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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMAD3-AAGAB (FusionGDB2 ID:83788)

Fusion Gene Summary for SMAD3-AAGAB

check button Fusion gene summary
Fusion gene informationFusion gene name: SMAD3-AAGAB
Fusion gene ID: 83788
HgeneTgene
Gene symbol

SMAD3

AAGAB

Gene ID

4088

79719

Gene nameSMAD family member 3alpha and gamma adaptin binding protein
SynonymsHSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3KPPP1|PPKP1|PPKP1A|p34
Cytomap

15q22.33

15q23

Type of geneprotein-codingprotein-coding
Descriptionmothers against decapentaplegic homolog 3MAD homolog 3MAD, mothers against decapentaplegic homolog 3SMA- and MAD-related protein 3SMAD, mothers against DPP homolog 3hMAD-3hSMAD3mad homolog JV15-2mad protein homologmad3mothers against DPP homologalpha- and gamma-adaptin-binding protein p34
Modification date2020032920200327
UniProtAcc.

Q6PD74

Ensembl transtripts involved in fusion geneENST00000327367, ENST00000439724, 
ENST00000537194, ENST00000540846, 
ENST00000559092, 		ENST00000538028, 
ENST00000542650, ENST00000561452, 
ENST00000261880, 
Fusion gene scores* DoF score17 X 13 X 12=26526 X 10 X 4=240
# samples 309
** MAII scorelog2(30/2652*10)=-3.14404636961671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMAD3 [Title/Abstract] AND AAGAB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMAD3(67358698)-AAGAB(67495236), # samples:4
AAGAB(67500900)-SMAD3(67457233), # samples:3
Anticipated loss of major functional domain due to fusion event.SMAD3-AAGAB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SMAD3-AAGAB seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
AAGAB-SMAD3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AAGAB-SMAD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMAD3

GO:0000122

negative regulation of transcription by RNA polymerase II

8774881

HgeneSMAD3

GO:0006357

regulation of transcription by RNA polymerase II

21947082

HgeneSMAD3

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876|18548003|21947082

HgeneSMAD3

GO:0007183

SMAD protein complex assembly

9111321|10823886

HgeneSMAD3

GO:0010628

positive regulation of gene expression

21307346

HgeneSMAD3

GO:0010718

positive regulation of epithelial to mesenchymal transition

21307346

HgeneSMAD3

GO:0030308

negative regulation of cell growth

8774881

HgeneSMAD3

GO:0045429

positive regulation of nitric oxide biosynthetic process

27038547

HgeneSMAD3

GO:0045599

negative regulation of fat cell differentiation

19816956

HgeneSMAD3

GO:0045893

positive regulation of transcription, DNA-templated

9111321|9311995|9732876

HgeneSMAD3

GO:0045944

positive regulation of transcription by RNA polymerase II

8774881|18832382

HgeneSMAD3

GO:0051481

negative regulation of cytosolic calcium ion concentration

27038547

HgeneSMAD3

GO:0071560

cellular response to transforming growth factor beta stimulus

12902338

HgeneSMAD3

GO:1901203

positive regulation of extracellular matrix assembly

21307346


check buttonFusion gene breakpoints across SMAD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AAGAB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67391361

+AAGABchr15

67529157

-
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67391595

+AAGABchr15

67529157

-
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67418322

+AAGABchr15

67529158

-
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67430437

+AAGABchr15

67529157

-
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67430438

-AAGABchr15

67529158

-
ChimerDB4BLCATCGA-GU-A42Q-01ASMAD3chr15

67430438

+AAGABchr15

67529158

-
ChimerDB4BLCATCGA-GU-A42QSMAD3chr15

67430438

+AAGABchr15

67529158

-
ChimerDB4SARCTCGA-K1-A42X-01ASMAD3chr15

67358698

-AAGABchr15

67495236

-
ChimerDB4SARCTCGA-K1-A42X-01ASMAD3chr15

67358698

+AAGABchr15

67495236

-
ChimerDB4SARCTCGA-K1-A42X-01ASMAD3chr15

67358698

+AAGABchr15

67496486

-
ChimerDB4SARCTCGA-K1-A42X-02ASMAD3chr15

67358698

-AAGABchr15

67495236

-
ChimerDB4SARCTCGA-K1-A42X-02ASMAD3chr15

67358698

+AAGABchr15

67495236

-
ChimerDB4SARCTCGA-K1-A42X-02ASMAD3chr15

67358698

+AAGABchr15

67496486

-
ChiTaRS5.0N/ACX866999SMAD3chr15

67462942

+AAGABchr15

67501883

-


Top

Fusion Gene ORF analysis for SMAD3-AAGAB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000327367ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67495236

