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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLX4IP-CDS2 (FusionGDB2 ID:83746)

Fusion Gene Summary for SLX4IP-CDS2

Fusion gene summary

Fusion gene information	Fusion gene name: SLX4IP-CDS2
	Fusion gene ID: 83746
		Hgene	Tgene
	Gene symbol	SLX4IP	CDS2
	Gene ID	128710	8760
	Gene name	SLX4 interacting protein	CDP-diacylglycerol synthase 2
	Synonyms	C20orf94\|bA204H22.1\|bA254M13.1\|dJ1099D15.3	-
	Cytomap	20p12.2	20p12.3
	Type of gene	protein-coding	protein-coding
	Description	protein SLX4IP	phosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase
	Modification date	20200313	20200327
	UniProtAcc	Q5VYV7	O95674
	Ensembl transtripts involved in fusion gene	ENST00000334534,	ENST00000379062, ENST00000379070, ENST00000535100, ENST00000460006,
Fusion gene scores	* DoF score	13 X 9 X 5=585	10 X 11 X 7=770
	# samples	13	13
	** MAII score	log2(13/585*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/770*10)=-2.56634682255381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLX4IP [Title/Abstract] AND CDS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLX4IP(10582467)-CDS2(5154169), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLX4IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CX-7082-01A	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+

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Fusion Gene ORF analysis for SLX4IP-CDS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000334534	ENST00000379062	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+
5CDS-intron	ENST00000334534	ENST00000379070	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+
5CDS-intron	ENST00000334534	ENST00000535100	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+
In-frame	ENST00000334534	ENST00000460006	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000334534

SLX4IP

chr20

10582467

ENST00000460006

CDS2

chr20

5154169

9519

585

180

1865

561

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334534	ENST00000460006	SLX4IP	chr20	10582467	+	CDS2	chr20	5154169	+	0.000611893	0.9993881

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Fusion Genomic Features for SLX4IP-CDS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLX4IP	chr20	10582467	+	CDS2	chr20	5154168	+	0.007618686	0.9923813
SLX4IP	chr20	10582467	+	CDS2	chr20	5154168	+	0.007618686	0.9923813

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLX4IP-CDS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:10582467/chr20:5154169)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLX4IP Q5VYV7	CDS2 O95674
	FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269\|PubMed:25375833, ECO:0000269\|PubMed:26946540, ECO:0000269\|PubMed:31548309}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

132_152

446.0

Transmembrane

Helical

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

166_186

446.0

Transmembrane

Helical

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

213_233

446.0

Transmembrane

Helical

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

262_282

446.0

Transmembrane

Helical

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

340_360

446.0

Transmembrane

Helical

Tgene

CDS2

chr20:10582467

chr20:5154169

ENST00000460006

79_99

446.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SLX4IP-CDS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>83746_83746_1_SLX4IP-CDS2_SLX4IP_chr20_10582467_ENST00000334534_CDS2_chr20_5154169_ENST00000460006_length(transcript)=9519nt_BP=585nt
GCGAAAGTGCTTCCCTTAAGCTTCTGAAGGTTGGCTGCAGTTCCGGCTACCTGTGTAGTCCGAGTTTCCACAGCCAGGTACTACTCCGCC
AGTGACCCTGGACAGTAACAAAACATATAAAGCCCGAGCCCAAACCCCGCCACCATCATAGGTCTGTAGTTACTGTGGAATCAATAAGCC
ATGGCATCTAAGAAATTTGCTGTTAAATGTGGGAATTTTGCTGTCCTCGTGGATCTTCATATCTTGCCACAAGGTTCAAACAAAGATACA
AGCTGGTTTTCTGAACAGAAGAAAGAGGAAGTCTGTTTACTGTTAAAAGAAACCATTGATTCAAGAGTTCAGGAGTACTTGGAAGTTCGC
AAACAGCACAGGCCATCAAATGCAGAATTCACAAGATCCAATCCCTTGTCCTTAAAAGGTTATGGCTTTCAAATCACAGCCTATTTCCTC
AAGAGAGGGATACGCCTTCGCTGCATCAGGAGCACACAGAATGCTGAACTCTGTGTATTCCCTGACAGATTTGTGGTTTGTGTCAGTCAG
CTTGCATTCAGTCGTGATCTTTTAGCAAGTCAGAATGAAGATTTGGAGTCAGAGTCAGAAGCAAAGGTAGATGGAGAGACTGCATCGGAC
AGTGAGAGCCGGGCAGAATCCGCACCCCTGCCAGTCTCTGCAGATGATACCCCGGAGGTCCTCAATAGGGCCCTTTCCAACTTGTCTTCA
AGATGGAAGAACTGGTGGGTGAGAGGCATCCTGACTTTGGCCATGATTGCATTTTTCTTCATCATCATTTACCTGGGACCAATGGTTTTG
ATGATAATCGTGATGTGCGTTCAGATTAAGTGTTTCCATGAGATAATCACTATTGGCTACAACGTCTACCACTCATATGATCTGCCCTGG
TTCAGGACGCTCAGCTGGTACTTTCTCCTGTGTGTAAACTATTTCTTCTATGGTGAGACAGTGACGGATTACTTCTTCACCCTGGTCCAG
AGAGAAGAGCCTTTGCGGATTCTCAGTAAATACCACCGGTTCATTTCCTTTACTCTCTATCTAATAGGATTCTGCATGTTTGTACTGAGT
CTGGTCAAGAAGCATTATCGACTGCAGTTCTACATGTTTGGCTGGACCCATGTGACATTGCTGATTGTTGTAACACAGTCACATCTTGTT
ATCCACAACCTATTTGAAGGAATGATCTGGTTCATTGTCCCCATATCTTGTGTGATCTGTAATGACATCATGGCCTATATGTTTGGCTTT
TTCTTTGGTCGGACCCCACTCATCAAGCTGTCCCCGAAGAAGACCTGGGAAGGCTTCATTGGGGGCTTCTTTGCTACTGTGGTGTTTGGC
CTTCTGCTGTCCTATGTGATGTCCGGGTACAGATGCTTTGTCTGCCCTGTGGAGTACAACAATGACACCAACAGCTTCACTGTGGACTGT
GAGCCCTCGGACCTGTTTCGCCTGCAGGAGTACAACATTCCTGGGGTGATCCAGTCAGTCATTGGCTGGAAAACGGTCCGGATGTACCCC
TTCCAGATTCACAGCATCGCTCTCTCCACCTTTGCCTCGCTCATTGGCCCCTTTGGAGGATTCTTCGCAAGTGGATTCAAACGAGCCTTT
AAAATCAAAGACTTTGCCAATACCATTCCTGGCCATGGAGGCATCATGGATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAAT
GTATACATCGCCAGTTTTATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGACTTTACGGCCAGATCAGCAGCTCCACATC
TTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACATCCACCACAGAGGACGAGTAGGGGCCACCCAGGGCCAGGAGAACA
GGAACAGAACTGAGCAGGGGCAGGTCTCCAAGGCAAGCCCAGCTGGTGTGACTTAGACAATGACGAGGCTTCAACTCACTGTCTTTTTTT
TTTTTTTTTGGAGGGTATTTTTTATTTGTGGGTTCAAAAAATCTGTATATACAGTCTATGTGTTTAGAATTTGTGTTGTAAGTAAACTAC
AGCTTTGAGTTGGAAAGAAGTCACGGGTTGTAAAACCATTTGGATTTTTTTAAAACAAAAGTATTAATAATCTGGAAGACAGTGTTGCCC
AGGTCAGGAGTGTTTTCTTGGTGGTTCCAGCCCCCATCAATTGAACTGTTTCTGGGCTCAGTCAGACACAGACATTCATCTGTGTCTGAC
CAAATCAGGGGACTTCCCCACCTGTGGTGGGAGGCACAGCTTAGATGTTTTGTACACCTGGTCTTTTCTAGAAATCCCTGCTTGGAGCTG
CAGAAGGGTTGCCTTCTGTAGGTCGGAGGAATGGAGGCTTACTAACCAGGTAAGCCTTCTATGCATCCACACCAAAATCCTGCAGAATGT
AAGTAAGCTCTGCTTTATAAGATGGGTTCACCTTCATCGCAGACTGAAAGTTTCAGTTTTTATTTTTTTCAGAAAGCACGAAAAATTATT
TATAATAGTCTGGAGAAAAAACACACTGTAATATTTCAAGTGTATGCAGTAGAATGTACTGTAACTGAGCCCTTTCCCACATGTCTAGGC
TCCAATGTCTCCTGTAGGTCCACCTAACTGTGTGTTTTCAGGGACAATGCCATCCATGTTTGTGCTGTAGACTTGCTGCTGCTGAATCCT
TTCTGGGGACTTTCTCATCGGGCAGGGAGCAGAGGGCTTCTCGTTCATGCACCCTTTGCCTGAACACCCATGTAGCTGCTGTGTTGTGTA
TATATTACTCTTAAGAGGAGTGTGTGTGTCTGTGTTTGTTTTAAAAGTCACTTATTTCTTACAGTGATTTCAATTGCACCATGACTTCTT
CACTAAAACCACAAAGTCCTGCTTAAAACTATGGAAAACCTAACCTGATTAGAGCCTTGACTATTTTGAAGATTAAATGCACACTTTTTA
TATAATGTGACCAGTTTAAATGTAGTTTGTATTGTACTGGGGGACCTTTCGTTGTTGTTGTTTGCTTAAACTGTGATTTTTTTTCCCCTC
CCTAATTTCAGGGGTGAGATTGACTTTGGGAAGACAGATTAGTTCTTTGTCAGGCCAACAAGTGATGGAGTGCGGGAGAGAGAACTTGGC
ACCCAAATATATCAAACTATTCCGTGCCGTGGATGTTTTCATTGCCAACGAGGGTGTAATGATTTGCTTCTGCACCTTGGTCTAGTGCTG
GTTTGTGGTGTTTTTGTTTGTAAATTAGCCTCACTGCCTCCCTGAAAGTGCACAGTCAGCCCAGGTCTCTAGAGTGTCCAGCAGAGGATG
GAGCCCTCGGGATGTTTCAGCTCACACATCCTTGAGTGACTTCCCATATGTGTGTGGGGCTGAAGCGGCTTCTTTCCGCTGAACTTTTAT
TTCCATTTCAGCCTCGTGGCTTCTCTTATTCAGGTCCAAGGCCCCTTAAAAACAAAACATATTATCGCAAGGGCTTTCATTTCAGTATTG
GCTGTGTCACTGGCAGGATGCATCACTCTCCAGGGCCTCTTTTTCGGAGCTACTCCCAATTCCACTCTTCTGTGATTCTGGCTGAGCAAG
TTCATGCCGGTAGAGGCTCATTAAGTGAGGTCCTGGGCACCCCCCAAACAGGAAGTGTTTTCAGGCCCTTACATGCTTATCCTTAAGGTG
AGTAGGTATCTCAGCAGCACACCCGAACAGTAAAGGTGATCAATAACGAAACTGTAGTTTTCAGATTGAAGAATGAACCTGGATCACCAA
ACTAGATACCGAAAGGGCTCCTCATTTGTCTCTTTTGTCCCATTGTGGGCATATGGTGGGCTCCTTGAGAGGAGGGAGTCTCAGCTGGGG
CCTGGCTGCAGAGACCTGCTCTTGAATAGGGCTGCCTTTGGGATCAGGGAGCCGAGCATACTGGGCAAGGCTCATCATGTTCCTTTGTGG
AAGTGGTTACTTGGTGGGGGTGGGGTGGGGAAGGGGGGTCTAGGAAGCCGAAGCTGAGTGCGCACTAGAGCTGCTAGCAGGCAGGCCAGA
GGGTCAGCTTGTGTTTTATTTTCTGATTTCTCCTGCATGCTTTCTGGAGATGAGGATTTTTTGTCAGGTAGCTAGGAGAGCACTGCCACC
TTGTGTCCATATAGCACAATGTTTCTCTTTCCTATTCACAGACAAGATTCAAGAAACCATTTTTACGTGTGTACATTCAAATCTTCATGA
ATGGCATCACTTGCTTTAGACCCATTTTTTTTTTATTGGTCAGAAATAAAATGTGACTGCAACTGTGTGCCCTCCCTTGTCGTGAATTCC
CTGTTTATCACTTCCATGCATGGTTTTATGCTTCTCATTTGTTTATGTATTCATGAATACTGCATAGTCCTGATTCAGAGACTTTTGCTT
TGCTTTCCAACTTGTATCCCTACATTCTCACAACAGCCTTCTTACCTCGGGTGAGAGTCATGAGCACCTTACCAGGCAGGGAGCTTCCCC
AGGATAGTGTGGTGGAGTCAGGACTCACTCCATCCTGCACTTTACCCACAGGACACCTGGAGGGTCCCCCAGCCCTGCTTGCTTTTGTGA
ACGTCGTGTGAGTACACCGAGGTGTTGCAGCTTTCCTTCCCTCTAGCTCAGGAGGCCTGGCCTGAGCCAGGTTGGAGCTTAAATTGCTGT
TGGCTCCTGCCTGGTGGAACAAGGGGGTCATAGAAACCAGGGCTGATGGGCACCCCCCAGCCCCTGGGAGCTCTGCTCATGACCGCTCAC
AGGGTACCGAGTCTTTGCCTTTTGTGTGTGCGCATGCTGCCCTCTTAACTGCTTTTAGTATTCAGAAAGGTTCCATTTATGTTTTACTCC
TGAAAGTGAAACCCTCTTAGGCAACTTGTTTCATATTCTGGGCATTTTAGTAGCTACAGTATTTTGCATTTAAAATGTAATTACTCTTAG
TATTGTACAGCCCTATAATGTATGAGAACTAGTTTCACATCCTTTGAAACTAATCTCTTTCATTGGGGAGGATACAACTTTTGACTTTAC
ACAGGTGGACTTTGAATCCATTTTTATAGAATTTTTTTCCACTGTAACTTGACCTATATTATGCAAGAAAATCCCAAAAATATGTTTTAA
GGGAGACTACACAGACCTTGTGATTTGGTCTGAGCTAGTTGCTGAGTTGACTGGAGCCTTATTTGAATGGATCTTTGAGTTGAGATCTTC
ACACTGTCAGTGAGCCCTTGGCTCAGCCCTTGTCACCTGTTTGTATGGGGACCATGTTTCCCAAAGCTCAGGTTCATCTCCACTATTGAC
AGAGTCGGGTAGTGGGAGAGTATAAGTGACTTGAGACAGAGTGTCCTTGCTCAGAAAACTGTGAAGCAGGGGTCTTGTTAGTTACAAAGC
CAGTCCTAGTTGCATGTCCAAGGGGGTAGATTTTCATCACCCTACTAAATGTGGTATGTCACTGCTGAAGCCTTTTCCTGTTTTAGTAAT
ATCTTAGGCACTATTGTCTTTTGTCTTCCAGAGTAACATATCTGGGCCCACCTTTCTTGCACACTGTGATTATGTGCTAAGAAAAGGGTG
GAGTTGGGAGGACAATTTCACTTGAACAGGTTTCTGTTCTTCTGAGGTCAGGGTGGGGAGGATGTCCAGGTGACTTTTATGGACACATTG
CAAGACAGTAAGCCGCGGATGGACTCTCACTTGTGCTTTGGAACACTGGACTCCAAAGAGCAGGTGGAACAAACTCTGGCCTGAAGATGA
TGGCTAATACTCAGGCAGAGCCCCGTATTCTTCCCTGACTTGGTCAAAACAAACTTCCTTTTCCCTTGATCACCCTGCACGCAGCTGCCC
AGCTTCCAGTTTTTAAAGAGATGAACAGCTCTCACTTCCTGACTCAGTTTCTCTTGTTGGGTGGGGGCCTTGTGCCACAACCTGCATGGG
GTGCTAGGGTTTAAACCAAGTGGTCACGAAGGATTCTTATCTCAGGGCTCTGCCTGGCCCACCTTCTCTTGGGCCTGGACTCTCCTTATC
CACATCCCTGCAGAAGGTGGGCCCTATTCTCAGAAGAGTCCTGGCTGCTGTTGCCATCTGAATGCGCCCTTCCCTTTCAGGTTGACCAGC
AGTGGCCTTACCTGGCCTCTCAGGTGGATGGAGGCTGTTCTCATCTGGGGCTGTCTCTTGATTAAGGCTGTCACCTGTTTGTATAGGGAC
CATGTTTCCCAACGCACTTTGAGTGCAGTTTAGGAGGTATCCTTTGGATGCTGAAGTGTTGGGATTTTGAGGACATGCGGATGATTTATG
AGAATAGAGGGGCAGAGTTTGTGAAGTCTAGGGTTTTTTGTCCAGTGGGTTTCAAATTTGTTGGCTGTTTAAAGACCCTGTCTCCTCCCC
CACCCTCCCCTTCCTTTTCCCATCAAATGCCTACCTACTGAGGCGCCTTCTCTTTTTATTCTTGAGCCAATGAGATATCAGTGTGTTTAT
TAATAAGGATTGCAATAGTATAGTGCTTAATATGTGCCAGGCATAGTGCTAAGGGTTTACATACGTTATCCCTTTTAATCCAGAAAACAG
CCTTTGATTAGGTATTGTTGTCTCCATTTTATAGATGAGGAAACTGAGGCAGTATGACTGAGGCCGAGAGCAGTGGTTAAGACAGACTTT
GGGATCAAATCACCCTAGGTGCGGGCAGGTTTCTAGGCTGCTCTAAGCTTCTACCTTGAAGGCAGTTGGGTCTGATAATAGTACCTTCTT
CCTGGGGTGGTTGTGAGGATATAACGAGGTAATGCATGTAAGCATTTAGTACCATGCCTGGCACATAGTAAGCACTCAATAAATGGTAGT
TACTTTTGTTGAGCTCAGCTGGTAGTTTGACCTCCGTTGGTGCAATGCCAGAGATGGGATTGTCAGCCACCACACTGCCACCACCCTGCA
CACAGTCTGGGTCCCTCCGAGAGAAGCACGCCAACCTTAACATCCCCTACAGCATCTTGGTGCTTCACACACCATTTAGGAGGCCACCCT
AACGAGGCAAGAGGACATGGGGGTGTGCAGAAGTTCTGTTCTTAGTGAGAATGGCTGGCCTGAGAATCCAGCTCACCTCCTCTGCCCACA
GTCTGGACTGCTTGTGGGAAGGCCATCTCCTCCTGTCTGGTGGTACCTCCACTCTGGGCAGGGAGGGCCTGTCTGTGACTCGCTCTGGAC
CCCACTTCCCGCTCTGGCCAAGGGCTGTCTTCTGTGCACATAGCTCAGGAGCCTGCAGCAGTTCCCTGTATGGGTGGATGTCCTCAGGGG
CCAAGAAGAGAAGAATGGGGACAACAGAAACCTGCTTTGTAGGGGATTATGTAGACTAAAAGCCTAGAAGTTCTGCCCACATCCTTATGA
CGCAGCCAATCTGGAGCTTCATGTTTCCTTCTAAAAGTAGTAACCGGGTAGAAGTGGGTGACCCATTGAGGACACATGATGTGAGGTATT
TCTGCCGGATTCTAGGTTAGCAAAGACTCAAATGGGTGACTCATGAATGAAGGGAGAACAGGCACAGGACTTAATGAAAAGAGTTTCTTG
AACTTAGTTTTCTGAATGGGGGTGGGGAGTTGGGGCACGTGTGTGTAAGGGGAGGCTGCCTCACTTTGAAGGAATGGTGTTGGCTAACAG
GATCCATGAAATTCCTAGGTCAGTTGAATAATAACTGAACTACTGGTTTGACTGTGGATTATTTCCTGGGTATTAGTGGGACCCAACAGC
ACATTGCTATTAATAGTATGGAAATAATGGTCCCTCTGTTTCATTGAATTGCTGAAGTAATGATAATGCCATGAACCAGGAGAAGATGGT
TGTGGGGGTTTCTAGGAAGCAGCTGCTGTGACAGGCCAATCCCAGGCTTGCCCCCGAGCCCTCCTGTCCTTCTGGGTTTGTGTTTGCCTT
GCCTGGTGCTTCCTCCCTCATTGTGTTGTTGAATAGACCTAGGCAGCCTTGTATCCATAGAAAGCCTCCACTGCTGGGCCGGGGAGGGGG
TTGTGGTAAGGGCCCTCTGGAAATCAAGCAGAGAATGCCTTTGCAGTGGTCTCCCGGGCATTGGGCAGGGCCTAGCCTTTTGCAGCCCCC
AGAGGACCTTGCCTGCATAAAGCACTCAGAAGGGTTAGCCACCTGGTGATTTTGTCTCTAGTGAAACTGTGTTTGCCGATAATCATCCAC
ATAGCCACCTCTGTCCTCGCAGTTTGGATGCCTTTTTTTGACACCTGCGCTAGGTTCTTGTATGCTGGCTTTTCTTAAAGGAACAGCAGA
GTAGAAAAGAGGTTGAGAATGTTTTCTAGCAGGCAGAATGTGCATACATGTTTTCATGAGTGTCCTTTGGGTGCTGTTTCTTTTAAATCC
TCTGTGCACAGGGCTCTGGCCTTTAGTAAACTGTTTTTCTGTCTTACGTCATGCTGACTGGGTGCTAGGGGCTGATTACAAAGGGGAAGA
GTTGAACAGACATCAGGGGCCGATGAAACCAAAGGACTAGGAGTCAGGAGAACAAGTCAGGGATTAGGAGACAGCGGTTTGGTTTATTGT
TATCCAGCTGGAGGACTCCTAGGGGCAGCAGCAGGAGGAATACCAGGGCCACGGAGGGGCCAGGAGTCTCACAGTGGAGGGCAGACTCTA
ACAGATGCCAGCTGAACGCTCGCTGGCCCTGGATGTCATACGAGTTGGGGACCAGAAATCTGGGCTCAGAGAACCCGTCCAGGGAGATTT
GAAGCCATGGGTTATCTTCTAGAGTTGATACTGATAATATATTTTAATTTTTATTGATGTTTAATACCTTCTGAAACAGGAGGGTAAGAT
CAGATGGGAAGCCCCTCTGTTGAAGGATCTTGGGAACCTTGGTGGTTTTTTTTTTTTTTTTGGTTTTTTTTTTTTGATCGAGCTGTGGAC
ATCCTTCTTAATTCGATTCTGAGGATTTGTTTAACTAAAAAGTTCCCAAACACAGAAAGGGCCTCCCCACCTGCTTTGGGGAGCTGTCTG
TGCTGGGAGTGCCAGGCATCCCATGGGACCCATCACTGCCAGTGTCTGTGCCTCCCAGAGGTCAGCCGTGTCTGCCCTGGCTCTGTCTCC
TCTGTGACAGGGCAGAGCATTTCTGGTCAGTTTCTCCATGGTGCCTCCCACCCCTTTGTAAAGTGGATGGACATGATGGAATTCAGTTGT
CTCACCCTGATAGCCTGGGTGTTGATATTCACTTTACCCGCACTCAGACACAGGCGACCTTGAAGCAGTTCTCGGTGTGTAGAGTCCACG
TGACAGTCCCCACAGCCTCCCCAGATAGCTGTGTGCCTGTGCGCTACTGCTGTGCCATTTTCCCAACTTGGCGTTTCACTAAATGCAGCT
GATCTCTCTCTCTGTGCACTCGTGATCCATGTTGAACAATACATGTAGGTTCTTTTTCCACGCAATGTAAGAACATGATATACTGTACGT

>83746_83746_1_SLX4IP-CDS2_SLX4IP_chr20_10582467_ENST00000334534_CDS2_chr20_5154169_ENST00000460006_length(amino acids)=561AA_BP=135
MASKKFAVKCGNFAVLVDLHILPQGSNKDTSWFSEQKKEEVCLLLKETIDSRVQEYLEVRKQHRPSNAEFTRSNPLSLKGYGFQITAYFL
KRGIRLRCIRSTQNAELCVFPDRFVVCVSQLAFSRDLLASQNEDLESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSS
RWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQ
REEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGF
FFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYP
FQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLX4IP-CDS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SLX4IP-CDS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SLX4IP-CDS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source