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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLTM-LPHN1 (FusionGDB2 ID:83723)

Fusion Gene Summary for SLTM-LPHN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLTM-LPHN1
Fusion gene ID: 83723
HgeneTgene
Gene symbol

SLTM

LPHN1

Gene ID

79811

22859

Gene nameSAFB like transcription modulatoradhesion G protein-coupled receptor L1
SynonymsMetCIRL1|CL1|LEC2|LPHN1
Cytomap

15q22.1

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionSAFB-like transcription modulatormodulator of estrogen-induced transcriptionadhesion G protein-coupled receptor L1CIRL-1calcium-independent alpha-latrotoxin receptor 1latrophilin-1lectomedin-2
Modification date2020031320200313
UniProtAcc

Q9NWH9

.
Ensembl transtripts involved in fusion geneENST00000380516, ENST00000557950, 
ENST00000536328, 		ENST00000591528, 
ENST00000340736, ENST00000361434, 
Fusion gene scores* DoF score12 X 13 X 5=7806 X 3 X 4=72
# samples 144
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/72*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLTM [Title/Abstract] AND LPHN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLTM(59224554)-LPHN1(14288556), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLTM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPHN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A49WSLTMchr15

59224554

-LPHN1chr19

14288556

-
ChimerDB4ESCATCGA-LN-A49WSLTMchr15

59224555

-LPHN1chr19

14288556

-


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Fusion Gene ORF analysis for SLTM-LPHN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380516ENST00000591528SLTMchr15

59224554

-LPHN1chr19

14288556

-
5CDS-intronENST00000380516ENST00000591528SLTMchr15

59224555

-LPHN1chr19

14288556

-
5UTR-3CDSENST00000557950ENST00000340736SLTMchr15

59224554

-LPHN1chr19

14288556

-
5UTR-3CDSENST00000557950ENST00000340736SLTMchr15

59224555

-LPHN1chr19

14288556

-
5UTR-3CDSENST00000557950ENST00000361434SLTMchr15

59224554

-LPHN1chr19

14288556

-
5UTR-3CDSENST00000557950ENST00000361434SLTMchr15

59224555

-LPHN1chr19

14288556

-
5UTR-intronENST00000557950ENST00000591528SLTMchr15

59224554

-LPHN1chr19

14288556

-
5UTR-intronENST00000557950ENST00000591528SLTMchr15

59224555

-LPHN1chr19

14288556

-
In-frameENST00000380516ENST00000340736SLTMchr15

59224554

-LPHN1chr19

14288556

-
In-frameENST00000380516ENST00000340736SLTMchr15

59224555

-LPHN1chr19

14288556

-
In-frameENST00000380516ENST00000361434SLTMchr15

59224554

-LPHN1chr19

14288556

-
In-frameENST00000380516ENST00000361434SLTMchr15

59224555

-LPHN1chr19

14288556

-
intron-3CDSENST00000536328ENST00000340736SLTMchr15

59224554

-LPHN1chr19

14288556

-
intron-3CDSENST00000536328ENST00000340736SLTMchr15

59224555

-LPHN1chr19

14288556

-
intron-3CDSENST00000536328ENST00000361434SLTMchr15

59224554

-LPHN1chr19

14288556

-
intron-3CDSENST00000536328ENST00000361434SLTMchr15

59224555

-LPHN1chr19

14288556

-
intron-intronENST00000536328ENST00000591528SLTMchr15

59224554

-LPHN1chr19

14288556

-
intron-intronENST00000536328ENST00000591528SLTMchr15

59224555

-LPHN1chr19

14288556

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380516SLTMchr1559224554-ENST00000340736LPHN1chr1914288556-56283382546921555
ENST00000380516SLTMchr1559224554-ENST00000361434LPHN1chr1914288556-55983382546771550
ENST00000380516SLTMchr1559224555-ENST00000340736LPHN1chr1914288556-56283382546921555
ENST00000380516SLTMchr1559224555-ENST00000361434LPHN1chr1914288556-55983382546771550

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380516ENST00000340736SLTMchr1559224554-LPHN1chr1914288556-0.0020310440.997969
ENST00000380516ENST00000361434SLTMchr1559224554-LPHN1chr1914288556-0.0021009190.99789906
ENST00000380516ENST00000340736SLTMchr1559224555-LPHN1chr1914288556-0.0020310440.997969
ENST00000380516ENST00000361434SLTMchr1559224555-LPHN1chr1914288556-0.0021009190.99789906

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Fusion Genomic Features for SLTM-LPHN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLTM-LPHN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59224554/chr19:14288556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLTM

Q9NWH9

.
FUNCTION: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLTMchr15:59224554chr19:14288556ENST00000380516-22122_56831035.0DomainSAP
HgeneSLTMchr15:59224555chr19:14288556ENST00000380516-22122_56831035.0DomainSAP
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241303_1314231475.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241315_1318231475.0Compositional biasNote=Poly-Gly
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241410_1420231475.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124413_416231475.0Compositional biasNote=Poly-Thr
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231303_1314231470.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231315_1318231470.0Compositional biasNote=Poly-Gly
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231410_1420231470.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123413_416231470.0Compositional biasNote=Poly-Thr
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241303_1314231475.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241315_1318231475.0Compositional biasNote=Poly-Gly
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241410_1420231475.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124413_416231475.0Compositional biasNote=Poly-Thr
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231303_1314231470.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231315_1318231470.0Compositional biasNote=Poly-Gly
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231410_1420231470.0Compositional biasNote=Poly-Pro
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123413_416231470.0Compositional biasNote=Poly-Thr
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124139_398231475.0DomainOlfactomedin-like
TgeneLPHN1chr15:59224554chr19:14288556ENST0000034073612440_129231475.0DomainSUEL-type lectin
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124799_850231475.0DomainGPS
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123139_398231470.0DomainOlfactomedin-like
TgeneLPHN1chr15:59224554chr19:14288556ENST0000036143412340_129231470.0DomainSUEL-type lectin
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123799_850231470.0DomainGPS
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124139_398231475.0DomainOlfactomedin-like
TgeneLPHN1chr15:59224555chr19:14288556ENST0000034073612440_129231475.0DomainSUEL-type lectin
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124799_850231475.0DomainGPS
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123139_398231470.0DomainOlfactomedin-like
TgeneLPHN1chr15:59224555chr19:14288556ENST0000036143412340_129231470.0DomainSUEL-type lectin
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123799_850231470.0DomainGPS
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124117_120231475.0RegionCarbohydrate binding
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123117_120231470.0RegionCarbohydrate binding
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124117_120231475.0RegionCarbohydrate binding
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123117_120231470.0RegionCarbohydrate binding
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241024_1050231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241072_1075231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241097_1474231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST0000034073612425_858231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124880_893231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124915_920231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124942_964231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124986_1002231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231024_1050231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231072_1075231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231097_1474231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST0000036143412325_858231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123880_893231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123915_920231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123942_964231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123986_1002231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241024_1050231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241072_1075231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241097_1474231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST0000034073612425_858231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124880_893231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124915_920231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124942_964231475.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124986_1002231475.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231024_1050231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231072_1075231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231097_1474231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST0000036143412325_858231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123880_893231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123915_920231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123942_964231470.0Topological domainCytoplasmic
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123986_1002231470.0Topological domainExtracellular
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241003_1023231475.0TransmembraneHelical%3B Name%3D5
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241051_1071231475.0TransmembraneHelical%3B Name%3D6
TgeneLPHN1chr15:59224554chr19:14288556ENST000003407361241076_1096231475.0TransmembraneHelical%3B Name%3D7
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124859_879231475.0TransmembraneHelical%3B Name%3D1
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124894_914231475.0TransmembraneHelical%3B Name%3D2
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124921_941231475.0TransmembraneHelical%3B Name%3D3
TgeneLPHN1chr15:59224554chr19:14288556ENST00000340736124965_985231475.0TransmembraneHelical%3B Name%3D4
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231003_1023231470.0TransmembraneHelical%3B Name%3D5
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231051_1071231470.0TransmembraneHelical%3B Name%3D6
TgeneLPHN1chr15:59224554chr19:14288556ENST000003614341231076_1096231470.0TransmembraneHelical%3B Name%3D7
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123859_879231470.0TransmembraneHelical%3B Name%3D1
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123894_914231470.0TransmembraneHelical%3B Name%3D2
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123921_941231470.0TransmembraneHelical%3B Name%3D3
TgeneLPHN1chr15:59224554chr19:14288556ENST00000361434123965_985231470.0TransmembraneHelical%3B Name%3D4
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241003_1023231475.0TransmembraneHelical%3B Name%3D5
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241051_1071231475.0TransmembraneHelical%3B Name%3D6
TgeneLPHN1chr15:59224555chr19:14288556ENST000003407361241076_1096231475.0TransmembraneHelical%3B Name%3D7
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124859_879231475.0TransmembraneHelical%3B Name%3D1
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124894_914231475.0TransmembraneHelical%3B Name%3D2
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124921_941231475.0TransmembraneHelical%3B Name%3D3
TgeneLPHN1chr15:59224555chr19:14288556ENST00000340736124965_985231475.0TransmembraneHelical%3B Name%3D4
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231003_1023231470.0TransmembraneHelical%3B Name%3D5
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231051_1071231470.0TransmembraneHelical%3B Name%3D6
TgeneLPHN1chr15:59224555chr19:14288556ENST000003614341231076_1096231470.0TransmembraneHelical%3B Name%3D7
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123859_879231470.0TransmembraneHelical%3B Name%3D1
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123894_914231470.0TransmembraneHelical%3B Name%3D2
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123921_941231470.0TransmembraneHelical%3B Name%3D3
TgeneLPHN1chr15:59224555chr19:14288556ENST00000361434123965_985231470.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLTMchr15:59224554chr19:14288556ENST00000380516-221609_728831035.0Coiled coilOntology_term=ECO:0000255
HgeneSLTMchr15:59224555chr19:14288556ENST00000380516-221609_728831035.0Coiled coilOntology_term=ECO:0000255
HgeneSLTMchr15:59224554chr19:14288556ENST00000380516-221108_239831035.0Compositional biasNote=Glu-rich
HgeneSLTMchr15:59224554chr19:14288556ENST00000380516-221569_906831035.0Compositional biasNote=Arg/Glu-rich
HgeneSLTMchr15:59224555chr19:14288556ENST00000380516-221108_239831035.0Compositional biasNote=Glu-rich
HgeneSLTMchr15:59224555chr19:14288556ENST00000380516-221569_906831035.0Compositional biasNote=Arg/Glu-rich
HgeneSLTMchr15:59224554chr19:14288556ENST00000380516-221384_462831035.0DomainRRM
HgeneSLTMchr15:59224555chr19:14288556ENST00000380516-221384_462831035.0DomainRRM


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Fusion Gene Sequence for SLTM-LPHN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83723_83723_1_SLTM-LPHN1_SLTM_chr15_59224554_ENST00000380516_LPHN1_chr19_14288556_ENST00000340736_length(transcript)=5628nt_BP=338nt
GCGGCCGCCGAGGCCTGGGTGGAAGTTGGCGCTGCTGCCGCCGCCCTGCAGCCCACTCGCTGCCTCGGCAGCGCGCTGCTCTTCTAAGAT
GGCTGCCGCTACCGGTGCGGTGGCAGCCTCGGCCGCCTCGGGTCAGGCGGAAGGTAAAAAGATCACCGATCTGCGGGTCATCGATCTGAA
GTCCGAGCTGAAGCGGCGGAACTTAGACATCACCGGAGTCAAGACCGTGCTCATCTCCCGACTCAAGCAGGCTATTGAAGAGGAAGGAGG
CGATCCAGATAATATTGAATTAACTGTTTCAACTGATACTCCAAACAAGAAACCAACTAAAGGCAAAGGCCTGAGCCGGGCCGGGCTCCC
GTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAATGC
CAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAGAT
CATGTCACAGAGGTGTAACAACCGCACCCAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAGTA
CCTGGAGGTGCAGTACGACTGTGTCCCCTACAAAGTGGAGCAGAAAGTCTTCGTGTGCCCAGGGACCCTGCAGAAGGTGCTGGAGCCCAC
CTCGACACACGAGTCAGAGCACCAGTCTGGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATCCC
CTACCGCACGGACACACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGCCACACCACCACCTACCGCCTGCCCAACCGCGT
GGATGGCACAGGCTTTGTGGTCTACGATGGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACGCG
CATCAAGAGCGGGGAGACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTACCGCTGGGGCGGAAAGACCGACATTGACCTGGC
GGTGGACGAGAACGGGCTGTGGGTCATCTACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTGCG
CTTTGAGGGCACGTGGGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATGGTGTGTGGGGTCCTGTACGTCCTGCGTTCCGT
GTACGTGGATGATGACAGCGAGGCGGCTGGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTCAC
CTTCCCCAACCCCTACCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAGCTGTACGTCTGGAACAACTATTTCGTGGTGCG
CTACAGCCTGGAGTTCGGGCCGCCCGACCCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACGCC
CCTCACCAGCACAGCCTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACCACGCACCCAGTGGGTGCCATCAACCAGCTGGG
ACCTGATCTGCCTCCAGCCACAGCCCCAGTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGCGA
GCCCCGAGAGGTACGGCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAGGGGACTCGAGGAATTGC
CTCCTTCCAGTGTCTACCAGCCTTGGGGCTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGC
CCAGAAGATCAAGAGTGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACACACCCGGGGCTCCATCTACGCGGGGGACGTCTC
CTCCTCTGTGAAGCTGATGGAGCAGCTGCTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGCAA
GAACTACAACAAGATGCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTGGTGGAGACAGTGGACAATCTGCTCCGGCCAGA
AGCTCTGGAGTCCTGGAAGGACATGAATGCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTCCT
GCTGGCCGACAATGTCAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTCCTGGAGGTCACAGTCCTGAACACAGAGGGCCA
GGTGCAGGAGCTGGTGTTCCCCCAGGAGGAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGCAA
TGGGGTGGTCAAAGTTGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACGGAGAATGCCACAGTGAAGCTGGCCGGCGAAGC
AGGCCCGGGTGGCCCTGGGGGCGCCTCTCTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTCCT
CATGGACCCTGTCATCTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCTAACTGCTCCTTCTGGAACTACTCGGAGCGTTC
CATGCTGGGCTACTGGTCGACCCAAGGCTGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAACTT
CGCTGTGCTCATGGCTCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTGTCGGTCATCACCTGGGTGGGCATTGTGATCTC
CCTGGTCTGCTTGGCCATCTGCATCTCCACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGCAT
CAACCTCTTCCTGGCTGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAGATTGCCTGCCCCATCTTCGCCGGCCTGCTGCA
CTATTTCTTCCTGGCTGCCTTCTCCTGGCTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTATTC
CCGCACCAAGTACTACTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATCGCGGCTGCCATTGACTACCGCAGCTACGGCAC
CGAGAAGGCCTGCTGGCTCCGAGTGGACAATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTGTT
CCTCATGGTGACCCTGCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCCAGCCGCCTGGACAACATTAAATCCTGGGCGCT
GGGGGCCATCGCGCTGCTGTTCCTGCTGGGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTATCT
CTTCACCACCTTCAACGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTACAGAAGAAGGTGCACAAGGAGTACAGCAAGTG
CCTGCGTCACTCCTACTGCTGCATCCGCTCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGCTA
CTACACAGGGACCCAGAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAGACGGAGTCCTCCTTCATGGCGGGTGACATCAA
CAGCACCCCCACCCTGAACCGAGGTACCATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTACAA
CACCCTCATCGCCGAGTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCCCCAGGGAGCTACCGGGAACCCAAGCACCCCTT
GGGAGGCCGGGAAGCCTGTGGCATGGACACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCTCC
CGGGGATGGGGGCCCTGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTTGAGAAGATGATCATCTCAGAGCTGGTGCACAA
CAACCTGCGGGGGAGCAGCAGCGCGGCCAAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAAGA
GGCGGGCGGGCCCGGGGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTGGAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTC
GGTGCTGTACCAGAGCGATCTGGACGAGTCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGCCG
GGACTCCCTCTATGCCAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGCAGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCC
ACCCCCTCCCGCACCCCCCGGCCCCCCCGAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTACTA
CCAGGTGCGGCGTCCTAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCAGGGCCCGATGGGGACGGGCAGATGCAGCTGGT
CACCAGTCTCTGAGGGCACCTCATGGACCAGGGGCTGGTGGCCCAGGCCAGGGAGGGAACCCTGGGCAGGGCTCTGGTGGGAGAGGGAGA
CAGATGGAGGCAGTGGCTGGTGGGCCACTCTCTCCAGGTGCCCCTCAGCCATGGGCCCTACAGTCCCCTCAGGGGACTCTAACCTGGGGG
CCTGAGGTGCCAGGGTTCACAGACAGGGTTTCCCACCAGCCACACGCACCAGCTCTATTTGGGGGAAGTGTAGTGAGGAGGAGCCCAGAG
GACCCCAGGGGAGTGAGGAGGGAGAACTTGGAAGGGTGCAGCCCACTTCCAGACTCTCCCCTCTCCCACCCTTCTACCCTGTGAAGGGAA
ATGAGGGCTTTAGTTTCCTGGGCAGGGAGGGGCAGCTTCTGAGGTTGCCAAAGGCCCCCACTGGATGGAACCTGTTAGCTGCTCCTCTCC
GCAGCCAGAAATGCTGCCGGCTGCACCCAGAGGGAGCAGTGAGGCAGGACAGATGGACAGGTTCCTCCTGCGCTGTAATTCCCTGCTCCC
TGGAGACTGGGAAAAGGCCGCAGGGCAGGGGGACTGGGCGGTGGTGGCTGGTGGTTTAAAGGTTGAACTTTCTCTGAAGCTCCTTTCCCC
TTGCTCTTGGTCCCTGCCCCGCAAGCAAACCTGCCCCCTCTGCCTCCCAGTGCACCCAATGACCCCCTCCCTTGGGGCGACTCCTGATGA
AGCACAACTCCCCGCAGGGCCCCCAGCCCACAGGGGTGGCCATATTTGGGCAGTTCCCAGTCCTGTGGGCTCGGCTATCTGGGGAGCAGA
TTTTGGGTCTGGATCTCCCTGGGGAGTGGGTCCTGGGCTTGGATCTTTCCCTAGGGGGCCCTCTTACTCCTTCCTCTCTCCTCCTCCTTC

>83723_83723_1_SLTM-LPHN1_SLTM_chr15_59224554_ENST00000380516_LPHN1_chr19_14288556_ENST00000340736_length(amino acids)=1555AA_BP=99
MALLPPPCSPLAASAARCSSKMAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELT
VSTDTPNKKPTKGKGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNR
TQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTE
YASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWV
IYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFI
SSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATA
PVPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGEN
AANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDM
NATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFI
LYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQ
GCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELL
FLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRV
DNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQ
GVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRG
TMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPP
RGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLD
ESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHE

--------------------------------------------------------------
>83723_83723_2_SLTM-LPHN1_SLTM_chr15_59224554_ENST00000380516_LPHN1_chr19_14288556_ENST00000361434_length(transcript)=5598nt_BP=338nt
GCGGCCGCCGAGGCCTGGGTGGAAGTTGGCGCTGCTGCCGCCGCCCTGCAGCCCACTCGCTGCCTCGGCAGCGCGCTGCTCTTCTAAGAT
GGCTGCCGCTACCGGTGCGGTGGCAGCCTCGGCCGCCTCGGGTCAGGCGGAAGGTAAAAAGATCACCGATCTGCGGGTCATCGATCTGAA
GTCCGAGCTGAAGCGGCGGAACTTAGACATCACCGGAGTCAAGACCGTGCTCATCTCCCGACTCAAGCAGGCTATTGAAGAGGAAGGAGG
CGATCCAGATAATATTGAATTAACTGTTTCAACTGATACTCCAAACAAGAAACCAACTAAAGGCAAAGGCCTGAGCCGGGCCGGGCTCCC
GTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAATGC
CAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAGAT
CATGTCACAGAGGTGTAACAACCGCACCCAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAGTA
CCTGGAGGTGCAGTACGACTGTGTCCCCTACATCTTCGTGTGCCCAGGGACCCTGCAGAAGGTGCTGGAGCCCACCTCGACACACGAGTC
AGAGCACCAGTCTGGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATCCCCTACCGCACGGACAC
ACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGCCACACCACCACCTACCGCCTGCCCAACCGCGTGGATGGCACAGGCTT
TGTGGTCTACGATGGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACGCGCATCAAGAGCGGGGA
GACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTACCGCTGGGGCGGAAAGACCGACATTGACCTGGCGGTGGACGAGAACGG
GCTGTGGGTCATCTACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTGCGCTTTGAGGGCACGTG
GGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATGGTGTGTGGGGTCCTGTACGTCCTGCGTTCCGTGTACGTGGATGATGA
CAGCGAGGCGGCTGGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTCACCTTCCCCAACCCCTA
CCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAGCTGTACGTCTGGAACAACTATTTCGTGGTGCGCTACAGCCTGGAGTT
CGGGCCGCCCGACCCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACGCCCCTCACCAGCACAGC
CTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACCACGCACCCAGTGGGTGCCATCAACCAGCTGGGACCTGATCTGCCTCC
AGCCACAGCCCCAGTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGCGAGCCCCGAGAGGTACG
GCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAGGGGACTCGAGGAATTGCCTCCTTCCAGTGTCT
ACCAGCCTTGGGGCTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGCCCAGAAGATCAAGAG
TGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACACACCCGGGGCTCCATCTACGCGGGGGACGTCTCCTCCTCTGTGAAGCT
GATGGAGCAGCTGCTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGCAAGAACTACAACAAGAT
GCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTGGTGGAGACAGTGGACAATCTGCTCCGGCCAGAAGCTCTGGAGTCCTG
GAAGGACATGAATGCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTCCTGCTGGCCGACAATGT
CAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTCCTGGAGGTCACAGTCCTGAACACAGAGGGCCAGGTGCAGGAGCTGGT
GTTCCCCCAGGAGGAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGCAATGGGGTGGTCAAAGT
TGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACGGAGAATGCCACAGTGAAGCTGGCCGGCGAAGCAGGCCCGGGTGGCCC
TGGGGGCGCCTCTCTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTCCTCATGGACCCTGTCAT
CTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCTAACTGCTCCTTCTGGAACTACTCGGAGCGTTCCATGCTGGGCTACTG
GTCGACCCAAGGCTGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAACTTCGCTGTGCTCATGGC
TCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTGTCGGTCATCACCTGGGTGGGCATTGTGATCTCCCTGGTCTGCTTGGC
CATCTGCATCTCCACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGCATCAACCTCTTCCTGGC
TGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAGATTGCCTGCCCCATCTTCGCCGGCCTGCTGCACTATTTCTTCCTGGC
TGCCTTCTCCTGGCTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTATTCCCGCACCAAGTACTA
CTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATCGCGGCTGCCATTGACTACCGCAGCTACGGCACCGAGAAGGCCTGCTG
GCTCCGAGTGGACAATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTGTTCCTCATGGTGACCCT
GCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCCAGCCGCCTGGACAACATTAAATCCTGGGCGCTGGGGGCCATCGCGCT
GCTGTTCCTGCTGGGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTATCTCTTCACCACCTTCAA
CGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTACAGAAGAAGGTGCACAAGGAGTACAGCAAGTGCCTGCGTCACTCCTA
CTGCTGCATCCGCTCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGCTACTACACAGGGACCCA
GAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAGACGGAGTCCTCCTTCATGGCGGGTGACATCAACAGCACCCCCACCCT
GAACCGAGGTACCATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTACAACACCCTCATCGCCGA
GTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCCCCAGGGAGCTACCGGGAACCCAAGCACCCCTTGGGAGGCCGGGAAGC
CTGTGGCATGGACACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCTCCCGGGGATGGGGGCCC
TGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTTGAGAAGATGATCATCTCAGAGCTGGTGCACAACAACCTGCGGGGGAG
CAGCAGCGCGGCCAAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAAGAGGCGGGCGGGCCCGG
GGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTGGAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTCGGTGCTGTACCAGAG
CGATCTGGACGAGTCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGCCGGGACTCCCTCTATGC
CAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGCAGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCCACCCCCTCCCGCACC
CCCCGGCCCCCCCGAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTACTACCAGGTGCGGCGTCC
TAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCAGGGCCCGATGGGGACGGGCAGATGCAGCTGGTCACCAGTCTCTGAGG
GCACCTCATGGACCAGGGGCTGGTGGCCCAGGCCAGGGAGGGAACCCTGGGCAGGGCTCTGGTGGGAGAGGGAGACAGATGGAGGCAGTG
GCTGGTGGGCCACTCTCTCCAGGTGCCCCTCAGCCATGGGCCCTACAGTCCCCTCAGGGGACTCTAACCTGGGGGCCTGAGGTGCCAGGG
TTCACAGACAGGGTTTCCCACCAGCCACACGCACCAGCTCTATTTGGGGGAAGTGTAGTGAGGAGGAGCCCAGAGGACCCCAGGGGAGTG
AGGAGGGAGAACTTGGAAGGGTGCAGCCCACTTCCAGACTCTCCCCTCTCCCACCCTTCTACCCTGTGAAGGGAAATGAGGGCTTTAGTT
TCCTGGGCAGGGAGGGGCAGCTTCTGAGGTTGCCAAAGGCCCCCACTGGATGGAACCTGTTAGCTGCTCCTCTCCGCAGCCAGAAATGCT
GCCGGCTGCACCCAGAGGGAGCAGTGAGGCAGGACAGATGGACAGGTTCCTCCTGCGCTGTAATTCCCTGCTCCCTGGAGACTGGGAAAA
GGCCGCAGGGCAGGGGGACTGGGCGGTGGTGGCTGGTGGTTTAAAGGTTGAACTTTCTCTGAAGCTCCTTTCCCCTTGCTCTTGGTCCCT
GCCCCGCAAGCAAACCTGCCCCCTCTGCCTCCCAGTGCACCCAATGACCCCCTCCCTTGGGGCGACTCCTGATGAAGCACAACTCCCCGC
AGGGCCCCCAGCCCACAGGGGTGGCCATATTTGGGCAGTTCCCAGTCCTGTGGGCTCGGCTATCTGGGGAGCAGATTTTGGGTCTGGATC
TCCCTGGGGAGTGGGTCCTGGGCTTGGATCTTTCCCTAGGGGGCCCTCTTACTCCTTCCTCTCTCCTCCTCCTTCCCCATTGCTGTAAAT

>83723_83723_2_SLTM-LPHN1_SLTM_chr15_59224554_ENST00000380516_LPHN1_chr19_14288556_ENST00000361434_length(amino acids)=1550AA_BP=99
MALLPPPCSPLAASAARCSSKMAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELT
VSTDTPNKKPTKGKGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNR
TQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYIFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWE
DYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATE
GNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDY
NPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPST
RRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIA
SELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQ
VHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNL
GLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLV
ESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGI
DKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFI
WSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIF
VFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNH
LLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNL
ADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESC
TAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAA

--------------------------------------------------------------
>83723_83723_3_SLTM-LPHN1_SLTM_chr15_59224555_ENST00000380516_LPHN1_chr19_14288556_ENST00000340736_length(transcript)=5628nt_BP=338nt
GCGGCCGCCGAGGCCTGGGTGGAAGTTGGCGCTGCTGCCGCCGCCCTGCAGCCCACTCGCTGCCTCGGCAGCGCGCTGCTCTTCTAAGAT
GGCTGCCGCTACCGGTGCGGTGGCAGCCTCGGCCGCCTCGGGTCAGGCGGAAGGTAAAAAGATCACCGATCTGCGGGTCATCGATCTGAA
GTCCGAGCTGAAGCGGCGGAACTTAGACATCACCGGAGTCAAGACCGTGCTCATCTCCCGACTCAAGCAGGCTATTGAAGAGGAAGGAGG
CGATCCAGATAATATTGAATTAACTGTTTCAACTGATACTCCAAACAAGAAACCAACTAAAGGCAAAGGCCTGAGCCGGGCCGGGCTCCC
GTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAATGC
CAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAGAT
CATGTCACAGAGGTGTAACAACCGCACCCAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAGTA
CCTGGAGGTGCAGTACGACTGTGTCCCCTACAAAGTGGAGCAGAAAGTCTTCGTGTGCCCAGGGACCCTGCAGAAGGTGCTGGAGCCCAC
CTCGACACACGAGTCAGAGCACCAGTCTGGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATCCC
CTACCGCACGGACACACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGCCACACCACCACCTACCGCCTGCCCAACCGCGT
GGATGGCACAGGCTTTGTGGTCTACGATGGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACGCG
CATCAAGAGCGGGGAGACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTACCGCTGGGGCGGAAAGACCGACATTGACCTGGC
GGTGGACGAGAACGGGCTGTGGGTCATCTACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTGCG
CTTTGAGGGCACGTGGGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATGGTGTGTGGGGTCCTGTACGTCCTGCGTTCCGT
GTACGTGGATGATGACAGCGAGGCGGCTGGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTCAC
CTTCCCCAACCCCTACCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAGCTGTACGTCTGGAACAACTATTTCGTGGTGCG
CTACAGCCTGGAGTTCGGGCCGCCCGACCCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACGCC
CCTCACCAGCACAGCCTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACCACGCACCCAGTGGGTGCCATCAACCAGCTGGG
ACCTGATCTGCCTCCAGCCACAGCCCCAGTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGCGA
GCCCCGAGAGGTACGGCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAGGGGACTCGAGGAATTGC
CTCCTTCCAGTGTCTACCAGCCTTGGGGCTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGC
CCAGAAGATCAAGAGTGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACACACCCGGGGCTCCATCTACGCGGGGGACGTCTC
CTCCTCTGTGAAGCTGATGGAGCAGCTGCTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGCAA
GAACTACAACAAGATGCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTGGTGGAGACAGTGGACAATCTGCTCCGGCCAGA
AGCTCTGGAGTCCTGGAAGGACATGAATGCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTCCT
GCTGGCCGACAATGTCAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTCCTGGAGGTCACAGTCCTGAACACAGAGGGCCA
GGTGCAGGAGCTGGTGTTCCCCCAGGAGGAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGCAA
TGGGGTGGTCAAAGTTGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACGGAGAATGCCACAGTGAAGCTGGCCGGCGAAGC
AGGCCCGGGTGGCCCTGGGGGCGCCTCTCTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTCCT
CATGGACCCTGTCATCTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCTAACTGCTCCTTCTGGAACTACTCGGAGCGTTC
CATGCTGGGCTACTGGTCGACCCAAGGCTGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAACTT
CGCTGTGCTCATGGCTCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTGTCGGTCATCACCTGGGTGGGCATTGTGATCTC
CCTGGTCTGCTTGGCCATCTGCATCTCCACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGCAT
CAACCTCTTCCTGGCTGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAGATTGCCTGCCCCATCTTCGCCGGCCTGCTGCA
CTATTTCTTCCTGGCTGCCTTCTCCTGGCTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTATTC
CCGCACCAAGTACTACTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATCGCGGCTGCCATTGACTACCGCAGCTACGGCAC
CGAGAAGGCCTGCTGGCTCCGAGTGGACAATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTGTT
CCTCATGGTGACCCTGCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCCAGCCGCCTGGACAACATTAAATCCTGGGCGCT
GGGGGCCATCGCGCTGCTGTTCCTGCTGGGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTATCT
CTTCACCACCTTCAACGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTACAGAAGAAGGTGCACAAGGAGTACAGCAAGTG
CCTGCGTCACTCCTACTGCTGCATCCGCTCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGCTA
CTACACAGGGACCCAGAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAGACGGAGTCCTCCTTCATGGCGGGTGACATCAA
CAGCACCCCCACCCTGAACCGAGGTACCATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTACAA
CACCCTCATCGCCGAGTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCCCCAGGGAGCTACCGGGAACCCAAGCACCCCTT
GGGAGGCCGGGAAGCCTGTGGCATGGACACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCTCC
CGGGGATGGGGGCCCTGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTTGAGAAGATGATCATCTCAGAGCTGGTGCACAA
CAACCTGCGGGGGAGCAGCAGCGCGGCCAAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAAGA
GGCGGGCGGGCCCGGGGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTGGAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTC
GGTGCTGTACCAGAGCGATCTGGACGAGTCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGCCG
GGACTCCCTCTATGCCAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGCAGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCC
ACCCCCTCCCGCACCCCCCGGCCCCCCCGAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTACTA
CCAGGTGCGGCGTCCTAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCAGGGCCCGATGGGGACGGGCAGATGCAGCTGGT
CACCAGTCTCTGAGGGCACCTCATGGACCAGGGGCTGGTGGCCCAGGCCAGGGAGGGAACCCTGGGCAGGGCTCTGGTGGGAGAGGGAGA
CAGATGGAGGCAGTGGCTGGTGGGCCACTCTCTCCAGGTGCCCCTCAGCCATGGGCCCTACAGTCCCCTCAGGGGACTCTAACCTGGGGG
CCTGAGGTGCCAGGGTTCACAGACAGGGTTTCCCACCAGCCACACGCACCAGCTCTATTTGGGGGAAGTGTAGTGAGGAGGAGCCCAGAG
GACCCCAGGGGAGTGAGGAGGGAGAACTTGGAAGGGTGCAGCCCACTTCCAGACTCTCCCCTCTCCCACCCTTCTACCCTGTGAAGGGAA
ATGAGGGCTTTAGTTTCCTGGGCAGGGAGGGGCAGCTTCTGAGGTTGCCAAAGGCCCCCACTGGATGGAACCTGTTAGCTGCTCCTCTCC
GCAGCCAGAAATGCTGCCGGCTGCACCCAGAGGGAGCAGTGAGGCAGGACAGATGGACAGGTTCCTCCTGCGCTGTAATTCCCTGCTCCC
TGGAGACTGGGAAAAGGCCGCAGGGCAGGGGGACTGGGCGGTGGTGGCTGGTGGTTTAAAGGTTGAACTTTCTCTGAAGCTCCTTTCCCC
TTGCTCTTGGTCCCTGCCCCGCAAGCAAACCTGCCCCCTCTGCCTCCCAGTGCACCCAATGACCCCCTCCCTTGGGGCGACTCCTGATGA
AGCACAACTCCCCGCAGGGCCCCCAGCCCACAGGGGTGGCCATATTTGGGCAGTTCCCAGTCCTGTGGGCTCGGCTATCTGGGGAGCAGA
TTTTGGGTCTGGATCTCCCTGGGGAGTGGGTCCTGGGCTTGGATCTTTCCCTAGGGGGCCCTCTTACTCCTTCCTCTCTCCTCCTCCTTC

>83723_83723_3_SLTM-LPHN1_SLTM_chr15_59224555_ENST00000380516_LPHN1_chr19_14288556_ENST00000340736_length(amino acids)=1555AA_BP=99
MALLPPPCSPLAASAARCSSKMAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELT
VSTDTPNKKPTKGKGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNR
TQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTE
YASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWV
IYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFI
SSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATA
PVPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGEN
AANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDM
NATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFI
LYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQ
GCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELL
FLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRV
DNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQ
GVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRG
TMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPP
RGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLD
ESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHE

--------------------------------------------------------------
>83723_83723_4_SLTM-LPHN1_SLTM_chr15_59224555_ENST00000380516_LPHN1_chr19_14288556_ENST00000361434_length(transcript)=5598nt_BP=338nt
GCGGCCGCCGAGGCCTGGGTGGAAGTTGGCGCTGCTGCCGCCGCCCTGCAGCCCACTCGCTGCCTCGGCAGCGCGCTGCTCTTCTAAGAT
GGCTGCCGCTACCGGTGCGGTGGCAGCCTCGGCCGCCTCGGGTCAGGCGGAAGGTAAAAAGATCACCGATCTGCGGGTCATCGATCTGAA
GTCCGAGCTGAAGCGGCGGAACTTAGACATCACCGGAGTCAAGACCGTGCTCATCTCCCGACTCAAGCAGGCTATTGAAGAGGAAGGAGG
CGATCCAGATAATATTGAATTAACTGTTTCAACTGATACTCCAAACAAGAAACCAACTAAAGGCAAAGGCCTGAGCCGGGCCGGGCTCCC
GTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAATGC
CAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGACGCCTTCAAGAT
CATGTCACAGAGGTGTAACAACCGCACCCAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAGTA
CCTGGAGGTGCAGTACGACTGTGTCCCCTACATCTTCGTGTGCCCAGGGACCCTGCAGAAGGTGCTGGAGCCCACCTCGACACACGAGTC
AGAGCACCAGTCTGGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATCCCCTACCGCACGGACAC
ACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGCCACACCACCACCTACCGCCTGCCCAACCGCGTGGATGGCACAGGCTT
TGTGGTCTACGATGGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACGCGCATCAAGAGCGGGGA
GACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTACCGCTGGGGCGGAAAGACCGACATTGACCTGGCGGTGGACGAGAACGG
GCTGTGGGTCATCTACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTGCGCTTTGAGGGCACGTG
GGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATGGTGTGTGGGGTCCTGTACGTCCTGCGTTCCGTGTACGTGGATGATGA
CAGCGAGGCGGCTGGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTCACCTTCCCCAACCCCTA
CCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAGCTGTACGTCTGGAACAACTATTTCGTGGTGCGCTACAGCCTGGAGTT
CGGGCCGCCCGACCCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACGCCCCTCACCAGCACAGC
CTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACCACGCACCCAGTGGGTGCCATCAACCAGCTGGGACCTGATCTGCCTCC
AGCCACAGCCCCAGTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGCGAGCCCCGAGAGGTACG
GCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAGGGGACTCGAGGAATTGCCTCCTTCCAGTGTCT
ACCAGCCTTGGGGCTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGCCCAGAAGATCAAGAG
TGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACACACCCGGGGCTCCATCTACGCGGGGGACGTCTCCTCCTCTGTGAAGCT
GATGGAGCAGCTGCTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGCAAGAACTACAACAAGAT
GCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTGGTGGAGACAGTGGACAATCTGCTCCGGCCAGAAGCTCTGGAGTCCTG
GAAGGACATGAATGCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTCCTGCTGGCCGACAATGT
CAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTCCTGGAGGTCACAGTCCTGAACACAGAGGGCCAGGTGCAGGAGCTGGT
GTTCCCCCAGGAGGAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGCAATGGGGTGGTCAAAGT
TGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACGGAGAATGCCACAGTGAAGCTGGCCGGCGAAGCAGGCCCGGGTGGCCC
TGGGGGCGCCTCTCTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTCCTCATGGACCCTGTCAT
CTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCTAACTGCTCCTTCTGGAACTACTCGGAGCGTTCCATGCTGGGCTACTG
GTCGACCCAAGGCTGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAACTTCGCTGTGCTCATGGC
TCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTGTCGGTCATCACCTGGGTGGGCATTGTGATCTCCCTGGTCTGCTTGGC
CATCTGCATCTCCACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGCATCAACCTCTTCCTGGC
TGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAGATTGCCTGCCCCATCTTCGCCGGCCTGCTGCACTATTTCTTCCTGGC
TGCCTTCTCCTGGCTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTATTCCCGCACCAAGTACTA
CTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATCGCGGCTGCCATTGACTACCGCAGCTACGGCACCGAGAAGGCCTGCTG
GCTCCGAGTGGACAATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTGTTCCTCATGGTGACCCT
GCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCCAGCCGCCTGGACAACATTAAATCCTGGGCGCTGGGGGCCATCGCGCT
GCTGTTCCTGCTGGGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTATCTCTTCACCACCTTCAA
CGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTACAGAAGAAGGTGCACAAGGAGTACAGCAAGTGCCTGCGTCACTCCTA
CTGCTGCATCCGCTCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGCTACTACACAGGGACCCA
GAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAGACGGAGTCCTCCTTCATGGCGGGTGACATCAACAGCACCCCCACCCT
GAACCGAGGTACCATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTACAACACCCTCATCGCCGA
GTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCCCCAGGGAGCTACCGGGAACCCAAGCACCCCTTGGGAGGCCGGGAAGC
CTGTGGCATGGACACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCTCCCGGGGATGGGGGCCC
TGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTTGAGAAGATGATCATCTCAGAGCTGGTGCACAACAACCTGCGGGGGAG
CAGCAGCGCGGCCAAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAAGAGGCGGGCGGGCCCGG
GGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTGGAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTCGGTGCTGTACCAGAG
CGATCTGGACGAGTCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGCCGGGACTCCCTCTATGC
CAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGCAGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCCACCCCCTCCCGCACC
CCCCGGCCCCCCCGAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTACTACCAGGTGCGGCGTCC
TAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCAGGGCCCGATGGGGACGGGCAGATGCAGCTGGTCACCAGTCTCTGAGG
GCACCTCATGGACCAGGGGCTGGTGGCCCAGGCCAGGGAGGGAACCCTGGGCAGGGCTCTGGTGGGAGAGGGAGACAGATGGAGGCAGTG
GCTGGTGGGCCACTCTCTCCAGGTGCCCCTCAGCCATGGGCCCTACAGTCCCCTCAGGGGACTCTAACCTGGGGGCCTGAGGTGCCAGGG
TTCACAGACAGGGTTTCCCACCAGCCACACGCACCAGCTCTATTTGGGGGAAGTGTAGTGAGGAGGAGCCCAGAGGACCCCAGGGGAGTG
AGGAGGGAGAACTTGGAAGGGTGCAGCCCACTTCCAGACTCTCCCCTCTCCCACCCTTCTACCCTGTGAAGGGAAATGAGGGCTTTAGTT
TCCTGGGCAGGGAGGGGCAGCTTCTGAGGTTGCCAAAGGCCCCCACTGGATGGAACCTGTTAGCTGCTCCTCTCCGCAGCCAGAAATGCT
GCCGGCTGCACCCAGAGGGAGCAGTGAGGCAGGACAGATGGACAGGTTCCTCCTGCGCTGTAATTCCCTGCTCCCTGGAGACTGGGAAAA
GGCCGCAGGGCAGGGGGACTGGGCGGTGGTGGCTGGTGGTTTAAAGGTTGAACTTTCTCTGAAGCTCCTTTCCCCTTGCTCTTGGTCCCT
GCCCCGCAAGCAAACCTGCCCCCTCTGCCTCCCAGTGCACCCAATGACCCCCTCCCTTGGGGCGACTCCTGATGAAGCACAACTCCCCGC
AGGGCCCCCAGCCCACAGGGGTGGCCATATTTGGGCAGTTCCCAGTCCTGTGGGCTCGGCTATCTGGGGAGCAGATTTTGGGTCTGGATC
TCCCTGGGGAGTGGGTCCTGGGCTTGGATCTTTCCCTAGGGGGCCCTCTTACTCCTTCCTCTCTCCTCCTCCTTCCCCATTGCTGTAAAT

>83723_83723_4_SLTM-LPHN1_SLTM_chr15_59224555_ENST00000380516_LPHN1_chr19_14288556_ENST00000361434_length(amino acids)=1550AA_BP=99
MALLPPPCSPLAASAARCSSKMAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELT
VSTDTPNKKPTKGKGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNR
TQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYIFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWE
DYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATE
GNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDY
NPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPST
RRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIA
SELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQ
VHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNL
GLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLV
ESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGI
DKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFI
WSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIF
VFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNH
LLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNL
ADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESC
TAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLTM-LPHN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLTM-LPHN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLTM-LPHN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource