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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMEK1-CCDC88C (FusionGDB2 ID:84044)

Fusion Gene Summary for SMEK1-CCDC88C

check button Fusion gene summary
Fusion gene informationFusion gene name: SMEK1-CCDC88C
Fusion gene ID: 84044
HgeneTgene
Gene symbol

SMEK1

CCDC88C

Gene ID

55671

440193

Gene nameprotein phosphatase 4 regulatory subunit 3Acoiled-coil domain containing 88C
SynonymsFLFL1|KIAA2010|MSTP033|PP4R3|PP4R3A|SMEK1|smk-1|smk1DAPLE|HKRP2|HYC1|KIAA1509|SCA40
Cytomap

14q32.12

14q32.11-q32.12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 3ASMEK homolog 1, suppressor of mek1protein DapleDvl-associating protein with a high frequency of leucine residueshook-related protein 2spinocerebellar ataxia 40
Modification date2020031320200313
UniProtAcc.

Q9P219

Ensembl transtripts involved in fusion geneENST00000337238, ENST00000554684, 
ENST00000554943, ENST00000428424, 
ENST00000555462, ENST00000555718, 
ENST00000389856, ENST00000553403, 
ENST00000554165, ENST00000331194, 
ENST00000389857, 
Fusion gene scores* DoF score5 X 5 X 4=10013 X 12 X 7=1092
# samples 815
** MAII scorelog2(8/100*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMEK1 [Title/Abstract] AND CCDC88C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC88C(91875003)-SMEK1(91929221), # samples:1
SMEK1(91951976)-CCDC88C(91739997), # samples:1
Anticipated loss of major functional domain due to fusion event.SMEK1-CCDC88C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCDC88C

GO:0003383

apical constriction

30948426

TgeneCCDC88C

GO:0007264

small GTPase mediated signal transduction

26126266


check buttonFusion gene breakpoints across SMEK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC88C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A928-01ASMEK1chr14

91951976

-CCDC88Cchr14

91739997

-


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Fusion Gene ORF analysis for SMEK1-CCDC88C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337238ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000337238ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000337238ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554684ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554684ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554684ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554943ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554943ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
5CDS-intronENST00000554943ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
Frame-shiftENST00000337238ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
Frame-shiftENST00000554684ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
Frame-shiftENST00000554943ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
In-frameENST00000337238ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
In-frameENST00000554684ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
In-frameENST00000554943ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000428424ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000428424ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000555462ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000555462ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000555718ENST00000331194SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-3CDSENST00000555718ENST00000389857SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000428424ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000428424ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000428424ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555462ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555462ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555462ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555718ENST00000389856SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555718ENST00000553403SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-
intron-intronENST00000555718ENST00000554165SMEK1chr14

91951976

-CCDC88Cchr14

91739997

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000554684SMEK1chr1491951976-ENST00000331194CCDC88Cchr1491739997-18237942241822533
ENST00000337238SMEK1chr1491951976-ENST00000389857CCDC88Cchr1491739997-29095801691608479
ENST00000554943SMEK1chr1491951976-ENST00000331194CCDC88Cchr1491739997-1442413801441454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000554684ENST00000331194SMEK1chr1491951976-CCDC88Cchr1491739997-0.0874003840.91259956
ENST00000337238ENST00000389857SMEK1chr1491951976-CCDC88Cchr1491739997-0.0231390780.976861
ENST00000554943ENST00000331194SMEK1chr1491951976-CCDC88Cchr1491739997-0.09844610.90155387

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Fusion Genomic Features for SMEK1-CCDC88C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMEK1-CCDC88C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:91875003/chr14:91929221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC88C

Q9P219

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMEK1chr14:91951976chr14:91739997ENST00000337238-4161_10099821.0DomainNote=WH1
HgeneSMEK1chr14:91951976chr14:91739997ENST00000554684-3151_10099821.0DomainNote=WH1
HgeneSMEK1chr14:91951976chr14:91739997ENST00000554943-3151_10099834.0DomainNote=WH1
TgeneCCDC88Cchr14:91951976chr14:91739997ENST00000331194461045_1094210553.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST00000331194461139_1393210553.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000033119446247_428210553.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000033119446456_1017210553.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST00000331194461661_1691210553.0MotifGBA
TgeneCCDC88Cchr14:91951976chr14:91739997ENST00000331194462026_2028210553.0RegionDVL1-binding
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000038985728302026_202816862029.0RegionDVL1-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMEK1chr14:91951976chr14:91739997ENST00000428424-1141_1000595.0DomainNote=WH1
HgeneSMEK1chr14:91951976chr14:91739997ENST00000555462-1131_1000595.0DomainNote=WH1
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000038985728301045_109416862029.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000038985728301139_139316862029.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST000003898572830247_42816862029.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST000003898572830456_101716862029.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Cchr14:91951976chr14:91739997ENST000003311944611_131210553.0DomainCalponin-homology (CH)
TgeneCCDC88Cchr14:91951976chr14:91739997ENST00000389857283011_13116862029.0DomainCalponin-homology (CH)
TgeneCCDC88Cchr14:91951976chr14:91739997ENST0000038985728301661_169116862029.0MotifGBA


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Fusion Gene Sequence for SMEK1-CCDC88C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84044_84044_1_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000337238_CCDC88C_chr14_91739997_ENST00000389857_length(transcript)=2909nt_BP=580nt
TGAGGGGCGAACCAAGATGGCGGCGGTTTTGGCTGTGTGAGGAAGACGGAAGAGACGGCGGCGGAGGGAAACCGACTTCCACTAGTCCGG
GTCGCTTGGGCGGCCGGGGGCCCTCAGAGTCTCCCGGGCAGTGGTAGCAGTTGCAGCAGGATCAGGCGCCTGTCGGCTTCTGACGTTTAA
AACAGGGGGAGCGGAAGGGAGCCACTGGCCGCGGTGGCAGGGCCAGGGCCCCTTTCCTGGGCGTCTACTGGCGGGGCCCCCGCCCCGGTT
CCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACGAGGACCGGCAGTGGGACGACCGGGGCACCGGGCA
TGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTGAGAGCGACGGTTCTCTACTTTTAGAGTCGAAAAT
AAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAGCAGAAAATTATGACTTGGCCCTTAGCTTTCAAGA
AAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGACACTCCCAGTTGCCGGGATGACCTGCTGAGTGACTACTTCCGAAAGGC
CAGCGATCCCCCAGCCATCGGAGGCCAACCAGGACCACCTGCCAAGAAAGAAGGGGCCAAGATGCCCACCAACTTTGTGGCCCCCACCGT
CAAAATGGCCGCCCCCACCTCGGAGGGGAGGCCGCTGAAGCCCGGGCAGTACGTAAAGCCAAACTTCAGACTGACTGAGGCCGAGGCCCC
ACCCAGCGTGGCCCCGAGACAGGCCCAGCCTCCCCAGAGCCTGTCTCTGGGCAGACCCCGGCAGGCTCCGGTGCCCCCAGCTTCCCATGC
ACCTGCCAGCCGCAGTGCCTCCTTGAGCCGGGCCTTCAGCCTGGCCTCAGCTGACCTTCTCCGGGCCAGCGGGCCAGAGGCCTGCAAACA
GGAGTCCCCTCAGAAGCTGGGGGCTCCTGAGGCCTTAGGGGGCAGAGAGACAGGCAGCCACACCCTGCAAAGCCCCGCACCCCCCAGCTC
CCATAGCCTGGCCCGGGAGCGGACCCCACTTGTGGGAAAGGCTGGCAGCTCCTGTCAGGGCCCAGGTCCCCGCAGCCGGCCGCTGGACAC
GAGGCGCTTCTCCCTGGCTCCCCCAAAGGAGGAGAGGCTGGCCCCCCTGCATCAGTCTGCCACAGCCCCCGCCATTGCCACTGCAGGTGC
TGGTGCTGCTGCTGCTGGCAGTGGCAGCAACTCCCAGCTCCTGCACTTCTCACCTGCTGCAGCCCCGGCTGCCAGGACCAAGCCCAAGGC
GCCCCCACGCTCAGGGGAGGTGGCCACCATCACCCCTGTCCGGGCAGGGCTCAGCCTCTCAGAGGGAGACGGGGTCCCGGGGCAGGGCTG
CAGTGAGGGGCTTCCGGCCAAGAGCCCAGGTCGGTCTCCCGATTTGGCTCCCCACCTCGGCCGGGCCCTGGAGGACTGCAGTCGAGGGAG
CGTCTCAAAGAGCAGTCCGGCCTCCCCGGAGCCCGGCGGGGATCCGCAGACCGTGTGGTATGAGTACGGCTGTGTGTGACTGTCTCGTGG
TTGAGCTCGCAAACCTGAAAACTACTGACGCGCCTTCCGACTCTCACGGCCTTTTCTCTTGCTTGCCTGCGGTGCCAGGAGAGGGTTTGG
AATGAGGAAAGGGGTTCCCACGCATTTCTGCTGTTTGTTCTGTGAATGGAAACACTGTGCCAAGCCCCAAGAGGATTACGCTTCCAGGTG
TGTAACGTGTTTTCTGTGTCTGCCGCTTCCAGCAGCTGATATCTTTGGAACAAATAATCCACGTCAGCATGGGGACCAATTAGGATGCAA
TGACAAACTGACTTCCCCCAAAGCAGACACTACTCCAGTATGTCCCAGTAGAACACTCATTTGCAATGTGTTGAGCTCCGTTAAGCACAC
ACACACTCACACAACAGGCTTACGAGGCTCAGGCCTGGCGGGTCAGAAAGCCCACTCCCTCTCCCAAGGCCACTGGATCCCAGGAGAAGC
CCAGACTGGCGATACTACAAAGGTCTCCAGGGCCTGGCAGACCCCAGAGTCAGGCCTGCTGTTAAAAAGTGAGAGTGCTGCTGTTCCATT
CCTGGGGTCCCAAGCACTTCCCTTTACCCCAGGACCCAGGGCAGCCTGCAGGGCAGCTGGCGGTGGCCTTGGCCATTTGCCCCCAGCCTC
CAGCTGGCTCCTGAGCTCTGCACCAGGGGGTTTGGGGACCACACAGGCACCTGCCTTCCTAGATTTCCCTGGCTCACTTTTCTGCAAACA
CTGGATCTGCCAGGCCTGGGGATTGGGGGGCAGGAAAGAGGCCCCCATCCAGCCCCCTCCAGGCCAGTGTGCACAGTGCACCGAGGGGTC
ATCCGCACAGAGCGAGGTGCAAGCTCGATGTGTAACCTGGCTGCGGCACCCGACATCCCCGGTCTCGGGGTGTTGATTTATTTCTGAATA
ACTTTTTGGGTATAGAAACCAATTTTTTTTAATATATGACATGTATATGTACACACTCATGTGAAATATGTATACTTTGGGGGGATCTAT
TTATGTTCCAGTGGGAGTCACTCTCTTCTGTCGGGAATCTTATCTGCTGCTTTGTGTCTTTGGTCAGATTCCTGACAATTTAGTTTCCTG
TTGTAAAGGTGCTTTTCCTGGGGTGAACTAAACCTATTGATTTTTTTTTTTTAAGATTTTTTTTTCCTTTTGATTTAATATACTGAGAAA
GAAATGGGAGACTTTTGAATGTTAACAAGATCCATTTTAGGAGTGTTTGGGGTTGTGTATTAAATAGCCATTCATTCTGGAACTCAAGGA

>84044_84044_1_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000337238_CCDC88C_chr14_91739997_ENST00000389857_length(amino acids)=479AA_BP=1
MTFKTGGAEGSHWPRWQGQGPFPGRLLAGPPPRFPGGTMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLL
ESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFV
APTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPE
ACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIA
TAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDC

--------------------------------------------------------------
>84044_84044_2_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000554684_CCDC88C_chr14_91739997_ENST00000331194_length(transcript)=1823nt_BP=794nt
CGCCTGTCGGCTTCTGACGTTTAAAACAGGGGGAGCGGAAGGGAGCCACTGGCCGCGGTGGCAGGGCCAGGTATAAGGAAGGAAAATATG
GCGGCGGCGGCGGCGGCCTGAGGAGGCGGCGGCGGCGCGGGAAGCTGCTTCGCGGAGATCATGGCGGAGGCGGGAGCAGGGCAGTGACGG
GAGCCCCGAGTTCCTAGCGCTGCGGGGCGGGAGGCTACGAAGCGCTGCGCGGCCCCCTCGGGGCTGCCGGGCGCCGGGCTCGCCAGGCCT
GGACAATAGCGCCGGGGAGCCGGAGGCGAGGAAAGGCGGCGGCCCAGAGCTCGGTCCCTGGAGCGGGCCATGCAGGCGGCGGCGCGGCCC
CGCGGCGCCCAGCGGCGGCAGTGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTC
CTGGGCGTCTACTGGCGGGGCCCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACG
AGGACCGGCAGTGGGACGACCGGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTG
AGAGCGACGGTTCTCTACTTTTAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAG
CAGAAAATTATGACTTGGCCCTTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGACACTCCCAGTTGCC
GGGATGACCTGCTGAGTGACTACTTCCGAAAGGCCAGCGATCCCCCAGCCATCGGAGGCCAACCAGGACCACCTGCCAAGAAAGAAGGGG
CCAAGATGCCCACCAACTTTGTGGCCCCCACCGTCAAAATGGCCGCCCCCACCTCGGAGGGGAGGCCGCTGAAGCCCGGGCAGTACGTAA
AGCCAAACTTCAGACTGACTGAGGCCGAGGCCCCACCCAGCGTGGCCCCGAGACAGGCCCAGCCTCCCCAGAGCCTGTCTCTGGGCAGAC
CCCGGCAGGCTCCGGTGCCCCCAGCTTCCCATGCACCTGCCAGCCGCAGTGCCTCCTTGAGCCGGGCCTTCAGCCTGGCCTCAGCTGACC
TTCTCCGGGCCAGCGGGCCAGAGGCCTGCAAACAGGAGTCCCCTCAGAAGCTGGGGGCTCCTGAGGCCTTAGGGGGCAGAGAGACAGGCA
GCCACACCCTGCAAAGCCCCGCACCCCCCAGCTCCCATAGCCTGGCCCGGGAGCGGACCCCACTTGTGGGAAAGGCTGGCAGCTCCTGTC
AGGGCCCAGGTCCCCGCAGCCGGCCGCTGGACACGAGGCGCTTCTCCCTGGCTCCCCCAAAGGAGGAGAGGCTGGCCCCCCTGCATCAGT
CTGCCACAGCCCCCGCCATTGCCACTGCAGGTGCTGGTGCTGCTGCTGCTGGCAGTGGCAGCAACTCCCAGCTCCTGCACTTCTCACCTG
CTGCAGCCCCGGCTGCCAGGACCAAGCCCAAGGCGCCCCCACGCTCAGGGGAGGTGGCCACCATCACCCCTGTCCGGGCAGGGCTCAGCC
TCTCAGAGGGAGACGGGGTCCCGGGGCAGGGCTGCAGTGAGGGGCTTCCGGCCAAGAGCCCAGGTCGGTCTCCCGATTTGGCTCCCCACC
TCGGCCGGGCCCTGGAGGACTGCAGTCGAGGGAGCGTCTCAAAGAGCAGTCCGGCCTCCCCGGAGCCCGGCGGGGATCCGCAGACCGTGT

>84044_84044_2_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000554684_CCDC88C_chr14_91739997_ENST00000331194_length(amino acids)=533AA_BP=1
MRGPLGAAGRRARQAWTIAPGSRRRGKAAAQSSVPGAGHAGGGAAPRRPAAAVRPGSPPLAGALTPRPSPLQGPFPGRLLAGPPPRFPGG
TMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAG
CDEIWEKICQDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSV
APRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSL
ARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPR

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>84044_84044_3_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000554943_CCDC88C_chr14_91739997_ENST00000331194_length(transcript)=1442nt_BP=413nt
TGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTCCTGGGCGTCTACTGGCGGGGC
CCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACGAGGACCGGCAGTGGGACGACC
GGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTGAGAGCGACGGTTCTCTACTTT
TAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAGCAGAAAATTATGACTTGGCCC
TTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGACACTCCCAGTTGCCGGGATGACCTGCTGAGTGACT
ACTTCCGAAAGGCCAGCGATCCCCCAGCCATCGGAGGCCAACCAGGACCACCTGCCAAGAAAGAAGGGGCCAAGATGCCCACCAACTTTG
TGGCCCCCACCGTCAAAATGGCCGCCCCCACCTCGGAGGGGAGGCCGCTGAAGCCCGGGCAGTACGTAAAGCCAAACTTCAGACTGACTG
AGGCCGAGGCCCCACCCAGCGTGGCCCCGAGACAGGCCCAGCCTCCCCAGAGCCTGTCTCTGGGCAGACCCCGGCAGGCTCCGGTGCCCC
CAGCTTCCCATGCACCTGCCAGCCGCAGTGCCTCCTTGAGCCGGGCCTTCAGCCTGGCCTCAGCTGACCTTCTCCGGGCCAGCGGGCCAG
AGGCCTGCAAACAGGAGTCCCCTCAGAAGCTGGGGGCTCCTGAGGCCTTAGGGGGCAGAGAGACAGGCAGCCACACCCTGCAAAGCCCCG
CACCCCCCAGCTCCCATAGCCTGGCCCGGGAGCGGACCCCACTTGTGGGAAAGGCTGGCAGCTCCTGTCAGGGCCCAGGTCCCCGCAGCC
GGCCGCTGGACACGAGGCGCTTCTCCCTGGCTCCCCCAAAGGAGGAGAGGCTGGCCCCCCTGCATCAGTCTGCCACAGCCCCCGCCATTG
CCACTGCAGGTGCTGGTGCTGCTGCTGCTGGCAGTGGCAGCAACTCCCAGCTCCTGCACTTCTCACCTGCTGCAGCCCCGGCTGCCAGGA
CCAAGCCCAAGGCGCCCCCACGCTCAGGGGAGGTGGCCACCATCACCCCTGTCCGGGCAGGGCTCAGCCTCTCAGAGGGAGACGGGGTCC
CGGGGCAGGGCTGCAGTGAGGGGCTTCCGGCCAAGAGCCCAGGTCGGTCTCCCGATTTGGCTCCCCACCTCGGCCGGGCCCTGGAGGACT
GCAGTCGAGGGAGCGTCTCAAAGAGCAGTCCGGCCTCCCCGGAGCCCGGCGGGGATCCGCAGACCGTGTGGTATGAGTACGGCTGTGTGT

>84044_84044_3_SMEK1-CCDC88C_SMEK1_chr14_91951976_ENST00000554943_CCDC88C_chr14_91739997_ENST00000331194_length(amino acids)=454AA_BP=1
MAGPPPRFPGGTMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENY
DLALSFQEKAGCDEIWEKICQDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNF
RLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTL
QSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAP
AARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEY

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Fusion Gene PPI Analysis for SMEK1-CCDC88C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMEK1-CCDC88C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMEK1-CCDC88C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource