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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATXN10-APPL1 (FusionGDB2 ID:8364)

Fusion Gene Summary for ATXN10-APPL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATXN10-APPL1
Fusion gene ID: 8364
HgeneTgene
Gene symbol

ATXN10

APPL1

Gene ID

25814

26060

Gene nameataxin 10adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
SynonymsE46L|HUMEEP|SCA10APPL|DIP13alpha|MODY14
Cytomap

22q13.31

3p14.3

Type of geneprotein-codingprotein-coding
Descriptionataxin-10brain protein E46 homologspinocerebellar ataxia type 10 proteinDCC-interacting protein 13-alphaAKT2 interactoradapter protein containing PH domain, PTB domain and leucine zipper motif 1adaptor protein containing pH domain, PTB domain and leucine zipper motif 1adaptor protein, phosphotyrosine interaction, PH domai
Modification date2020031320200313
UniProtAcc

Q9UBB4

Q9UKG1

Ensembl transtripts involved in fusion geneENST00000252934, ENST00000381061, 
ENST00000402380, ENST00000498009, 
ENST00000288266, 
Fusion gene scores* DoF score16 X 12 X 11=21124 X 5 X 3=60
# samples 195
** MAII scorelog2(19/2112*10)=-3.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATXN10 [Title/Abstract] AND APPL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATXN10(46136418)-APPL1(57280104), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATXN10

GO:0031175

neuron projection development

16498633

TgeneAPPL1

GO:0006606

protein import into nucleus

26583432

TgeneAPPL1

GO:2000045

regulation of G1/S transition of mitotic cell cycle

15016378


check buttonFusion gene breakpoints across ATXN10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APPL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H7-01AATXN10chr22

46136418

-APPL1chr3

57280104

+
ChimerDB4BRCATCGA-BH-A0H7-01AATXN10chr22

46136418

+APPL1chr3

57280104

+
ChimerDB4BRCATCGA-BH-A0H7ATXN10chr22

46136418

+APPL1chr3

57280103

+


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Fusion Gene ORF analysis for ATXN10-APPL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252934ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280104

+
In-frameENST00000252934ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280103

+
In-frameENST00000381061ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280104

+
In-frameENST00000381061ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280103

+
intron-3CDSENST00000402380ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280104

+
intron-3CDSENST00000402380ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280103

+
intron-3CDSENST00000498009ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280104

+
intron-3CDSENST00000498009ENST00000288266ATXN10chr22

46136418

+APPL1chr3

57280103

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381061ATXN10chr2246136418+ENST00000288266APPL1chr357280104+668412472662902878
ENST00000252934ATXN10chr2246136418+ENST00000288266APPL1chr357280104+687514382653093942
ENST00000381061ATXN10chr2246136418+ENST00000288266APPL1chr357280103+668412472662902878
ENST00000252934ATXN10chr2246136418+ENST00000288266APPL1chr357280103+687514382653093942

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381061ENST00000288266ATXN10chr2246136418+APPL1chr357280104+0.0001321950.9998678
ENST00000252934ENST00000288266ATXN10chr2246136418+APPL1chr357280104+0.0001421910.9998578
ENST00000381061ENST00000288266ATXN10chr2246136418+APPL1chr357280103+0.0001321950.9998678
ENST00000252934ENST00000288266ATXN10chr2246136418+APPL1chr357280103+0.0001421910.9998578

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Fusion Genomic Features for ATXN10-APPL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATXN10chr2246136418+APPL1chr357280103+0.0001414140.9998586
ATXN10chr2246136418+APPL1chr357280103+0.0001414140.9998586
ATXN10chr2246136418+APPL1chr357280103+0.0001414140.9998586
ATXN10chr2246136418+APPL1chr357280103+0.0001414140.9998586

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATXN10-APPL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46136418/chr3:57280104)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATXN10

Q9UBB4

APPL1

Q9UKG1

FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:26073777, PubMed:19661063, PubMed:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:26073777, PubMed:19661063, PubMed:24879834). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPPL1chr22:46136418chr3:57280103ENST00000288266622215_259158710.0Coiled coilOntology_term=ECO:0000255
TgeneAPPL1chr22:46136418chr3:57280103ENST00000288266622621_673158710.0Coiled coilOntology_term=ECO:0000255
TgeneAPPL1chr22:46136418chr3:57280104ENST00000288266622215_259158710.0Coiled coilOntology_term=ECO:0000255
TgeneAPPL1chr22:46136418chr3:57280104ENST00000288266622621_673158710.0Coiled coilOntology_term=ECO:0000255
TgeneAPPL1chr22:46136418chr3:57280103ENST00000288266622277_375158710.0DomainPH
TgeneAPPL1chr22:46136418chr3:57280103ENST00000288266622496_656158710.0DomainPID
TgeneAPPL1chr22:46136418chr3:57280104ENST00000288266622277_375158710.0DomainPH
TgeneAPPL1chr22:46136418chr3:57280104ENST00000288266622496_656158710.0DomainPID
TgeneAPPL1chr22:46136418chr3:57280103ENST00000288266622403_414158710.0MotifNote=F%26H
TgeneAPPL1chr22:46136418chr3:57280104ENST00000288266622403_414158710.0MotifNote=F%26H

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPPL1chr22:46136418chr3:57280103ENST000002882666223_268158710.0DomainBAR
TgeneAPPL1chr22:46136418chr3:57280104ENST000002882666223_268158710.0DomainBAR
TgeneAPPL1chr22:46136418chr3:57280103ENST000002882666221_428158710.0RegionNote=Required for RAB5A binding
TgeneAPPL1chr22:46136418chr3:57280104ENST000002882666221_428158710.0RegionNote=Required for RAB5A binding


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Fusion Gene Sequence for ATXN10-APPL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8364_8364_1_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000252934_APPL1_chr3_57280103_ENST00000288266_length(transcript)=6875nt_BP=1438nt
GGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGGC
GGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATCC
TACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGGC
GGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGCT
CTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCTGTTGA
GCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAATGCTTG
CATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCG
AGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTAT
TGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTT
TACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGA
ATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGA
AAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGC
TGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGC
TACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAG
AGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGA
CATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGT
GAAGTATGAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCA
GTACAAGAAGAAAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAA
TGAACAACTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACA
GACAATAGAGGATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCG
AAAGGCTGGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTT
AATGAGTCAGGCCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACG
ATATTGTTTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTAC
AATAAACAACATATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCAC
TCCTTCCCCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGG
ATCCTTAGGATCTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTC
TCCTGTGTGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTAC
AAAATCTGAAACTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGA
TGTTGTTTATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTG
TGACTGTTTAAAGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGA
AAATAAGCGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAA
CAATGAGGGGGAAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACA
AAAAGAAATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTT
GATAGCTGCTTCCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGG
AGAAGGAGGAAAGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAAT
GGCAGAAGGTAACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGAT
TGAACTTGATGACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCT
CCCTGAAGCAGACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGT
GTCCATAAGAAATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCA
TTTAGCTGAATAAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTA
TAAAATAATTAGAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCA
CATTTCTCTAATGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTA
TCACATTCTTAGTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTT
TTGTTCAATACATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTT
TATTGAAAGTCAAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAA
TGTAATCTTTTAAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCAC
AAAGGCAAATAACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTT
TGTGAAAGATTGAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAA
CATTTCTCTACTGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGT
GTTTCACATGAAAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTT
AGCCACTAAGACTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAAT
GGCATCTGTTTTAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAG
GATCATGATATTCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTA
GAAATTTATGAAATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGT
TAAAGTTGGAATTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCC
ATTAAGTCTTTTGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAG
GCAGCTTTACTAAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACT
GGCAGACTTAGGGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAG
GTCAGATCGAAGTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGA
ACTATATGAACTATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGC
CTAGTGGTAAAGCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCT
TTTCTCACATTCAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTAC
AATGCATTCTGTTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAA
AAATTTTGAGAACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGA
TTATTGTTTAATTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGAT
GTGCATCCTAGGGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGA
ATCCTATTAATGCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACA
GAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGC
CTCAGCCTCCCGAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTG
TTAGCCAGGATGTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCC
CGGCCCTAAAATGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAG
AAAGCAACCCTTTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTG
AAACTGGAACTATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTG
TAACTAATATGCAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAG
TGTACAATTCAAAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGG
GTGGAGAACTTATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAA

>8364_8364_1_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000252934_APPL1_chr3_57280103_ENST00000288266_length(amino acids)=942AA_BP=390
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRN
ACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI
LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLR
HAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE
GDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSEN
LNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGG
NLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEA
VTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGG
STKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATH
QENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQS

--------------------------------------------------------------
>8364_8364_2_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000252934_APPL1_chr3_57280104_ENST00000288266_length(transcript)=6875nt_BP=1438nt
GGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGGC
GGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATCC
TACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGGC
GGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGCT
CTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCTGTTGA
GCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAATGCTTG
CATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCG
AGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTAT
TGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTT
TACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGA
ATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGA
AAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGC
TGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGC
TACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAG
AGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGA
CATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGT
GAAGTATGAAGTAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCA
GTACAAGAAGAAAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAA
TGAACAACTGGAAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACA
GACAATAGAGGATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCG
AAAGGCTGGATACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTT
AATGAGTCAGGCCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACG
ATATTGTTTTCAGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTAC
AATAAACAACATATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCAC
TCCTTCCCCATCTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGG
ATCCTTAGGATCTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTC
TCCTGTGTGTGAAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTAC
AAAATCTGAAACTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGA
TGTTGTTTATGAAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTG
TGACTGTTTAAAGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGA
AAATAAGCGCCTTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAA
CAATGAGGGGGAAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACA
AAAAGAAATAGAGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTT
GATAGCTGCTTCCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGG
AGAAGGAGGAAAGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAAT
GGCAGAAGGTAACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGAT
TGAACTTGATGACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCT
CCCTGAAGCAGACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGT
GTCCATAAGAAATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCA
TTTAGCTGAATAAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTA
TAAAATAATTAGAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCA
CATTTCTCTAATGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTA
TCACATTCTTAGTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTT
TTGTTCAATACATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTT
TATTGAAAGTCAAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAA
TGTAATCTTTTAAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCAC
AAAGGCAAATAACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTT
TGTGAAAGATTGAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAA
CATTTCTCTACTGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGT
GTTTCACATGAAAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTT
AGCCACTAAGACTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAAT
GGCATCTGTTTTAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAG
GATCATGATATTCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTA
GAAATTTATGAAATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGT
TAAAGTTGGAATTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCC
ATTAAGTCTTTTGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAG
GCAGCTTTACTAAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACT
GGCAGACTTAGGGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAG
GTCAGATCGAAGTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGA
ACTATATGAACTATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGC
CTAGTGGTAAAGCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCT
TTTCTCACATTCAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTAC
AATGCATTCTGTTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAA
AAATTTTGAGAACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGA
TTATTGTTTAATTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGAT
GTGCATCCTAGGGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGA
ATCCTATTAATGCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACA
GAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGC
CTCAGCCTCCCGAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTG
TTAGCCAGGATGTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCC
CGGCCCTAAAATGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAG
AAAGCAACCCTTTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTG
AAACTGGAACTATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTG
TAACTAATATGCAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAG
TGTACAATTCAAAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGG
GTGGAGAACTTATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAA

>8364_8364_2_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000252934_APPL1_chr3_57280104_ENST00000288266_length(amino acids)=942AA_BP=390
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRN
ACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI
LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLR
HAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE
GDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSEN
LNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGG
NLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEA
VTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGG
STKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATH
QENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQS

--------------------------------------------------------------
>8364_8364_3_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000381061_APPL1_chr3_57280103_ENST00000288266_length(transcript)=6684nt_BP=1247nt
AGGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGG
CGGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATC
CTACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGG
CGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGC
TCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGG
AATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGC
ATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTA
ATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGC
CGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACAC
TGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTG
CAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGC
TTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATC
TTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATG
TGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTGAAGTATGAAG
TAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCAGTACAAGAAGA
AAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAATGAACAACTGG
AAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACAGACAATAGAGG
ATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCGAAAGGCTGGAT
ACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTTAATGAGTCAGG
CCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACGATATTGTTTTC
AGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTACAATAAACAACA
TATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCACTCCTTCCCCAT
CTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGGATCCTTAGGAT
CTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTCTCCTGTGTGTG
AAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTACAAAATCTGAAA
CTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGATGTTGTTTATG
AAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTGTGACTGTTTAA
AGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGAAAATAAGCGCC
TTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAACAATGAGGGGG
AAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACAAAAAGAAATAG
AGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTTGATAGCTGCTT
CCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGGAGAAGGAGGAA
AGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAATGGCAGAAGGTA
ACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGATTGAACTTGATG
ACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCTCCCTGAAGCAG
ACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGTGTCCATAAGAA
ATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCATTTAGCTGAAT
AAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTATAAAATAATTA
GAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCACATTTCTCTAA
TGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTATCACATTCTTA
GTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTTTTGTTCAATAC
ATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTTTATTGAAAGTC
AAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAATGTAATCTTTT
AAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCACAAAGGCAAATA
ACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTTTGTGAAAGATT
GAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAACATTTCTCTAC
TGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGTGTTTCACATGA
AAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTTAGCCACTAAGA
CTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAATGGCATCTGTTT
TAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAGGATCATGATAT
TCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTAGAAATTTATGA
AATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGTTAAAGTTGGAA
TTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCCATTAAGTCTTT
TGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAGGCAGCTTTACT
AAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACTGGCAGACTTAG
GGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAGGTCAGATCGAA
GTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGAACTATATGAAC
TATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGCCTAGTGGTAAA
GCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCTTTTCTCACATT
CAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTACAATGCATTCTG
TTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAAAAATTTTGAGA
ACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGATTATTGTTTAA
TTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGATGTGCATCCTAG
GGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGAATCCTATTAAT
GCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACAGAGTCTTGCTC
TGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCC
GAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGAT
GTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCCTAAAA
TGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAGAAAGCAACCCT
TTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTGAAACTGGAACT
ATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTGTAACTAATATG
CAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAGTGTACAATTCA
AAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGGGTGGAGAACTT
ATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAATAAAGTCCATG

>8364_8364_3_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000381061_APPL1_chr3_57280103_ENST00000288266_length(amino acids)=878AA_BP=326
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVW
VHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERV
TLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVI
DLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYK
KKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKA
GYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTIN
NISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPV
CEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDC
LKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKE

--------------------------------------------------------------
>8364_8364_4_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000381061_APPL1_chr3_57280104_ENST00000288266_length(transcript)=6684nt_BP=1247nt
AGGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGG
CGGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATC
CTACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGG
CGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGC
TCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGG
AATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGC
ATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTA
ATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGC
CGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACAC
TGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTG
CAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGC
TTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATC
TTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATG
TGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTGAAGTATGAAG
TAACAGAAGATGTGTACACATCCAGAAAGAAACAACACCAGACCATGATGCATTATTTTTGTGCATTAAATACTCTTCAGTACAAGAAGA
AAATAGCATTGTTAGAACCTCTACTTGGGTACATGCAAGCTCAGATAAGTTTCTTTAAGATGGGTTCTGAAAATCTTAATGAACAACTGG
AAGAATTTTTAGCTAATATTGGAACAAGCGTTCAGAATGTTCGCAGGGAAATGGACAGTGATATAGAGACCATGCAACAGACAATAGAGG
ATTTGGAAGTAGCCAGTGATCCCTTATATGTGCCTGACCCAGACCCCACCAAATTTCCTGTTAATCGAAATTTAACCCGAAAGGCTGGAT
ACCTTAATGCTAGGAATAAAACAGGCTTGGTGTCATCTACCTGGGACAGACAGTTTTACTTCACGCAGGGTGGAAATTTAATGAGTCAGG
CCCGTGGGGATGTAGCAGGAGGCCTGGCCATGGACATAGACAACTGTTCAGTGATGGCTGTGGACTGTGAAGACAGACGATATTGTTTTC
AGATCACCTCTTTCGATGGAAAAAAATCTTCAATTTTGCAAGCAGAGAGTAAAAAAGATCATGAAGAGTGGATCTGTACAATAAACAACA
TATCTAAACAAATATACTTAAGTGAAAATCCAGAGGAAACTGCTGCACGAGTAAATCAATCAGCTCTGGAAGCTGTCACTCCTTCCCCAT
CTTTCCAGCAGAGGCACGAGAGCCTGCGGCCAGCAGCAGGACAATCTCGGCCACCGACAGCTCGAACCAGCAGTTCAGGATCCTTAGGAT
CTGAGTCTACAAATTTGGCTGCCCTCTCTCTAGATTCTCTTGTTGCCCCAGACACCCCAATACAGTTTGACATAATTTCTCCTGTGTGTG
AAGATCAGCCTGGCCAGGCAAAAGCCTTTGGCCAGGGAGGCAGGCGTACAAATCCATTTGGAGAATCTGGAGGAAGTACAAAATCTGAAA
CTGAAGATTCTATTCTTCATCAGTTATTTATTGTCCGATTCCTTGGTTCAATGGAGGTGAAATCAGATGACCATCCAGATGTTGTTTATG
AAACTATGCGCCAAATCTTAGCTGCCCGGGCCATCCATAACATCTTTCGTATGACAGAATCGCATTTATTAGTCACTTGTGACTGTTTAA
AGTTAATTGATCCACAGACACAAGTTACAAGGCTCACGTTTCCATTACCTTGTGTAGTTTTGTATGCTACACACCAGGAAAATAAGCGCC
TTTTTGGATTTGTTCTTCGGACATCAAGCGGGAGAAGTGAAAGTAATCTGTCATCAGTCTGCTATATATTTGAGTCAAACAATGAGGGGG
AAAAGATATGTGATTCTGTTGGACTGGCAAAACAGATAGCTTTGCATGCTGAACTGGATCGTAGGGCATCAGAAAAACAAAAAGAAATAG
AGAGAGTAAAAGAGAAGCAACAGAAAGAACTCAATAAACAAAAACAGATTGAAAAGGACTTGGAAGAACAAAGTCGGTTGATAGCTGCTT
CCAGTAGACCAAACCAAGCCAGTAGTGAGGGGCAGTTTGTTGTCCTTAGCAGTAGCCAGTCAGAAGAGAGTGATTTGGGAGAAGGAGGAA
AGAAGAGAGAATCAGAAGCATAAGCTTATACTTTTGGTAGATATTCCCCCTTGGAATTTGACAGTTTCTATGGTGAAATGGCAGAAGGTA
ACAACTATGTTGAAATATCAAGGAGGAGATTAAGCTTTATATTTGCTTATTTGTTGTAGCTACATTTTAAAAAAAAGATTGAACTTGATG
ACTTAGGTTTGCATTGATCTTTTTTCCCCCTTAAACATAATGTACTATGTATTAACATCTAAAGGAAACCTGCTCATCTCCCTGAAGCAG
ACTGCTGAGGAATTACATTTGCTCAAGAATTTTTTCCGTCAAATTGTGAACTTTTAATTCTTGCATTGTAATTGGCTGTGTCCATAAGAA
ATCATTTATTCTTCAGGCTTAGACATTCATGGATATGCTTTTCTTTCATTAGGAACATTTTGCTGGTGATGAGGAAGCATTTAGCTGAAT
AAGTTTAAAGCCCTTTATACAGAGAATTCTACAAGTTTGCAAATATTTTAACAATATTAAATGTGCAATAGAACTTTTATAAAATAATTA
GAACAGAGATTTTACAGTTAAGGTTTCAAATTGTGGCAGGTGGTACTGTTGATCTCAGGGTACTTTCTGGGATTGCTCACATTTCTCTAA
TGTACTGCACTTGATGCCAGTAGGAAAGAAGCTTAAGTGTCTTCAGTTCAAGATTGATAGAGCCCTTGGCATTTTATTATCACATTCTTA
GTTCTCAGGTTGGGACTTCAATTACTGCTGCAGAGCAGTAGTGGTTAAAAATAAGATATTGGAATTTATTAAAAGATTTTTGTTCAATAC
ATTTTAGATTAGGATTGACAAGTAAAGATACTGCTATGGAATGATACATTGTATTTTCTGCATTGTGTGAAATAGTTTTTATTGAAAGTC
AAGTGACATTTCAAAAGAAGTTCTATAACAATTATGTTTCATGCTTAAAGTAAAAATTCCCAGAGTTTAGTTTAGAAAATGTAATCTTTT
AAATTTCAGACTGATATATTCCCAGTATTTTCATAATGCCATGTTTTGATAAAGTACTGAATCACCACTTTATATCCACAAAGGCAAATA
ACTAATGTATGATAATAGAATAATTTGCACTAATTATTGTAAATATGTCTACTCTTCAAATGAGTAAAAGGTCCAATTTTGTGAAAGATT
GAAAATGAATTGAATGCCTAGTAGAGTATAGGAGAAGTTGACCAAGGAAGGATTTAACCTGGTGCCAAGGTTAAAATAACATTTCTCTAC
TGCCTATTGTTTATGTTAAACCTTAATTTTTTTTCTGTAATCACTTTTAACACTGCTAATAGAAATTATGTTTTCATGTGTTTCACATGA
AAAAGTATATATATACAAAGTTAATATAGTGGGTAAAATACTTTACATAGTCACACATTTACAAATTTTTCAAGAGGTTAGCCACTAAGA
CTTTAATAATTTTACAAGGGAAAAAGCCTTTTTTTTTCTTTGATATACAGTTTTTTCTTCTTAGTTCTGCATTAGAAATGGCATCTGTTT
TAGGTCTCAAAATATAACTCAGCTGTTTCACACTGTATATGTACATTGTTTTCTGTAGGAATAGGATAATGATATATAGGATCATGATAT
TCCTTCTATCCATGTGCCAAATGGGTGTAATGTTTATTTACTGATGCTTTATGTTACCAAAACATACAGTAAAAAAGTAGAAATTTATGA
AATACTTTTGATAAAAAGTTTATTTTGTGCTTACCAAAAGGAATGCTTTCACAATAGTGTATCAGTTCTTTTGTTTTGTTAAAGTTGGAA
TTTATTCTGTTGCCAGCATTTAAGTAGTCATGGCAAGTCCTGTTTTTAAGACCTTTTGGAGACTGGAGCTTTCTGTTCCATTAAGTCTTT
TGTTTATACTACAAATTGTCACCTCACTTAGTTCAGATGAAATCTGTTACTCTACAAGGAAGGTGTTCATCATTAGGAGGCAGCTTTACT
AAGCTGGTGCTTTGCATGGTAGCAAGTGCTGCCCTTTATCAGCACCCTGGGTCATAGTGTAGGCTAGAGTTAAGGCACTGGCAGACTTAG
GGATGCTGGACAGACCTGTAGTTCGTTTTAAGTCATGTTCACAGGAATTTCTACAATAATAAACCCATCATCTCCATAGGTCAGATCGAA
GTGCATTCCAATGCTAAATAGAAGTTATGAGTGGGTTTAACAATTTTAGATGATTCAGCTTTTGTTCCATTACTGTTGAACTATATGAAC
TATTCCATTACTGCAGAGATTTAAGTATCTGTTTTAATAAGCTCTTTTTGTTATTTAAAGGCTGCCCATGGGTTTCTGCCTAGTGGTAAA
GCTGATTGTTACCCTCCTTTGAAATCCCTTCTAGTTCTGAGATGCTTTGAGGGTAACTGGATTCGATTTTGGGATATCTTTTCTCACATT
CAGACTTACACTTAATGGTGTTAGAAATCAACAAAACTCCTTTTTAAAAAGAAAAGATATTAAGCCTGCCTACTTCTACAATGCATTCTG
TTACCTATTTGAACAGTATGTTTGTAACTATGGCAATGAAGTCAGTAGATAGGAAACCAGTTATTCCTTCTACCTTTAAAAATTTTGAGA
ACTTGCCAACCAGGGATTAAAGCTATTATCTTGAACAGAGTCCCTAAAGCTAGTCTAGTTTTTGCCACATCTGCAATGATTATTGTTTAA
TTTCAAAAGAATCCTCAGGCTCTACAATCTAGGGGTGGTAAATGTGTTTCCACTATACTTGGGAAAAGGTCAGTAGGATGTGCATCCTAG
GGAAGATAAAATCGTATATGGTAAAGGCATTTGAGTTAATTTTGCATTATATCTAGGAACCATATTATTTAAAATTTGAATCCTATTAAT
GCTGAGAGATCCTAAGAGCTAGTATGTTGTAAAACCTGCCACCTGAATAAAATGAAAAAAAAAGTGTTTTTTTGAGACAGAGTCTTGCTC
TGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGGTCACTGCAAACTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCC
GAGTAGCTGGGACCACAGGGGCCCACCACCGCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGAT
GTTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCCTAAAA
TGAAATTATTAATGTTGGTTCTGAAACAGCCTCTTAGCATTCAGATTGTATTTTAAATACTTAAACACACCAATTGTAGAAAGCAACCCT
TTATTTTTAGCAAGTTTGGTTTACTCTTCTCCCATGAGATTTTGTCTTTCTACATTAACTAGTAAGACATAAAGATTTGAAACTGGAACT
ATATTATACTTTTTAACCAATCTCTGTGGCTTCACTCATGAAATTTACTTCAGTTAATATGAGACTGGGGGTTAAGTTGTAACTAATATG
CAAAATTGCTTTGTATATTTGGTGATTTTGTAATGTAAGTGAATTGATTCTTATTTCACTGATACTATTAATCATGCAGTGTACAATTCA
AAATCATGCAATGTTTCACTTTAGAATTGGATTTGAAGAACTCGACTTTATGTGATCATGGTATTGGTATACATGTGGGGTGGAGAACTT
ATTTTTTCATTTTGTCACAATAGGTATATACTGACAAGGCTTCAGGAAAAAAGTTGTTAGAAGATTTTTTAATGTATAATAAAGTCCATG

>8364_8364_4_ATXN10-APPL1_ATXN10_chr22_46136418_ENST00000381061_APPL1_chr3_57280104_ENST00000288266_length(amino acids)=878AA_BP=326
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVW
VHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERV
TLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVI
DLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYK
KKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKA
GYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTIN
NISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPV
CEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDC
LKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKE

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Fusion Gene PPI Analysis for ATXN10-APPL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATXN10-APPL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATXN10-APPL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource