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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMAD3-MAP2K5 (FusionGDB2 ID:83800)

Fusion Gene Summary for SMAD3-MAP2K5

Fusion gene summary

Fusion gene information	Fusion gene name: SMAD3-MAP2K5
	Fusion gene ID: 83800
		Hgene	Tgene
	Gene symbol	SMAD3	MAP2K5
	Gene ID	4088	5607
	Gene name	SMAD family member 3	mitogen-activated protein kinase kinase 5
	Synonyms	HSPC193\|HsT17436\|JV15-2\|LDS1C\|LDS3\|MADH3	HsT17454\|MAPKK5\|MEK5\|PRKMK5
	Cytomap	15q22.33	15q23
	Type of gene	protein-coding	protein-coding
	Description	mothers against decapentaplegic homolog 3MAD homolog 3MAD, mothers against decapentaplegic homolog 3SMA- and MAD-related protein 3SMAD, mothers against DPP homolog 3hMAD-3hSMAD3mad homolog JV15-2mad protein homologmad3mothers against DPP homolog	dual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
	Modification date	20200329	20200327
	UniProtAcc	.	Q13163
	Ensembl transtripts involved in fusion gene	ENST00000327367, ENST00000540846, ENST00000439724, ENST00000537194, ENST00000559092,	ENST00000354498, ENST00000395476, ENST00000560591, ENST00000340972, ENST00000178640,
Fusion gene scores	* DoF score	17 X 13 X 12=2652	13 X 18 X 12=2808
	# samples	30	19
	** MAII score	log2(30/2652*10)=-3.14404636961671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2808*10)=-3.88547161197361 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMAD3 [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMAD3(67418322)-MAP2K5(67855621), # samples:2 SMAD3(67358698)-MAP2K5(67879184), # samples:2
Anticipated loss of major functional domain due to fusion event.	SMAD3-MAP2K5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. SMAD3-MAP2K5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. SMAD3-MAP2K5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SMAD3-MAP2K5 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMAD3	GO:0000122	negative regulation of transcription by RNA polymerase II	8774881
Hgene	SMAD3	GO:0006357	regulation of transcription by RNA polymerase II	21947082
Hgene	SMAD3	GO:0007179	transforming growth factor beta receptor signaling pathway	9732876\|18548003\|21947082
Hgene	SMAD3	GO:0007183	SMAD protein complex assembly	9111321\|10823886
Hgene	SMAD3	GO:0010628	positive regulation of gene expression	21307346
Hgene	SMAD3	GO:0010718	positive regulation of epithelial to mesenchymal transition	21307346
Hgene	SMAD3	GO:0030308	negative regulation of cell growth	8774881
Hgene	SMAD3	GO:0045429	positive regulation of nitric oxide biosynthetic process	27038547
Hgene	SMAD3	GO:0045599	negative regulation of fat cell differentiation	19816956
Hgene	SMAD3	GO:0045893	positive regulation of transcription, DNA-templated	9111321\|9311995\|9732876
Hgene	SMAD3	GO:0045944	positive regulation of transcription by RNA polymerase II	8774881\|18832382
Hgene	SMAD3	GO:0051481	negative regulation of cytosolic calcium ion concentration	27038547
Hgene	SMAD3	GO:0071560	cellular response to transforming growth factor beta stimulus	12902338
Hgene	SMAD3	GO:1901203	positive regulation of extracellular matrix assembly	21307346

Fusion gene breakpoints across SMAD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAP2K5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A1LL-01A	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
ChimerDB4	BRCA	TCGA-E2-A1LL-01A	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
ChimerDB4	BRCA	TCGA-E2-A1LL-01A	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
ChimerDB4	STAD	TCGA-CD-8527-01A	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
ChimerDB4	STAD	TCGA-CD-8527-01A	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
ChimerDB4	STAD	TCGA-CD-8527-01A	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
ChimerDB4	STAD	TCGA-VQ-A925-01A	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
ChimerDB4	STAD	TCGA-VQ-A925	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+

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Fusion Gene ORF analysis for SMAD3-MAP2K5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
5CDS-3UTR	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
5CDS-3UTR	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
5CDS-3UTR	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
5CDS-3UTR	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
5CDS-3UTR	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
5CDS-3UTR	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
5CDS-3UTR	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
5CDS-3UTR	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
5CDS-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
5CDS-intron	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
5CDS-intron	ENST00000327367	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
5CDS-intron	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
5CDS-intron	ENST00000327367	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
5CDS-intron	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
5CDS-intron	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
5CDS-intron	ENST00000327367	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
5UTR-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
5UTR-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
5UTR-3UTR	ENST00000540846	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
5UTR-3UTR	ENST00000540846	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
5UTR-3UTR	ENST00000540846	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
5UTR-3UTR	ENST00000540846	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
5UTR-3UTR	ENST00000540846	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
5UTR-3UTR	ENST00000540846	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
5UTR-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
5UTR-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
Frame-shift	ENST00000327367	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3CDS	ENST00000327367	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000327367	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3CDS	ENST00000439724	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3CDS	ENST00000537194	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3CDS	ENST00000540846	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3CDS	ENST00000559092	ENST00000178640	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000327367	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000327367	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000327367	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000327367	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000327367	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000327367	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000439724	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000537194	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000354498	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000395476	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-3UTR	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-3UTR	ENST00000559092	ENST00000560591	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-3UTR	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-3UTR	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000327367	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-intron	ENST00000439724	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-intron	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000439724	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000439724	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000439724	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-intron	ENST00000537194	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-intron	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000537194	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000537194	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000537194	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-intron	ENST00000540846	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-intron	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000540846	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000540846	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000540846	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67855621	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67418322	+	MAP2K5	chr15	67873092	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879184	+
intron-intron	ENST00000559092	ENST00000340972	SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+
intron-intron	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000559092	ENST00000354498	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000559092	ENST00000395476	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+
intron-intron	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67984817	+
intron-intron	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67985856	+
intron-intron	ENST00000559092	ENST00000560591	SMAD3	chr15	67358698	+	MAP2K5	chr15	67995675	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for SMAD3-MAP2K5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SMAD3	chr15	67418322	+	MAP2K5	chr15	67855620	+	0.009079428	0.99092054
SMAD3	chr15	67418322	+	MAP2K5	chr15	67873091	+	0.006722168	0.99327785
SMAD3	chr15	67358698	+	MAP2K5	chr15	67984816	+	2.44E-05	0.99997556
SMAD3	chr15	67358698	+	MAP2K5	chr15	67995674	+	6.85E-06	0.9999932
SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+	4.80E-06	0.99999523
SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+	4.80E-06	0.99999523
SMAD3	chr15	67358698	+	MAP2K5	chr15	67985855	+	1.75E-06	0.9999982
SMAD3	chr15	67358698	+	MAP2K5	chr15	67855620	+	1.47E-06	0.99999857
SMAD3	chr15	67418322	+	MAP2K5	chr15	67855620	+	0.009079428	0.99092054
SMAD3	chr15	67418322	+	MAP2K5	chr15	67873091	+	0.006722168	0.99327785
SMAD3	chr15	67358698	+	MAP2K5	chr15	67984816	+	2.44E-05	0.99997556
SMAD3	chr15	67358698	+	MAP2K5	chr15	67995674	+	6.85E-06	0.9999932
SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+	4.80E-06	0.99999523
SMAD3	chr15	67358698	+	MAP2K5	chr15	67879183	+	4.80E-06	0.99999523
SMAD3	chr15	67358698	+	MAP2K5	chr15	67985855	+	1.75E-06	0.9999982
SMAD3	chr15	67358698	+	MAP2K5	chr15	67855620	+	1.47E-06	0.99999857

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMAD3-MAP2K5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67418322/:67855621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MAP2K5 Q13163
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269\|PubMed:7759517, ECO:0000269\|PubMed:9384584}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SMAD3-MAP2K5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SMAD3-MAP2K5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SMAD3-MAP2K5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SMAD3-MAP2K5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source