-
5CDS-5UTRENST00000327367ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67496486

-
5CDS-5UTRENST00000327367ENST00000538028SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000327367ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67495236

-
5CDS-5UTRENST00000327367ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67496486

-
5CDS-5UTRENST00000327367ENST00000542650SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000327367ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67495236

-
5CDS-5UTRENST00000327367ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67496486

-
5CDS-5UTRENST00000327367ENST00000561452SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000439724ENST00000538028SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000439724ENST00000542650SMAD3chr15

67430437

+AAGABchr15

67529157

-
5CDS-5UTRENST00000439724ENST00000542650SMAD3chr15

67430438

+AAGABchr15

67529158

-
5CDS-5UTRENST00000439724ENST00000542650SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000439724ENST00000561452SMAD3chr15

67430437

+AAGABchr15

67529157

-
5CDS-5UTRENST00000439724ENST00000561452SMAD3chr15

67430438

+AAGABchr15

67529158

-
5CDS-5UTRENST00000439724ENST00000561452SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000537194ENST00000538028SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000537194ENST00000542650SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000537194ENST00000561452SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000540846ENST00000538028SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000540846ENST00000542650SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000540846ENST00000561452SMAD3chr15

67462942

+AAGABchr15

67501883

-
5CDS-5UTRENST00000559092ENST00000542650SMAD3chr15

67391361

+AAGABchr15

67529157

-
5CDS-5UTRENST00000559092ENST00000561452SMAD3chr15

67391361

+AAGABchr15

67529157

-
5CDS-intronENST00000439724ENST00000538028SMAD3chr15

67430437

+AAGABchr15

67529157

-
5CDS-intronENST00000439724ENST00000538028SMAD3chr15

67430438

+AAGABchr15

67529158

-
5CDS-intronENST00000559092ENST00000538028SMAD3chr15

67391361

+AAGABchr15

67529157

-
5UTR-3CDSENST00000540846ENST00000261880SMAD3chr15

67418322

+AAGABchr15

67529158

-
5UTR-5UTRENST00000540846ENST00000542650SMAD3chr15

67418322

+AAGABchr15

67529158

-
5UTR-5UTRENST00000540846ENST00000561452SMAD3chr15

67418322

+AAGABchr15

67529158

-
5UTR-intronENST00000540846ENST00000538028SMAD3chr15

67418322

+AAGABchr15

67529158

-
Frame-shiftENST00000327367ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67496486

-
Frame-shiftENST00000439724ENST00000261880SMAD3chr15

67430437

+AAGABchr15

67529157

-
Frame-shiftENST00000439724ENST00000261880SMAD3chr15

67430438

+AAGABchr15

67529158

-
In-frameENST00000327367ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67495236

-
In-frameENST00000327367ENST00000261880SMAD3chr15

67462942

+AAGABchr15

67501883

-
In-frameENST00000439724ENST00000261880SMAD3chr15

67462942

+AAGABchr15

67501883

-
In-frameENST00000537194ENST00000261880SMAD3chr15

67462942

+AAGABchr15

67501883

-
In-frameENST00000540846ENST00000261880SMAD3chr15

67462942

+AAGABchr15

67501883

-
In-frameENST00000559092ENST00000261880SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-3CDSENST00000327367ENST00000261880SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-3CDSENST00000327367ENST00000261880SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-3CDSENST00000327367ENST00000261880SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-3CDSENST00000327367ENST00000261880SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-3CDSENST00000327367ENST00000261880SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-3CDSENST00000439724ENST00000261880SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-3CDSENST00000439724ENST00000261880SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-3CDSENST00000439724ENST00000261880SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-3CDSENST00000439724ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-3CDSENST00000439724ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-3CDSENST00000537194ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-3CDSENST00000540846ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-3CDSENST00000559092ENST00000261880SMAD3chr15

67462942

+AAGABchr15

67501883

-
intron-5UTRENST00000327367ENST00000542650SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000542650SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000542650SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000327367ENST00000542650SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000542650SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000327367ENST00000561452SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000561452SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000561452SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000327367ENST00000561452SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000327367ENST00000561452SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000439724ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000439724ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000439724ENST00000542650SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000439724ENST00000542650SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000439724ENST00000542650SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000439724ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000439724ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000439724ENST00000561452SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000439724ENST00000561452SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000439724ENST00000561452SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000439724ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000439724ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000537194ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000537194ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000537194ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000537194ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000540846ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000540846ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000540846ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000540846ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000559092ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000559092ENST00000538028SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000559092ENST00000538028SMAD3chr15

67462942

+AAGABchr15

67501883

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000559092ENST00000542650SMAD3chr15

67462942

+AAGABchr15

67501883

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67495236

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67358698

+AAGABchr15

67496486

-
intron-5UTRENST00000559092ENST00000561452SMAD3chr15

67462942

+AAGABchr15

67501883

-
intron-intronENST00000327367ENST00000538028SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-intronENST00000327367ENST00000538028SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-intronENST00000327367ENST00000538028SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-intronENST00000327367ENST00000538028SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-intronENST00000327367ENST00000538028SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-intronENST00000439724ENST00000538028SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-intronENST00000439724ENST00000538028SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-intronENST00000439724ENST00000538028SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-intronENST00000537194ENST00000538028SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-intronENST00000537194ENST00000538028SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-intronENST00000537194ENST00000538028SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-intronENST00000537194ENST00000538028SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-intronENST00000537194ENST00000538028SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-intronENST00000540846ENST00000538028SMAD3chr15

67391361

+AAGABchr15

67529157

-
intron-intronENST00000540846ENST00000538028SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-intronENST00000540846ENST00000538028SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-intronENST00000540846ENST00000538028SMAD3chr15

67430438

+AAGABchr15

67529158

-
intron-intronENST00000559092ENST00000538028SMAD3chr15

67391595

+AAGABchr15

67529157

-
intron-intronENST00000559092ENST00000538028SMAD3chr15

67418322

+AAGABchr15

67529158

-
intron-intronENST00000559092ENST00000538028SMAD3chr15

67430437

+AAGABchr15

67529157

-
intron-intronENST00000559092ENST00000538028SMAD3chr15

67430438

+AAGABchr15

67529158

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327367SMAD3chr1567358698+ENST00000261880AAGABchr1567495236-23825165150172
ENST00000559092SMAD3chr1567391361+ENST00000261880AAGABchr1567529157-31064432561317353

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327367ENST00000261880SMAD3chr1567358698+AAGABchr1567495236-0.19974920.80025077
ENST00000559092ENST00000261880SMAD3chr1567391361+AAGABchr1567529157-0.0008617650.99913824

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Fusion Genomic Features for SMAD3-AAGAB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMAD3-AAGAB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:67358698/chr15:67495236)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AAGAB

