGTATGTGCAGTTTGTTGTATGTCAATTATACCTCAATAAATCTGTAATAAAAAACTAAATTAAACCTTGCATTA
AAATAATATCACAGTATCAGTGGACTAAACATTAAAATGTACCACTCTAATCATTGGCCTCATGATTGAAGCATCCTGAACTATGAATTA
GACATCAGTTAGCAATAATAAGCATTTTTTACACTATCATTGAGGAATAATTACATGGAGCATGAAATTTGGGCCTCCAGTATAACTTAC
TGAATGTGGATTTTATTTCTCTTTTTAATGATGTAAGAAAATTGTCAGGAGAATGGCTCTTATTTATGTGTGTTTTAACTTATGCTTTGT
TGCCTCTGAGGGTCTTTAGACCTGCTGTGAAAGGATCACATTTGTTGTGGTGCTGCCAGTTTTGCTTTATTCTAAATTTTGTACCAAAGC
AACTTTAGAATAATCAGAATATTTCATCTAACTGCTTAGAACTATAAATAGCATTCTAAATTTGAGTAAATACAATTTTTTAGGTTACTC
AAGAACCAGCATTAGTAATTTCTAGTAAAATTGTTTCAAAATCTACAGGGTACAATGATTACAAATTAATCTTCTAACAAAATAAAATAT
GAAATATTAGTCATGTTAATTAATAAACTGTATTATTTTGTATAGCTTTTTATTTGCTTACCTGACATTTTATGAGAGCTTCATAGTTGG
TCGGTATGTAGTGCTTCTTGGGACTGAAGAAATTCTAATTGTTGTTTAAGTTCCAAGGTGTGCTACAATATAGGAGGCACAGTCATCAGT
TTGTGACATACATTATTTACTGCCTATTTCATTCTGATTCTATATTTTTAGCTTTATGCTGAACTGTTCAATGATGCTGGGATTCTCTCT
TTGCATGTCATATGTGAATGTGTGGTTCAAGCTGTAACTGTTGAAATTATTTTAGAATTTATGACGATTTCTCAGCAGGGCCTATGTTTA
TATATATATATATATTTATTCTTTAGTTTTTGTGATATGCTTATATTTTTAAGGAAGTAAGTTATAGCATACTTTTTTAAAAGTAGGAAC
CACAATCTTTATATGGAGCAGCTTGTTATATCTGATTTTCATGTAACTCATTGGAAACTCTGCCATGACTCTTAAAGTAGTCTTACTTGT
TTTTTAAAATGCTGGTATTAAACTAAATGGACTCCTTTCACTAACTGCTGATTTCAGAGTTTAAATGTTAGCAGGATATTTGTGTATTAG
CAGTGCCTTCAGTATAAGAGAGAAATATTCATTATCTGTCATTTATCATAGTCGTATAAGTTTCCATGATTTTATTTTCTGTTATTTTCA
TAAGTTCAGATGTTTATCAGTTCCCAACATTGTTTCTTTATCTGTAGTGGGATCTTGAGTAATGAGGCTCAAGTAAATCCTCAATGTGTA
TAATTATTGCCTCATAAACTCTCTCTTTGTTTTTAAAGGAAACATCTATTATGGTAATACAAAGAAAAGTTAAATTGTGACAGTAATGTT
ATATTAACCTCTTCCTACTTTAAAGTGTGAAATGTTTCACCTCAGCTGTACAAACTCCAGCATTGAGAATTTGCCTCACTCATTACTCCT
GTGTGACAGTTATATAAATAGCATGCAGCTCACATCTGTTTTAGAGCATAGAAGAAGCGGCACCTGCCATCTTCTGAAAACTCCAAAGGG
AAATTTCAGTAGACATAGTGCACTAAACCCATAAGGATACTTGACCAATATTTGAGCACAGCAAGCTGACAGTTCTATACAGATAGGCAG
TGAAAGAGTTTTATTTTCCAGCCAGGCGCAGTGGCTCAAATCCCAGCACTTCGGGAGGCTAAGGCAGGCGGATCACTTGAGGTCCGGAGT
TCCAGACAAGCCTGGCCAACATGATGAAGCCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGATGGCACATGCCTTTAGTCCCA
GCTACTCGGGAGGCTGAGGCATGAGAATCATTTGAACCCGCGAGGCAGAGTCTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTG
GAGAGCAGAGCAAGACTCTGTCTCAAAAAAAAGAAAAAAGTTTTATTATCCTTACTTTTTTTTTAACATTATTATTCTAAAGGTCAAAAC
TGAGAAGAGATTAAGATAGGAGAGAGCTCCATAATGGCTGGATAGTGGTCAGGCATTCTCTATTCTTTTCCCCCTGTAGACCCATTCTAA
ATGTGGGCCTGAGGTCAATGGGAGATGTGCCCTCCCTATGGAGGATGTAAGAAGCAGAGGCCATTTCTGCCCCATGTTGAGGAAACAATC
TGTTGATAGACCTGGAATTTAGAGTATATCTGAAAAGCAGTTGGACTTCAAGAAATTTAAAATTCTCTCTTTGAGATGGGGTGGACTAAG
ACCACCCCCAAAGTTTAAAAATATGCTCATTCAACTTGAATCTTCTGAGGACTTTTTGTGAAAATGGTGGACTGTTTAGGGCATAGGACA
GATTCCCCAAATTGCTTTATGCTTCCACATAACTAGAGCACTTCAATCTATTTAAGCCTTTGTCTCCTAACTGAAACATTATTTCTAAAT
ATTTCTATTCAATAAGTTTTTTCTTTTTTGAGCAACTTAAGTGAATTTTGAAGATTGCTCCTTCCAGTCTCGTTCCTTTTCACATTTTCC
TGCATTACCTAATAATTACCTCAGCGTTAGAATTTGAATGTATTAATTGATTTAAACATCATGTAGACTAAAGTCTTAAACATCTAAGAC
TCAGTTGTAGTTGCAGAAAAAAATTAAAGTCACCTCTACTGAACCTTGGTTTCAATTTAAGATTTTTCTTGCTTTTCAAAGGGGTAACTA
ATAAAGATTGAAGGGTTTTTTTCCCGATTGGTGGAGGAATGAAGAACTATTGATGCAAGTTTTTTTATTGTTTCTTTCTATGATCAGGTA
CCTGCTTTCATTTTAGACTGCTACTTCCAAACTAAGCTAGATTCTTGGTTTTAATGAGAGGAGGCAGAGAGAGGGAGGCAGATGGAAGAA
GAAAAACAGTTAAATAAGACATACCCAGTCACTGCATTTTTGGACTATACCGTATCTTTCTAGCACAAGGAAATAGATAAACTGTAAGGT
CTTTTTTACTCACTTTTTATTTATGTGTTCTATTTGTGTTAGTCATAACTGTTTATAGTGGTTGTCTAATTTTTACTTTTATTATATGAG
ATAGAGCTGTGCAGATCTTCACTCAAGTTAGTTCTGTCACGCTTCTTCCCATTATTTAGAGCACAGTTTTTTAAAGCAACTGTACAATTT
CTCAGCCTTATGAGCTTGCTGTATTTCTTGGTATCATGTTGCTTCCAAATTTTGTTTTTACTGTAGAAGACAATTAATTTATTGTAGAGA
AGTGGCTGTGAAAGTCGTTCTCTGTCTTTAAAAATCAATTGCAGAAGTTCATTTGTCATTTTTCTAGAGATAAATTATAGTACTCAAACT
GGCAGTGCTCAGTATATACATTTTGTAAGCTTTGTCAGTGAAACCATCAGTTTTGCAGGAGCTTCCTTTCCTAGTCAAGATAAAGCTTAA
AATTCCAGAAATTAATGTCGTTCGGACTGACTTTATTCATATTTCCATCAAACTTCTCCAATACAGTAAGAGATAGTGTTGAACCAGCAT
CAAGTCTCCAGAAACATGGCAGAGCAGACAGGCCGTTAAGTTTCACAGACATCATAGATCCTTTTCTTAAAGAAGAAAAACATGTATAAA
ATAGTTTTAGTAGTCCAAAATGTCAACTATCTGTAGCTGCTTTTGTGTGTGTGTCAGTGAACAAATAATAATGCCTTGCTCAATCAATGC
ATTCAGCCATCTCAAGTGCAATTTGTGAAGGAGACTATGGTTTCCAAAAGATACATTTTTTTACAAAGTTAAACCTGTAAAAAGTCTTTT
TTTTTTTCCCTCCAGCCGTACACCAACTGCACTTGGTTGTTTCAGCAGTTGGTATACTATTAAATTGTCCAGGCCAAATAGGTTTCTGTA
GCTGTTTTAGTAATTTGAAGCCAAATTCTCATGCTGTTTCTCATTAAAAAGAATGAGAATTTGGTCCATAGTTAGCTTTAAGTTCTCTCT
TCCTTTCTTTCCCTTACAGTTAAGGGTTTGGTGGGGGATGGGGAGGTTGTTTTCGTTTTTTGGATTTTTTTGTCTTTTGGCTTTAAGTAT
CATATTTTCTTTTGCCTGTATCCAACTGCTTCTTTGAGTATTTTCATCTAGTTTAATGTGAGTAATAGATGCTGTGCTGTCATTGAAGTG
TTCAACATTTTGTTCATTTAAACAAAAGTGTAATTCATACATATATAGATACATATCTTAATTGATTTCTCAACTATTTTATAAGTAACT
GGAATTTTTCATTAGATCTTATACAGAGAAGTATTTTATTAAAAATTCAAAAGGGAAGACTTTTATGTGCTCATTTTGTAATTTTTGATT
TTAAATATCTTTACATTGTCTGCCAATTAAAGTGTTTTAAACTTGCATTGGAATGGACTCCGAATGTATTTTTGTGGTGTTACGTTATCC
GTAGATTTCTAGCATGAAGTTAGCCTCACGATGCTGTGCAAAGGATTTTAAAATATGAGAGTCACTGAAAGAGTTTAAACATCTGTTCAT

>8360_8360_1_ATR-XRN1_ATR_chr3_142253922_ENST00000350721_XRN1_chr3_142123918_ENST00000264951_length(amino acids)=2450AA_BP=0
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSH
EAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFF
SSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE
IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSP
QAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLL
NLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRF
LTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSV
RVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRD
TEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDA
ESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKG
IIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDS
GDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEV
PGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAI
VEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDE
EFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNI
WQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLN
ISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSA
NEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLG
SLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPG
GVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPIS

--------------------------------------------------------------
>8360_8360_2_ATR-XRN1_ATR_chr3_142253922_ENST00000350721_XRN1_chr3_142123918_ENST00000392981_length(transcript)=7689nt_BP=4067nt
TTCCGGGAGGAGTTTTGGCCTCCACACGGCTCCGTCGGGCGCCGCGCTCTTCCGGCAGCGGTAGCTTTGGAGACGCCGGGAACCCGCGTT
GGCGTGGTTGACTAGTGCCTCGCAGCCTCAGCATGGGGGAACATGGCCTGGAGCTGGCTTCCATGATCCCCGCCCTGCGGGAGCTGGGCA
GTGCCACACCAGAGGAATATAATACAGTTGTACAGAAGCCAAGACAAATTCTGTGTCAATTCATTGACCGGATACTTACAGATGTAAATG
TTGTTGCTGTAGAACTTGTAAAGAAAACTGACTCTCAGCCAACCTCCGTGATGTTGCTTGATTTCATCCAGCATATCATGAAATCCTCCC
CACTTATGTTTGTAAATGTGAGTGGAAGCCATGAGGCCAAAGGCAGTTGTATTGAATTCAGTAATTGGATCATAACGAGACTTCTGCGGA
TTGCAGCAACTCCCTCCTGTCATTTGTTACACAAGAAAATCTGTGAAGTCATCTGTTCATTATTATTTCTTTTTAAAAGCAAGAGTCCTG
CTATTTTTGGGGTACTCACAAAAGAATTATTACAACTTTTTGAAGACTTGGTTTACCTCCATAGAAGAAATGTGATGGGTCATGCTGTGG
AATGGCCAGTGGTCATGAGCCGATTTTTAAGTCAATTAGATGAACACATGGGATATTTACAATCAGCTCCTTTGCAGTTGATGAGTATGC
AAAATTTAGAATTTATTGAAGTCACTTTATTAATGGTTCTTACTCGTATTATTGCAATTGTGTTTTTTAGAAGGCAAGAACTCTTACTTT
GGCAGATAGGTTGTGTTCTGCTAGAGTATGGTAGTCCAAAAATTAAATCCCTAGCAATTAGCTTTTTAACAGAACTTTTTCAGCTTGGAG
GACTACCAGCACAACCAGCTAGCACTTTTTTCAGCTCATTTTTGGAATTATTAAAACACCTTGTAGAAATGGATACTGACCAATTGAAAC
TCTATGAAGAGCCATTATCAAAGCTGATAAAGACACTATTTCCCTTTGAAGCAGAAGCTTATAGAAATATTGAACCTGTCTATTTAAATA
TGCTGCTGGAAAAACTCTGTGTCATGTTTGAAGACGGTGTGCTCATGCGGCTTAAGTCTGATTTGCTAAAAGCAGCTTTGTGCCATTTAC
TGCAGTATTTCCTTAAATTTGTGCCAGCTGGGTATGAATCTGCTTTACAAGTCAGGAAGGTCTATGTGAGAAATATTTGTAAAGCTCTTT
TGGATGTGCTTGGAATTGAGGTAGATGCAGAGTACTTGTTGGGCCCACTTTATGCAGCTTTGAAAATGGAAAGTATGGAAATCATTGAGG
AGATTCAATGCCAAACTCAACAGGAAAACCTCAGCAGTAATAGTGATGGAATATCACCCAAAAGGCGTCGTCTCAGCTCGTCTCTAAACC
CTTCTAAAAGAGCACCAAAACAGACTGAGGAAATTAAACATGTGGACATGAACCAAAAGAGCATATTATGGAGTGCACTGAAACAGAAAG
CTGAATCCCTTCAGATTTCCCTTGAATACAGTGGCCTAAAGAATCCTGTTATTGAGATGTTAGAAGGAATTGCTGTTGTCTTACAACTGA
CTGCTCTGTGTACTGTTCATTGTTCTCATCAAAACATGAACTGCCGTACTTTCAAGGACTGTCAACATAAATCCAAGAAGAAACCTTCTG
TAGTGATAACTTGGATGTCATTGGATTTTTACACAAAAGTGCTTAAGAGCTGTAGAAGTTTGTTAGAATCTGTTCAGAAACTGGACCTGG
AGGCAACCATTGATAAGGTGGTGAAAATTTATGATGCTTTGATTTATATGCAAGTAAACAGTTCATTTGAAGATCATATCCTGGAAGATT
TATGTGGTATGCTCTCACTTCCATGGATTTATTCCCATTCTGATGATGGCTGTTTAAAGTTGACCACATTTGCCGCTAATCTTCTAACAT
TAAGCTGTAGGATTTCAGATAGCTATTCACCACAGGCACAATCACGATGTGTGTTTCTTCTGACTCTGTTTCCAAGAAGAATATTCCTTG
AGTGGAGAACAGCAGTTTACAACTGGGCCCTGCAGAGCTCCCATGAAGTAATCCGGGCTAGTTGTGTTAGTGGATTTTTTATCTTATTGC
AGCAGCAGAATTCTTGTAACAGAGTTCCCAAGATTCTTATAGATAAAGTCAAAGATGATTCTGACATTGTCAAGAAAGAATTTGCTTCTA
TACTTGGTCAACTTGTCTGTACTCTTCACGGCATGTTTTATCTGACAAGTTCTTTAACAGAACCTTTCTCTGAACACGGACATGTGGACC
TCTTCTGTAGGAACTTGAAAGCCACTTCTCAACATGAATGTTCATCTTCTCAACTAAAAGCTTCTGTCTGCAAGCCATTCCTTTTCCTAC
TGAAAAAAAAAATACCTAGTCCAGTAAAACTTGCTTTCATAGATAATCTACATCATCTTTGTAAGCATCTTGATTTTAGAGAAGATGAAA
CAGATGTAAAAGCAGTTCTTGGAACTTTATTAAATTTAATGGAAGATCCAGACAAAGATGTTAGAGTGGCTTTTAGTGGAAATATCAAGC
ACATATTGGAATCCTTGGACTCTGAAGATGGATTTATAAAGGAGCTTTTTGTCTTAAGAATGAAGGAAGCATATACACATGCCCAAATAT
CAAGAAATAATGAGCTGAAGGATACCTTGATTCTTACAACAGGGGATATTGGAAGGGCCGCAAAAGGAGATTTGGTACCATTTGCACTCT
TACACTTATTGCATTGTTTGTTATCCAAGTCAGCATCTGTCTCTGGAGCAGCATACACAGAAATTAGAGCTCTGGTTGCAGCTAAAAGTG
TTAAACTGCAAAGTTTTTTCAGCCAGTATAAGAAACCCATCTGTCAGTTTTTGGTAGAATCCCTTCACTCTAGTCAGATGACAGCACTTC
CGAATACTCCATGCCAGAATGCTGACGTGCGAAAACAAGATGTGGCTCACCAGAGAGAAATGGCTTTAAATACGTTGTCTGAAATTGCCA
ACGTTTTCGACTTTCCTGATCTTAATCGTTTTCTTACTAGGACATTACAAGTTCTACTACCTGATCTTGCTGCCAAAGCAAGCCCTGCAG
CTTCTGCTCTCATTCGAACTTTAGGAAAACAATTAAATGTCAATCGTAGAGAGATTTTAATAAACAACTTCAAATATATTTTTTCTCATT
TGGTCTGTTCTTGTTCCAAAGATGAATTAGAACGTGCCCTTCATTATCTGAAGAATGAAACAGAAATTGAACTGGGGAGCCTGTTGAGAC
AAGATTTCCAAGGATTGCATAATGAATTATTGCTGCGTATTGGAGAACACTATCAACAGGTTTTTAATGGTTTGTCAATACTTGCCTCAT
TTGCATCCAGTGATGATCCATATCAGGGCCCGAGAGATATCATATCACCTGAACTGATGGCTGATTATTTACAACCCAAATTGTTGGGCA
TTTTGGCTTTTTTTAACATGCAGTTACTGAGCTCTAGTGTTGGCATTGAAGATAAGAAAATGGCCTTGAACAGTTTGATGTCTTTGATGA
AGTTAATGGGACCCAAACATGTCAGTTCTGTGAGGGTGAAGATGATGACCACACTGAGAACTGGCCTTCGATTCAAGGATGATTTTCCTG
AATTGTGTTGCAGAGCTTGGGACTGCTTTGTTCGCTGCCTGGATCATGCTTGTCTGGGCTCCCTTCTCAGTCATGTAATAGTAGCTTTGT
TACCTCTTATACACATCCAGCCTAAAGAAACTGCAGCTATCTTCCACTACCTCATAATTGAAAACAGGGATGCTGTGCAAGATTTTCTTC
ATGAAATATATTTTTTACCTGATCATCCAGAATTAAAAAAGATAAAAGCCGTTCTCCAGGAATACAGAAAGGAGACCTCTGAGAGCACTG
ATCTTCAGACAACTCTTCAGCTCTCTATGAAGGCCATTCAACATGAAAATGTCGATGTTCGTATTCATGCTCTTACAAGCTTGAAGGAAA
CCTTGTATAAAAATCAGAAGCGATTATTGGAAGCCATGGAGACATGTAACCACTCCCTCAAAAAGGAAGAGAGGAAAAGAAACCAACATA
GTGAGTGCCTAATGTGCTGGTATGATAGAGACACAGAGTTTATCTATCCTTCTCCATGGCCAGAAAAGTTCCCTGCCATAGAACGATGTT
GTACAAGGTATAAAATAATATCCTTAGATGCTTGGCGTGTAGACATAAACAAAAACAAAATAACCAGAATTGACCAGAAAGCATTATATT
TCTGTGGATTTCCTACTCTGAAACACATCAGACACAAATTTTTTTTGAAGAAAAGTGGTGTTCAAGTATTCCAGCAAAGCAGTCGTGGAG
AAAACATGATGTTGGAAATCTTAGTGGATGCAGAATCAGATGAACTTACCGTAGAAAATGTAGCTTCATCAGTGCTTGGAAAATCTGTCT
TTGTTAATTGGCCTCACCTTGAGGAAGCTAGAGTCGTGGCTGTATCAGATGGAGAAACTAAGTTTTACTTGGAAGAACCTCCAGGAACAC
AGAAGCTTTATTCAGGAAGAACTGCCCCACCATCTAAAGTGGTTCATCTTGGAGATAAAGAACAATCTAACTGGGCAAAAGAAGTACAAG
GAATTTCAGAACACTACCTGAGAAGAAAAGGAATAATAATAAATGAAACATCTGCAGTTGTGTATGCTCAGTTACTCACAGGTCGTAAAT
ATCAAATAAATCAAAATGGTGAAGTTCGTCTAGAGAAACAGTGGTCAAAACAAGTTGTTCCTTTTGTTTATCAAACTATTGTCAAGGACA
TCCGAGCTTTCGACTCCCGTTTCTCCAATATCAAAACATTGGATGATTTGTTTCCTCTGAGAAGTATGGTCTTTATGCTGGGAACTCCCT
ATTATGGCTGCACTGGAGAAGTTCAGGATTCAGGTGATGTGATTACAGAAGGTAGGATTCGTGTGATTTTCAGCATTCCATGTGAACCCA
ATCTTGATGCTTTAATACAGAACCAGCATAAATATTCTATAAAGTACAACCCAGGATATGTGTTGGCCAGTCGCCTTGGAGTGAGTGGAT
ACCTTGTTTCAAGGTTTACAGGAAGTATTTTTATTGGAAGAGGATCTAGGAGAAACCCTCATGGAGACCATAAAGCAAATGTGGGTTTAA
ATCTCAAATTCAACAAGAAAAATGAGGAGGTACCTGGATATACTAAGAAAGTTGGAAGTGAATGGATGTATTCATCTGCAGCAGAACAAC
TTCTGGCAGAGTACTTAGAGAGAGCTCCAGAACTATTTAGTTATATAGCCAAAAATAGCCAAGAGGATGTGTTCTATGAAGATGACATTT
GGCCTGGAGAAAATGAGAATGGTGCTGAAAAAGTTCAAGAAATTATTACTTGGCTAAAAGGACATCCTGTCAGTACTTTATCTCGTTCTT
CTTGTGATTTACAAATTCTGGATGCAGCTATTGTTGAGAAAATTGAGGAAGAAGTCGAAAAGTGCAAGCAAAGAAAGAATAATAAGAAGG
TGCGAGTAACAGTGAAACCCCATTTGCTATACAGACCTTTAGAACAGCAACATGGAGTCATTCCTGATCGGGATGCAGAATTTTGTCTTT
TTGACCGTGTTGTAAATGTGAGAGAAAACTTCTCAGTTCCAGTTGGCCTTCGAGGCACCATCATAGGAATAAAAGGAGCTAATAGAGAAG
CCGATGTACTATTTGAAGTATTATTTGATGAAGAATTTCCTGGAGGGTTAACAATAAGATGCTCACCTGGTAGAGGTTATCGACTGCCAA
CAAGTGCCTTGGTGAACCTTTCTCATGGGAGTCGCTCTGAAACTGGAAATCAGAAGTTGACAGCCATCGTAAAACCACAACCAGCTGTAC
ATCAACATAGCTCAAGTTCATCAGTTTCCTCTGGGCATTTGGGAGCCCTCAACCATTCCCCTCAATCACTTTTTGTTCCTACTCAAGTAC
CTACTAAAGATGATGATGAATTCTGCAACATTTGGCAGTCCTTACAGGGATCTGGAAAGATGCAATACTTTCAGCCAACTATACAAGAGA
AGGGTGCAGTTCTACCTCAAGAAATAAGCCAAGTAAATCAACATCATAAATCTGGCTTTAATGACAACAGTGTTAAATATCAGCAAAGAA
AACATGACCCTCACAGAAAATTTAAAGAAGAGTGTAAGAGTCCTAAAGCTGAGTGTTGGTCCCAAAAAATGTCCAATAAGCAGCCTAACT
CTGGAATTGAGAACTTTTTAGCATCTTTGAATATCTCCAAAGAAAATGAAGTACAGTCATCTCATCATGGGGAGCCTCCAAGTGAAGAGC
ATTTGTCACCACAGTCATTTGCCATGAAGGGAACACGGATGCTTAAAGAAATTCTAAAAATTGATGGCTCTAACACTGTGGACCATAAGA
ATGAAATCAAACAGATTGCTAATGAAATCCCTGTTTCCTCTAACAGAAGAGATGAATATGGATTACCCTCTCAGCCTAAACAAAATAAGA
AATTAGCATCTTATATGAACAAGCCTCACAGTGCTAATGAGTACCATAATGTTCAGTCTATGGACAATATGTGTTGGCCTGCCCCCAGCC
AGATCCCTCCTGTATCCACACCAGTAACTGAACTTTCTCGAATTTGTTCCCTTGTTGGAATGCCACAACCTGATTTCTCCTTTCTTAGGA
TGCCACAGACAATGACCGTTTGCCAAGTAAAATTATCTAATGGCTTACTGGTACATGGGCCACAGTGCCACTCTGAAAATGAAGCCAAAG
AGAAAGCTGCACTTTTTGCTTTACAACAGTTGGGCTCCTTAGGCATGAATTTCCCTTTGCCTTCACAAGTATTTGCAAATTATCCTTCAG
CTGTACCACCTGGAACCATTCCTCCAGCCTTTCCCCCACCTACTGCTAATATAATGCCTTCGTCGTCTCATCTCTTTGGCTCAATGCCAT
GGGGACCATCGGTGCCAGTTCCTGGGAAGCCCTTCCATCATACTTTATATTCTGGGACCATGCCCATGGCTGGGGGAATACCAGGGGGTG
TGCACAATCAGTTTATACCTCTGCAGGTTACTAAAAAAAGGGTTGCAAACAAAAAGAACTTTGAGAATAAGGAAGCCCAGAGTTCTCAAG
CCACTCCAGTTCAGACTAGCCAGCCAGATTCTTCCAACATTGTCAAAGTAAGTCCACGGGAGAGCTCATCAGCTTCTTTGAAGTCCTCTC
CGATTGCTCAACCTGCATCTTCTTTTCAAGTTGAAACTGCCTCTCAAGGCCATAGTATATCTCACCATAAGTCAACACCAATCTCTTCTT
CAAGAAGAAAATCAAGAAAACTGGCTGTTAATTTTGGTGTTTCTAAACCTTCTGAGTAAATTTGGCTCTTAGAATTAAGTTAATTTCTTC
TCTTTCCATCTACCTTTTTATAAATACATATCTATGTCTCATAAAAATTAGAATGTACTATTTTAAAATAATATGTGTAAATTGAAATTT
TTTTCATTTTTAAGTTATCAGGCACTTTTCATGCTGTTTAAAAGACTGTGTATCAAATTGTGCACTTTAAGTATGTGCAGTTTGTTGTAT

>8360_8360_2_ATR-XRN1_ATR_chr3_142253922_ENST00000350721_XRN1_chr3_142123918_ENST00000392981_length(amino acids)=2438AA_BP=0
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSH
EAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFF
SSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE
IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSP
QAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLL
NLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRF
LTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSV
RVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRD
TEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDA
ESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKG
IIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDS
GDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEV
PGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAI
VEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDE
EFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNI
WQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLN
ISKENEVQSSHHGEPPSEEHLSPQSFAMKGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHS
ANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQL
GSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVT
KKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVN

--------------------------------------------------------------
>8360_8360_3_ATR-XRN1_ATR_chr3_142253922_ENST00000383101_XRN1_chr3_142123918_ENST00000264951_length(transcript)=12187nt_BP=3875nt
TTCCGGGAGGAGTTTTGGCCTCCACACGGCTCCGTCGGGCGCCGCGCTCTTCCGGCAGCGGTAGCTTTGGAGACGCCGGGAACCCGCGTT
GGCGTGGTTGACTAGTGCCTCGCAGCCTCAGCATGGGGGAACATGGCCTGGAGCTGGCTTCCATGATCCCCGCCCTGCGGGAGCTGGGCA
GTGCCACACCAGAGGAATATAATACAGTTGTACAGAAGCCAAGACAAATTCTGTGTCAATTCATTGACCGGATACTTACAGATGTAAATG
TTGTTGCTGTAGAACTTGTAAAGAAAACTGACTCTCAGCCAACCTCCGTGATGTTGCTTGATTTCATCCAGCATATCATGAAATCCTCCC
CACTTATGTTTGTAAATGTGAGTGGAAGCCATGAGGCCAAAGGCAGTTGTATTGAATTCAGTAATTGGATCATAACGAGACTTCTGCGGA
TTGCAGCAACTCCCTCCTGTCATTTGTTACACAAGAAAATCTGTGAAGTCATCTGTTCATTATTATTTCTTTTTAAAAGCAAGAGTCCTG
CTATTTTTGGGGTACTCACAAAAGAATTATTACAACTTTTTGAAGACTTGGTTTACCTCCATAGAAGAAATGTGATGGGTCATGCTGTGG
AATGGCCAGTGGTCATGAGCCGATTTTTAAGTCAATTAGATGAACACATGGGATATTTACAATCAGCTCCTTTGCAGTTGATGAGTATGC
AAAATTTAGAATTTATTGAAGTCACTTTATTAATGGTTCTTACTCGTATTATTGCAATTGTGTTTTTTAGAAGGCAAGAACTCTTACTTT
GGCAGATAGGTTGTGTTCTGCTAGAGTATGGTAGTCCAAAAATTAAATCCCTAGCAATTAGCTTTTTAACAGAACTTTTTCAGCTTGGAG
GACTACCAGCACAACCAGCTAGCACTTTTTTCAGCTCATTTTTGGAATTATTAAAACACCTTGTAGAAATGGATACTGACCAATTGAAAC
TCTATGAAGAGCCATTATCAAAGCTGATAAAGACACTATTTCCCTTTGAAGCAGAAGCTTATAGAAATATTGAACCTGTCTATTTAAATA
TGCTGCTGGAAAAACTCTGTGTCATGTTTGAAGACGGTGTGCTCATGCGGCTTAAGTCTGATTTGCTAAAAGCAGCTTTGTGCCATTTAC
TGCAGTATTTCCTTAAATTTGTGCCAGCTGGGTATGAATCTGCTTTACAAGTCAGGAAGGTCTATGTGAGAAATATTTGTAAAGCTCTTT
TGGATGTGCTTGGAATTGAGGTAGATGCAGAGTACTTGTTGGGCCCACTTTATGCAGCTTTGAAAATGGAAAGTATGGAAATCATTGAGG
AGATTCAATGCCAAACTCAACAGGAAAACCTCAGCAGTAATAGTGATGGAATATCACCCAAAAGGCGTCGTCTCAGCTCGTCTCTAAACC
CTTCTAAAAGAGCACCAAAACAGACTGAGGACCGTACTTTCAAGGACTGTCAACATAAATCCAAGAAGAAACCTTCTGTAGTGATAACTT
GGATGTCATTGGATTTTTACACAAAAGTGCTTAAGAGCTGTAGAAGTTTGTTAGAATCTGTTCAGAAACTGGACCTGGAGGCAACCATTG
ATAAGGTGGTGAAAATTTATGATGCTTTGATTTATATGCAAGTAAACAGTTCATTTGAAGATCATATCCTGGAAGATTTATGTGGTATGC
TCTCACTTCCATGGATTTATTCCCATTCTGATGATGGCTGTTTAAAGTTGACCACATTTGCCGCTAATCTTCTAACATTAAGCTGTAGGA
TTTCAGATAGCTATTCACCACAGGCACAATCACGATGTGTGTTTCTTCTGACTCTGTTTCCAAGAAGAATATTCCTTGAGTGGAGAACAG
CAGTTTACAACTGGGCCCTGCAGAGCTCCCATGAAGTAATCCGGGCTAGTTGTGTTAGTGGATTTTTTATCTTATTGCAGCAGCAGAATT
CTTGTAACAGAGTTCCCAAGATTCTTATAGATAAAGTCAAAGATGATTCTGACATTGTCAAGAAAGAATTTGCTTCTATACTTGGTCAAC
TTGTCTGTACTCTTCACGGCATGTTTTATCTGACAAGTTCTTTAACAGAACCTTTCTCTGAACACGGACATGTGGACCTCTTCTGTAGGA
ACTTGAAAGCCACTTCTCAACATGAATGTTCATCTTCTCAACTAAAAGCTTCTGTCTGCAAGCCATTCCTTTTCCTACTGAAAAAAAAAA
TACCTAGTCCAGTAAAACTTGCTTTCATAGATAATCTACATCATCTTTGTAAGCATCTTGATTTTAGAGAAGATGAAACAGATGTAAAAG
CAGTTCTTGGAACTTTATTAAATTTAATGGAAGATCCAGACAAAGATGTTAGAGTGGCTTTTAGTGGAAATATCAAGCACATATTGGAAT
CCTTGGACTCTGAAGATGGATTTATAAAGGAGCTTTTTGTCTTAAGAATGAAGGAAGCATATACACATGCCCAAATATCAAGAAATAATG
AGCTGAAGGATACCTTGATTCTTACAACAGGGGATATTGGAAGGGCCGCAAAAGGAGATTTGGTACCATTTGCACTCTTACACTTATTGC
ATTGTTTGTTATCCAAGTCAGCATCTGTCTCTGGAGCAGCATACACAGAAATTAGAGCTCTGGTTGCAGCTAAAAGTGTTAAACTGCAAA
GTTTTTTCAGCCAGTATAAGAAACCCATCTGTCAGTTTTTGGTAGAATCCCTTCACTCTAGTCAGATGACAGCACTTCCGAATACTCCAT
GCCAGAATGCTGACGTGCGAAAACAAGATGTGGCTCACCAGAGAGAAATGGCTTTAAATACGTTGTCTGAAATTGCCAACGTTTTCGACT
TTCCTGATCTTAATCGTTTTCTTACTAGGACATTACAAGTTCTACTACCTGATCTTGCTGCCAAAGCAAGCCCTGCAGCTTCTGCTCTCA
TTCGAACTTTAGGAAAACAATTAAATGTCAATCGTAGAGAGATTTTAATAAACAACTTCAAATATATTTTTTCTCATTTGGTCTGTTCTT
GTTCCAAAGATGAATTAGAACGTGCCCTTCATTATCTGAAGAATGAAACAGAAATTGAACTGGGGAGCCTGTTGAGACAAGATTTCCAAG
GATTGCATAATGAATTATTGCTGCGTATTGGAGAACACTATCAACAGGTTTTTAATGGTTTGTCAATACTTGCCTCATTTGCATCCAGTG
ATGATCCATATCAGGGCCCGAGAGATATCATATCACCTGAACTGATGGCTGATTATTTACAACCCAAATTGTTGGGCATTTTGGCTTTTT
TTAACATGCAGTTACTGAGCTCTAGTGTTGGCATTGAAGATAAGAAAATGGCCTTGAACAGTTTGATGTCTTTGATGAAGTTAATGGGAC
CCAAACATGTCAGTTCTGTGAGGGTGAAGATGATGACCACACTGAGAACTGGCCTTCGATTCAAGGATGATTTTCCTGAATTGTGTTGCA
GAGCTTGGGACTGCTTTGTTCGCTGCCTGGATCATGCTTGTCTGGGCTCCCTTCTCAGTCATGTAATAGTAGCTTTGTTACCTCTTATAC
ACATCCAGCCTAAAGAAACTGCAGCTATCTTCCACTACCTCATAATTGAAAACAGGGATGCTGTGCAAGATTTTCTTCATGAAATATATT
TTTTACCTGATCATCCAGAATTAAAAAAGATAAAAGCCGTTCTCCAGGAATACAGAAAGGAGACCTCTGAGAGCACTGATCTTCAGACAA
CTCTTCAGCTCTCTATGAAGGCCATTCAACATGAAAATGTCGATGTTCGTATTCATGCTCTTACAAGCTTGAAGGAAACCTTGTATAAAA
ATCAGAAGCGATTATTGGAAGCCATGGAGACATGTAACCACTCCCTCAAAAAGGAAGAGAGGAAAAGAAACCAACATAGTGAGTGCCTAA
TGTGCTGGTATGATAGAGACACAGAGTTTATCTATCCTTCTCCATGGCCAGAAAAGTTCCCTGCCATAGAACGATGTTGTACAAGGTATA
AAATAATATCCTTAGATGCTTGGCGTGTAGACATAAACAAAAACAAAATAACCAGAATTGACCAGAAAGCATTATATTTCTGTGGATTTC
CTACTCTGAAACACATCAGACACAAATTTTTTTTGAAGAAAAGTGGTGTTCAAGTATTCCAGCAAAGCAGTCGTGGAGAAAACATGATGT
TGGAAATCTTAGTGGATGCAGAATCAGATGAACTTACCGTAGAAAATGTAGCTTCATCAGTGCTTGGAAAATCTGTCTTTGTTAATTGGC
CTCACCTTGAGGAAGCTAGAGTCGTGGCTGTATCAGATGGAGAAACTAAGTTTTACTTGGAAGAACCTCCAGGAACACAGAAGCTTTATT
CAGGAAGAACTGCCCCACCATCTAAAGTGGTTCATCTTGGAGATAAAGAACAATCTAACTGGGCAAAAGAAGTACAAGGAATTTCAGAAC
ACTACCTGAGAAGAAAAGGAATAATAATAAATGAAACATCTGCAGTTGTGTATGCTCAGTTACTCACAGGTCGTAAATATCAAATAAATC
AAAATGGTGAAGTTCGTCTAGAGAAACAGTGGTCAAAACAAGTTGTTCCTTTTGTTTATCAAACTATTGTCAAGGACATCCGAGCTTTCG
ACTCCCGTTTCTCCAATATCAAAACATTGGATGATTTGTTTCCTCTGAGAAGTATGGTCTTTATGCTGGGAACTCCCTATTATGGCTGCA
CTGGAGAAGTTCAGGATTCAGGTGATGTGATTACAGAAGGTAGGATTCGTGTGATTTTCAGCATTCCATGTGAACCCAATCTTGATGCTT
TAATACAGAACCAGCATAAATATTCTATAAAGTACAACCCAGGATATGTGTTGGCCAGTCGCCTTGGAGTGAGTGGATACCTTGTTTCAA
GGTTTACAGGAAGTATTTTTATTGGAAGAGGATCTAGGAGAAACCCTCATGGAGACCATAAAGCAAATGTGGGTTTAAATCTCAAATTCA
ACAAGAAAAATGAGGAGGTACCTGGATATACTAAGAAAGTTGGAAGTGAATGGATGTATTCATCTGCAGCAGAACAACTTCTGGCAGAGT
ACTTAGAGAGAGCTCCAGAACTATTTAGTTATATAGCCAAAAATAGCCAAGAGGATGTGTTCTATGAAGATGACATTTGGCCTGGAGAAA
ATGAGAATGGTGCTGAAAAAGTTCAAGAAATTATTACTTGGCTAAAAGGACATCCTGTCAGTACTTTATCTCGTTCTTCTTGTGATTTAC
AAATTCTGGATGCAGCTATTGTTGAGAAAATTGAGGAAGAAGTCGAAAAGTGCAAGCAAAGAAAGAATAATAAGAAGGTGCGAGTAACAG
TGAAACCCCATTTGCTATACAGACCTTTAGAACAGCAACATGGAGTCATTCCTGATCGGGATGCAGAATTTTGTCTTTTTGACCGTGTTG
TAAATGTGAGAGAAAACTTCTCAGTTCCAGTTGGCCTTCGAGGCACCATCATAGGAATAAAAGGAGCTAATAGAGAAGCCGATGTACTAT
TTGAAGTATTATTTGATGAAGAATTTCCTGGAGGGTTAACAATAAGATGCTCACCTGGTAGAGGTTATCGACTGCCAACAAGTGCCTTGG
TGAACCTTTCTCATGGGAGTCGCTCTGAAACTGGAAATCAGAAGTTGACAGCCATCGTAAAACCACAACCAGCTGTACATCAACATAGCT
CAAGTTCATCAGTTTCCTCTGGGCATTTGGGAGCCCTCAACCATTCCCCTCAATCACTTTTTGTTCCTACTCAAGTACCTACTAAAGATG
ATGATGAATTCTGCAACATTTGGCAGTCCTTACAGGGATCTGGAAAGATGCAATACTTTCAGCCAACTATACAAGAGAAGGGTGCAGTTC
TACCTCAAGAAATAAGCCAAGTAAATCAACATCATAAATCTGGCTTTAATGACAACAGTGTTAAATATCAGCAAAGAAAACATGACCCTC
ACAGAAAATTTAAAGAAGAGTGTAAGAGTCCTAAAGCTGAGTGTTGGTCCCAAAAAATGTCCAATAAGCAGCCTAACTCTGGAATTGAGA
ACTTTTTAGCATCTTTGAATATCTCCAAAGAAAATGAAGTACAGTCATCTCATCATGGGGAGCCTCCAAGTGAAGAGCATTTGTCACCAC
AGTCATTTGCCATGGGAACACGGATGCTTAAAGAAATTCTAAAAATTGATGGCTCTAACACTGTGGACCATAAGAATGAAATCAAACAGA
TTGCTAATGAAATCCCTGTTTCCTCTAACAGAAGAGATGAATATGGATTACCCTCTCAGCCTAAACAAAATAAGAAATTAGCATCTTATA
TGAACAAGCCTCACAGTGCTAATGAGTACCATAATGTTCAGTCTATGGACAATATGTGTTGGCCTGCCCCCAGCCAGATCCCTCCTGTAT
CCACACCAGTAACTGAACTTTCTCGAATTTGTTCCCTTGTTGGAATGCCACAACCTGATTTCTCCTTTCTTAGGATGCCACAGACAATGA
CCGTTTGCCAAGTAAAATTATCTAATGGCTTACTGGTACATGGGCCACAGTGCCACTCTGAAAATGAAGCCAAAGAGAAAGCTGCACTTT
TTGCTTTACAACAGTTGGGCTCCTTAGGCATGAATTTCCCTTTGCCTTCACAAGTATTTGCAAATTATCCTTCAGCTGTACCACCTGGAA
CCATTCCTCCAGCCTTTCCCCCACCTACTGGCTGGGATCACTATGGAAGCAACTATGCATTGGGGGCAGCTAATATAATGCCTTCGTCGT
CTCATCTCTTTGGCTCAATGCCATGGGGACCATCGGTGCCAGTTCCTGGGAAGCCCTTCCATCATACTTTATATTCTGGGACCATGCCCA
TGGCTGGGGGAATACCAGGGGGTGTGCACAATCAGTTTATACCTCTGCAGGTTACTAAAAAAAGGGTTGCAAACAAAAAGAACTTTGAGA
ATAAGGAAGCCCAGAGTTCTCAAGCCACTCCAGTTCAGACTAGCCAGCCAGATTCTTCCAACATTGTCAAAGTAAGTCCACGGGAGAGCT
CATCAGCTTCTTTGAAGTCCTCTCCGATTGCTCAACCTGCATCTTCTTTTCAAGTTGAAACTGCCTCTCAAGGCCATAGTATATCTCACC
ATAAGTCAACACCAATCTCTTCTTCAAGAAGAAAATCAAGAAAACTGGCTGTTAATTTTGGTGTTTCTAAACCTTCTGAGTAAATTTGGC
TCTTAGAATTAAGTTAATTTCTTCTCTTTCCATCTACCTTTTTATAAATACATATCTATGTCTCATAAAAATTAGAATGTACTATTTTAA
AATAATATGTGTAAATTGAAATTTTTTTCATTTTTAAGTTATCAGGCACTTTTCATGCTGTTTAAAAGACTGTGTATCAAATTGTGCACT
TTAAGTATGTGCAGTTTGTTGTATGTCAATTATACCTCAATAAATCTGTAATAAAAAACTAAATTAAACCTTGCATTAAAATAATATCAC
AGTATCAGTGGACTAAACATTAAAATGTACCACTCTAATCATTGGCCTCATGATTGAAGCATCCTGAACTATGAATTAGACATCAGTTAG
CAATAATAAGCATTTTTTACACTATCATTGAGGAATAATTACATGGAGCATGAAATTTGGGCCTCCAGTATAACTTACTGAATGTGGATT
TTATTTCTCTTTTTAATGATGTAAGAAAATTGTCAGGAGAATGGCTCTTATTTATGTGTGTTTTAACTTATGCTTTGTTGCCTCTGAGGG
TCTTTAGACCTGCTGTGAAAGGATCACATTTGTTGTGGTGCTGCCAGTTTTGCTTTATTCTAAATTTTGTACCAAAGCAACTTTAGAATA
ATCAGAATATTTCATCTAACTGCTTAGAACTATAAATAGCATTCTAAATTTGAGTAAATACAATTTTTTAGGTTACTCAAGAACCAGCAT
TAGTAATTTCTAGTAAAATTGTTTCAAAATCTACAGGGTACAATGATTACAAATTAATCTTCTAACAAAATAAAATATGAAATATTAGTC
ATGTTAATTAATAAACTGTATTATTTTGTATAGCTTTTTATTTGCTTACCTGACATTTTATGAGAGCTTCATAGTTGGTCGGTATGTAGT
GCTTCTTGGGACTGAAGAAATTCTAATTGTTGTTTAAGTTCCAAGGTGTGCTACAATATAGGAGGCACAGTCATCAGTTTGTGACATACA
TTATTTACTGCCTATTTCATTCTGATTCTATATTTTTAGCTTTATGCTGAACTGTTCAATGATGCTGGGATTCTCTCTTTGCATGTCATA
TGTGAATGTGTGGTTCAAGCTGTAACTGTTGAAATTATTTTAGAATTTATGACGATTTCTCAGCAGGGCCTATGTTTATATATATATATA
TATTTATTCTTTAGTTTTTGTGATATGCTTATATTTTTAAGGAAGTAAGTTATAGCATACTTTTTTAAAAGTAGGAACCACAATCTTTAT
ATGGAGCAGCTTGTTATATCTGATTTTCATGTAACTCATTGGAAACTCTGCCATGACTCTTAAAGTAGTCTTACTTGTTTTTTAAAATGC
TGGTATTAAACTAAATGGACTCCTTTCACTAACTGCTGATTTCAGAGTTTAAATGTTAGCAGGATATTTGTGTATTAGCAGTGCCTTCAG
TATAAGAGAGAAATATTCATTATCTGTCATTTATCATAGTCGTATAAGTTTCCATGATTTTATTTTCTGTTATTTTCATAAGTTCAGATG
TTTATCAGTTCCCAACATTGTTTCTTTATCTGTAGTGGGATCTTGAGTAATGAGGCTCAAGTAAATCCTCAATGTGTATAATTATTGCCT
CATAAACTCTCTCTTTGTTTTTAAAGGAAACATCTATTATGGTAATACAAAGAAAAGTTAAATTGTGACAGTAATGTTATATTAACCTCT
TCCTACTTTAAAGTGTGAAATGTTTCACCTCAGCTGTACAAACTCCAGCATTGAGAATTTGCCTCACTCATTACTCCTGTGTGACAGTTA
TATAAATAGCATGCAGCTCACATCTGTTTTAGAGCATAGAAGAAGCGGCACCTGCCATCTTCTGAAAACTCCAAAGGGAAATTTCAGTAG
ACATAGTGCACTAAACCCATAAGGATACTTGACCAATATTTGAGCACAGCAAGCTGACAGTTCTATACAGATAGGCAGTGAAAGAGTTTT
ATTTTCCAGCCAGGCGCAGTGGCTCAAATCCCAGCACTTCGGGAGGCTAAGGCAGGCGGATCACTTGAGGTCCGGAGTTCCAGACAAGCC
TGGCCAACATGATGAAGCCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGATGGCACATGCCTTTAGTCCCAGCTACTCGGGAG
GCTGAGGCATGAGAATCATTTGAACCCGCGAGGCAGAGTCTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGAGAGCAGAGCA
AGACTCTGTCTCAAAAAAAAGAAAAAAGTTTTATTATCCTTACTTTTTTTTTAACATTATTATTCTAAAGGTCAAAACTGAGAAGAGATT
AAGATAGGAGAGAGCTCCATAATGGCTGGATAGTGGTCAGGCATTCTCTATTCTTTTCCCCCTGTAGACCCATTCTAAATGTGGGCCTGA
GGTCAATGGGAGATGTGCCCTCCCTATGGAGGATGTAAGAAGCAGAGGCCATTTCTGCCCCATGTTGAGGAAACAATCTGTTGATAGACC
TGGAATTTAGAGTATATCTGAAAAGCAGTTGGACTTCAAGAAATTTAAAATTCTCTCTTTGAGATGGGGTGGACTAAGACCACCCCCAAA
GTTTAAAAATATGCTCATTCAACTTGAATCTTCTGAGGACTTTTTGTGAAAATGGTGGACTGTTTAGGGCATAGGACAGATTCCCCAAAT
TGCTTTATGCTTCCACATAACTAGAGCACTTCAATCTATTTAAGCCTTTGTCTCCTAACTGAAACATTATTTCTAAATATTTCTATTCAA
TAAGTTTTTTCTTTTTTGAGCAACTTAAGTGAATTTTGAAGATTGCTCCTTCCAGTCTCGTTCCTTTTCACATTTTCCTGCATTACCTAA
TAATTACCTCAGCGTTAGAATTTGAATGTATTAATTGATTTAAACATCATGTAGACTAAAGTCTTAAACATCTAAGACTCAGTTGTAGTT
GCAGAAAAAAATTAAAGTCACCTCTACTGAACCTTGGTTTCAATTTAAGATTTTTCTTGCTTTTCAAAGGGGTAACTAATAAAGATTGAA
GGGTTTTTTTCCCGATTGGTGGAGGAATGAAGAACTATTGATGCAAGTTTTTTTATTGTTTCTTTCTATGATCAGGTACCTGCTTTCATT
TTAGACTGCTACTTCCAAACTAAGCTAGATTCTTGGTTTTAATGAGAGGAGGCAGAGAGAGGGAGGCAGATGGAAGAAGAAAAACAGTTA
AATAAGACATACCCAGTCACTGCATTTTTGGACTATACCGTATCTTTCTAGCACAAGGAAATAGATAAACTGTAAGGTCTTTTTTACTCA
CTTTTTATTTATGTGTTCTATTTGTGTTAGTCATAACTGTTTATAGTGGTTGTCTAATTTTTACTTTTATTATATGAGATAGAGCTGTGC
AGATCTTCACTCAAGTTAGTTCTGTCACGCTTCTTCCCATTATTTAGAGCACAGTTTTTTAAAGCAACTGTACAATTTCTCAGCCTTATG
AGCTTGCTGTATTTCTTGGTATCATGTTGCTTCCAAATTTTGTTTTTACTGTAGAAGACAATTAATTTATTGTAGAGAAGTGGCTGTGAA
AGTCGTTCTCTGTCTTTAAAAATCAATTGCAGAAGTTCATTTGTCATTTTTCTAGAGATAAATTATAGTACTCAAACTGGCAGTGCTCAG
TATATACATTTTGTAAGCTTTGTCAGTGAAACCATCAGTTTTGCAGGAGCTTCCTTTCCTAGTCAAGATAAAGCTTAAAATTCCAGAAAT
TAATGTCGTTCGGACTGACTTTATTCATATTTCCATCAAACTTCTCCAATACAGTAAGAGATAGTGTTGAACCAGCATCAAGTCTCCAGA
AACATGGCAGAGCAGACAGGCCGTTAAGTTTCACAGACATCATAGATCCTTTTCTTAAAGAAGAAAAACATGTATAAAATAGTTTTAGTA
GTCCAAAATGTCAACTATCTGTAGCTGCTTTTGTGTGTGTGTCAGTGAACAAATAATAATGCCTTGCTCAATCAATGCATTCAGCCATCT
CAAGTGCAATTTGTGAAGGAGACTATGGTTTCCAAAAGATACATTTTTTTACAAAGTTAAACCTGTAAAAAGTCTTTTTTTTTTTCCCTC
CAGCCGTACACCAACTGCACTTGGTTGTTTCAGCAGTTGGTATACTATTAAATTGTCCAGGCCAAATAGGTTTCTGTAGCTGTTTTAGTA
ATTTGAAGCCAAATTCTCATGCTGTTTCTCATTAAAAAGAATGAGAATTTGGTCCATAGTTAGCTTTAAGTTCTCTCTTCCTTTCTTTCC
CTTACAGTTAAGGGTTTGGTGGGGGATGGGGAGGTTGTTTTCGTTTTTTGGATTTTTTTGTCTTTTGGCTTTAAGTATCATATTTTCTTT
TGCCTGTATCCAACTGCTTCTTTGAGTATTTTCATCTAGTTTAATGTGAGTAATAGATGCTGTGCTGTCATTGAAGTGTTCAACATTTTG
TTCATTTAAACAAAAGTGTAATTCATACATATATAGATACATATCTTAATTGATTTCTCAACTATTTTATAAGTAACTGGAATTTTTCAT
TAGATCTTATACAGAGAAGTATTTTATTAAAAATTCAAAAGGGAAGACTTTTATGTGCTCATTTTGTAATTTTTGATTTTAAATATCTTT
ACATTGTCTGCCAATTAAAGTGTTTTAAACTTGCATTGGAATGGACTCCGAATGTATTTTTGTGGTGTTACGTTATCCGTAGATTTCTAG
CATGAAGTTAGCCTCACGATGCTGTGCAAAGGATTTTAAAATATGAGAGTCACTGAAAGAGTTTAAACATCTGTTCATGTTAAATGCTCT

>8360_8360_3_ATR-XRN1_ATR_chr3_142253922_ENST00000383101_XRN1_chr3_142123918_ENST00000264951_length(amino acids)=2386AA_BP=0
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSH
EAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFF
SSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTED
RTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSD
DGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILID
KVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFID
NLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTG
DIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDV
AHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALH
YLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVG
IEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIF
HYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQKRLLEAMET
CNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFF
LKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVV
HLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLD
DLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRG
SRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEI
ITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPV
GLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLG
ALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSP
KAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNR
RDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGL
LVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSSHLFGSMPWGP
SVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIA

--------------------------------------------------------------
>8360_8360_4_ATR-XRN1_ATR_chr3_142253922_ENST00000383101_XRN1_chr3_142123918_ENST00000392981_length(transcript)=7497nt_BP=3875nt
TTCCGGGAGGAGTTTTGGCCTCCACACGGCTCCGTCGGGCGCCGCGCTCTTCCGGCAGCGGTAGCTTTGGAGACGCCGGGAACCCGCGTT
GGCGTGGTTGACTAGTGCCTCGCAGCCTCAGCATGGGGGAACATGGCCTGGAGCTGGCTTCCATGATCCCCGCCCTGCGGGAGCTGGGCA
GTGCCACACCAGAGGAATATAATACAGTTGTACAGAAGCCAAGACAAATTCTGTGTCAATTCATTGACCGGATACTTACAGATGTAAATG
TTGTTGCTGTAGAACTTGTAAAGAAAACTGACTCTCAGCCAACCTCCGTGATGTTGCTTGATTTCATCCAGCATATCATGAAATCCTCCC
CACTTATGTTTGTAAATGTGAGTGGAAGCCATGAGGCCAAAGGCAGTTGTATTGAATTCAGTAATTGGATCATAACGAGACTTCTGCGGA
TTGCAGCAACTCCCTCCTGTCATTTGTTACACAAGAAAATCTGTGAAGTCATCTGTTCATTATTATTTCTTTTTAAAAGCAAGAGTCCTG
CTATTTTTGGGGTACTCACAAAAGAATTATTACAACTTTTTGAAGACTTGGTTTACCTCCATAGAAGAAATGTGATGGGTCATGCTGTGG
AATGGCCAGTGGTCATGAGCCGATTTTTAAGTCAATTAGATGAACACATGGGATATTTACAATCAGCTCCTTTGCAGTTGATGAGTATGC
AAAATTTAGAATTTATTGAAGTCACTTTATTAATGGTTCTTACTCGTATTATTGCAATTGTGTTTTTTAGAAGGCAAGAACTCTTACTTT
GGCAGATAGGTTGTGTTCTGCTAGAGTATGGTAGTCCAAAAATTAAATCCCTAGCAATTAGCTTTTTAACAGAACTTTTTCAGCTTGGAG
GACTACCAGCACAACCAGCTAGCACTTTTTTCAGCTCATTTTTGGAATTATTAAAACACCTTGTAGAAATGGATACTGACCAATTGAAAC
TCTATGAAGAGCCATTATCAAAGCTGATAAAGACACTATTTCCCTTTGAAGCAGAAGCTTATAGAAATATTGAACCTGTCTATTTAAATA
TGCTGCTGGAAAAACTCTGTGTCATGTTTGAAGACGGTGTGCTCATGCGGCTTAAGTCTGATTTGCTAAAAGCAGCTTTGTGCCATTTAC
TGCAGTATTTCCTTAAATTTGTGCCAGCTGGGTATGAATCTGCTTTACAAGTCAGGAAGGTCTATGTGAGAAATATTTGTAAAGCTCTTT
TGGATGTGCTTGGAATTGAGGTAGATGCAGAGTACTTGTTGGGCCCACTTTATGCAGCTTTGAAAATGGAAAGTATGGAAATCATTGAGG
AGATTCAATGCCAAACTCAACAGGAAAACCTCAGCAGTAATAGTGATGGAATATCACCCAAAAGGCGTCGTCTCAGCTCGTCTCTAAACC
CTTCTAAAAGAGCACCAAAACAGACTGAGGACCGTACTTTCAAGGACTGTCAACATAAATCCAAGAAGAAACCTTCTGTAGTGATAACTT
GGATGTCATTGGATTTTTACACAAAAGTGCTTAAGAGCTGTAGAAGTTTGTTAGAATCTGTTCAGAAACTGGACCTGGAGGCAACCATTG
ATAAGGTGGTGAAAATTTATGATGCTTTGATTTATATGCAAGTAAACAGTTCATTTGAAGATCATATCCTGGAAGATTTATGTGGTATGC
TCTCACTTCCATGGATTTATTCCCATTCTGATGATGGCTGTTTAAAGTTGACCACATTTGCCGCTAATCTTCTAACATTAAGCTGTAGGA
TTTCAGATAGCTATTCACCACAGGCACAATCACGATGTGTGTTTCTTCTGACTCTGTTTCCAAGAAGAATATTCCTTGAGTGGAGAACAG
CAGTTTACAACTGGGCCCTGCAGAGCTCCCATGAAGTAATCCGGGCTAGTTGTGTTAGTGGATTTTTTATCTTATTGCAGCAGCAGAATT
CTTGTAACAGAGTTCCCAAGATTCTTATAGATAAAGTCAAAGATGATTCTGACATTGTCAAGAAAGAATTTGCTTCTATACTTGGTCAAC
TTGTCTGTACTCTTCACGGCATGTTTTATCTGACAAGTTCTTTAACAGAACCTTTCTCTGAACACGGACATGTGGACCTCTTCTGTAGGA
ACTTGAAAGCCACTTCTCAACATGAATGTTCATCTTCTCAACTAAAAGCTTCTGTCTGCAAGCCATTCCTTTTCCTACTGAAAAAAAAAA
TACCTAGTCCAGTAAAACTTGCTTTCATAGATAATCTACATCATCTTTGTAAGCATCTTGATTTTAGAGAAGATGAAACAGATGTAAAAG
CAGTTCTTGGAACTTTATTAAATTTAATGGAAGATCCAGACAAAGATGTTAGAGTGGCTTTTAGTGGAAATATCAAGCACATATTGGAAT
CCTTGGACTCTGAAGATGGATTTATAAAGGAGCTTTTTGTCTTAAGAATGAAGGAAGCATATACACATGCCCAAATATCAAGAAATAATG
AGCTGAAGGATACCTTGATTCTTACAACAGGGGATATTGGAAGGGCCGCAAAAGGAGATTTGGTACCATTTGCACTCTTACACTTATTGC
ATTGTTTGTTATCCAAGTCAGCATCTGTCTCTGGAGCAGCATACACAGAAATTAGAGCTCTGGTTGCAGCTAAAAGTGTTAAACTGCAAA
GTTTTTTCAGCCAGTATAAGAAACCCATCTGTCAGTTTTTGGTAGAATCCCTTCACTCTAGTCAGATGACAGCACTTCCGAATACTCCAT
GCCAGAATGCTGACGTGCGAAAACAAGATGTGGCTCACCAGAGAGAAATGGCTTTAAATACGTTGTCTGAAATTGCCAACGTTTTCGACT
TTCCTGATCTTAATCGTTTTCTTACTAGGACATTACAAGTTCTACTACCTGATCTTGCTGCCAAAGCAAGCCCTGCAGCTTCTGCTCTCA
TTCGAACTTTAGGAAAACAATTAAATGTCAATCGTAGAGAGATTTTAATAAACAACTTCAAATATATTTTTTCTCATTTGGTCTGTTCTT
GTTCCAAAGATGAATTAGAACGTGCCCTTCATTATCTGAAGAATGAAACAGAAATTGAACTGGGGAGCCTGTTGAGACAAGATTTCCAAG
GATTGCATAATGAATTATTGCTGCGTATTGGAGAACACTATCAACAGGTTTTTAATGGTTTGTCAATACTTGCCTCATTTGCATCCAGTG
ATGATCCATATCAGGGCCCGAGAGATATCATATCACCTGAACTGATGGCTGATTATTTACAACCCAAATTGTTGGGCATTTTGGCTTTTT
TTAACATGCAGTTACTGAGCTCTAGTGTTGGCATTGAAGATAAGAAAATGGCCTTGAACAGTTTGATGTCTTTGATGAAGTTAATGGGAC
CCAAACATGTCAGTTCTGTGAGGGTGAAGATGATGACCACACTGAGAACTGGCCTTCGATTCAAGGATGATTTTCCTGAATTGTGTTGCA
GAGCTTGGGACTGCTTTGTTCGCTGCCTGGATCATGCTTGTCTGGGCTCCCTTCTCAGTCATGTAATAGTAGCTTTGTTACCTCTTATAC
ACATCCAGCCTAAAGAAACTGCAGCTATCTTCCACTACCTCATAATTGAAAACAGGGATGCTGTGCAAGATTTTCTTCATGAAATATATT
TTTTACCTGATCATCCAGAATTAAAAAAGATAAAAGCCGTTCTCCAGGAATACAGAAAGGAGACCTCTGAGAGCACTGATCTTCAGACAA
CTCTTCAGCTCTCTATGAAGGCCATTCAACATGAAAATGTCGATGTTCGTATTCATGCTCTTACAAGCTTGAAGGAAACCTTGTATAAAA
ATCAGAAGCGATTATTGGAAGCCATGGAGACATGTAACCACTCCCTCAAAAAGGAAGAGAGGAAAAGAAACCAACATAGTGAGTGCCTAA
TGTGCTGGTATGATAGAGACACAGAGTTTATCTATCCTTCTCCATGGCCAGAAAAGTTCCCTGCCATAGAACGATGTTGTACAAGGTATA
AAATAATATCCTTAGATGCTTGGCGTGTAGACATAAACAAAAACAAAATAACCAGAATTGACCAGAAAGCATTATATTTCTGTGGATTTC
CTACTCTGAAACACATCAGACACAAATTTTTTTTGAAGAAAAGTGGTGTTCAAGTATTCCAGCAAAGCAGTCGTGGAGAAAACATGATGT
TGGAAATCTTAGTGGATGCAGAATCAGATGAACTTACCGTAGAAAATGTAGCTTCATCAGTGCTTGGAAAATCTGTCTTTGTTAATTGGC
CTCACCTTGAGGAAGCTAGAGTCGTGGCTGTATCAGATGGAGAAACTAAGTTTTACTTGGAAGAACCTCCAGGAACACAGAAGCTTTATT
CAGGAAGAACTGCCCCACCATCTAAAGTGGTTCATCTTGGAGATAAAGAACAATCTAACTGGGCAAAAGAAGTACAAGGAATTTCAGAAC
ACTACCTGAGAAGAAAAGGAATAATAATAAATGAAACATCTGCAGTTGTGTATGCTCAGTTACTCACAGGTCGTAAATATCAAATAAATC
AAAATGGTGAAGTTCGTCTAGAGAAACAGTGGTCAAAACAAGTTGTTCCTTTTGTTTATCAAACTATTGTCAAGGACATCCGAGCTTTCG
ACTCCCGTTTCTCCAATATCAAAACATTGGATGATTTGTTTCCTCTGAGAAGTATGGTCTTTATGCTGGGAACTCCCTATTATGGCTGCA
CTGGAGAAGTTCAGGATTCAGGTGATGTGATTACAGAAGGTAGGATTCGTGTGATTTTCAGCATTCCATGTGAACCCAATCTTGATGCTT
TAATACAGAACCAGCATAAATATTCTATAAAGTACAACCCAGGATATGTGTTGGCCAGTCGCCTTGGAGTGAGTGGATACCTTGTTTCAA
GGTTTACAGGAAGTATTTTTATTGGAAGAGGATCTAGGAGAAACCCTCATGGAGACCATAAAGCAAATGTGGGTTTAAATCTCAAATTCA
ACAAGAAAAATGAGGAGGTACCTGGATATACTAAGAAAGTTGGAAGTGAATGGATGTATTCATCTGCAGCAGAACAACTTCTGGCAGAGT
ACTTAGAGAGAGCTCCAGAACTATTTAGTTATATAGCCAAAAATAGCCAAGAGGATGTGTTCTATGAAGATGACATTTGGCCTGGAGAAA
ATGAGAATGGTGCTGAAAAAGTTCAAGAAATTATTACTTGGCTAAAAGGACATCCTGTCAGTACTTTATCTCGTTCTTCTTGTGATTTAC
AAATTCTGGATGCAGCTATTGTTGAGAAAATTGAGGAAGAAGTCGAAAAGTGCAAGCAAAGAAAGAATAATAAGAAGGTGCGAGTAACAG
TGAAACCCCATTTGCTATACAGACCTTTAGAACAGCAACATGGAGTCATTCCTGATCGGGATGCAGAATTTTGTCTTTTTGACCGTGTTG
TAAATGTGAGAGAAAACTTCTCAGTTCCAGTTGGCCTTCGAGGCACCATCATAGGAATAAAAGGAGCTAATAGAGAAGCCGATGTACTAT
TTGAAGTATTATTTGATGAAGAATTTCCTGGAGGGTTAACAATAAGATGCTCACCTGGTAGAGGTTATCGACTGCCAACAAGTGCCTTGG
TGAACCTTTCTCATGGGAGTCGCTCTGAAACTGGAAATCAGAAGTTGACAGCCATCGTAAAACCACAACCAGCTGTACATCAACATAGCT
CAAGTTCATCAGTTTCCTCTGGGCATTTGGGAGCCCTCAACCATTCCCCTCAATCACTTTTTGTTCCTACTCAAGTACCTACTAAAGATG
ATGATGAATTCTGCAACATTTGGCAGTCCTTACAGGGATCTGGAAAGATGCAATACTTTCAGCCAACTATACAAGAGAAGGGTGCAGTTC
TACCTCAAGAAATAAGCCAAGTAAATCAACATCATAAATCTGGCTTTAATGACAACAGTGTTAAATATCAGCAAAGAAAACATGACCCTC
ACAGAAAATTTAAAGAAGAGTGTAAGAGTCCTAAAGCTGAGTGTTGGTCCCAAAAAATGTCCAATAAGCAGCCTAACTCTGGAATTGAGA
ACTTTTTAGCATCTTTGAATATCTCCAAAGAAAATGAAGTACAGTCATCTCATCATGGGGAGCCTCCAAGTGAAGAGCATTTGTCACCAC
AGTCATTTGCCATGAAGGGAACACGGATGCTTAAAGAAATTCTAAAAATTGATGGCTCTAACACTGTGGACCATAAGAATGAAATCAAAC
AGATTGCTAATGAAATCCCTGTTTCCTCTAACAGAAGAGATGAATATGGATTACCCTCTCAGCCTAAACAAAATAAGAAATTAGCATCTT
ATATGAACAAGCCTCACAGTGCTAATGAGTACCATAATGTTCAGTCTATGGACAATATGTGTTGGCCTGCCCCCAGCCAGATCCCTCCTG
TATCCACACCAGTAACTGAACTTTCTCGAATTTGTTCCCTTGTTGGAATGCCACAACCTGATTTCTCCTTTCTTAGGATGCCACAGACAA
TGACCGTTTGCCAAGTAAAATTATCTAATGGCTTACTGGTACATGGGCCACAGTGCCACTCTGAAAATGAAGCCAAAGAGAAAGCTGCAC
TTTTTGCTTTACAACAGTTGGGCTCCTTAGGCATGAATTTCCCTTTGCCTTCACAAGTATTTGCAAATTATCCTTCAGCTGTACCACCTG
GAACCATTCCTCCAGCCTTTCCCCCACCTACTGCTAATATAATGCCTTCGTCGTCTCATCTCTTTGGCTCAATGCCATGGGGACCATCGG
TGCCAGTTCCTGGGAAGCCCTTCCATCATACTTTATATTCTGGGACCATGCCCATGGCTGGGGGAATACCAGGGGGTGTGCACAATCAGT
TTATACCTCTGCAGGTTACTAAAAAAAGGGTTGCAAACAAAAAGAACTTTGAGAATAAGGAAGCCCAGAGTTCTCAAGCCACTCCAGTTC
AGACTAGCCAGCCAGATTCTTCCAACATTGTCAAAGTAAGTCCACGGGAGAGCTCATCAGCTTCTTTGAAGTCCTCTCCGATTGCTCAAC
CTGCATCTTCTTTTCAAGTTGAAACTGCCTCTCAAGGCCATAGTATATCTCACCATAAGTCAACACCAATCTCTTCTTCAAGAAGAAAAT
CAAGAAAACTGGCTGTTAATTTTGGTGTTTCTAAACCTTCTGAGTAAATTTGGCTCTTAGAATTAAGTTAATTTCTTCTCTTTCCATCTA
CCTTTTTATAAATACATATCTATGTCTCATAAAAATTAGAATGTACTATTTTAAAATAATATGTGTAAATTGAAATTTTTTTCATTTTTA
AGTTATCAGGCACTTTTCATGCTGTTTAAAAGACTGTGTATCAAATTGTGCACTTTAAGTATGTGCAGTTTGTTGTATGTCAATTATACC

>8360_8360_4_ATR-XRN1_ATR_chr3_142253922_ENST00000383101_XRN1_chr3_142123918_ENST00000392981_length(amino acids)=2374AA_BP=0
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSH
EAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFF
SSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTED
RTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSD
DGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILID
KVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFID
NLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTG
DIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDV
AHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALH
YLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVG
IEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIF
HYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQKRLLEAMET
CNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFF
LKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVV
HLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLD
DLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRG
SRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEI
ITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPV
GLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLG
ALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSP
KAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMKGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSN
RRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNG
LLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTANIMPSSSHLFGSMPWGPSVPVPGKPFHHT
LYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETAS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATR-XRN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATR-XRN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATR-XRN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource