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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATRX-ZNF304 (FusionGDB2 ID:8363)

Fusion Gene Summary for ATRX-ZNF304

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRX-ZNF304
Fusion gene ID: 8363
HgeneTgene
Gene symbol

ATRX

ZNF304

Gene ID

546

57343

Gene nameATRX chromatin remodelerzinc finger protein 304
SynonymsJMS|MRX52|RAD54|RAD54L|XH2|XNP|ZNF-HX-
Cytomap

Xq21.1

19q13.43

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ATRXATP-dependent helicase ATRXX-linked helicase IIX-linked nuclear proteinalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)zinc finger protein 304KRAB-containing zinc finger protein
Modification date2020031320200313
UniProtAcc

P46100

.
Ensembl transtripts involved in fusion geneENST00000373344, ENST00000395603, 
ENST00000480283, ENST00000373341, 
ENST00000282286, ENST00000391705, 
ENST00000443917, ENST00000598744, 
Fusion gene scores* DoF score17 X 13 X 9=19891 X 2 X 1=2
# samples 232
** MAII scorelog2(23/1989*10)=-3.11233750988937
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: ATRX [Title/Abstract] AND ZNF304 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATRX(77041468)-ZNF304(57865093), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATRX

GO:0006334

nucleosome assembly

20651253

HgeneATRX

GO:0006338

chromatin remodeling

20651253

TgeneZNF304

GO:0045944

positive regulation of transcription by RNA polymerase II

26081979


check buttonFusion gene breakpoints across ATRX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF304 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-6290-01AATRXchrX

77041468

-ZNF304chr19

57865093

+
ChimerDB4LGGTCGA-CS-6290ATRXchrX

77041468

-ZNF304chr19

57862889

+
ChimerDB4LGGTCGA-CS-6290ATRXchrX

77041468

-ZNF304chr19

57865093

+


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Fusion Gene ORF analysis for ATRX-ZNF304

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373344ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000373344ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000373344ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000373344ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000373344ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000395603ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000395603ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000395603ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57862889

+
5CDS-5UTRENST00000395603ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5CDS-5UTRENST00000395603ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57862889

+
5UTR-3CDSENST00000480283ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57862889

+
5UTR-5UTRENST00000480283ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57862889

+
5UTR-5UTRENST00000480283ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57862889

+
5UTR-5UTRENST00000480283ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
5UTR-5UTRENST00000480283ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57862889

+
In-frameENST00000373344ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
In-frameENST00000395603ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-3CDSENST00000373341ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000282286ATRXchrX

77041468

-ZNF304chr19

57862889

+
intron-5UTRENST00000373341ENST00000391705ATRXchrX

77041468

-ZNF304chr19

57862889

+
intron-5UTRENST00000373341ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000443917ATRXchrX

77041468

-ZNF304chr19

57862889

+
intron-5UTRENST00000373341ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57865093

+
intron-5UTRENST00000373341ENST00000598744ATRXchrX

77041468

-ZNF304chr19

57862889

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373344ATRXchrX77041468-ENST00000391705ZNF304chr1957865093+42312353132181622
ENST00000395603ATRXchrX77041468-ENST00000391705ZNF304chr1957865093+42312353132181622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373344ENST00000391705ATRXchrX77041468-ZNF304chr1957865093+0.0041039030.9958961
ENST00000395603ENST00000391705ATRXchrX77041468-ZNF304chr1957865093+0.0041039030.9958961

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Fusion Genomic Features for ATRX-ZNF304


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATRXchrX77041467-ZNF304chr1957865092+4.95E-101
ATRXchrX77041467-ZNF304chr1957865092+4.95E-101
ATRXchrX77041467-ZNF304chr1957865092+4.95E-101
ATRXchrX77041467-ZNF304chr1957865092+4.95E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATRX-ZNF304


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:77041468/chr19:57865093)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRX

P46100

.
FUNCTION: Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF304chrX:77041468chr19:57865093ENST000002822860314_8811660.0DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST000003917051414_8811660.0DomainKRAB
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603115_13911660.0Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603251_27311660.0Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603279_30111660.0Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603307_32911660.0Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603335_35711660.0Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603363_38511660.0Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603391_41311660.0Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603419_44111660.0Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603447_46911660.0Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603475_49711660.0Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603503_52511660.0Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603531_55311660.0Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603559_58111660.0Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603587_60911660.0Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST0000028228603615_63711660.0Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST000002822860389_11111660.0Zinc fingerC2H2-type 1
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514115_13911660.0Zinc fingerC2H2-type 2
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514251_27311660.0Zinc fingerC2H2-type 3
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514279_30111660.0Zinc fingerC2H2-type 4
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514307_32911660.0Zinc fingerC2H2-type 5
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514335_35711660.0Zinc fingerC2H2-type 6
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514363_38511660.0Zinc fingerC2H2-type 7
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514391_41311660.0Zinc fingerC2H2-type 8
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514419_44111660.0Zinc fingerC2H2-type 9
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514447_46911660.0Zinc fingerC2H2-type 10
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514475_49711660.0Zinc fingerC2H2-type 11
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514503_52511660.0Zinc fingerC2H2-type 12
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514531_55311660.0Zinc fingerC2H2-type 13
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514559_58111660.0Zinc fingerC2H2-type 14
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514587_60911660.0Zinc fingerC2H2-type 15
TgeneZNF304chrX:77041468chr19:57865093ENST0000039170514615_63711660.0Zinc fingerC2H2-type 16
TgeneZNF304chrX:77041468chr19:57865093ENST000003917051489_11111660.0Zinc fingerC2H2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351151_115662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351166_116962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351202_120662493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351259_126662493.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351443_146662493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351499_150262493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351929_193962493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351941_194862493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352222_222562493.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352262_226562493.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352420_242562493.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135745_75062493.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341151_115662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341166_116962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341202_120662455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341259_126662455.0Compositional biasNote=Poly-Asp
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341443_146662455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341499_150262455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341929_193962455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341941_194862455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342222_222562455.0Compositional biasNote=Poly-Lys
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342262_226562455.0Compositional biasNote=Poly-Glu
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342420_242562455.0Compositional biasNote=Poly-Gln
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134745_75062455.0Compositional biasNote=Poly-Ser
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351581_176862493.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135159_29662493.0DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352025_220562493.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341581_176862455.0DomainHelicase ATP-binding
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134159_29662455.0DomainADD
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342025_220562455.0DomainHelicase C-terminal
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351719_172262493.0MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135581_59462493.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341719_172262455.0MotifNote=DEGH box
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134581_59462455.0MotifNote=PxVxL motif
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351594_160162493.0Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341594_160162455.0Nucleotide bindingATP
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135170_20662493.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-135217_27262493.0Zinc fingerPHD-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134170_20662455.0Zinc fingerGATA-type%3B atypical
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-134217_27262455.0Zinc fingerPHD-type%3B atypical


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Fusion Gene Sequence for ATRX-ZNF304


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8363_8363_1_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000373344_ZNF304_chr19_57865093_ENST00000391705_length(transcript)=4231nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTT
CTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCACAGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACT
AGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTTCTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGG
TCTTTTCCAGAAAGCACACCCATGTGAGATGTGTGACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTAC
ACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAAGATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAA
TTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTGTGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGG
GATGGACTTACCAGATAGCTCTGGCCTTTTCCAGCACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTC
TTTCCCACACAGCTCCAGTCTCAGGCAACACCAAGGAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCT
GGACACCTTTACTCTTCTTGACAGCCAGATGACTCATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAA
ATCAGCTCTTATTAATCACAGAAAAATCCACAGTGGAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCA
CCTAAAAATGCACCAGAAATTTCACACTGGAAAAAGACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGT
TCAGCATCAGAGAGTTCACACTGGAGAAAGATCTTATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCA
CCAGAGAATTCACACAGGAGAAAGGCCTTATAAGTGCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAG
ATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTGAATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCA
TACCGGGGCAAGGCCCTATGAATGCATAGAATGTGGAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGG
AGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGGCCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAG
GCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCAGCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTA
TGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATAGCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTG
CAATGAATGTGGGAAATGCTTTAGCCACAACTCCAGCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGA
ATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTGTTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGG
GAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGCACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGC
CTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGAAAGCTCACACTGGAGAAAGAGCTCACGAGTGCAACAGTTTTGGTGGCCCTTTAGC
TGCATCTCTTAAACTTGTTTAACACCAGAAAATTCACACAAGAGAAAGGCCTTATGAATGCAGAAAATATGTCATCTTGTTCATCCTCAT
AGGACTCACACCAGAGCAATGCTCTGTGAGTACCCTTTGTGAGGGAACCATCAGCTAGCAGATGAGCACCGTATATTCATTCCACCCTGG
GGAGATTCCTGATAAGCACCACATATGTGGGAGGCTTTCATGAGGTGTGTTGCACTTTGTAACTGTCTAGAGCTCTTGATGGAATTATAT
CACTGCCAGTGCCTGTGGCGGAAGCCATCTTATTGCTACCAGCTGTGTGTGTCAATCACTCCATTTTGCTCAGGGAAGGCAGACTTCTGT
GCTTTCTTTCCTGTTCCCTACAGGTAATCATGAATATTTTCAAGGACTTCCCCCCCCCCCCACTTCACCCCCTACCATTGAGGGTCCTCA
TCTTTTCCCTCATGATTAGGTTCTGAGCAAACATGATCTAGCTCTCACCAAAAGGACCTGAGCTAGGGTCTGCTGGGATTTCCTGACACG
ATTTTCCATCTTCATGGACAATGTTAACTGTAAACGTGATAGCTGTGACTTACTTGTCTTACTGCCAAATCGCCCAAATTTGGAACTGCT
TGTCCCATGCTGCTCTGATTTATACAGTGATAAGGGCCTATTGTGGCAGTCTTTACTCTTGGGGATTTTGTTACTGTGTAGAGTGGATTG
AGAAAAGAATTGGGTTCTGTCATGAAGGGAGTAGCACCTTTTGTGGGCACCACCTTTATGTGCCTCAGAGGGGACCAAAGGATGGCAGAA
AACTGTTCTCAGTCTAGTTTGACCTAATTTACACTATTGCCCTAGGCTTGCTAGGAAAGACTGAAAAAATTTTTGTGCCTAACTTTGTGG
CCTGGCTGCCAGGATTTCCTGTGAGCCCAGTGAGGAGGGCATAGTTGGTGCGAAAATCTCCTGTGCTTGTGGAAGCAACATAAGTTGGGT
CCCTTAACTGTCACGTACTCCCCAGCACTGTTGAGGGATTGCTGTCTTCTGTACCTGTACAGGATCAAGTCCCTGATATCCAGAACCCCA
TAGGCAAGTAACATTGACTGTAAGACCTCTGTAGGGCAATGTGAAAATCATGATTGCTACAGAAGCACTGAGATAATGGAGTGGGGATGA
CTGTGGCAAACAAAAGGAGATTCGAACATTCTAGAGGGGCATCCACAAGTCTCGGTGCAGTTATGATGGTGTGGGATGGGAGTGCATAGA
AATTCTCAGGACCTTCAGACATCTGTATCTCCTGTGGCCAAGGCCACTGTCAGAGGAAATAATCTAAATGTTTGTGGATTCCTGTGTCTC
CCTGGGCAGTTGACCTGCACAGACAGGAACCTCAGCAGTGACAGAAGAGAGATCCAGGGATGGGTCTTCTCTGACCCAGCCAGCATTCCG
AGTGACTGAGGTGGATGTGGACATCATTGCTTACCAATTTTTACCAACATTGAGGCAGGGCTCACTCTCCTAAATTGTAGGGAGAGGAAT
ATGGTAAAGCCAAAATAGTTGACAGATCTAACTTTCCTAGTGGAACAGTATATATAGATTTTAATGAGGAACATTTATTTAATAGCTTTA
TGGAGGTATGATTAACATGCAATAAACTGCAAATATGTAAAGTGTAAAATGTGCTGTTTCAGCATGTGTGTACACCTATGAAACCACCAC
AGTCAAGATATCCAACACAACAAAAGATTGTCCCTTTATAATCCTCAATTTTTCCTTATCTTGTTTTCCACAATTCACAAGCAACAGCAA
GCATTTTCTATAATTTTATAAATGAAACCATATGGTGTGTACTTTTTAGGGGGTGGGGCTCTGGCTTTTTCAGTAAACATAACTATTTTA
AGGTTAATCCATTATCTTGTTGCATGAATCAATTGTTTGCTCATTTGTATTGCTGCGTAGTATTTCAGTATTTCATTGTATACCACAATT
TTTCTTCTTTGTCAACTTAATTGTTATGGATGTTTGGGTAACTTTCAGTTTTTGGCTATTACAAATAAACCTCTGAAGATTTGTGTGCAA

>8363_8363_1_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000373344_ZNF304_chr19_57865093_ENST00000391705_length(amino acids)=622AA_BP=1
MYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFS
FSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDY
DGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHY
TCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECG
KFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRK
DTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH

--------------------------------------------------------------
>8363_8363_2_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000395603_ZNF304_chr19_57865093_ENST00000391705_length(transcript)=4231nt_BP=235nt
CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGG
GGAGGTTCCAGCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGC
AATCACAGAAGCCGACAAGGCGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGAGTTGTGTGACCTTCGAGGATGTGTTCGTGTACTT
CTCTCGGGAGGAGTGGGAACTCCTTGAGGAGGCACAGAGATTCCTGTACCGTGATGTGATGCTGGAGAACTTTGCACTTGTGGCTACACT
AGGTTTTTGGTGTGAAGCAGAACATGAGGCACCTTCTGAGCAGAGCGTTTCTGTAGAAGGAGTGTCACAGGTCAGGACTGCTGAGTCAGG
TCTTTTCCAGAAAGCACACCCATGTGAGATGTGTGACCCACTCTTGAAAGACATTTTGCACCTGGCTGAACACCAGGGATCACACCTTAC
ACAGAAACTGTGCACACGTGGGCTGTGTAGGAGAAGATTCTCGTTCAGTGCAAACTTTTACCAGCACCAGAAGCAACATAATGGAGAGAA
TTGCTTCAGAGGGGATGATGGAGGGGCCTCATTTGTGAAGAGCTGTACAGTCCACATGTTAGGGAGATCCTTTACGTGCAGGGAGGAAGG
GATGGACTTACCAGATAGCTCTGGCCTTTTCCAGCACCAGACCACTTACAATAGGGTGAGTCCATGCAGAAGGACTGAATGCATGGAGTC
TTTCCCACACAGCTCCAGTCTCAGGCAACACCAAGGAGACTATGATGGACAGATGCTTTTCAGTTGCGGTGATGAAGGGAAAGCCTTCCT
GGACACCTTTACTCTTCTTGACAGCCAGATGACTCATGCTGAGGTGAGACCCTTCAGATGCCTACCATGTGGAAATGTGTTCAAGGAGAA
ATCAGCTCTTATTAATCACAGAAAAATCCACAGTGGAGAAATATCTCATGTGTGTAAGGAGTGTGGAAAAGCCTTCATTCACTTGCACCA
CCTAAAAATGCACCAGAAATTTCACACTGGAAAAAGACACTATACATGCAGTGAATGTGGGAAGGCCTTCAGCCGCAAGGACACACTTGT
TCAGCATCAGAGAGTTCACACTGGAGAAAGATCTTATGACTGCAGTGAATGTGGAAAAGCCTACAGCAGAAGCTCCCACCTTGTTCAGCA
CCAGAGAATTCACACAGGAGAAAGGCCTTATAAGTGCAACAAATGTGGGAAAGCCTTTAGCCGTAAAGACACACTTGTTCAGCACCAGAG
ATTTCATACTGGAGAAAGGCCTTATGAGTGCAGTGAATGTGGAAAATTCTTTAGCCAAAGCTCCCACCTTATTGAGCACTGGAGAATTCA
TACCGGGGCAAGGCCCTATGAATGCATAGAATGTGGAAAATTCTTTAGCCATAACTCTAGCCTCATTAAACATCGGAGAGTCCACACAGG
AGCAAGATCCTACGTGTGCAGCAAATGTGGGAAGGCCTTTGGCTGCAAAGACACACTTGTTCAGCACCAGATAATTCACACTGGAGCAAG
GCCTTATGAGTGCAGTGAATGTGGGAAGGCCTTCAGCCGTAAAGACACACTTGTGCAACACCAAAAAATCCACACTGGAGAAAGGCCTTA
TGAGTGTGGTGAATGTGGTAAATTCTTCAGCCATAGCTCCAACCTTATTGTACACCAGAGAATTCACACTGGAGCAAAGCCTTATGAGTG
CAATGAATGTGGGAAATGCTTTAGCCACAACTCCAGCCTCATTTTGCACCAGAGAGTTCACACAGGAGCAAGGCCTTATGTGTGCAGTGA
ATGTGGGAAGGCTTACATTAGTAGCTCCCACCTTGTTCAACACAAGAAAGTTCACACTGGAGCAAGACCTTATGAGTGCAGTGAATGTGG
GAAATTCTTTAGCCGCAACTCTGGCCTCATTCTGCACCAGAGGGTTCACACTGGAGAAAAGCCTTACGTATGCAGCGAATGTGGGAAAGC
CTATAGCAGAAGCTCCCATCTTGTTCGTCACCAGAAAGCTCACACTGGAGAAAGAGCTCACGAGTGCAACAGTTTTGGTGGCCCTTTAGC
TGCATCTCTTAAACTTGTTTAACACCAGAAAATTCACACAAGAGAAAGGCCTTATGAATGCAGAAAATATGTCATCTTGTTCATCCTCAT
AGGACTCACACCAGAGCAATGCTCTGTGAGTACCCTTTGTGAGGGAACCATCAGCTAGCAGATGAGCACCGTATATTCATTCCACCCTGG
GGAGATTCCTGATAAGCACCACATATGTGGGAGGCTTTCATGAGGTGTGTTGCACTTTGTAACTGTCTAGAGCTCTTGATGGAATTATAT
CACTGCCAGTGCCTGTGGCGGAAGCCATCTTATTGCTACCAGCTGTGTGTGTCAATCACTCCATTTTGCTCAGGGAAGGCAGACTTCTGT
GCTTTCTTTCCTGTTCCCTACAGGTAATCATGAATATTTTCAAGGACTTCCCCCCCCCCCCACTTCACCCCCTACCATTGAGGGTCCTCA
TCTTTTCCCTCATGATTAGGTTCTGAGCAAACATGATCTAGCTCTCACCAAAAGGACCTGAGCTAGGGTCTGCTGGGATTTCCTGACACG
ATTTTCCATCTTCATGGACAATGTTAACTGTAAACGTGATAGCTGTGACTTACTTGTCTTACTGCCAAATCGCCCAAATTTGGAACTGCT
TGTCCCATGCTGCTCTGATTTATACAGTGATAAGGGCCTATTGTGGCAGTCTTTACTCTTGGGGATTTTGTTACTGTGTAGAGTGGATTG
AGAAAAGAATTGGGTTCTGTCATGAAGGGAGTAGCACCTTTTGTGGGCACCACCTTTATGTGCCTCAGAGGGGACCAAAGGATGGCAGAA
AACTGTTCTCAGTCTAGTTTGACCTAATTTACACTATTGCCCTAGGCTTGCTAGGAAAGACTGAAAAAATTTTTGTGCCTAACTTTGTGG
CCTGGCTGCCAGGATTTCCTGTGAGCCCAGTGAGGAGGGCATAGTTGGTGCGAAAATCTCCTGTGCTTGTGGAAGCAACATAAGTTGGGT
CCCTTAACTGTCACGTACTCCCCAGCACTGTTGAGGGATTGCTGTCTTCTGTACCTGTACAGGATCAAGTCCCTGATATCCAGAACCCCA
TAGGCAAGTAACATTGACTGTAAGACCTCTGTAGGGCAATGTGAAAATCATGATTGCTACAGAAGCACTGAGATAATGGAGTGGGGATGA
CTGTGGCAAACAAAAGGAGATTCGAACATTCTAGAGGGGCATCCACAAGTCTCGGTGCAGTTATGATGGTGTGGGATGGGAGTGCATAGA
AATTCTCAGGACCTTCAGACATCTGTATCTCCTGTGGCCAAGGCCACTGTCAGAGGAAATAATCTAAATGTTTGTGGATTCCTGTGTCTC
CCTGGGCAGTTGACCTGCACAGACAGGAACCTCAGCAGTGACAGAAGAGAGATCCAGGGATGGGTCTTCTCTGACCCAGCCAGCATTCCG
AGTGACTGAGGTGGATGTGGACATCATTGCTTACCAATTTTTACCAACATTGAGGCAGGGCTCACTCTCCTAAATTGTAGGGAGAGGAAT
ATGGTAAAGCCAAAATAGTTGACAGATCTAACTTTCCTAGTGGAACAGTATATATAGATTTTAATGAGGAACATTTATTTAATAGCTTTA
TGGAGGTATGATTAACATGCAATAAACTGCAAATATGTAAAGTGTAAAATGTGCTGTTTCAGCATGTGTGTACACCTATGAAACCACCAC
AGTCAAGATATCCAACACAACAAAAGATTGTCCCTTTATAATCCTCAATTTTTCCTTATCTTGTTTTCCACAATTCACAAGCAACAGCAA
GCATTTTCTATAATTTTATAAATGAAACCATATGGTGTGTACTTTTTAGGGGGTGGGGCTCTGGCTTTTTCAGTAAACATAACTATTTTA
AGGTTAATCCATTATCTTGTTGCATGAATCAATTGTTTGCTCATTTGTATTGCTGCGTAGTATTTCAGTATTTCATTGTATACCACAATT
TTTCTTCTTTGTCAACTTAATTGTTATGGATGTTTGGGTAACTTTCAGTTTTTGGCTATTACAAATAAACCTCTGAAGATTTGTGTGCAA

>8363_8363_2_ATRX-ZNF304_ATRX_chrX_77041468_ENST00000395603_ZNF304_chr19_57865093_ENST00000391705_length(amino acids)=622AA_BP=1
MYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFS
FSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDY
DGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHY
TCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECG
KFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRK
DTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATRX-ZNF304


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1351189_13266.6666666666666672493.0DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1341189_13266.6666666666666672455.0DAXX
HgeneATRXchrX:77041468chr19:57865093ENST00000373344-1352010_22806.6666666666666672493.0MECP2
HgeneATRXchrX:77041468chr19:57865093ENST00000395603-1342010_22806.6666666666666672455.0MECP2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATRX-ZNF304


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATRX-ZNF304


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource