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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLIT3-PPARGC1B (FusionGDB2 ID:83676)

Fusion Gene Summary for SLIT3-PPARGC1B

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT3-PPARGC1B
Fusion gene ID: 83676
HgeneTgene
Gene symbol

SLIT3

PPARGC1B

Gene ID

6586

133522

Gene nameslit guidance ligand 3PPARG coactivator 1 beta
SynonymsMEGF5|SLIL2|SLIT1|Slit-3|slit2ERRL1|PERC|PGC-1(beta)|PGC1B
Cytomap

5q34-q35.1

5q32

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3peroxisome proliferator-activated receptor gamma coactivator 1-betaPGC-1-related estrogen receptor alpha coactivatorPPAR-gamma coactivator 1-betaPPARGC-1-betaPPARgamma coactivator 1 betaperoxisome proliferator-activated receptor gamma, coactivator 1
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332966, ENST00000404867, 
ENST00000519560, ENST00000521130, 
ENST00000309241, ENST00000403750, 
ENST00000461780, ENST00000360453, 
ENST00000394320, 
Fusion gene scores* DoF score9 X 6 X 5=2708 X 7 X 7=392
# samples 89
** MAII scorelog2(8/270*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLIT3 [Title/Abstract] AND PPARGC1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLIT3(168671709)-PPARGC1B(149225323), # samples:1
Anticipated loss of major functional domain due to fusion event.SLIT3-PPARGC1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLIT3-PPARGC1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT3

GO:0007411

axon guidance

11748139

HgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT3

GO:0050919

negative chemotaxis

11748139

TgenePPARGC1B

GO:0006355

regulation of transcription, DNA-templated

23836911

TgenePPARGC1B

GO:0030520

intracellular estrogen receptor signaling pathway

11854298

TgenePPARGC1B

GO:0045944

positive regulation of transcription by RNA polymerase II

11854298


check buttonFusion gene breakpoints across SLIT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPARGC1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01ASLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+


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Fusion Gene ORF analysis for SLIT3-PPARGC1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332966ENST00000309241SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000332966ENST00000403750SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000332966ENST00000461780SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000404867ENST00000309241SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000404867ENST00000403750SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000404867ENST00000461780SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000519560ENST00000309241SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000519560ENST00000403750SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5CDS-intronENST00000519560ENST00000461780SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5UTR-3CDSENST00000521130ENST00000360453SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5UTR-3CDSENST00000521130ENST00000394320SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5UTR-intronENST00000521130ENST00000309241SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5UTR-intronENST00000521130ENST00000403750SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
5UTR-intronENST00000521130ENST00000461780SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
Frame-shiftENST00000332966ENST00000394320SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
Frame-shiftENST00000404867ENST00000394320SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
Frame-shiftENST00000519560ENST00000394320SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
In-frameENST00000332966ENST00000360453SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
In-frameENST00000404867ENST00000360453SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+
In-frameENST00000519560ENST00000360453SLIT3chr5

168671709

-PPARGC1Bchr5

149225323

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000519560SLIT3chr5168671709-ENST00000360453PPARGC1Bchr5149225323+10217617490250
ENST00000332966SLIT3chr5168671709-ENST00000360453PPARGC1Bchr5149225323+67441464669201
ENST00000404867SLIT3chr5168671709-ENST00000360453PPARGC1Bchr5149225323+6013410596198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000519560ENST00000360453SLIT3chr5168671709-PPARGC1Bchr5149225323+0.0111056320.98889434
ENST00000332966ENST00000360453SLIT3chr5168671709-PPARGC1Bchr5149225323+0.010081860.9899182
ENST00000404867ENST00000360453SLIT3chr5168671709-PPARGC1Bchr5149225323+0.009847610.9901524

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Fusion Genomic Features for SLIT3-PPARGC1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLIT3chr5168671708-PPARGC1Bchr5149225322+0.0005413310.99945873
SLIT3chr5168671708-PPARGC1Bchr5149225322+0.0005413310.99945873

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLIT3-PPARGC1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:168671709/chr5:149225323)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-33634_611131473.0DomainNote=LRRNT
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-33634_611131524.0DomainNote=LRRNT
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-33662_831131473.0RepeatNote=LRR 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-33686_1071131473.0RepeatNote=LRR 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-33662_831131524.0RepeatNote=LRR 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-33686_1071131524.0RepeatNote=LRR 2
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000360453811902_976899985.0DomainRRM
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000403750811902_976874960.0DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361034_10721131473.0DomainEGF-like 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361074_11101131473.0DomainEGF-like 5
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361119_11551131473.0DomainEGF-like 6
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361158_13321131473.0DomainLaminin G-like
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361340_13651131473.0DomainEGF-like 7
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361368_14031131473.0DomainEGF-like 8
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361408_14441131473.0DomainEGF-like 9
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-3361449_15231131473.0DomainCTCK
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336215_2651131473.0DomainNote=LRRCT 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336271_3071131473.0DomainNote=LRRNT 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336437_4871131473.0DomainNote=LRRCT 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336496_5321131473.0DomainNote=LRRNT 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336663_7131131473.0DomainNote=LRRCT 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336716_7521131473.0DomainNote=LRRNT 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336857_9071131473.0DomainNote=LRRCT 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336918_9531131473.0DomainEGF-like 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336955_9941131473.0DomainEGF-like 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336996_10321131473.0DomainEGF-like 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361034_10721131524.0DomainEGF-like 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361074_11101131524.0DomainEGF-like 5
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361119_11551131524.0DomainEGF-like 6
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361158_13321131524.0DomainLaminin G-like
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361340_13651131524.0DomainEGF-like 7
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361368_14031131524.0DomainEGF-like 8
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361408_14441131524.0DomainEGF-like 9
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-3361449_15231131524.0DomainCTCK
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336215_2651131524.0DomainNote=LRRCT 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336271_3071131524.0DomainNote=LRRNT 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336437_4871131524.0DomainNote=LRRCT 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336496_5321131524.0DomainNote=LRRNT 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336663_7131131524.0DomainNote=LRRCT 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336716_7521131524.0DomainNote=LRRNT 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336857_9071131524.0DomainNote=LRRCT 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336918_9531131524.0DomainEGF-like 1
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336955_9941131524.0DomainEGF-like 2
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336996_10321131524.0DomainEGF-like 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336110_1311131473.0RepeatNote=LRR 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336134_1551131473.0RepeatNote=LRR 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336158_1791131473.0RepeatNote=LRR 5
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336182_2031131473.0RepeatNote=LRR 6
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336308_3291131473.0RepeatNote=LRR 7
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336332_3531131473.0RepeatNote=LRR 8
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336356_3771131473.0RepeatNote=LRR 9
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336380_4011131473.0RepeatNote=LRR 10
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336404_4251131473.0RepeatNote=LRR 11
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336533_5541131473.0RepeatNote=LRR 12
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336558_5791131473.0RepeatNote=LRR 13
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336582_6031131473.0RepeatNote=LRR 14
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336606_6271131473.0RepeatNote=LRR 15
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336630_6511131473.0RepeatNote=LRR 16
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336753_7751131473.0RepeatNote=LRR 17
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336776_7971131473.0RepeatNote=LRR 18
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336800_8211131473.0RepeatNote=LRR 19
HgeneSLIT3chr5:168671709chr5:149225323ENST00000404867-336824_8451131473.0RepeatNote=LRR 20
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336110_1311131524.0RepeatNote=LRR 3
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336134_1551131524.0RepeatNote=LRR 4
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336158_1791131524.0RepeatNote=LRR 5
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336182_2031131524.0RepeatNote=LRR 6
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336308_3291131524.0RepeatNote=LRR 7
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336332_3531131524.0RepeatNote=LRR 8
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336356_3771131524.0RepeatNote=LRR 9
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336380_4011131524.0RepeatNote=LRR 10
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336404_4251131524.0RepeatNote=LRR 11
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336533_5541131524.0RepeatNote=LRR 12
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336558_5791131524.0RepeatNote=LRR 13
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336582_6031131524.0RepeatNote=LRR 14
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336606_6271131524.0RepeatNote=LRR 15
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336630_6511131524.0RepeatNote=LRR 16
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336753_7751131524.0RepeatNote=LRR 17
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336776_7971131524.0RepeatNote=LRR 18
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336800_8211131524.0RepeatNote=LRR 19
HgeneSLIT3chr5:168671709chr5:149225323ENST00000519560-336824_8451131524.0RepeatNote=LRR 20
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000309241912430_4509381024.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000309241912772_8239381024.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000360453811430_450899985.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000360453811772_823899985.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000394320911430_4509381018.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000394320911772_8239381018.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000403750811430_450874960.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000403750811772_823874960.0Compositional biasNote=Glu-rich
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000309241912902_9769381024.0DomainRRM
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000394320911902_9769381018.0DomainRRM
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000309241912156_1609381024.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000309241912691_6949381024.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000360453811156_160899985.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000360453811691_694899985.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000394320911156_1609381018.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000394320911691_6949381018.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000403750811156_160874960.0MotifNote=LXXLL motif 1
TgenePPARGC1Bchr5:168671709chr5:149225323ENST00000403750811691_694874960.0MotifNote=HCFC1-binding-motif (HBM)
TgenePPARGC1Bchr5:168671709chr5:149225323ENST000003092419121_919381024.0RegionNote=Abolishes DNA transcriptional activity when missing
TgenePPARGC1Bchr5:168671709chr5:149225323ENST000003604538111_91899985.0RegionNote=Abolishes DNA transcriptional activity when missing
TgenePPARGC1Bchr5:168671709chr5:149225323ENST000003943209111_919381018.0RegionNote=Abolishes DNA transcriptional activity when missing
TgenePPARGC1Bchr5:168671709chr5:149225323ENST000004037508111_91874960.0RegionNote=Abolishes DNA transcriptional activity when missing


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Fusion Gene Sequence for SLIT3-PPARGC1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83676_83676_1_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000332966_PPARGC1B_chr5_149225323_ENST00000360453_length(transcript)=674nt_BP=414nt
CGCGCGCCTCCTCGGGCTCCACGCGTCTTGCCCCGCAGAGGCAGCCTCCTCCAGGAGCGGGGCCCTGCACACCATGGCCCCCGGGTGGGC
AGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCAGCCGTCGCCTGCCCCAC
CAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCCCGCAACGCTGAGCGCCT
TGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTGCATCTGGAAGACAACCA
GGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTC
TGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCA
CTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTT

>83676_83676_1_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000332966_PPARGC1B_chr5_149225323_ENST00000360453_length(amino acids)=201AA_BP=115
MHTMAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNL
RVLHLEDNQVSVIERGAFQDLKQLERLGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASG

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>83676_83676_2_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000404867_PPARGC1B_chr5_149225323_ENST00000360453_length(transcript)=601nt_BP=341nt
ATGGCCCCCGGGTGGGCAGGGGTCGGCGCCGCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCA
GCCGTCGCCTGCCCCACCAAGTGTACCTGCTCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCC
CGCAACGCTGAGCGCCTTGACCTGGACAGAAATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTG
CATCTGGAAGACAACCAGGTCAGCGTCATCGAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTC
ATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGC
TACGGAGGGCTCCGGCACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAG

>83676_83676_2_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000404867_PPARGC1B_chr5_149225323_ENST00000360453_length(amino acids)=198AA_BP=112
MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVL
HLEDNQVSVIERGAFQDLKQLERLGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSK

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>83676_83676_3_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000519560_PPARGC1B_chr5_149225323_ENST00000360453_length(transcript)=1021nt_BP=761nt
GAGAGCGAGCGCCGGCCAGCTCACCCGGCCGCCCCGTGCCCCAGCCGCAGCCGCCGCGCTCCCCAGCCCAGCCCCAAGCCGGACCTCCCC
GGGCGCCACGCCCCATTGCGCTCGCCCCAGGTCCCCAACCCGGCCCGCGGGCCAGCGGGGCCAGGGGGCGCTCCGCACCTGGGCACTCCC
AGCGATGCGCAGCGGGGCAGCGCCGGCCCCGCCGATGGAGCTGCTGTTGCTGCCGCCGCCGCCGCCCGGAGCGCCCCGCTCCGCCCGCGC
CCCGTGCGCCTGAGCACCGAGCTCGCCCCTCCTCCGCGCTAACTCCGCCGCCCGCTCCCCAGGCCGCCCGCGCTCCCCGCGCGCCTCCTC
GGGCTCCACGCGTCTTGCCCCGCAGAGGCAGCCTCCTCCAGGAGCGGGGCCCTGCACACCATGGCCCCCGGGTGGGCAGGGGTCGGCGCC
GCCGTGCGCGCCCGCCTGGCGCTGGCCTTGGCGCTGGCGAGCGTCCTGAGTGGGCCTCCAGCCGTCGCCTGCCCCACCAAGTGTACCTGC
TCCGCTGCCAGCGTGGACTGCCACGGGCTGGGCCTCCGCGCGGTTCCTCGGGGCATCCCCCGCAACGCTGAGCGCCTTGACCTGGACAGA
AATAATATCACCAGGATCACCAAGATGGACTTCGCTGGGCTCAAGAACCTCCGAGTCTTGCATCTGGAAGACAACCAGGTCAGCGTCATC
GAGAGAGGCGCCTTCCAGGACCTGAAGCAGCTAGAGCGACTAGGCGAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCC
CTCTCTTTGACAAAGGGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGGCACTTCTGCTGGCCC
AGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCGTCAGGGAAAAGCAAGTATGAAGCCATGGATTTTGACAGCTTACTG

>83676_83676_3_SLIT3-PPARGC1B_SLIT3_chr5_168671709_ENST00000519560_PPARGC1B_chr5_149225323_ENST00000360453_length(amino acids)=250AA_BP=
MLQVLEGASLDDADLVVFQMQDSEVLEPSEVHLGDPGDIISVQVKALSVAGDAPRNRAEAQPVAVHAGSGAGTLGGAGDGWRPTQDARQR
QGQRQAGAHGGADPCPPGGHGVQGPAPGGGCLCGARRVEPEEARGERGRPGERAAELARRRGELGAQAHGARAERGAPGGGGGSNSSSIG

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Fusion Gene PPI Analysis for SLIT3-PPARGC1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLIT3-PPARGC1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLIT3-PPARGC1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource