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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLIT2-PACRGL (FusionGDB2 ID:83669)

Fusion Gene Summary for SLIT2-PACRGL

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT2-PACRGL
Fusion gene ID: 83669
HgeneTgene
Gene symbol

SLIT2

PACRGL

Gene ID

9353

133015

Gene nameslit guidance ligand 2parkin coregulated like
SynonymsSLIL3|Slit-2C4orf28
Cytomap

4p15.31

4p15.31

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 2 proteinPACRG-like proteinPARK2 co-regulated likePARK2 coregulated like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000273739, ENST00000503823, 
ENST00000503837, ENST00000504154, 
ENST00000509394, 		ENST00000507634, 
ENST00000295290, ENST00000360916, 
ENST00000444671, ENST00000502374, 
ENST00000502938, ENST00000503585, 
ENST00000508753, ENST00000513459, 
ENST00000538990, 
Fusion gene scores* DoF score5 X 5 X 2=504 X 6 X 2=48
# samples 65
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLIT2 [Title/Abstract] AND PACRGL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLIT2(20270504)-PACRGL(20728908), # samples:2
Anticipated loss of major functional domain due to fusion event.SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT2

GO:0001933

negative regulation of protein phosphorylation

18345009

HgeneSLIT2

GO:0002689

negative regulation of leukocyte chemotaxis

11309622

HgeneSLIT2

GO:0007411

axon guidance

11748139

HgeneSLIT2

GO:0008045

motor neuron axon guidance

10102268

HgeneSLIT2

GO:0010593

negative regulation of lamellipodium assembly

16439689

HgeneSLIT2

GO:0010596

negative regulation of endothelial cell migration

18345009

HgeneSLIT2

GO:0014912

negative regulation of smooth muscle cell migration

16439689

HgeneSLIT2

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT2

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneSLIT2

GO:0030336

negative regulation of cell migration

19005219

HgeneSLIT2

GO:0030837

negative regulation of actin filament polymerization

19759280

HgeneSLIT2

GO:0031290

retinal ganglion cell axon guidance

10864954|19498462

HgeneSLIT2

GO:0043116

negative regulation of vascular permeability

18345009

HgeneSLIT2

GO:0048754

branching morphogenesis of an epithelial tube

18345009

HgeneSLIT2

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT2

GO:0050919

negative chemotaxis

11748139

HgeneSLIT2

GO:0050929

induction of negative chemotaxis

10197527

HgeneSLIT2

GO:0051058

negative regulation of small GTPase mediated signal transduction

16439689

HgeneSLIT2

GO:0071504

cellular response to heparin

17062560

HgeneSLIT2

GO:0071672

negative regulation of smooth muscle cell chemotaxis

16439689

HgeneSLIT2

GO:0071676

negative regulation of mononuclear cell migration

16439689

HgeneSLIT2

GO:0090024

negative regulation of neutrophil chemotaxis

19759280

HgeneSLIT2

GO:0090260

negative regulation of retinal ganglion cell axon guidance

17062560

HgeneSLIT2

GO:0090288

negative regulation of cellular response to growth factor stimulus

16439689


check buttonFusion gene breakpoints across SLIT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PACRGL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AP-A052-01ASLIT2chr4

20555591

+PACRGLchr4

20754188

+
ChimerDB4UCECTCGA-AP-A052-01ASLIT2chr4

20555591

+PACRGLchr4

20754250

+
ChimerDB4UCECTCGA-KP-A3VZ-01ASLIT2chr4

20270504

+PACRGLchr4

20728908

+


Top

Fusion Gene ORF analysis for SLIT2-PACRGL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000273739ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-3UTRENST00000273739ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-3UTRENST00000503823ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-3UTRENST00000503823ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-3UTRENST00000503837ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-3UTRENST00000503837ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-3UTRENST00000504154ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-3UTRENST00000504154ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000273739ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000273739ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000273739ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000503823ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503823ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503823ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000503837ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000503837ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000503837ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000504154ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754250

+
5CDS-intronENST00000504154ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754188

+
5CDS-intronENST00000504154ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754250

+
Frame-shiftENST00000273739ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000273739ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000503823ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000503837ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000504154ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3UTRENST00000509394ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-3UTRENST00000509394ENST00000507634SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000295290SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000360916SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000444671SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000502374SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000502938SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000503585SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000508753SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-intronENST00000509394ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000513459SLIT2chr4

20555591

+PACRGLchr4

20754250

+
intron-intronENST00000509394ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754188

+
intron-intronENST00000509394ENST00000538990SLIT2chr4

20555591

+PACRGLchr4

20754250

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000503823SLIT2chr420270504+ENST00000538990PACRGLchr420728908+14569514691122217
ENST00000504154SLIT2chr420270504+ENST00000538990PACRGLchr420728908+1152647165818217
ENST00000273739SLIT2chr420270504+ENST00000538990PACRGLchr420728908+1126621139792217
ENST00000503837SLIT2chr420270504+ENST00000538990PACRGLchr420728908+9003950566188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000503823ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0389025250.9610975
ENST00000504154ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0260364410.97396356
ENST00000273739ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0282525660.97174746
ENST00000503837ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0226513170.9773487

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Fusion Genomic Features for SLIT2-PACRGL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLIT2chr420555591+PACRGLchr420754187+0.71292070.28707927
SLIT2chr420270504+PACRGLchr420728907+0.0008067340.99919325
SLIT2chr420555591+PACRGLchr420754187+0.71292070.28707927
SLIT2chr420270504+PACRGLchr420728907+0.0008067340.99919325

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLIT2-PACRGL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:20270504/chr4:20728908)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43631_551311522.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43731_551311526.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43731_551311530.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436104_1251311522.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43656_771311522.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43680_1011311522.0RepeatNote=LRR 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437104_1251311526.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43756_771311526.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43780_1011311526.0RepeatNote=LRR 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437104_1251311530.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43756_771311530.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43780_1011311530.0RepeatNote=LRR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361036_10741311522.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361076_11121311522.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361121_11571311522.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361160_13331311522.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361332_13681311522.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361453_15281311522.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436209_2591311522.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436264_3001311522.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436430_4801311522.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436497_5331311522.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436664_7141311522.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436718_7541311522.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436859_9091311522.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436918_9551311522.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436957_9961311522.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436998_10341311522.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371036_10741311526.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371076_11121311526.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371121_11571311526.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371160_13331311526.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371332_13681311526.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371453_15281311526.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437209_2591311526.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437264_3001311526.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437430_4801311526.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437497_5331311526.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437664_7141311526.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437718_7541311526.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437859_9091311526.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437918_9551311526.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437957_9961311526.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437998_10341311526.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371036_10741311530.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371076_11121311530.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371121_11571311530.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371160_13331311530.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371332_13681311530.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371453_15281311530.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437209_2591311530.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437264_3001311530.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437430_4801311530.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437497_5331311530.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437664_7141311530.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437718_7541311530.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437859_9091311530.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437918_9551311530.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437957_9961311530.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437998_10341311530.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436128_1491311522.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436152_1731311522.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436176_1971311522.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436301_3221311522.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436325_3461311522.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436349_3701311522.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436373_3941311522.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436397_4181311522.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436534_5551311522.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436559_5801311522.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436583_6041311522.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436607_6281311522.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436631_6521311522.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436755_7771311522.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436778_7991311522.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436802_8231311522.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436826_8471311522.0RepeatNote=LRR 20
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437128_1491311526.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437152_1731311526.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437176_1971311526.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437301_3221311526.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437325_3461311526.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437349_3701311526.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437373_3941311526.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437397_4181311526.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437534_5551311526.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437559_5801311526.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437583_6041311526.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437607_6281311526.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437631_6521311526.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437755_7771311526.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437778_7991311526.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437802_8231311526.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437826_8471311526.0RepeatNote=LRR 20
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437128_1491311530.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437152_1731311530.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437176_1971311530.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437301_3221311530.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437325_3461311530.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437349_3701311530.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437373_3941311530.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437397_4181311530.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437534_5551311530.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437559_5801311530.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437583_6041311530.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437607_6281311530.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437631_6521311530.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437755_7771311530.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437778_7991311530.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437802_8231311530.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437826_8471311530.0RepeatNote=LRR 20


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Fusion Gene Sequence for SLIT2-PACRGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83669_83669_1_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000273739_PACRGL_chr4_20728908_ENST00000538990_length(transcript)=1126nt_BP=621nt
GCCCAAGGAGCTCCTGCTCTGCCAGAGGAGGGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGTGGGCTCTACTGCCTTGTTCCATATTA
TTTGGTGCACATTTTCCCTGGCACTCTGGGTTGCTAGCCCCGCCGGGCACTGGGCCTCAGACACTGCGCGGTTCCCTCGGAGCAGCAAGC
TAAAGAAAGCCCCCAGTGCCGGCGAGGAAGGAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTT
AGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGC
GCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTGGATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTT
TGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAGATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACT
AGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTT
AGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTTGAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGT
GTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAATCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACA
CTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGAAAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTA
TTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTGCAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATA
ACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTATAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTAT

>83669_83669_1_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000273739_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------
>83669_83669_2_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503823_PACRGL_chr4_20728908_ENST00000538990_length(transcript)=1456nt_BP=951nt
TGCCCCGCGCGCTCTGCTACGGGCCCGCTGGGCTTCCGCGCCTTCTAGCTTCCGGAGCCCACTTTGATCGGGGCCATAATACCTATTGAG
ATCCCCTCTTCTGTCTTGTACCTTCGCCACTGGCATCGGATTTGCAGAAGCGTGCGTGGGATCAGAGGACCGCCCTCCCCACAACAACCG
GCCCCTGCATCTTAGCAGCCGTTGGAAGCCCCAGCTCTTTTACCGCCAAGTTCATCCTTGGGAGACAGAAGACGCGTGATCTCCTCTCCG
CTGCTCTTGGGGTCTCCTTGCAGCCCTGGCCAGGCGGATTCATCCTCAGGACCTAAAGTTGCCCAAGGAGCTCCTGCTCTGCCAGAGGAG
GGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGTGGGCTCTACTGCCTTGTTCCATATTATTTGGTGCACATTTTCCCTGGCACTCTGGG
TTGCTAGCCCCGCCGGGCACTGGGCCTCAGACACTGCGCGGTTCCCTCGGAGCAGCAAGCTAAAGAAAGCCCCCAGTGCCGGCGAGGAAG
GAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACC
GCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCG
CAACACCGAGAGACTGGATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCA
GCTTATGGAGAATAAGATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCT
TCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATAC
TGCTCCATATGCTGTTGAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTAT
TTTATTCTTTTGTAAATCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAG
AACAGTTACTAATGGAAAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGA
ACCATTATTGAGTTTGCAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGC
TGTGCCCTTATTTTTATAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTATAGAAGTTTAAAATAGTGGACAAATGTTTGT

>83669_83669_2_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503823_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------
>83669_83669_3_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503837_PACRGL_chr4_20728908_ENST00000538990_length(transcript)=900nt_BP=395nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT
GAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAA
TCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGA
AAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTG
CAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTA
TAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTATAGAAGTTTAAAATAGTGGACAAATGTTTGTGAATACACTTTTAAAA

>83669_83669_3_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503837_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=188AA_BP=0
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK
ISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVEEGSQQKLFFLPVDVSSTNCGYSFILFFCK

--------------------------------------------------------------
>83669_83669_4_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000504154_PACRGL_chr4_20728908_ENST00000538990_length(transcript)=1152nt_BP=647nt
CGGATTCATCCTCAGGACCTAAAGTTGCCCAAGGAGCTCCTGCTCTGCCAGAGGAGGGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGT
GGGCTCTACTGCCTTGTTCCATATTATTTGGTGCACATTTTCCCTGGCACTCTGGGTTGCTAGCCCCGCCGGGCACTGGGCCTCAGACAC
TGCGCGGTTCCCTCGGAGCAGCAAGCTAAAGAAAGCCCCCAGTGCCGGCGAGGAAGGAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGG
CAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGC
AGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTGGATTTAAATGGAAATAAC
ATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAGATTAGCACCATTGAAAGA
GGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACT
GCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTTGAAGAAGGGAGCCAACAA
AAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAATCACAGCCACCATTCATT
ATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGAAAGTTATTAAAATAAGTT
CTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTGCAAGATAAGATGTATTTG
TATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTATAGATAGTTTGCCATTTC

>83669_83669_4_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000504154_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLIT2-PACRGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLIT2-PACRGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLIT2-PACRGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource