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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMAD3-IQCH (FusionGDB2 ID:83797)

Fusion Gene Summary for SMAD3-IQCH

check button Fusion gene summary
Fusion gene informationFusion gene name: SMAD3-IQCH
Fusion gene ID: 83797
HgeneTgene
Gene symbol

SMAD3

IQCH

Gene ID

4088

128153

Gene nameSMAD family member 3spermatogenesis associated 17
SynonymsHSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3CFAP305|FAP305|IQCH|MOT17|MSRG-11|MSRG11
Cytomap

15q22.33

1q41

Type of geneprotein-codingprotein-coding
Descriptionmothers against decapentaplegic homolog 3MAD homolog 3MAD, mothers against decapentaplegic homolog 3SMA- and MAD-related protein 3SMAD, mothers against DPP homolog 3hMAD-3hSMAD3mad homolog JV15-2mad protein homologmad3mothers against DPP homologspermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11
Modification date2020032920200313
UniProtAcc.

Q86VS3

Ensembl transtripts involved in fusion geneENST00000327367, ENST00000439724, 
ENST00000537194, ENST00000540846, 
ENST00000559092, 		ENST00000335894, 
ENST00000358767, ENST00000360277, 
ENST00000546225, ENST00000512104, 
ENST00000560790, 
Fusion gene scores* DoF score17 X 13 X 12=26528 X 11 X 6=528
# samples 3012
** MAII scorelog2(30/2652*10)=-3.14404636961671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMAD3 [Title/Abstract] AND IQCH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMAD3(67358698)-IQCH(67636401), # samples:1
SMAD3(67462942)-IQCH(67649683), # samples:1
SMAD3(67358698)-IQCH(67664449), # samples:1
Anticipated loss of major functional domain due to fusion event.SMAD3-IQCH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SMAD3-IQCH seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMAD3-IQCH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMAD3

GO:0000122

negative regulation of transcription by RNA polymerase II

8774881

HgeneSMAD3

GO:0006357

regulation of transcription by RNA polymerase II

21947082

HgeneSMAD3

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876|18548003|21947082

HgeneSMAD3

GO:0007183

SMAD protein complex assembly

9111321|10823886

HgeneSMAD3

GO:0010628

positive regulation of gene expression

21307346

HgeneSMAD3

GO:0010718

positive regulation of epithelial to mesenchymal transition

21307346

HgeneSMAD3

GO:0030308

negative regulation of cell growth

8774881

HgeneSMAD3

GO:0045429

positive regulation of nitric oxide biosynthetic process

27038547

HgeneSMAD3

GO:0045599

negative regulation of fat cell differentiation

19816956

HgeneSMAD3

GO:0045893

positive regulation of transcription, DNA-templated

9111321|9311995|9732876

HgeneSMAD3

GO:0045944

positive regulation of transcription by RNA polymerase II

8774881|18832382

HgeneSMAD3

GO:0051481

negative regulation of cytosolic calcium ion concentration

27038547

HgeneSMAD3

GO:0071560

cellular response to transforming growth factor beta stimulus

12902338

HgeneSMAD3

GO:1901203

positive regulation of extracellular matrix assembly

21307346


check buttonFusion gene breakpoints across SMAD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQCH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RH-01ASMAD3chr15

67358698

+IQCHchr15

67636401

+
ChimerDB4COADTCGA-AA-3489-01ASMAD3chr15

67462942

+IQCHchr15

67649683

+
ChimerDB4STADTCGA-VQ-AA6D-01ASMAD3chr15

67358698

+IQCHchr15

67664449

+


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Fusion Gene ORF analysis for SMAD3-IQCH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000327367ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-5UTRENST00000327367ENST00000335894SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000327367ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67664449

+
5CDS-5UTRENST00000327367ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-5UTRENST00000327367ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67664449

+
5CDS-5UTRENST00000327367ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-5UTRENST00000327367ENST00000546225SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000327367ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67664449

+
5CDS-5UTRENST00000439724ENST00000335894SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000439724ENST00000546225SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000537194ENST00000335894SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000537194ENST00000546225SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000540846ENST00000335894SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-5UTRENST00000540846ENST00000546225SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000327367ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-intronENST00000327367ENST00000360277SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000327367ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-intronENST00000327367ENST00000512104SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000327367ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67664449

+
5CDS-intronENST00000327367ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67636401

+
5CDS-intronENST00000327367ENST00000560790SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000327367ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67664449

+
5CDS-intronENST00000439724ENST00000360277SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000439724ENST00000512104SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000439724ENST00000560790SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000537194ENST00000360277SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000537194ENST00000512104SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000537194ENST00000560790SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000540846ENST00000360277SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000540846ENST00000512104SMAD3chr15

67462942

+IQCHchr15

67649683

+
5CDS-intronENST00000540846ENST00000560790SMAD3chr15

67462942

+IQCHchr15

67649683

+
Frame-shiftENST00000327367ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67664449

+
In-frameENST00000327367ENST00000358767SMAD3chr15

67462942

+IQCHchr15

67649683

+
In-frameENST00000439724ENST00000358767SMAD3chr15

67462942

+IQCHchr15

67649683

+
In-frameENST00000537194ENST00000358767SMAD3chr15

67462942

+IQCHchr15

67649683

+
In-frameENST00000540846ENST00000358767SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-3CDSENST00000439724ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-3CDSENST00000537194ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-3CDSENST00000540846ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-3CDSENST00000559092ENST00000358767SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-3CDSENST00000559092ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000439724ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000439724ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000439724ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000439724ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000439724ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000439724ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000537194ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000537194ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000537194ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000537194ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000537194ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000537194ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000540846ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000540846ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000540846ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000540846ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000540846ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000540846ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000559092ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000559092ENST00000335894SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-5UTRENST00000559092ENST00000335894SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000559092ENST00000358767SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000559092ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-5UTRENST00000559092ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-5UTRENST00000559092ENST00000546225SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-5UTRENST00000559092ENST00000546225SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000439724ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000439724ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000439724ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000439724ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000439724ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000537194ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000537194ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000537194ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000537194ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000537194ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000540846ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000540846ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000540846ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000540846ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000540846ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000559092ENST00000360277SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000559092ENST00000360277SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-intronENST00000559092ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000559092ENST00000512104SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-intronENST00000559092ENST00000512104SMAD3chr15

67358698

+IQCHchr15

67664449

+
intron-intronENST00000559092ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67636401

+
intron-intronENST00000559092ENST00000560790SMAD3chr15

67462942

+IQCHchr15

67649683

+
intron-intronENST00000559092ENST00000560790SMAD3chr15

67358698

+IQCHchr15

67664449

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327367SMAD3chr1567462942+ENST00000358767IQCHchr1567649683+41379683102940876
ENST00000540846SMAD3chr1567462942+ENST00000358767IQCHchr1567649683+38907212732693806
ENST00000439724SMAD3chr1567462942+ENST00000358767IQCHchr1567649683+3721552262524832
ENST00000537194SMAD3chr1567462942+ENST00000358767IQCHchr1567649683+34703011952273692

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327367ENST00000358767SMAD3chr1567462942+IQCHchr1567649683+0.0009151790.99908483
ENST00000540846ENST00000358767SMAD3chr1567462942+IQCHchr1567649683+0.000488360.9995116
ENST00000439724ENST00000358767SMAD3chr1567462942+IQCHchr1567649683+0.0007666760.99923337
ENST00000537194ENST00000358767SMAD3chr1567462942+IQCHchr1567649683+0.001162810.9988372

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Fusion Genomic Features for SMAD3-IQCH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMAD3chr1567462942+IQCHchr1567649682+0.99998311.69E-05
SMAD3chr1567358698+IQCHchr1567636400+3.04E-060.9999969
SMAD3chr1567358698+IQCHchr1567664448+1.21E-081
SMAD3chr1567462942+IQCHchr1567649682+0.99998311.69E-05
SMAD3chr1567358698+IQCHchr1567636400+3.04E-060.9999969
SMAD3chr1567358698+IQCHchr1567664448+1.21E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SMAD3-IQCH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:67358698/chr15:67636401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IQCH

Q86VS3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a regulatory role in spermatogenesis. {ECO:0000269|PubMed:15897968}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD3chr15:67462942chr15:67649683ENST00000327367+5910_136219426.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67649683ENST00000439724+5910_136175382.0DomainMH1
TgeneIQCHchr15:67462942chr15:67649683ENST00000335894521369_3982121028.0DomainIQ
TgeneIQCHchr15:67462942chr15:67649683ENST00000360277012369_39801009.3333333333334DomainIQ
TgeneIQCHchr15:67462942chr15:67649683ENST0000051210406369_3980169.0DomainIQ
TgeneIQCHchr15:67462942chr15:67649683ENST00000546225520369_3980685.0DomainIQ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD3chr15:67462942chr15:67649683ENST00000327367+59232_425219426.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67649683ENST00000439724+59232_425175382.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67649683ENST00000537194+3710_13624231.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67649683ENST00000537194+37232_42524231.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67649683ENST00000540846+5910_136114321.0DomainMH1
HgeneSMAD3chr15:67462942chr15:67649683ENST00000540846+59232_425114321.0DomainMH2
HgeneSMAD3chr15:67462942chr15:67649683ENST00000327367+59137_231219426.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67649683ENST00000439724+59137_231175382.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67649683ENST00000537194+37137_23124231.0RegionNote=Linker
HgeneSMAD3chr15:67462942chr15:67649683ENST00000540846+59137_231114321.0RegionNote=Linker


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Fusion Gene Sequence for SMAD3-IQCH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83797_83797_1_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000327367_IQCH_chr15_67649683_ENST00000358767_length(transcript)=4137nt_BP=968nt
ACTTGGAGTCTCGCGGCCGCCGCCTCCGCCCCGCGTTCGGGGCCTTCCCGACCCTGCACTGCTGCCGTCCGCCCGCCCGGCCGCTCTTCT
CTTCGCCGTGGGAGCCGCTCCGGGCGCAGGGCCGCGCGCCGAGCCCCGCAGGCTGCAGCGCCGCGGCCCGGCCCGGCGCCCCGGCAACTT
CGCCGAGAGTTGAGGCGAAGTTTGGGCGACCGCGGCAGGCCCCGGCCGAGCTCCCCTCTGCGCCCCCGGCGTCCCGTCGAGCCCAGCCCC
GCCGGGGGCGCTCCTCGCCGCCCGCGCGCCCTCCCCAGCCATGTCGTCCATCCTGCCTTTCACTCCCCCGATCGTGAAGCGCCTGCTGGG
CTGGAAGAAGGGCGAGCAGAACGGGCAGGAGGAGAAATGGTGCGAGAAGGCGGTCAAGAGCCTGGTCAAGAAACTCAAGAAGACGGGGCA
GCTGGACGAGCTGGAGAAGGCCATCACCACGCAGAACGTCAACACCAAGTGCATCACCATCCCCAGGTCCCTGGATGGCCGGTTGCAGGT
GTCCCATCGGAAGGGGCTCCCTCATGTCATCTACTGCCGCCTGTGGCGATGGCCAGACCTGCACAGCCACCACGAGCTACGGGCCATGGA
GCTGTGTGAGTTCGCCTTCAATATGAAGAAGGACGAGGTCTGCGTGAATCCCTACCACTACCAGAGAGTAGAGACACCAGTTCTACCTCC
TGTGTTGGTGCCACGCCACACAGAGATCCCGGCCGAGTTCCCCCCACTGGACGACTACAGCCATTCCATCCCCGAAAACACTAACTTCCC
CGCAGGCATCGAGCCCCAGAGCAATATTCCAGAGACCCCACCCCCTGGCTACCTGAGTGAAGATGGAGAAACCAGTGACCACCAGATGAA
CCACAGCATGGACGCAGGTTCTCCAAACCTATCCCCGAATCCGATGTCCCCAGCACATAATAACTTGGCCACTTTCACTATACCTCGGGA
ACCACCTCCATCTCCAGCAGAAGTGAAGTTCTTTCCCAAGAAACAAAGATCAAAGGGGAAAAGCAGAAGGTCAAGAGGACATCATGATAG
GAAGGCCATGAAAGTCAAAACACCTTTGAGAGCCCTGAAATCACTGTGGGATTATGACTTTTTAATTTATGATGGTGTCATAGACAATAC
AGCCCCAGACTTCTTAGCATTCAAGGAACATTTTAGCTTAGCTTGGGGAGGTATTTTTTCTCTCTTGGAACACGTCGAGAAGTTTCTCAG
GAACTATGCTATACCAGAAGTCAAAATAAAAGGGAATAATTTGGTGGCCCTCCTTCCAGAGTTTGAGCTGACGAATAAACTTACCAGATA
TGACCTTCTCTCAGTGTTAGAGGACCCAGCTCATGTCCAAATGCTGATAAATCTTCCAGGGCAAAGGTACAAGGGCCAAGATGGAAATTC
GGAGGCCGCCATGAAGATCCAAGCCACATGGAAATGCTACAAAGCAAGAAAATTCTTCCTCTTTTATCGCCAGCAGAAGTGGGCATCAGG
TGTGATTGCCATTGCTTGGCTGTTATATTGCCATAAGACTCGACTAAAGAAGATACTAAAGGAATCACGTCAGAGACACCTGGAGAATTT
TCGCATTCGAGCCAAGCATCTGGCAGCCAACTGGAATCGCATCAGGACCTCCAGGAGGACTATTATCCATATCCCATCATTAGGGTATTC
CCAGCCTGTGAGAGAACATATTGCCGATTTCAACACACAGCAGAACATGCAGCTGGGGAGGCTGTGTGACATCTTAGATGCCAATGTGAA
TGTCATCTACATCTGCTCCCATCATATGAATGACGAGTTAGTGCTGTATTACAAAAAAATCCTAAGTCTACATGCAGCCGTCAAATCTGG
GAACCTTGAGGACAGAAGTGACCTGCAGGACAGGTTCAAAATTATCACACCTGAAGCTGTAAACATCTTCCCTATGATAGAGCAGCTGAG
TCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATAT
TCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCC
AGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAA
ATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGAT
AGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCA
GACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGAT
AGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCT
GACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAA
GAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCT
CTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGG
GGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCA
CCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACC
TCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAG
AAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTT
TATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTC
AGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTA
GCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGA
ATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCAT
TCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAA
GCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTC
TCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTA
GTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAG
CAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATT

>83797_83797_1_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000327367_IQCH_chr15_67649683_ENST00000358767_length(amino acids)=876AA_BP=0
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCR
LWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLATFTIPREPPPSPAEVKFFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALK
SLWDYDFLIYDGVIDNTAPDFLAFKEHFSLAWGGIFSLLEHVEKFLRNYAIPEVKIKGNNLVALLPEFELTNKLTRYDLLSVLEDPAHVQ
MLINLPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFYRQQKWASGVIAIAWLLYCHKTRLKKILKESRQRHLENFRIRAKHLAANWNR
IRTSRRTIIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDANVNVIYICSHHMNDELVLYYKKILSLHAAVKSGNLEDRSDLQDRFK
IITPEAVNIFPMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVKISEELAGIL
AQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVDPQVLTYLCL
QIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPML

--------------------------------------------------------------
>83797_83797_2_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000439724_IQCH_chr15_67649683_ENST00000358767_length(transcript)=3721nt_BP=552nt
CCCTGTGACCTCCCAACTTCACAAACATGTCTTGCCTGCACCCTAGGCAAACGTGGAAAGGCGCAGCTCTGGTACACCGGAAAGCATGGT
GGATGGGGAGGTCCCTGGATGGCCGGTTGCAGGTGTCCCATCGGAAGGGGCTCCCTCATGTCATCTACTGCCGCCTGTGGCGATGGCCAG
ACCTGCACAGCCACCACGAGCTACGGGCCATGGAGCTGTGTGAGTTCGCCTTCAATATGAAGAAGGACGAGGTCTGCGTGAATCCCTACC
ACTACCAGAGAGTAGAGACACCAGTTCTACCTCCTGTGTTGGTGCCACGCCACACAGAGATCCCGGCCGAGTTCCCCCCACTGGACGACT
ACAGCCATTCCATCCCCGAAAACACTAACTTCCCCGCAGGCATCGAGCCCCAGAGCAATATTCCAGAGACCCCACCCCCTGGCTACCTGA
GTGAAGATGGAGAAACCAGTGACCACCAGATGAACCACAGCATGGACGCAGGTTCTCCAAACCTATCCCCGAATCCGATGTCCCCAGCAC
ATAATAACTTGGCCACTTTCACTATACCTCGGGAACCACCTCCATCTCCAGCAGAAGTGAAGTTCTTTCCCAAGAAACAAAGATCAAAGG
GGAAAAGCAGAAGGTCAAGAGGACATCATGATAGGAAGGCCATGAAAGTCAAAACACCTTTGAGAGCCCTGAAATCACTGTGGGATTATG
ACTTTTTAATTTATGATGGTGTCATAGACAATACAGCCCCAGACTTCTTAGCATTCAAGGAACATTTTAGCTTAGCTTGGGGAGGTATTT
TTTCTCTCTTGGAACACGTCGAGAAGTTTCTCAGGAACTATGCTATACCAGAAGTCAAAATAAAAGGGAATAATTTGGTGGCCCTCCTTC
CAGAGTTTGAGCTGACGAATAAACTTACCAGATATGACCTTCTCTCAGTGTTAGAGGACCCAGCTCATGTCCAAATGCTGATAAATCTTC
CAGGGCAAAGGTACAAGGGCCAAGATGGAAATTCGGAGGCCGCCATGAAGATCCAAGCCACATGGAAATGCTACAAAGCAAGAAAATTCT
TCCTCTTTTATCGCCAGCAGAAGTGGGCATCAGGTGTGATTGCCATTGCTTGGCTGTTATATTGCCATAAGACTCGACTAAAGAAGATAC
TAAAGGAATCACGTCAGAGACACCTGGAGAATTTTCGCATTCGAGCCAAGCATCTGGCAGCCAACTGGAATCGCATCAGGACCTCCAGGA
GGACTATTATCCATATCCCATCATTAGGGTATTCCCAGCCTGTGAGAGAACATATTGCCGATTTCAACACACAGCAGAACATGCAGCTGG
GGAGGCTGTGTGACATCTTAGATGCCAATGTGAATGTCATCTACATCTGCTCCCATCATATGAATGACGAGTTAGTGCTGTATTACAAAA
AAATCCTAAGTCTACATGCAGCCGTCAAATCTGGGAACCTTGAGGACAGAAGTGACCTGCAGGACAGGTTCAAAATTATCACACCTGAAG
CTGTAAACATCTTCCCTATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTG
AGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCC
TTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGC
CAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAG
ACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAA
GCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCT
GCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCG
GCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCC
TGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATG
CAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCT
ATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCA
CCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTT
GAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGT
CTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACA
GATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGA
GAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCC
GCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATC
TTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAA
ATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCA
AAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGC
TCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTAT
ACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCA
CATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAA
AATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGT

>83797_83797_2_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000439724_IQCH_chr15_67649683_ENST00000358767_length(amino acids)=832AA_BP=0
MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPV
LPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLATFTI
PREPPPSPAEVKFFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFLIYDGVIDNTAPDFLAFKEHFSLAWGGIFSLLEHVEK
FLRNYAIPEVKIKGNNLVALLPEFELTNKLTRYDLLSVLEDPAHVQMLINLPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFYRQQKW
ASGVIAIAWLLYCHKTRLKKILKESRQRHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDA
NVNVIYICSHHMNDELVLYYKKILSLHAAVKSGNLEDRSDLQDRFKIITPEAVNIFPMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAF
CDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVD
MLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQ
LALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVENNRRG

--------------------------------------------------------------
>83797_83797_3_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000537194_IQCH_chr15_67649683_ENST00000358767_length(transcript)=3470nt_BP=301nt
AGTAATCCTGCTGCGTTCCTCTTAGAGCATTCTAATTTGGACGTGACGTTCATCCTGGGTTAGTTTACTGGGCTGAGATTGGCTACAGGC
CTGTGTGCTTGGGTCAGAGTGTTAAGGAGGAGACCCACTGTCCAACCTTCTCAGATCCTTTGCGGGTAGCCCTGGCGTCCCGCGGAGACC
CCACCCCCTGGCTACCTGAGTGAAGATGGAGAAACCAGTGACCACCAGATGAACCACAGCATGGACGCAGGTTCTCCAAACCTATCCCCG
AATCCGATGTCCCCAGCACATAATAACTTGGCCACTTTCACTATACCTCGGGAACCACCTCCATCTCCAGCAGAAGTGAAGTTCTTTCCC
AAGAAACAAAGATCAAAGGGGAAAAGCAGAAGGTCAAGAGGACATCATGATAGGAAGGCCATGAAAGTCAAAACACCTTTGAGAGCCCTG
AAATCACTGTGGGATTATGACTTTTTAATTTATGATGGTGTCATAGACAATACAGCCCCAGACTTCTTAGCATTCAAGGAACATTTTAGC
TTAGCTTGGGGAGGTATTTTTTCTCTCTTGGAACACGTCGAGAAGTTTCTCAGGAACTATGCTATACCAGAAGTCAAAATAAAAGGGAAT
AATTTGGTGGCCCTCCTTCCAGAGTTTGAGCTGACGAATAAACTTACCAGATATGACCTTCTCTCAGTGTTAGAGGACCCAGCTCATGTC
CAAATGCTGATAAATCTTCCAGGGCAAAGGTACAAGGGCCAAGATGGAAATTCGGAGGCCGCCATGAAGATCCAAGCCACATGGAAATGC
TACAAAGCAAGAAAATTCTTCCTCTTTTATCGCCAGCAGAAGTGGGCATCAGGTGTGATTGCCATTGCTTGGCTGTTATATTGCCATAAG
ACTCGACTAAAGAAGATACTAAAGGAATCACGTCAGAGACACCTGGAGAATTTTCGCATTCGAGCCAAGCATCTGGCAGCCAACTGGAAT
CGCATCAGGACCTCCAGGAGGACTATTATCCATATCCCATCATTAGGGTATTCCCAGCCTGTGAGAGAACATATTGCCGATTTCAACACA
CAGCAGAACATGCAGCTGGGGAGGCTGTGTGACATCTTAGATGCCAATGTGAATGTCATCTACATCTGCTCCCATCATATGAATGACGAG
TTAGTGCTGTATTACAAAAAAATCCTAAGTCTACATGCAGCCGTCAAATCTGGGAACCTTGAGGACAGAAGTGACCTGCAGGACAGGTTC
AAAATTATCACACCTGAAGCTGTAAACATCTTCCCTATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGG
CTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAG
GAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATT
TTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATC
GAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGG
GACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGC
CTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAA
CAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTG
GATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATG
CTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGT
AGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCAT
CCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAA
GGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACA
TAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGC
TAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACT
TATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAG
TCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTAT
TTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAA
AGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTG
CTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTA
GTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTC
AAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAA
TTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAA
TGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGAT

>83797_83797_3_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000537194_IQCH_chr15_67649683_ENST00000358767_length(amino acids)=692AA_BP=1
MSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLATFTIPREPPPSPAEVKFFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWD
YDFLIYDGVIDNTAPDFLAFKEHFSLAWGGIFSLLEHVEKFLRNYAIPEVKIKGNNLVALLPEFELTNKLTRYDLLSVLEDPAHVQMLIN
LPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFYRQQKWASGVIAIAWLLYCHKTRLKKILKESRQRHLENFRIRAKHLAANWNRIRTS
RRTIIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDANVNVIYICSHHMNDELVLYYKKILSLHAAVKSGNLEDRSDLQDRFKIITP
EAVNIFPMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVKISEELAGILAQHA
QPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVDPQVLTYLCLQIGK
ACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSR

--------------------------------------------------------------
>83797_83797_4_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000540846_IQCH_chr15_67649683_ENST00000358767_length(transcript)=3890nt_BP=721nt
AAATATGAGCTTGTGCTTGCTGGAGGAGGATGACAGAGGAGCCTGCTGCTGAGTTCACTGGTGCTGGGGTTAGGTCACTGCTGGGCTGAA
GCGCACTGACCATAAGAGCAACATGTGGGCAAGAGCCGCGGCACTGGGGTAATTTATTGCCGCCGCTCGCTTCACCAGGAACCCCACACG
CTGGGTTCCCACAGGATGCGACATTCCCACAGGATGGGACAACTGCATGGAAACCCACACTCGGGCCTGTGTTGAGCAACCACGTTTGAG
TCCCTGGATGGCCGGTTGCAGGTGTCCCATCGGAAGGGGCTCCCTCATGTCATCTACTGCCGCCTGTGGCGATGGCCAGACCTGCACAGC
CACCACGAGCTACGGGCCATGGAGCTGTGTGAGTTCGCCTTCAATATGAAGAAGGACGAGGTCTGCGTGAATCCCTACCACTACCAGAGA
GTAGAGACACCAGTTCTACCTCCTGTGTTGGTGCCACGCCACACAGAGATCCCGGCCGAGTTCCCCCCACTGGACGACTACAGCCATTCC
ATCCCCGAAAACACTAACTTCCCCGCAGGCATCGAGCCCCAGAGCAATATTCCAGAGACCCCACCCCCTGGCTACCTGAGTGAAGATGGA
GAAACCAGTGACCACCAGATGAACCACAGCATGGACGCAGGTTCTCCAAACCTATCCCCGAATCCGATGTCCCCAGCACATAATAACTTG
GCCACTTTCACTATACCTCGGGAACCACCTCCATCTCCAGCAGAAGTGAAGTTCTTTCCCAAGAAACAAAGATCAAAGGGGAAAAGCAGA
AGGTCAAGAGGACATCATGATAGGAAGGCCATGAAAGTCAAAACACCTTTGAGAGCCCTGAAATCACTGTGGGATTATGACTTTTTAATT
TATGATGGTGTCATAGACAATACAGCCCCAGACTTCTTAGCATTCAAGGAACATTTTAGCTTAGCTTGGGGAGGTATTTTTTCTCTCTTG
GAACACGTCGAGAAGTTTCTCAGGAACTATGCTATACCAGAAGTCAAAATAAAAGGGAATAATTTGGTGGCCCTCCTTCCAGAGTTTGAG
CTGACGAATAAACTTACCAGATATGACCTTCTCTCAGTGTTAGAGGACCCAGCTCATGTCCAAATGCTGATAAATCTTCCAGGGCAAAGG
TACAAGGGCCAAGATGGAAATTCGGAGGCCGCCATGAAGATCCAAGCCACATGGAAATGCTACAAAGCAAGAAAATTCTTCCTCTTTTAT
CGCCAGCAGAAGTGGGCATCAGGTGTGATTGCCATTGCTTGGCTGTTATATTGCCATAAGACTCGACTAAAGAAGATACTAAAGGAATCA
CGTCAGAGACACCTGGAGAATTTTCGCATTCGAGCCAAGCATCTGGCAGCCAACTGGAATCGCATCAGGACCTCCAGGAGGACTATTATC
CATATCCCATCATTAGGGTATTCCCAGCCTGTGAGAGAACATATTGCCGATTTCAACACACAGCAGAACATGCAGCTGGGGAGGCTGTGT
GACATCTTAGATGCCAATGTGAATGTCATCTACATCTGCTCCCATCATATGAATGACGAGTTAGTGCTGTATTACAAAAAAATCCTAAGT
CTACATGCAGCCGTCAAATCTGGGAACCTTGAGGACAGAAGTGACCTGCAGGACAGGTTCAAAATTATCACACCTGAAGCTGTAAACATC
TTCCCTATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGA
AATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGG
AGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAG
AAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACC
AACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATC
TCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGA
GATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTC
GCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCC
CGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACC
ACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAG
AACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCA
AGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCA
ACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAA
AGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGA
AATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAAC
AATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTC
CTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTA
TAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTAT
ATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGAT
AAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGT
AGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAA
AAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGC
TTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGT
GTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAATAA

>83797_83797_4_SMAD3-IQCH_SMAD3_chr15_67462942_ENST00000540846_IQCH_chr15_67649683_ENST00000358767_length(amino acids)=806AA_BP=1
MDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSI
PENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLATFTIPREPPPSPAEVKFFPKKQRSKGKSRR
SRGHHDRKAMKVKTPLRALKSLWDYDFLIYDGVIDNTAPDFLAFKEHFSLAWGGIFSLLEHVEKFLRNYAIPEVKIKGNNLVALLPEFEL
TNKLTRYDLLSVLEDPAHVQMLINLPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFYRQQKWASGVIAIAWLLYCHKTRLKKILKESR
QRHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDANVNVIYICSHHMNDELVLYYKKILSL
HAAVKSGNLEDRSDLQDRFKIITPEAVNIFPMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWR
KKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFIS
SGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPR

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Fusion Gene PPI Analysis for SMAD3-IQCH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMAD3-IQCH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMAD3-IQCH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource