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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMAD7-DYM (FusionGDB2 ID:83829)

Fusion Gene Summary for SMAD7-DYM

check button Fusion gene summary
Fusion gene informationFusion gene name: SMAD7-DYM
Fusion gene ID: 83829
HgeneTgene
Gene symbol

SMAD7

DYM

Gene ID

4092

54808

Gene nameSMAD family member 7dymeclin
SynonymsCRCS3|MADH7|MADH8DMC|SMC
Cytomap

18q21.1

18q21.1

Type of geneprotein-codingprotein-coding
Descriptionmothers against decapentaplegic homolog 7MAD (mothers against decapentaplegic, Drosophila) homolog 7MAD homolog 8Mothers against decapentaplegic, drosophila, homolog of, 7SMAD, mothers against DPP homolog 7hSMAD7mothers against DPP homolog 8dymeclindyggve-Melchior-Clausen syndrome protein
Modification date2020032020200313
UniProtAcc.

Q7RTS9

Ensembl transtripts involved in fusion geneENST00000262158, ENST00000589634, 
ENST00000591805, ENST00000585986, 
ENST00000578396, ENST00000584977, 
ENST00000269445, ENST00000442713, 
Fusion gene scores* DoF score4 X 4 X 5=8019 X 11 X 13=2717
# samples 624
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2717*10)=-3.50090825461346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMAD7 [Title/Abstract] AND DYM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMAD7(46468851)-DYM(46645296), # samples:2
SMAD7(46468851)-DYM(46570574), # samples:2
Anticipated loss of major functional domain due to fusion event.SMAD7-DYM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMAD7

GO:0000122

negative regulation of transcription by RNA polymerase II

17438144

HgeneSMAD7

GO:0010801

negative regulation of peptidyl-threonine phosphorylation

18593713

HgeneSMAD7

GO:0010944

negative regulation of transcription by competitive promoter binding

17438144

HgeneSMAD7

GO:0022409

positive regulation of cell-cell adhesion

18593713

HgeneSMAD7

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

12151385|17438144|18762808

HgeneSMAD7

GO:0030514

negative regulation of BMP signaling pathway

17438144

HgeneSMAD7

GO:0031397

negative regulation of protein ubiquitination

18593713

HgeneSMAD7

GO:0031398

positive regulation of protein ubiquitination

16720724

HgeneSMAD7

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278251

HgeneSMAD7

GO:0032925

regulation of activin receptor signaling pathway

16720724

HgeneSMAD7

GO:0033137

negative regulation of peptidyl-serine phosphorylation

18593713

HgeneSMAD7

GO:0034629

cellular protein-containing complex localization

18593713

HgeneSMAD7

GO:0043433

negative regulation of DNA-binding transcription factor activity

17438144

HgeneSMAD7

GO:0050821

protein stabilization

18593713

HgeneSMAD7

GO:0051444

negative regulation of ubiquitin-protein transferase activity

18593713

HgeneSMAD7

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

17438144


check buttonFusion gene breakpoints across SMAD7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DYM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FD-01ASMAD7chr18

46468851

-DYMchr18

46690157

-
ChimerDB4LIHCTCGA-DD-A73F-01ASMAD7chr18

46468851

-DYMchr18

46645296

-
ChimerDB4UCSTCGA-NA-A4R0-01ASMAD7chr18

46468851

-DYMchr18

46570574

-
ChimerDB4UCSTCGA-NA-A4ROSMAD7chr18

46468851

-DYMchr18

46570574

-


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Fusion Gene ORF analysis for SMAD7-DYM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262158ENST00000578396SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000262158ENST00000578396SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000262158ENST00000578396SMAD7chr18

46468851

-DYMchr18

46570574

-
5CDS-intronENST00000262158ENST00000584977SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000262158ENST00000584977SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000262158ENST00000584977SMAD7chr18

46468851

-DYMchr18

46570574

-
5CDS-intronENST00000589634ENST00000578396SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000589634ENST00000578396SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000589634ENST00000578396SMAD7chr18

46468851

-DYMchr18

46570574

-
5CDS-intronENST00000589634ENST00000584977SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000589634ENST00000584977SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000589634ENST00000584977SMAD7chr18

46468851

-DYMchr18

46570574

-
5CDS-intronENST00000591805ENST00000578396SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000591805ENST00000578396SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000591805ENST00000578396SMAD7chr18

46468851

-DYMchr18

46570574

-
5CDS-intronENST00000591805ENST00000584977SMAD7chr18

46468851

-DYMchr18

46690157

-
5CDS-intronENST00000591805ENST00000584977SMAD7chr18

46468851

-DYMchr18

46645296

-
5CDS-intronENST00000591805ENST00000584977SMAD7chr18

46468851

-DYMchr18

46570574

-
5UTR-3CDSENST00000585986ENST00000269445SMAD7chr18

46468851

-DYMchr18

46690157

-
5UTR-3CDSENST00000585986ENST00000269445SMAD7chr18

46468851

-DYMchr18

46645296

-
5UTR-3CDSENST00000585986ENST00000269445SMAD7chr18

46468851

-DYMchr18

46570574

-
5UTR-3CDSENST00000585986ENST00000442713SMAD7chr18

46468851

-DYMchr18

46690157

-
5UTR-3CDSENST00000585986ENST00000442713SMAD7chr18

46468851

-DYMchr18

46645296

-
5UTR-3CDSENST00000585986ENST00000442713SMAD7chr18

46468851

-DYMchr18

46570574

-
5UTR-intronENST00000585986ENST00000578396SMAD7chr18

46468851

-DYMchr18

46690157

-
5UTR-intronENST00000585986ENST00000578396SMAD7chr18

46468851

-DYMchr18

46645296

-
5UTR-intronENST00000585986ENST00000578396SMAD7chr18

46468851

-DYMchr18

46570574

-
5UTR-intronENST00000585986ENST00000584977SMAD7chr18

46468851

-DYMchr18

46690157

-
5UTR-intronENST00000585986ENST00000584977SMAD7chr18

46468851

-DYMchr18

46645296

-
5UTR-intronENST00000585986ENST00000584977SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000262158ENST00000269445SMAD7chr18

46468851

-DYMchr18

46690157

-
Frame-shiftENST00000262158ENST00000269445SMAD7chr18

46468851

-DYMchr18

46645296

-
Frame-shiftENST00000262158ENST00000269445SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000262158ENST00000442713SMAD7chr18

46468851

-DYMchr18

46690157

-
Frame-shiftENST00000262158ENST00000442713SMAD7chr18

46468851

-DYMchr18

46645296

-
Frame-shiftENST00000262158ENST00000442713SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000589634ENST00000269445SMAD7chr18

46468851

-DYMchr18

46690157

-
Frame-shiftENST00000589634ENST00000269445SMAD7chr18

46468851

-DYMchr18

46645296

-
Frame-shiftENST00000589634ENST00000269445SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000589634ENST00000442713SMAD7chr18

46468851

-DYMchr18

46690157

-
Frame-shiftENST00000589634ENST00000442713SMAD7chr18

46468851

-DYMchr18

46645296

-
Frame-shiftENST00000589634ENST00000442713SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000591805ENST00000269445SMAD7chr18

46468851

-DYMchr18

46645296

-
Frame-shiftENST00000591805ENST00000269445SMAD7chr18

46468851

-DYMchr18

46570574

-
Frame-shiftENST00000591805ENST00000442713SMAD7chr18

46468851

-DYMchr18

46645296

-
In-frameENST00000591805ENST00000269445SMAD7chr18

46468851

-DYMchr18

46690157

-
In-frameENST00000591805ENST00000442713SMAD7chr18

46468851

-DYMchr18

46690157

-
In-frameENST00000591805ENST00000442713SMAD7chr18

46468851

-DYMchr18

46570574

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591805SMAD7chr1846468851-ENST00000442713DYMchr1846570574-770234101493130
ENST00000591805SMAD7chr1846468851-ENST00000442713DYMchr1846690157-1170234244783179
ENST00000591805SMAD7chr1846468851-ENST00000269445DYMchr1846690157-1019234244783179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591805ENST00000442713SMAD7chr1846468851-DYMchr1846570574-0.149589970.85041004
ENST00000591805ENST00000442713SMAD7chr1846468851-DYMchr1846690157-0.0063795380.99362046
ENST00000591805ENST00000269445SMAD7chr1846468851-DYMchr1846690157-0.0099967940.9900032

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Fusion Genomic Features for SMAD7-DYM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMAD7-DYM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:46468851/chr18:46645296)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYM

Q7RTS9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-34207_210247427.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-3427_35247427.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-3449_56247427.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-34207_210246426.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-3427_35246426.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-3449_56246426.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-3427_3532212.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-34207_210247427.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-3427_35247427.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-3449_56247427.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-34207_210246426.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-3427_35246426.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-3449_56246426.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-3427_3532212.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-3464_207247427.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-3464_207246426.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-3464_207247427.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-3464_207246426.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-34208_211247427.0MotifNote=PY-motif
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-34208_211246426.0MotifNote=PY-motif
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-34208_211247427.0MotifNote=PY-motif
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-34208_211246426.0MotifNote=PY-motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-34207_21032212.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-3449_5632212.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-34207_21032212.0Compositional biasNote=Poly-Pro
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-3449_5632212.0Compositional biasNote=Poly-Gly
HgeneSMAD7chr18:46468851chr18:46570574ENST00000262158-34261_426247427.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46570574ENST00000589634-34261_426246426.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-34261_42632212.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-3464_20732212.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46690157ENST00000262158-34261_426247427.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46690157ENST00000589634-34261_426246426.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-34261_42632212.0DomainMH2
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-3464_20732212.0DomainMH1
HgeneSMAD7chr18:46468851chr18:46570574ENST00000591805-34208_21132212.0MotifNote=PY-motif
HgeneSMAD7chr18:46468851chr18:46690157ENST00000591805-34208_21132212.0MotifNote=PY-motif


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Fusion Gene Sequence for SMAD7-DYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83829_83829_1_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46570574_ENST00000442713_length(transcript)=770nt_BP=234nt
AGTAAATACGGAGAATCACGTCGAACACCAGTGGCCCAGATACTGTCGTGGCCGCGCACCTTTGGAGTTTTGGGGCAAAGAGAGTTGGAT
GGAAGGCCGAACTGGAGTCTCCCCCCCCTCCTTACTCCAGATACCCGATGGATTTTCTCAAACCAACTGCAGACTGTCCAGATGCTGTGC
CTTCCTCCGCTGAAACAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTCAGAAATTTCCAGAATTGAAATTCAAATATGTGGAAGAG
GAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAACTCAGCAGTCGGCCTGTACTGGAATCCACAGGACATCCAG
CTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACCCCTCCAGCCAAGCAGCCCTTCAAGTTCTTTTATTTCTGGG
TAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGATTGCACGAGTGTGTTTTCCTCACACACTTTGATTTGGAGA
ATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAAGGGGAGGAAATACACAACAATAATAAATGTAAAAACCTGC
TATTCAACATGCAGTTTTATTTCGAAGCCAAAAATCTAGAGCTTTCCCAAGATCCTGTTGCCTTAGGCACATCACACTTCAACAGTGCAC

>83829_83829_1_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46570574_ENST00000442713_length(amino acids)=130AA_BP=44
MESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSEISRIEIQICGRGAARGVFYPLCLVSCLQLSSRPVLESTGHPAVHH

--------------------------------------------------------------
>83829_83829_2_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46690157_ENST00000269445_length(transcript)=1019nt_BP=234nt
AGTAAATACGGAGAATCACGTCGAACACCAGTGGCCCAGATACTGTCGTGGCCGCGCACCTTTGGAGTTTTGGGGCAAAGAGAGTTGGAT
GGAAGGCCGAACTGGAGTCTCCCCCCCCTCCTTACTCCAGATACCCGATGGATTTTCTCAAACCAACTGCAGACTGTCCAGATGCTGTGC
CTTCCTCCGCTGAAACAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTCAGTTTATTTTCTTTGCTGTCTAAAAAACACAACAAAGT
TCTGGAACAAGCCACACAGTCCTTGAGAGGTTCGCTGAGTTCTAATGATGTTCCTCTACCAGATTATGCACAAGACCTAAATGTCATTGA
AGAAGTGATTCGAATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTA
CAAACGCGATCTCTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTC
AAGGTTGCTGCAAGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACT
GAAGAAATTTCCAGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAA
CTCAGCAGTCGGCCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACC
CCTCCAGCCAAGCAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGA
TTGCACGAGTGTGTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAA

>83829_83829_2_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46690157_ENST00000269445_length(amino acids)=179AA_BP=
MLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNI

--------------------------------------------------------------
>83829_83829_3_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46690157_ENST00000442713_length(transcript)=1170nt_BP=234nt
AGTAAATACGGAGAATCACGTCGAACACCAGTGGCCCAGATACTGTCGTGGCCGCGCACCTTTGGAGTTTTGGGGCAAAGAGAGTTGGAT
GGAAGGCCGAACTGGAGTCTCCCCCCCCTCCTTACTCCAGATACCCGATGGATTTTCTCAAACCAACTGCAGACTGTCCAGATGCTGTGC
CTTCCTCCGCTGAAACAGGGGGAACGAATTATCTGGCCCCTGGGGGGCTTTCAGTTTATTTTCTTTGCTGTCTAAAAAACACAACAAAGT
TCTGGAACAAGCCACACAGTCCTTGAGAGGTTCGCTGAGTTCTAATGATGTTCCTCTACCAGATTATGCACAAGACCTAAATGTCATTGA
AGAAGTGATTCGAATGATGTTAGAGATCATCAACTCCTGCCTGACAAATTCCCTTCACCACAACCCAAACTTGGTATACGCCCTGCTTTA
CAAACGCGATCTCTTTGAACAATTTCGAACTCATCCTTCATTTCAGGATATAATGCAAAATATTGATCTGGTGATCTCCTTCTTTAGCTC
AAGGTTGCTGCAAGCTGGAGCTGAGCTGTCAGTGGAACGGGTCCTGGAAATCATTAAGCAAGGCGTCGTTGCGCTGCCCAAAGACAGACT
GAAGAAATTTCCAGAATTGAAATTCAAATATGTGGAAGAGGAGCAGCCCGAGGAGTTTTTTATCCCCTATGTCTGGTCTCTTGTCTACAA
CTCAGCAGTCGGCCTGTACTGGAATCCACAGGACATCCAGCTGTTCACCATGGATTCCGACTGAGGGCAGGATGCTCTCCCACCCGGACC
CCTCCAGCCAAGCAGCCCTTCAAGTTCTTTTATTTCTGGGTAACAGAAGTAGACAGACAGGTTACTTGGTGTATCTTCTGTTAAAGAGGA
TTGCACGAGTGTGTTTTCCTCACACACTTTGATTTGGAGAATTGGTGCTAGTTGGCAATAGATAACTCAGCGTAGATAGTATTGCAAAAA
GGGGAGGAAATACACAACAATAATAAATGTAAAAACCTGCTATTCAACATGCAGTTTTATTTCGAAGCCAAAAATCTAGAGCTTTCCCAA
GATCCTGTTGCCTTAGGCACATCACACTTCAACAGTGCACACTATCCAACAGTGCACACTATTCAACAGTGCACACTATTCAAAAGCGTA

>83829_83829_3_SMAD7-DYM_SMAD7_chr18_46468851_ENST00000591805_DYM_chr18_46690157_ENST00000442713_length(amino acids)=179AA_BP=
MLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNI

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Fusion Gene PPI Analysis for SMAD7-DYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMAD7-DYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMAD7-DYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource