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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMARCC1-SPINK8 (FusionGDB2 ID:83950)

Fusion Gene Summary for SMARCC1-SPINK8

Fusion gene summary

Fusion gene information	Fusion gene name: SMARCC1-SPINK8
	Fusion gene ID: 83950
		Hgene	Tgene
	Gene symbol	SMARCC1	SPINK8
	Gene ID	6599	646424
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	serine peptidase inhibitor Kazal type 8 (putative)
	Synonyms	BAF155\|CRACC1\|Rsc8\|SRG3\|SWI3	-
	Cytomap	3p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	SWI/SNF complex subunit SMARCC1BRG1-associated factor 155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1chromatin remodeling complex BAF155 subunitmammalian chromatin remode	serine protease inhibitor Kazal-type 8
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000425518, ENST00000254480,	ENST00000434006,
Fusion gene scores	* DoF score	19 X 26 X 11=5434	5 X 3 X 9=135
	# samples	37	12
	** MAII score	log2(37/5434*10)=-3.87641738970566 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/135*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMARCC1 [Title/Abstract] AND SPINK8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMARCC1(47777524)-SPINK8(48351436), # samples:3
Anticipated loss of major functional domain due to fusion event.	SMARCC1-SPINK8 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SMARCC1-SPINK8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMARCC1	GO:0006337	nucleosome disassembly	8895581
Hgene	SMARCC1	GO:0006338	chromatin remodeling	10078207\|11018012\|11726552
Hgene	SMARCC1	GO:0045893	positive regulation of transcription, DNA-templated	11018012

Fusion gene breakpoints across SMARCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPINK8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2293-01A	SMARCC1	chr3	47721927	-	SPINK8	chr3	48351436	-
ChimerDB4	OV	TCGA-24-2293	SMARCC1	chr3	47721926	-	SPINK8	chr3	48351436	-
ChimerDB4	PRAD	TCGA-HC-8265-01A	SMARCC1	chr3	47777524	-	SPINK8	chr3	48351436	-
ChimerDB4	PRAD	TCGA-HC-8265-01B	SMARCC1	chr3	47777524	-	SPINK8	chr3	48351436	-
ChimerDB4	PRAD	TCGA-HC-8265	SMARCC1	chr3	47777523	-	SPINK8	chr3	48351436	-
ChimerDB4	PRAD	TCGA-HC-8265	SMARCC1	chr3	47777524	-	SPINK8	chr3	48351436	-
ChimerDB4	UCEC	TCGA-AX-A062	SMARCC1	chr3	47721926	-	SPINK8	chr3	48351436	-

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Fusion Gene ORF analysis for SMARCC1-SPINK8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000425518	ENST00000434006	SMARCC1	chr3	47721927	-	SPINK8	chr3	48351436	-
5UTR-3CDS	ENST00000425518	ENST00000434006	SMARCC1	chr3	47721926	-	SPINK8	chr3	48351436	-
5UTR-3CDS	ENST00000425518	ENST00000434006	SMARCC1	chr3	47777524	-	SPINK8	chr3	48351436	-
5UTR-3CDS	ENST00000425518	ENST00000434006	SMARCC1	chr3	47777523	-	SPINK8	chr3	48351436	-
Frame-shift	ENST00000254480	ENST00000434006	SMARCC1	chr3	47777524	-	SPINK8	chr3	48351436	-
Frame-shift	ENST00000254480	ENST00000434006	SMARCC1	chr3	47777523	-	SPINK8	chr3	48351436	-
In-frame	ENST00000254480	ENST00000434006	SMARCC1	chr3	47721927	-	SPINK8	chr3	48351436	-
In-frame	ENST00000254480	ENST00000434006	SMARCC1	chr3	47721926	-	SPINK8	chr3	48351436	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000254480	SMARCC1	chr3	47721927	-	ENST00000434006	SPINK8	chr3	48351436	-	1778	1577	96	1631	511
ENST00000254480	SMARCC1	chr3	47721926	-	ENST00000434006	SPINK8	chr3	48351436	-	1778	1577	96	1631	511

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000254480	ENST00000434006	SMARCC1	chr3	47721927	-	SPINK8	chr3	48351436	-	0.001127335	0.9988727
ENST00000254480	ENST00000434006	SMARCC1	chr3	47721926	-	SPINK8	chr3	48351436	-	0.001127335	0.9988727

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Fusion Genomic Features for SMARCC1-SPINK8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMARCC1-SPINK8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47777524/chr3:48351436)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

329_336

485

1106.0

Compositional bias

Note=Poly-Pro

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

329_336

485

1106.0

Compositional bias

Note=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

914_946

485

1106.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

914_946

485

1106.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

769_863

485

1106.0

Compositional bias

Note=Glu-rich

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

867_878

485

1106.0

Compositional bias

Note=Poly-Ala

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

977_1105

485

1106.0

Compositional bias

Note=Pro-rich

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

769_863

485

1106.0

Compositional bias

Note=Glu-rich

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

867_878

485

1106.0

Compositional bias

Note=Poly-Ala

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

977_1105

485

1106.0

Compositional bias

Note=Pro-rich

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

449_546

485

1106.0

Domain

SWIRM

Hgene

SMARCC1

chr3:47721926

chr3:48351436

ENST00000254480

618_669

485

1106.0

Domain

SANT

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

449_546

485

1106.0

Domain

SWIRM

Hgene

SMARCC1

chr3:47721927

chr3:48351436

ENST00000254480

618_669

485

1106.0

Domain

SANT

Tgene

SPINK8

chr3:47721926

chr3:48351436

ENST00000434006

36_96

98.0

Domain

Kazal-like

Tgene

SPINK8

chr3:47721927

chr3:48351436

ENST00000434006

36_96

98.0

Domain

Kazal-like

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Fusion Gene Sequence for SMARCC1-SPINK8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>83950_83950_1_SMARCC1-SPINK8_SMARCC1_chr3_47721926_ENST00000254480_SPINK8_chr3_48351436_ENST00000434006_length(transcript)=1778nt_BP=1577nt
GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG
GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG
ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC
CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTG
GTGGTGCAGCTTCTTCAGTTCCAGGAAGATGCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATG
GATTTCAAAGCTGGAGGCGCCTTATGTCACATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAG
AACCCATCTCGAATGGATCGTAATGTGGAAATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATC
TACCTCATTCCAGACATTGATCTGAAGTTGGCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCA
AAAGCTTCCCACCACATTTACCCATATTCTTCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTA
GTGCATTGGGGCTTTTACCCAGACAGCTATGATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAA
AAACCATGGAAGGTTCATGTGAAATGGATTTTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAAT
AGGAAGCCTGTGAGTTTTCGTCAGCGGATTTCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCT
AATGCTCGAAAGAGGAAACATTCGCCTTCGCCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGCCAAGCTAGC
CTTTATGGGAAGCGCAGAAGTCAGAAAGAGGAAGATGAGCAAGAAGATCTAACCAAGGATATGGAAGACCCAACACCTGTACCCAATATA
GAAGAAGTAGTACTTCCCAAAAATGTGAACCTAAAGAAAGATAGTGAAAATACACCTGTTAAAGGAGGAACTGTAGCGGATCTAGATGAG
CAGGATGAAGAAACAGTCACAGCAGGAGGAAAGGAAGATGAAGATCCTGCCAAAGGTGATCAGAGTCGATCAGTTGACCTTGGGGAAGAT
AATGTGACAGAGCAGACCAATCACATTATTATTCCTAGTTATGCATCATGGTTTGATTATAACTGTATTCATGTGATTGAACGGCGTGCT
CTTCCTGAGTTCTTCAATGGAAAAAACAAATCCAAGACTCCAGAAATATTTGAAGGGCTTAACATAACTAAACTGTATGATGGACAATGT
GAAAACTCTTGAACGTACGACAAAGAATTATAAAACCTACTGAATCTCCAGATTGCCAAGTGAAACACAATGGTTGCCTCTTCAAATATA

>83950_83950_1_SMARCC1-SPINK8_SMARCC1_chr3_47721926_ENST00000254480_SPINK8_chr3_48351436_ENST00000434006_length(amino acids)=511AA_BP=
MWGRRAATMAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVV
QLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYL
IPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKP
WKVHVKWILDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGQASLY
GKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNV

--------------------------------------------------------------
>83950_83950_2_SMARCC1-SPINK8_SMARCC1_chr3_47721927_ENST00000254480_SPINK8_chr3_48351436_ENST00000434006_length(transcript)=1778nt_BP=1577nt
GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG
GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG
ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC
CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTG
GTGGTGCAGCTTCTTCAGTTCCAGGAAGATGCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATG
GATTTCAAAGCTGGAGGCGCCTTATGTCACATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAG
AACCCATCTCGAATGGATCGTAATGTGGAAATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATC
TACCTCATTCCAGACATTGATCTGAAGTTGGCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCA
AAAGCTTCCCACCACATTTACCCATATTCTTCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTA
GTGCATTGGGGCTTTTACCCAGACAGCTATGATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAA
AAACCATGGAAGGTTCATGTGAAATGGATTTTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAAT
AGGAAGCCTGTGAGTTTTCGTCAGCGGATTTCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCT
AATGCTCGAAAGAGGAAACATTCGCCTTCGCCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGCCAAGCTAGC
CTTTATGGGAAGCGCAGAAGTCAGAAAGAGGAAGATGAGCAAGAAGATCTAACCAAGGATATGGAAGACCCAACACCTGTACCCAATATA
GAAGAAGTAGTACTTCCCAAAAATGTGAACCTAAAGAAAGATAGTGAAAATACACCTGTTAAAGGAGGAACTGTAGCGGATCTAGATGAG
CAGGATGAAGAAACAGTCACAGCAGGAGGAAAGGAAGATGAAGATCCTGCCAAAGGTGATCAGAGTCGATCAGTTGACCTTGGGGAAGAT
AATGTGACAGAGCAGACCAATCACATTATTATTCCTAGTTATGCATCATGGTTTGATTATAACTGTATTCATGTGATTGAACGGCGTGCT
CTTCCTGAGTTCTTCAATGGAAAAAACAAATCCAAGACTCCAGAAATATTTGAAGGGCTTAACATAACTAAACTGTATGATGGACAATGT
GAAAACTCTTGAACGTACGACAAAGAATTATAAAACCTACTGAATCTCCAGATTGCCAAGTGAAACACAATGGTTGCCTCTTCAAATATA

>83950_83950_2_SMARCC1-SPINK8_SMARCC1_chr3_47721927_ENST00000254480_SPINK8_chr3_48351436_ENST00000434006_length(amino acids)=511AA_BP=
MWGRRAATMAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVV
QLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYL
IPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKP
WKVHVKWILDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGQASLY
GKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMARCC1-SPINK8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SMARCC1-SPINK8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SMARCC1-SPINK8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source