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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATXN10-TUBGCP6 (FusionGDB2 ID:8379)

Fusion Gene Summary for ATXN10-TUBGCP6

Fusion gene summary

Fusion gene information	Fusion gene name: ATXN10-TUBGCP6
	Fusion gene ID: 8379
		Hgene	Tgene
	Gene symbol	ATXN10	TUBGCP6
	Gene ID	25814	85378
	Gene name	ataxin 10	tubulin gamma complex associated protein 6
	Synonyms	E46L\|HUMEEP\|SCA10	GCP-6\|GCP6\|MCCRP\|MCCRP1\|MCPHCR
	Cytomap	22q13.31	22q13.33
	Type of gene	protein-coding	protein-coding
	Description	ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein	gamma-tubulin complex component 6
	Modification date	20200313	20200329
	UniProtAcc	Q9UBB4	.
	Ensembl transtripts involved in fusion gene	ENST00000252934, ENST00000381061, ENST00000402380, ENST00000498009,	ENST00000439308, ENST00000491449, ENST00000248846,
Fusion gene scores	* DoF score	16 X 12 X 11=2112	5 X 2 X 4=40
	# samples	19	5
	** MAII score	log2(19/2112*10)=-3.47453851102751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ATXN10 [Title/Abstract] AND TUBGCP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATXN10(46136418)-TUBGCP6(50666457), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATXN10	GO:0031175	neuron projection development	16498633
Tgene	TUBGCP6	GO:0007020	microtubule nucleation	11694571

Fusion gene breakpoints across ATXN10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TUBGCP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6941-01A	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
ChimerDB4	HNSC	TCGA-CV-6941	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-

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Fusion Gene ORF analysis for ATXN10-TUBGCP6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000252934	ENST00000439308	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
5CDS-intron	ENST00000252934	ENST00000491449	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
5CDS-intron	ENST00000381061	ENST00000439308	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
5CDS-intron	ENST00000381061	ENST00000491449	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
In-frame	ENST00000252934	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
In-frame	ENST00000381061	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-3CDS	ENST00000402380	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-3CDS	ENST00000498009	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-intron	ENST00000402380	ENST00000439308	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-intron	ENST00000402380	ENST00000491449	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-intron	ENST00000498009	ENST00000439308	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-
intron-intron	ENST00000498009	ENST00000491449	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000381061

ATXN10

chr22

46136418

ENST00000248846

TUBGCP6

chr22

50666457

5464

1247

266

5416

1716

ENST00000252934

ATXN10

chr22

46136418

ENST00000248846

TUBGCP6

chr22

50666457

5655

1438

265

5607

1780

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000381061	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-	0.003729156	0.9962708
ENST00000252934	ENST00000248846	ATXN10	chr22	46136418	+	TUBGCP6	chr22	50666457	-	0.003683176	0.9963168

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Fusion Genomic Features for ATXN10-TUBGCP6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATXN10-TUBGCP6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46136418/chr22:50666457)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATXN10 Q9UBB4	.
FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1027_1269

430

1820.0

Region

Note=9 X 27 AA tandem repeats

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1027_1053

430

1820.0

Repeat

Note=1

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1054_1080

430

1820.0

Repeat

Note=2

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1081_1107

430

1820.0

Repeat

Note=3

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1108_1134

430

1820.0

Repeat

Note=4

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1135_1161

430

1820.0

Repeat

Note=5

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1162_1188

430

1820.0

Repeat

Note=6

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1189_1215

430

1820.0

Repeat

Note=7

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1216_1242

430

1820.0

Repeat

Note=8

Tgene

TUBGCP6

chr22:46136418

chr22:50666457

ENST00000248846

1243_1269

430

1820.0

Repeat

Note=9

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ATXN10-TUBGCP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8379_8379_1_ATXN10-TUBGCP6_ATXN10_chr22_46136418_ENST00000252934_TUBGCP6_chr22_50666457_ENST00000248846_length(transcript)=5655nt_BP=1438nt
GGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGGC
GGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATCC
TACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGGC
GGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGCT
CTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCTGTTGA
GCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAATGCTTG
CATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCG
AGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTAT
TGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTT
TACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGA
ATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGA
AAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGC
TGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGC
TACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAG
AGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGA
CATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGC
CTTCACCAGTGGCCTGAGGAGGTACCTGCAGTATTACCGGGCCTGCGTCCTTTCCACTCCGCCCACCCTGAGCCTCCTCACCATTGGTTT
TCTCTTCAAGAAACTTGGCCGGCAGCTCAGGTACCTGGCCGAGCTCTGTGGCGTTGGCGCTGTGCTCCCGGGCACCTGTGGAGGAGGCCC
CAGGGCCGCGTTTCCCACCGGCGTGAAGCTGCTGTCCTACCTCTACCAGGAGGCTCTGCACAACTGCAGCAACGAGCACTACCCTGTACT
GCTGTCCCTGCTGAAGACCAGCTGCGAGCCCTACACCCGGTTCATCCACGACTGGGTGTACAGCGGGGTGTTCAGAGACGCTTATGGCGA
GTTCATGATTCAGGTGAACCACGAGTACCTCAGCTTCCGAGATAAGTTGTACTGGACACATGGCTACGTGCTCATCTCCAAAGAGGTGGA
GGACTGTGTTCCCGTGTTTCTGAAGCACATTGCCCACGACATATACGTCTGCGGAAAGACCATTAACCTGCTGAAGCTCTGCTGCCCCCG
GCATTACCTCTGTTGGTCCGACGTCCCTGTCCCCCGGATCTCGGTGATTTTCTCCCTTGAGGAGTTGAAGGAGATTGAGAAGGACTGTGC
CGTCTACGTTGGGCGCATGGAGAGGGTGGCCCGCCACAGCTCTGTCAGCAAGGAGGAGAAGGAATTACGTATGGAAATTGCAAAACAAGA
ATTAATCGCTCATGCCCGGGAAGCAGCATCCAGGGTCCTGAGTGCACTGAGTGACCGGCAGATGTCAGAACGGATGGCCTTGGATGCCCG
GAAGCGTGAGCAGTTTCAGAGGCTGAAAGAACAATTTGTGAAGGACCAGGAGCGACGCCAGGCGGCCAGGCAGGAGGAGCTGGATGATGA
CTTCAGCTACGCCCGTGAACTCCGAGACAGGGAGAGAAGGCTGAAGTCCCTGGAGGAGGAGCTGGAGAGGAAGGCGAGGCAGGCACTGGT
CGACCACTACAGCAAGCTCTCTGCAGAGGCAGCTCGTCGGGAGCAGAAGGCACTGTGGAGAATCCAGAGGCACCGACTGGAGAGTGCACG
GCTTCGTTTTCTCTTAGAAGATGAGAAACACATTCAGGAGATGCTGAAAGCAGTGTCTGAGGCTCACCAGCCCCAGGAGCCGCCAGACGT
CCTCTTGAGCGTGCACCCCCAGGTCACGTCTCCGGGCCCTGAGCACCCAGAGGGAGGCCAAGGCTGTGATTCTGGGTCTGCAGAGCAACA
CTCGCCTGCCTGGGATGGCTGGAACAGGCCAGGCCTGCTGACCCCACAGCCCCTTAAGCCTCTAGCAGTGGGGGCTGGTGGCAGGGGGCT
GCAGCAGGCGGAGGGGGCCAGACCCTTCTCTGACAGCCTCAGCATTGGAGACTTCCTACCTGTGGGCCCAGGGGCTGAGCCGTCCGTGCA
GACTGGCATGGTCCCTCTCCTGGAGGTGGCGCTGCAGACCATTAACTTGGACCTGCCCCCCTCAGCTCCTGGGGAGGCACCCGCAGCAGC
CAGCACTCAGCCCTCCAGGCCACAGGAGTACGACTTTAGTACTGTCCTGAGGCCAGCTGTGGCCACCTCACCTGCACCAGGGCCCCTGCA
GGCTGCAGAGTGCAGCTTGGGCAGCTCAGGGCTACAGCTGTGGGAGGACAGTTGTGGGAAGATGGATGCCTGTGGCTCCGCCTCGCGGGA
GACTCTGCTCCCCTCACACCCACCCAGGCGTGCTGCTCTGGAGGAGGGGAGCAGCCAGCCCACAGAGCGGCTCTTTGGGCAGGTGTCAGG
GGGTGGTCTTCCCACAGGGGACTACGCTTCTGAAATAGCTCCCACCCGGCCACGGTGGAACACCCACGGGCACGTGTCTGACGCCAGCAT
CAGGGTCGGGGAGAATGTGTCAGATGTGGCTCCCACCCAGCCACGGTGGAACACCCACGGACACGTATCCAATGCCAGCATCAGCTTAGG
GGAGTCTGTGTCAGATGTGGCTCCCACTCGGCCACGGTGGAACATCCATGGACATGTGTCCAACGCCAGCATCAGGGTCGGGGAGAATGT
GTCAGATGTGGCTCCCACCAGGCCACGGTGGAATACCCACGGGCACGTGTCCAACGCCAGCATCAGGGTTGGGGAGAACGTGTCGGACGT
GGCTCCCACCCGGCCACGGTGGAACACCCATGGACACGTGTCCGATGCCAGCATCAGCTTGGGGGAGTCTGTGTCAGACATGGCTCCCGC
CCGGCCACGGTGGAACACCCATGGACACGTGTCTGATGCCAGCATCAGCTTGGGGGAGTCTGTGTCAGACATGGCTCCCACCCGGCCACG
GTGGAACACCCACGGACATGTGTCTGACACCAGCATCAGGGTTGGGGAGAACGTATCGGACGTGGCTCCCATCCGGTCACGGTGCAACAC
CCATGGACACGTGTCCGACGCCAGCATCAGCTTGGGGGAGCCTGTGTCGGATGTGGTTTCCACCCGGCCACGGTGGAACACCCATGTACC
CATCCCTCCGCCCCACATGGTGCTGGGGGCTCTCTCACCAGAAGCTGAGCCCAACACACCCAGGCCCCAACAGAGCCCCCCTGGCCACAC
GTCCCAGTCAGCGCTCAGCCTGGGAGCACAGAGCACTGTGCTGGACTGTGGGCCACGGCTGCCTGTAGAAGTGGGGCCATCTCTGTCCTC
CCCCAGCTCGGGCTGCGGGGAGGGGAGCATCAGCGTGGGGGAGAACGTGTCAGACGTGGCTCCCACCCAACCATGGTGGCCCAACACCCC
GGGAGACAGTGTCTCTGAAGAACTAGGCCCTGGGAGGAGCGGGGACACTGAGGACCTCTCTCCAAATTGGCCTCTCAACTCACAGGAAGA
CACAGCTGCCCAGAGCAGCCCAGGCCGTGGTGAGGAGGCGGAGGCATCGGCGGCGGAGGCTCAGGGTGGGGAGCAGGCCTACCTGGCAGG
CCTGGCAGGGCAGTACCACTTGGAGCGGTACCCGGACAGTTACGAGTCCATGTCCGAGCCGCCCATTGCTCATCTTTTGCGCCCCGTGCT
TCCCCGGGCCTTCGCCTTCCCCGTGGACCCCCAGGTCCAGTCTGCCGCTGATGAGACTGCTGTGCAGCTGAGCGAGTTGCTGACGCTGCC
CGTGCTCATGAAGCGCTCCATCACGGCACCGCTGGCCGCCCACATCTCCTTGGTGAACAAGGCCGCTGTCGACTACTTCTTCGTGGAGCT
GCACCTGGAGGCGCACTATGAGGCACTGCGGCACTTCCTGCTGATGGAGGACGGCGAGTTCGCCCAGTCCCTCAGCGACCTGCTCTTTGA
GAAGCTTGGAGCTGGGCAAACGCCCGGAGAGCTGCTCAACCCGCTGGTGCTGAACTCTGTGCTGAGCAAGGCCCTGCAGTGCAGCCTGCA
TGGGGACACCCCGCACGCCTCCAACCTCTCCCTCGCTCTCAAGTACCTGCCCGAGGTGTTTGCCCCCAACGCCCCGGATGTGCTGAGCTG
CCTGGAGCTCAGGTACAAGGTGGACTGGCCTCTCAACATTGTCATCACCGAGGGCTGCGTGAGCAAGTACAGCGGCGTCTTCTCCTTCCT
GCTGCAGCTGAAGCTCATGATGTGGGCGCTCAAGGACGTCTGCTTCCACCTCAAGCGCACAGCCCTGCTGAGCCACATGGCCGGCTCTGT
GCAGTTCCGTCAGCTGCAGCTGTTCAAGCACGAGATGCAGCATTTCGTGAAGGTCATCCAGGGCTACATCGCCAACCAGATCCTGCACGT
CACCTGGTGCGAGTTCAGGGCCAGGTTGGCCACCGTGGGCGACCTGGAGGAGATCCAGCGTGCGCACGCAGAGTACCTGCACAAGGCCGT
CTTCAGGGGCCTGCTCACGGAGAAGGCGGCGCCCGTCATGAACGTCATCCACAGCATCTTCAGCCTCGTGCTCAAGTTCCGCAGCCAGCT
CATCTCCCAGGCCTGGGGGCCCCCTGGGGGCCCGCGGGGTGCAGAGCACCCCAACTTTGCACTCATGCAGCAGTCCTACAACACCTTCAA
GTACTACTCCCACTTTCTCTTCAAAGTGGTGACCAAGCTGGTGAACCGCGGCTACCAGCCCCACCTGGAGGACTTTCTGCTGCGCATCAA

>8379_8379_1_ATXN10-TUBGCP6_ATXN10_chr22_46136418_ENST00000252934_TUBGCP6_chr22_50666457_ENST00000248846_length(amino acids)=1780AA_BP=391
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRN
ACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI
LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLR
HAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE
GDISNVANGFKSHLIRLIGNLCYKNKDNQDKAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGG
GPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKE
VEDCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAK
QELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQA
LVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAE
QHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPA
AASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQV
SGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGE
NVSDVAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGESVSDMAPTR
PRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVVSTRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPG
HTSQSALSLGAQSTVLDCGPRLPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDLSPNWPLNSQ
EDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLT
LPVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCS
LHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAG
SVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRS

--------------------------------------------------------------
>8379_8379_2_ATXN10-TUBGCP6_ATXN10_chr22_46136418_ENST00000381061_TUBGCP6_chr22_50666457_ENST00000248846_length(transcript)=5464nt_BP=1247nt
AGGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGG
CGGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATC
CTACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGG
CGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGC
TCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGG
AATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGC
ATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTA
ATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGC
CGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACAC
TGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTG
CAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGC
TTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATC
TTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATG
TGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGCCTTCACCAGTG
GCCTGAGGAGGTACCTGCAGTATTACCGGGCCTGCGTCCTTTCCACTCCGCCCACCCTGAGCCTCCTCACCATTGGTTTTCTCTTCAAGA
AACTTGGCCGGCAGCTCAGGTACCTGGCCGAGCTCTGTGGCGTTGGCGCTGTGCTCCCGGGCACCTGTGGAGGAGGCCCCAGGGCCGCGT
TTCCCACCGGCGTGAAGCTGCTGTCCTACCTCTACCAGGAGGCTCTGCACAACTGCAGCAACGAGCACTACCCTGTACTGCTGTCCCTGC
TGAAGACCAGCTGCGAGCCCTACACCCGGTTCATCCACGACTGGGTGTACAGCGGGGTGTTCAGAGACGCTTATGGCGAGTTCATGATTC
AGGTGAACCACGAGTACCTCAGCTTCCGAGATAAGTTGTACTGGACACATGGCTACGTGCTCATCTCCAAAGAGGTGGAGGACTGTGTTC
CCGTGTTTCTGAAGCACATTGCCCACGACATATACGTCTGCGGAAAGACCATTAACCTGCTGAAGCTCTGCTGCCCCCGGCATTACCTCT
GTTGGTCCGACGTCCCTGTCCCCCGGATCTCGGTGATTTTCTCCCTTGAGGAGTTGAAGGAGATTGAGAAGGACTGTGCCGTCTACGTTG
GGCGCATGGAGAGGGTGGCCCGCCACAGCTCTGTCAGCAAGGAGGAGAAGGAATTACGTATGGAAATTGCAAAACAAGAATTAATCGCTC
ATGCCCGGGAAGCAGCATCCAGGGTCCTGAGTGCACTGAGTGACCGGCAGATGTCAGAACGGATGGCCTTGGATGCCCGGAAGCGTGAGC
AGTTTCAGAGGCTGAAAGAACAATTTGTGAAGGACCAGGAGCGACGCCAGGCGGCCAGGCAGGAGGAGCTGGATGATGACTTCAGCTACG
CCCGTGAACTCCGAGACAGGGAGAGAAGGCTGAAGTCCCTGGAGGAGGAGCTGGAGAGGAAGGCGAGGCAGGCACTGGTCGACCACTACA
GCAAGCTCTCTGCAGAGGCAGCTCGTCGGGAGCAGAAGGCACTGTGGAGAATCCAGAGGCACCGACTGGAGAGTGCACGGCTTCGTTTTC
TCTTAGAAGATGAGAAACACATTCAGGAGATGCTGAAAGCAGTGTCTGAGGCTCACCAGCCCCAGGAGCCGCCAGACGTCCTCTTGAGCG
TGCACCCCCAGGTCACGTCTCCGGGCCCTGAGCACCCAGAGGGAGGCCAAGGCTGTGATTCTGGGTCTGCAGAGCAACACTCGCCTGCCT
GGGATGGCTGGAACAGGCCAGGCCTGCTGACCCCACAGCCCCTTAAGCCTCTAGCAGTGGGGGCTGGTGGCAGGGGGCTGCAGCAGGCGG
AGGGGGCCAGACCCTTCTCTGACAGCCTCAGCATTGGAGACTTCCTACCTGTGGGCCCAGGGGCTGAGCCGTCCGTGCAGACTGGCATGG
TCCCTCTCCTGGAGGTGGCGCTGCAGACCATTAACTTGGACCTGCCCCCCTCAGCTCCTGGGGAGGCACCCGCAGCAGCCAGCACTCAGC
CCTCCAGGCCACAGGAGTACGACTTTAGTACTGTCCTGAGGCCAGCTGTGGCCACCTCACCTGCACCAGGGCCCCTGCAGGCTGCAGAGT
GCAGCTTGGGCAGCTCAGGGCTACAGCTGTGGGAGGACAGTTGTGGGAAGATGGATGCCTGTGGCTCCGCCTCGCGGGAGACTCTGCTCC
CCTCACACCCACCCAGGCGTGCTGCTCTGGAGGAGGGGAGCAGCCAGCCCACAGAGCGGCTCTTTGGGCAGGTGTCAGGGGGTGGTCTTC
CCACAGGGGACTACGCTTCTGAAATAGCTCCCACCCGGCCACGGTGGAACACCCACGGGCACGTGTCTGACGCCAGCATCAGGGTCGGGG
AGAATGTGTCAGATGTGGCTCCCACCCAGCCACGGTGGAACACCCACGGACACGTATCCAATGCCAGCATCAGCTTAGGGGAGTCTGTGT
CAGATGTGGCTCCCACTCGGCCACGGTGGAACATCCATGGACATGTGTCCAACGCCAGCATCAGGGTCGGGGAGAATGTGTCAGATGTGG
CTCCCACCAGGCCACGGTGGAATACCCACGGGCACGTGTCCAACGCCAGCATCAGGGTTGGGGAGAACGTGTCGGACGTGGCTCCCACCC
GGCCACGGTGGAACACCCATGGACACGTGTCCGATGCCAGCATCAGCTTGGGGGAGTCTGTGTCAGACATGGCTCCCGCCCGGCCACGGT
GGAACACCCATGGACACGTGTCTGATGCCAGCATCAGCTTGGGGGAGTCTGTGTCAGACATGGCTCCCACCCGGCCACGGTGGAACACCC
ACGGACATGTGTCTGACACCAGCATCAGGGTTGGGGAGAACGTATCGGACGTGGCTCCCATCCGGTCACGGTGCAACACCCATGGACACG
TGTCCGACGCCAGCATCAGCTTGGGGGAGCCTGTGTCGGATGTGGTTTCCACCCGGCCACGGTGGAACACCCATGTACCCATCCCTCCGC
CCCACATGGTGCTGGGGGCTCTCTCACCAGAAGCTGAGCCCAACACACCCAGGCCCCAACAGAGCCCCCCTGGCCACACGTCCCAGTCAG
CGCTCAGCCTGGGAGCACAGAGCACTGTGCTGGACTGTGGGCCACGGCTGCCTGTAGAAGTGGGGCCATCTCTGTCCTCCCCCAGCTCGG
GCTGCGGGGAGGGGAGCATCAGCGTGGGGGAGAACGTGTCAGACGTGGCTCCCACCCAACCATGGTGGCCCAACACCCCGGGAGACAGTG
TCTCTGAAGAACTAGGCCCTGGGAGGAGCGGGGACACTGAGGACCTCTCTCCAAATTGGCCTCTCAACTCACAGGAAGACACAGCTGCCC
AGAGCAGCCCAGGCCGTGGTGAGGAGGCGGAGGCATCGGCGGCGGAGGCTCAGGGTGGGGAGCAGGCCTACCTGGCAGGCCTGGCAGGGC
AGTACCACTTGGAGCGGTACCCGGACAGTTACGAGTCCATGTCCGAGCCGCCCATTGCTCATCTTTTGCGCCCCGTGCTTCCCCGGGCCT
TCGCCTTCCCCGTGGACCCCCAGGTCCAGTCTGCCGCTGATGAGACTGCTGTGCAGCTGAGCGAGTTGCTGACGCTGCCCGTGCTCATGA
AGCGCTCCATCACGGCACCGCTGGCCGCCCACATCTCCTTGGTGAACAAGGCCGCTGTCGACTACTTCTTCGTGGAGCTGCACCTGGAGG
CGCACTATGAGGCACTGCGGCACTTCCTGCTGATGGAGGACGGCGAGTTCGCCCAGTCCCTCAGCGACCTGCTCTTTGAGAAGCTTGGAG
CTGGGCAAACGCCCGGAGAGCTGCTCAACCCGCTGGTGCTGAACTCTGTGCTGAGCAAGGCCCTGCAGTGCAGCCTGCATGGGGACACCC
CGCACGCCTCCAACCTCTCCCTCGCTCTCAAGTACCTGCCCGAGGTGTTTGCCCCCAACGCCCCGGATGTGCTGAGCTGCCTGGAGCTCA
GGTACAAGGTGGACTGGCCTCTCAACATTGTCATCACCGAGGGCTGCGTGAGCAAGTACAGCGGCGTCTTCTCCTTCCTGCTGCAGCTGA
AGCTCATGATGTGGGCGCTCAAGGACGTCTGCTTCCACCTCAAGCGCACAGCCCTGCTGAGCCACATGGCCGGCTCTGTGCAGTTCCGTC
AGCTGCAGCTGTTCAAGCACGAGATGCAGCATTTCGTGAAGGTCATCCAGGGCTACATCGCCAACCAGATCCTGCACGTCACCTGGTGCG
AGTTCAGGGCCAGGTTGGCCACCGTGGGCGACCTGGAGGAGATCCAGCGTGCGCACGCAGAGTACCTGCACAAGGCCGTCTTCAGGGGCC
TGCTCACGGAGAAGGCGGCGCCCGTCATGAACGTCATCCACAGCATCTTCAGCCTCGTGCTCAAGTTCCGCAGCCAGCTCATCTCCCAGG
CCTGGGGGCCCCCTGGGGGCCCGCGGGGTGCAGAGCACCCCAACTTTGCACTCATGCAGCAGTCCTACAACACCTTCAAGTACTACTCCC
ACTTTCTCTTCAAAGTGGTGACCAAGCTGGTGAACCGCGGCTACCAGCCCCACCTGGAGGACTTTCTGCTGCGCATCAACTTCAACAACT

>8379_8379_2_ATXN10-TUBGCP6_ATXN10_chr22_46136418_ENST00000381061_TUBGCP6_chr22_50666457_ENST00000248846_length(amino acids)=1716AA_BP=327
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVW
VHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERV
TLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVI
DLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLF
KKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFM
IQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVY
VGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFS
YARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLL
SVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTG
MVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETL
LPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGES
VSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARP
RWNTHGHVSDASISLGESVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVVSTRPRWNTHVPIP
PPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPRLPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGD
SVSEELGPGRSGDTEDLSPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPR
AFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKL
GAGQTPGELLNPLVLNSVLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQ
LKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFR
GLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFN

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Fusion Gene PPI Analysis for ATXN10-TUBGCP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ATXN10-TUBGCP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ATXN10-TUBGCP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source