Q6PD74

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be involved in endocytic recycling of growth factor receptors such as EGFR. {ECO:0000269|PubMed:23064416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD3chr15:67462942chr15:67501883ENST00000327367+5910_136219426.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67501883ENST00000439724+5910_136175382.0DomainMH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD3chr15:67358698chr15:67495236ENST00000327367+1910_13668426.0DomainMH1
HgeneSMAD3chr15:67358698chr15:67495236ENST00000327367+19232_42568426.0DomainMH2
HgeneSMAD3chr15:67358698chr15:67495236ENST00000439724+1910_1360382.0DomainMH1
HgeneSMAD3chr15:67358698chr15:67495236ENST00000439724+19232_4250382.0DomainMH2
HgeneSMAD3chr15:67358698chr15:67495236ENST00000537194+1710_1360231.0DomainMH1
HgeneSMAD3chr15:67358698chr15:67495236ENST00000537194+17232_4250231.0DomainMH2
HgeneSMAD3chr15:67358698chr15:67495236ENST00000540846+1910_1360321.0DomainMH1
HgeneSMAD3chr15:67358698chr15:67495236ENST00000540846+19232_4250321.0DomainMH2
HgeneSMAD3chr15:67391361chr15:67529157ENST00000327367+1910_1360426.0DomainMH1
HgeneSMAD3chr15:67391361chr15:67529157ENST00000327367+19232_4250426.0DomainMH2
HgeneSMAD3chr15:67391361chr15:67529157ENST00000439724+1910_1360382.0DomainMH1
HgeneSMAD3chr15:67391361chr15:67529157ENST00000439724+19232_4250382.0DomainMH2
HgeneSMAD3chr15:67391361chr15:67529157ENST00000537194+1710_1360231.0DomainMH1
HgeneSMAD3chr15:67391361chr15:67529157ENST00000537194+17232_4250231.0DomainMH2
HgeneSMAD3chr15:67391361chr15:67529157ENST00000540846+1910_1360321.0DomainMH1
HgeneSMAD3chr15:67391361chr15:67529157ENST00000540846+19232_4250321.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67501883ENST00000327367+59232_425219426.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67501883ENST00000439724+59232_425175382.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67501883ENST00000537194+3710_13624231.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67501883ENST00000537194+37232_42524231.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67501883ENST00000540846+5910_136114321.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67501883ENST00000540846+59232_425114321.0DomainMH2
HgeneSMAD3chr15:67358698chr15:67495236ENST00000327367+19137_23168426.0RegionNote=Linker
HgeneSMAD3chr15:67358698chr15:67495236ENST00000439724+19137_2310382.0RegionNote=Linker
HgeneSMAD3chr15:67358698chr15:67495236ENST00000537194+17137_2310231.0RegionNote=Linker
HgeneSMAD3chr15:67358698chr15:67495236ENST00000540846+19137_2310321.0RegionNote=Linker
HgeneSMAD3chr15:67391361chr15:67529157ENST00000327367+19137_2310426.0RegionNote=Linker
HgeneSMAD3chr15:67391361chr15:67529157ENST00000439724+19137_2310382.0RegionNote=Linker
HgeneSMAD3chr15:67391361chr15:67529157ENST00000537194+17137_2310231.0RegionNote=Linker
HgeneSMAD3chr15:67391361chr15:67529157ENST00000540846+19137_2310321.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67501883ENST00000327367+59137_231219426.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67501883ENST00000439724+59137_231175382.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67501883ENST00000537194+37137_23124231.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67501883ENST00000540846+59137_231114321.0RegionNote=Linker


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Fusion Gene Sequence for SMAD3-AAGAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83788_83788_1_SMAD3-AAGAB_SMAD3_chr15_67358698_ENST00000327367_AAGAB_chr15_67495236_ENST00000261880_length(transcript)=2382nt_BP=516nt
ACTTGGAGTCTCGCGGCCGCCGCCTCCGCCCCGCGTTCGGGGCCTTCCCGACCCTGCACTGCTGCCGTCCGCCCGCCCGGCCGCTCTTCT
CTTCGCCGTGGGAGCCGCTCCGGGCGCAGGGCCGCGCGCCGAGCCCCGCAGGCTGCAGCGCCGCGGCCCGGCCCGGCGCCCCGGCAACTT
CGCCGAGAGTTGAGGCGAAGTTTGGGCGACCGCGGCAGGCCCCGGCCGAGCTCCCCTCTGCGCCCCCGGCGTCCCGTCGAGCCCAGCCCC
GCCGGGGGCGCTCCTCGCCGCCCGCGCGCCCTCCCCAGCCATGTCGTCCATCCTGCCTTTCACTCCCCCGATCGTGAAGCGCCTGCTGGG
CTGGAAGAAGGGCGAGCAGAACGGGCAGGAGGAGAAATGGTGCGAGAAGGCGGTCAAGAGCCTGGTCAAGAAACTCAAGAAGACGGGGCA
GCTGGACGAGCTGGAGAAGGCCATCACCACGCAGAACGTCAACACCAAGTGCATCACCATCCCCAGGTGGCCAAAGCATTCTGGATGGCA
ATCGGGGGAGACAGAGATGAAATTGAAGGCCTTTCATCTGATGAAGAGCACTGAATTATTCATACTAGGGTTTGACCAACAAAGATGCTA
GCTGTCTCTGAGATACCTCTCTACTCAGCCCAGTCATATTTTGCCAAAATTGCCCTTATCATGTTGGCTGCCTGACTTGTTTATAGGGTC
CCCTTAATTTTAGTTTTTAGTAGGAGGTTAAGGAGAAATCTTTTTTTTCCTCAGTATATTGTAAGAGAGTGAGGAATACAGTGATAGTAA
TGAGTGAGGATTTCTTAAATATACTTTTTTTTTGTTCTAGGAATGAGGGTAGGATAAATCTCAGAGGTCTGTGTGATTTACTCAAGTTGA
AGACAACCTCCAGGCCATTCCTGGTCAACCTTTTAAGTAGCATTTCCAGCATTCACACTTGATACTGCACATCAGGAGTTGTGTCACCTT
TCCTGGGTGATTTGGGTTTTCTCCATTCAAGGAGCTTGTAGCTCTGAGCTATGATGCTTTTATTGGGAGGAAAGGAGGCAGCTGCAGAAT
TGATGTGAGCTATGTGGGGCCGAAGTCTCAGCCCGCAGCTAAGTCTCTACCTAAGAAAATGCCTCTGGGCATTCTTTTGAAGTATAGTGT
CTGAGCTCATGCTAGAAAGAATCAAAAAGCCAGTGTGGATTTTTAGACTGTAATAAATGAGGCAAAGGATTTCTATTCCAGTGGGAAGAA
AACCTCTCTACTGAGTTGTGGGGGATATGTTGTATGTTAGAGAGAACCTTAAGGAGTCCTTGTATGGGCCATGGAGACAGTATGTGATAA
CATACCGTGATTTTCATGAAGAAATTCTTCTGTCTTAGAGTTCTCCCCTGCTGCTTGAGATGCCAGAGCTGTGTTGTTGCACACCTGCAA
AACAAGGCACATTTCCCCCTTTCTCTTTAAAGCCAAAGAGAGATCACTGCCAAAGTGGGAGCACTAAGGGGTGGGTGGGGAAGTGAAATG
TTAGGCGATGAATTCCTGAGCACCTTGTTTTTCTTCCAAGGTTCGTAGCTCCTCTCTGCCCTTCCAAGCCTGTAACCTCGGAGGACTATC
TTTTGTTCTTTATCCTTTGTCTTGTTTGAGTGGGTCAGCCCCAGAGGAACTGATAAGCAAATGGCAAGTTTTTAAAGGAAGAGTGGAAAG
TACTGCAAATAAAAATCCTTATTTGTTTTTGTAGACTTTGTAATGCATATCATTAGCCCTCACTGTGATCATTACTGCTGTGGCTCTGAA
CTGGCACATAGTACAGTGGATGGAAGGTGCCCGCACACCAGCTGAGAACTGGTTCTGGCCTAGGTGGGCTCTAGAACCATTTACACAGCA
TGAAAGAAACAGGTTGGGTTAGGAGCAGAAAGAAATAAGGCTCACACCCCTCCAGACACTACCTTATAAGCACTGCAGAACCTGAAACAG
ATGGCAGAAGGAATGGAATGCTACAGGGGCCAGCAGGAGTGACCACAGGGAGGGGACAGCTCAGTGACTGGAGCATTCAGGAAGAGGCTT
TCCAGGGAACACTGGACATTGCTTAGTGACCTTTTGTTCCTTTTTTTTTTTTTTTCTTTTACTGTTCTGAAAGACTTTGAGTCTGTGGTT
CACCACCAGCCCATCAGTGTTTCTTTGAGGTGATTGCATTAGGGAAGTTGGCTCTGGGATTGCAAAAAAAAAAAAAAGGTGGAACATGTT
TTCCTTAAAAGATGGAAGGTTTTAGAAAATATACTAGGCCATCTGGTTAGAAAAAACAGACCAGACTAGAAAAAGCTGTGAATTTGATTT

>83788_83788_1_SMAD3-AAGAB_SMAD3_chr15_67358698_ENST00000327367_AAGAB_chr15_67495236_ENST00000261880_length(amino acids)=172AA_BP=
MGMVMHLVLTFCVVMAFSSSSSCPVFLSFLTRLLTAFSHHFSSCPFCSPFFQPSRRFTIGGVKGRMDDMAGEGARAARSAPGGAGLDGTP

--------------------------------------------------------------
>83788_83788_2_SMAD3-AAGAB_SMAD3_chr15_67391361_ENST00000559092_AAGAB_chr15_67529157_ENST00000261880_length(transcript)=3106nt_BP=443nt
AGCACAGAGGCAAACCACAGAGTACATTTGAGGCCCAGATCTGCTTATTTCGAGGGTGGGGCCGCGTTTTTCTCCTGCCACAGTGAGCTA
ATTAAAGAAAACAAGCTTCGGGAGTTGGGAGAGAACTGTCCACAGGACACTTGGGGAGGCTTGCTTTGGTTGTGGAGGCCTCCACAGCCC
CCGGAAGGCAGGTGGAAGTGGGCATGGAGGGTCCTACGCATCCCCAGCGGGGGTCTGAGGGCCCACTGTTGCTCAGCTGGGGGATTTGGG
GACGGTGGGAGGGCATACATGGATGGGAGGGTGGACTCCGTTCCTGAGGGGGCCAGTGTGGAGGAGGGTCAGGCAGCCCATGGAGATGGG
ACAGTGTTCTGAAATGCTTCACAAATGTGGACTTTTGCCCCAAACTGTGGACAGAGCGTATGTCCTGAGCGAGGATCAACTCTATATCCT
TGGAACAGAAGATCTTATTGTGGAAGTGACTTCCAATGATGCTGTGAGATTTTATCCCTGGACCATTGATAATAAATACTATTCAGCAGA
CATCAATCTATGTGTGGTGCCAAACAAATTTCTTGTTACTGCAGAGATTGCAGAATCTGTCCAAGCATTTGTGGTTTACTTTGACAGCAC
ACAAAAATCGGGCCTTGATAGTGTCTCCTCATGGCTTCCACTGGCAAAAGCATGGTTACCTGAGGTGATGATCTTGGTCTGCGATAGAGT
GTCTGAAGATGGTATAAACCGACAAAAAGCTCAAGAATGGTGCATCAAACATGGCTTTGAATTGGTAGAACTTAGTCCAGAGGAGTTGCC
TGAGGAGGATGATGACTTCCCAGAATCTACAGGAGTAAAGCGAATTGTCCAAGCCCTGAATGCCAATGTGTGGTCCAATGTAGTGATGAA
GAATGATAGGAACCAAGGCTTTAGCCTTCTCAACTCATTGACTGGAACAAACCATAGCATTGGGTCAGCAGATCCCTGTCACCCAGAGCA
ACCCCATTTGCCAGCAGCAGATAGTACTGAATCCCTCTCTGATCATCGGGGTGGTGCATCTAACACAACAGATGCCCAGGTTGATAGCAT
TGTGGATCCCATGTTAGATCTGGATATTCAAGAATTAGCCAGTCTTACCACTGGAGGAGGAGATGTGGAGAATTTTGAAAGACTCTTTTC
AAAGTTAAAGGAAATGAAAGACAAGGCTGCGACGCTTCCTCATGAGCAAAGAAAAGTGCATGCAGAAAAGGTGGCCAAAGCATTCTGGAT
GGCAATCGGGGGAGACAGAGATGAAATTGAAGGCCTTTCATCTGATGAAGAGCACTGAATTATTCATACTAGGGTTTGACCAACAAAGAT
GCTAGCTGTCTCTGAGATACCTCTCTACTCAGCCCAGTCATATTTTGCCAAAATTGCCCTTATCATGTTGGCTGCCTGACTTGTTTATAG
GGTCCCCTTAATTTTAGTTTTTAGTAGGAGGTTAAGGAGAAATCTTTTTTTTCCTCAGTATATTGTAAGAGAGTGAGGAATACAGTGATA
GTAATGAGTGAGGATTTCTTAAATATACTTTTTTTTTGTTCTAGGAATGAGGGTAGGATAAATCTCAGAGGTCTGTGTGATTTACTCAAG
TTGAAGACAACCTCCAGGCCATTCCTGGTCAACCTTTTAAGTAGCATTTCCAGCATTCACACTTGATACTGCACATCAGGAGTTGTGTCA
CCTTTCCTGGGTGATTTGGGTTTTCTCCATTCAAGGAGCTTGTAGCTCTGAGCTATGATGCTTTTATTGGGAGGAAAGGAGGCAGCTGCA
GAATTGATGTGAGCTATGTGGGGCCGAAGTCTCAGCCCGCAGCTAAGTCTCTACCTAAGAAAATGCCTCTGGGCATTCTTTTGAAGTATA
GTGTCTGAGCTCATGCTAGAAAGAATCAAAAAGCCAGTGTGGATTTTTAGACTGTAATAAATGAGGCAAAGGATTTCTATTCCAGTGGGA
AGAAAACCTCTCTACTGAGTTGTGGGGGATATGTTGTATGTTAGAGAGAACCTTAAGGAGTCCTTGTATGGGCCATGGAGACAGTATGTG
ATAACATACCGTGATTTTCATGAAGAAATTCTTCTGTCTTAGAGTTCTCCCCTGCTGCTTGAGATGCCAGAGCTGTGTTGTTGCACACCT
GCAAAACAAGGCACATTTCCCCCTTTCTCTTTAAAGCCAAAGAGAGATCACTGCCAAAGTGGGAGCACTAAGGGGTGGGTGGGGAAGTGA
AATGTTAGGCGATGAATTCCTGAGCACCTTGTTTTTCTTCCAAGGTTCGTAGCTCCTCTCTGCCCTTCCAAGCCTGTAACCTCGGAGGAC
TATCTTTTGTTCTTTATCCTTTGTCTTGTTTGAGTGGGTCAGCCCCAGAGGAACTGATAAGCAAATGGCAAGTTTTTAAAGGAAGAGTGG
AAAGTACTGCAAATAAAAATCCTTATTTGTTTTTGTAGACTTTGTAATGCATATCATTAGCCCTCACTGTGATCATTACTGCTGTGGCTC
TGAACTGGCACATAGTACAGTGGATGGAAGGTGCCCGCACACCAGCTGAGAACTGGTTCTGGCCTAGGTGGGCTCTAGAACCATTTACAC
AGCATGAAAGAAACAGGTTGGGTTAGGAGCAGAAAGAAATAAGGCTCACACCCCTCCAGACACTACCTTATAAGCACTGCAGAACCTGAA
ACAGATGGCAGAAGGAATGGAATGCTACAGGGGCCAGCAGGAGTGACCACAGGGAGGGGACAGCTCAGTGACTGGAGCATTCAGGAAGAG
GCTTTCCAGGGAACACTGGACATTGCTTAGTGACCTTTTGTTCCTTTTTTTTTTTTTTTCTTTTACTGTTCTGAAAGACTTTGAGTCTGT
GGTTCACCACCAGCCCATCAGTGTTTCTTTGAGGTGATTGCATTAGGGAAGTTGGCTCTGGGATTGCAAAAAAAAAAAAAAGGTGGAACA
TGTTTTCCTTAAAAGATGGAAGGTTTTAGAAAATATACTAGGCCATCTGGTTAGAAAAAACAGACCAGACTAGAAAAAGCTGTGAATTTG

>83788_83788_2_SMAD3-AAGAB_SMAD3_chr15_67391361_ENST00000559092_AAGAB_chr15_67529157_ENST00000261880_length(amino acids)=353AA_BP=61
MGDLGTVGGHTWMGGWTPFLRGPVWRRVRQPMEMGQCSEMLHKCGLLPQTVDRAYVLSEDQLYILGTEDLIVEVTSNDAVRFYPWTIDNK
YYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELS
PEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMAD3-AAGAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMAD3-AAGAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMAD3-AAGAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource