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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMC3-MXI1 (FusionGDB2 ID:84001)

Fusion Gene Summary for SMC3-MXI1

check button Fusion gene summary
Fusion gene informationFusion gene name: SMC3-MXI1
Fusion gene ID: 84001
HgeneTgene
Gene symbol

SMC3

MXI1

Gene ID

9126

4601

Gene namestructural maintenance of chromosomes 3MAX interactor 1, dimerization protein
SynonymsBAM|BMH|CDLS3|CSPG6|HCAP|SMC3L1MAD2|MXD2|MXI|bHLHc11
Cytomap

10q25.2

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionstructural maintenance of chromosomes protein 3SMC protein 3basement membrane-associated chondroitin proteoglycanchondroitin sulfate proteoglycan 6 (bamacan)chromosome-associated polypeptidemax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11
Modification date2020032720200313
UniProtAcc.

P50539

Ensembl transtripts involved in fusion geneENST00000361804, ENST00000462899, 
ENST00000369612, ENST00000485566, 
ENST00000239007, ENST00000332674, 
ENST00000361248, ENST00000393134, 
Fusion gene scores* DoF score6 X 7 X 3=12617 X 10 X 9=1530
# samples 719
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1530*10)=-3.00946032924907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMC3 [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMC3(112350330)-MXI1(112038938), # samples:2
SMC3(112350330)-MXI1(112038937), # samples:2
Anticipated loss of major functional domain due to fusion event.SMC3-MXI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SMC3-MXI1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
SMC3-MXI1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMC3

GO:0051321

meiotic cell cycle

12498344

TgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718


check buttonFusion gene breakpoints across SMC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MXI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01ASMC3chr10

112350330

-MXI1chr10

112038938

+
ChimerDB4ESCATCGA-L5-A4OQ-01ASMC3chr10

112350330

+MXI1chr10

112038938

+
ChimerDB4ESCATCGA-L5-A4OQSMC3chr10

112350330

+MXI1chr10

112038937

+
ChimerDB4ESCATCGA-L5-A4OQSMC3chr10

112350890

+MXI1chr10

112038937

+


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Fusion Gene ORF analysis for SMC3-MXI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000361804ENST00000369612SMC3chr10

112350330

+MXI1chr10

112038938

+
5CDS-3UTRENST00000361804ENST00000369612SMC3chr10

112350330

+MXI1chr10

112038937

+
5CDS-3UTRENST00000361804ENST00000369612SMC3chr10

112350890

+MXI1chr10

112038937

+
5CDS-3UTRENST00000361804ENST00000485566SMC3chr10

112350330

+MXI1chr10

112038938

+
5CDS-3UTRENST00000361804ENST00000485566SMC3chr10

112350330

+MXI1chr10

112038937

+
5CDS-3UTRENST00000361804ENST00000485566SMC3chr10

112350890

+MXI1chr10

112038937

+
Frame-shiftENST00000361804ENST00000239007SMC3chr10

112350890

+MXI1chr10

112038937

+
Frame-shiftENST00000361804ENST00000332674SMC3chr10

112350890

+MXI1chr10

112038937

+
Frame-shiftENST00000361804ENST00000361248SMC3chr10

112350890

+MXI1chr10

112038937

+
Frame-shiftENST00000361804ENST00000393134SMC3chr10

112350890

+MXI1chr10

112038937

+
In-frameENST00000361804ENST00000239007SMC3chr10

112350330

+MXI1chr10

112038938

+
In-frameENST00000361804ENST00000239007SMC3chr10

112350330

+MXI1chr10

112038937

+
In-frameENST00000361804ENST00000332674SMC3chr10

112350330

+MXI1chr10

112038938

+
In-frameENST00000361804ENST00000332674SMC3chr10

112350330

+MXI1chr10

112038937

+
In-frameENST00000361804ENST00000361248SMC3chr10

112350330

+MXI1chr10

112038938

+
In-frameENST00000361804ENST00000361248SMC3chr10

112350330

+MXI1chr10

112038937

+
In-frameENST00000361804ENST00000393134SMC3chr10

112350330

+MXI1chr10

112038938

+
In-frameENST00000361804ENST00000393134SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000239007SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3CDSENST00000462899ENST00000239007SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000239007SMC3chr10

112350890

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000332674SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3CDSENST00000462899ENST00000332674SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000332674SMC3chr10

112350890

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000361248SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3CDSENST00000462899ENST00000361248SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000361248SMC3chr10

112350890

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000393134SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3CDSENST00000462899ENST00000393134SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3CDSENST00000462899ENST00000393134SMC3chr10

112350890

+MXI1chr10

112038937

+
intron-3UTRENST00000462899ENST00000369612SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3UTRENST00000462899ENST00000369612SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3UTRENST00000462899ENST00000369612SMC3chr10

112350890

+MXI1chr10

112038937

+
intron-3UTRENST00000462899ENST00000485566SMC3chr10

112350330

+MXI1chr10

112038938

+
intron-3UTRENST00000462899ENST00000485566SMC3chr10

112350330

+MXI1chr10

112038937

+
intron-3UTRENST00000462899ENST00000485566SMC3chr10

112350890

+MXI1chr10

112038937

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361804SMC3chr10112350330+ENST00000332674MXI1chr10112038938+46251796602246728
ENST00000361804SMC3chr10112350330+ENST00000361248MXI1chr10112038938+37661796602246728
ENST00000361804SMC3chr10112350330+ENST00000239007MXI1chr10112038938+37661796602246728
ENST00000361804SMC3chr10112350330+ENST00000393134MXI1chr10112038938+23521796602246728
ENST00000361804SMC3chr10112350330+ENST00000332674MXI1chr10112038937+46251796602246728
ENST00000361804SMC3chr10112350330+ENST00000361248MXI1chr10112038937+37661796602246728
ENST00000361804SMC3chr10112350330+ENST00000239007MXI1chr10112038937+37661796602246728
ENST00000361804SMC3chr10112350330+ENST00000393134MXI1chr10112038937+23521796602246728

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361804ENST00000332674SMC3chr10112350330+MXI1chr10112038938+0.0006986170.9993013
ENST00000361804ENST00000361248SMC3chr10112350330+MXI1chr10112038938+0.0015283380.9984717
ENST00000361804ENST00000239007SMC3chr10112350330+MXI1chr10112038938+0.0015283380.9984717
ENST00000361804ENST00000393134SMC3chr10112350330+MXI1chr10112038938+0.0045530630.99544686
ENST00000361804ENST00000332674SMC3chr10112350330+MXI1chr10112038937+0.0006986170.9993013
ENST00000361804ENST00000361248SMC3chr10112350330+MXI1chr10112038937+0.0015283380.9984717
ENST00000361804ENST00000239007SMC3chr10112350330+MXI1chr10112038937+0.0015283380.9984717
ENST00000361804ENST00000393134SMC3chr10112350330+MXI1chr10112038937+0.0045530630.99544686

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Fusion Genomic Features for SMC3-MXI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMC3chr10112350330+MXI1chr10112038937+9.74E-050.9999026
SMC3chr10112350330+MXI1chr10112038937+9.74E-050.9999026
SMC3chr10112350890+MXI1chr10112038937+3.84E-050.9999616
SMC3chr10112350330+MXI1chr10112038937+9.74E-050.9999026
SMC3chr10112350330+MXI1chr10112038937+9.74E-050.9999026
SMC3chr10112350890+MXI1chr10112038937+3.84E-050.9999616

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SMC3-MXI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:112350330/chr10:112038938)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MXI1

P50539

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+1629179_3505561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+1629393_5035561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+1629179_3505561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+1629393_5035561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+162932_395561218.0Nucleotide bindingATP
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+162932_395561218.0Nucleotide bindingATP
TgeneMXI1chr10:112350330chr10:112038937ENST000003612481567_11932183.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038937ENST000003696122667_11942193.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038938ENST000003612481567_11932183.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038938ENST000003696122667_11942193.0DomainbHLH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+1629669_9165561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+1629958_9895561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+1629669_9165561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+1629958_9895561218.0Coiled coilOntology_term=ECO:0000255
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+16291115_11505561218.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+16291115_11505561218.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneSMC3chr10:112350330chr10:112038937ENST00000361804+1629530_6425561218.0DomainNote=SMC hinge
HgeneSMC3chr10:112350330chr10:112038938ENST00000361804+1629530_6425561218.0DomainNote=SMC hinge
TgeneMXI1chr10:112350330chr10:112038937ENST000002390072667_11978229.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038937ENST000003326742667_119145296.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038938ENST000002390072667_11978229.0DomainbHLH
TgeneMXI1chr10:112350330chr10:112038938ENST000003326742667_119145296.0DomainbHLH


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Fusion Gene Sequence for SMC3-MXI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84001_84001_1_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000239007_length(transcript)=3766nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG

>84001_84001_1_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000239007_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_2_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000332674_length(transcript)=4625nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG
ACCTTACCCCTGGCTGTTTGGACTTTGTATACTTTAAATAATTTAACTACCCTTAATTACTTAAAAAAAAAAAAAAGCTTTATGATTTTC
ATAACTTATTGCTGATTTTAATGGATTGTTAATTTCAGTCCTGTAGTTTTATTTTATGTTTAGATAGGGCTGGGCAAGGAAAAAGAAAAT
AAAGACAACCATATTTAGCAGTGCAGTTGAGTTGTGTGTTAATGTTAGACTATCCCTTTGTGAGTGACACTTTAACAGCATTCACTGCTT
CTATATATAGTGTACCATCTTGGTCATACATTACGCCTCAACATATACTTGTGCTCTTCCTTTGCCTCCAGAAGAAGTTTTTCCTTGATT
GTGCTATGTTTCAGTGGAAGAAATTCTTTGAAGTAGATGTGAGTGAAAAACTGCATGCCTTTAGAAGCCCAGTATCAGAACTTGCTACGT
TTCAGGTGCTAGGGACTTAATGAAAAACAGGACAAAACAATTCCTTTTTGTGGCCCAGGTAAATTATTTCTGGTTTCACTTATAATTACT
AATGGCTGAGTCAAGATGTTGTCTCTGTGTTTGCTTACTCTTGATCAAGTGTGAGACAGTTTGAAGACTGTGCTACCATACAAAGTGAAT
GAAGCCAGTGACTAAGCTTCTGTTTGTTTTGTTATTCTCATGGCCTTCGCTTGCATTATTTGGGCCTTCATTCAGATGAACTTGAGGTGC
CATTTTGTTGCATATGTACAGGATTATGGGCTGGAAAGCATTTGTTATAAACCTATAGTGCACATTTTAACTGCCCCCTAAATTACCCTT
CCCTGGGTTTGTTTTCCTTGGGGTGGTGTAGATTGTATGAGTAAGAAGTATTAATTTTTTAAAAGACAAATCAACTTTGAAGACACAAAA

>84001_84001_2_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000332674_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_3_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000361248_length(transcript)=3766nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG

>84001_84001_3_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000361248_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_4_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000393134_length(transcript)=2352nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT

>84001_84001_4_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038937_ENST00000393134_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_5_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000239007_length(transcript)=3766nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG

>84001_84001_5_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000239007_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_6_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000332674_length(transcript)=4625nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG
ACCTTACCCCTGGCTGTTTGGACTTTGTATACTTTAAATAATTTAACTACCCTTAATTACTTAAAAAAAAAAAAAAGCTTTATGATTTTC
ATAACTTATTGCTGATTTTAATGGATTGTTAATTTCAGTCCTGTAGTTTTATTTTATGTTTAGATAGGGCTGGGCAAGGAAAAAGAAAAT
AAAGACAACCATATTTAGCAGTGCAGTTGAGTTGTGTGTTAATGTTAGACTATCCCTTTGTGAGTGACACTTTAACAGCATTCACTGCTT
CTATATATAGTGTACCATCTTGGTCATACATTACGCCTCAACATATACTTGTGCTCTTCCTTTGCCTCCAGAAGAAGTTTTTCCTTGATT
GTGCTATGTTTCAGTGGAAGAAATTCTTTGAAGTAGATGTGAGTGAAAAACTGCATGCCTTTAGAAGCCCAGTATCAGAACTTGCTACGT
TTCAGGTGCTAGGGACTTAATGAAAAACAGGACAAAACAATTCCTTTTTGTGGCCCAGGTAAATTATTTCTGGTTTCACTTATAATTACT
AATGGCTGAGTCAAGATGTTGTCTCTGTGTTTGCTTACTCTTGATCAAGTGTGAGACAGTTTGAAGACTGTGCTACCATACAAAGTGAAT
GAAGCCAGTGACTAAGCTTCTGTTTGTTTTGTTATTCTCATGGCCTTCGCTTGCATTATTTGGGCCTTCATTCAGATGAACTTGAGGTGC
CATTTTGTTGCATATGTACAGGATTATGGGCTGGAAAGCATTTGTTATAAACCTATAGTGCACATTTTAACTGCCCCCTAAATTACCCTT
CCCTGGGTTTGTTTTCCTTGGGGTGGTGTAGATTGTATGAGTAAGAAGTATTAATTTTTTAAAAGACAAATCAACTTTGAAGACACAAAA

>84001_84001_6_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000332674_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_7_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000361248_length(transcript)=3766nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT
CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG
CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT
CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT
TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT
TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT
TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT
TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA
GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG
TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT
GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC
ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG
AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG
TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT
CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC
CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG

>84001_84001_7_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000361248_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------
>84001_84001_8_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000393134_length(transcript)=2352nt_BP=1796nt
TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC
GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA
ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT
CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG
GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG
TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT
GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT
GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG
AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC
AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT
GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA
GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC
AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA
CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG
CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC
AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC
CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA
AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA
GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT
CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA
GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC
AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA
AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT
GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT
GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC
CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT

>84001_84001_8_SMC3-MXI1_SMC3_chr10_112350330_ENST00000361804_MXI1_chr10_112038938_ENST00000393134_length(amino acids)=728AA_BP=578
MTLRPCGCCSGAGLLPGQGPGIMYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEG
TGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKL
LREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRET
SGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE
EKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKE
KNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDH
FRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQL
ENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMC3-MXI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMC3-MXI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMC3-MXI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource