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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMEK2-IL18RAP (FusionGDB2 ID:84053)

Fusion Gene Summary for SMEK2-IL18RAP

check button Fusion gene summary
Fusion gene informationFusion gene name: SMEK2-IL18RAP
Fusion gene ID: 84053
HgeneTgene
Gene symbol

SMEK2

IL18RAP

Gene ID

57223

8807

Gene nameprotein phosphatase 4 regulatory subunit 3Binterleukin 18 receptor accessory protein
SynonymsFLFL2|PP4R3B|PSY2|SMEK2|smk1ACPL|CD218b|CDw218b|IL-18R-beta|IL-18RAcP|IL-18Rbeta|IL-1R-7|IL-1R7|IL-1RAcPL|IL18RB
Cytomap

2p16.1

2q12.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 3BSMEK homolog 2, suppressor of mek1interleukin-18 receptor accessory proteinCD218 antigen-like family member BIL-18 receptor accessory proteinIL-18 receptor betacluster of differentiation w218binterleukin-1 receptor 7interleukin-18 receptor beta
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000272313, ENST00000345102, 
ENST00000407823, ENST00000477749, 
ENST00000264260, ENST00000409369, 
Fusion gene scores* DoF score8 X 6 X 8=3841 X 1 X 1=1
# samples 81
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SMEK2 [Title/Abstract] AND IL18RAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMEK2(55785911)-IL18RAP(103053672), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIL18RAP

GO:0035655

interleukin-18-mediated signaling pathway

25500532

TgeneIL18RAP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

25500532


check buttonFusion gene breakpoints across SMEK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IL18RAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-6397-02ASMEK2chr2

55785911

-IL18RAPchr2

103053672

+


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Fusion Gene ORF analysis for SMEK2-IL18RAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000272313ENST00000264260SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
In-frameENST00000272313ENST00000409369SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
In-frameENST00000345102ENST00000264260SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
In-frameENST00000345102ENST00000409369SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
In-frameENST00000407823ENST00000264260SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
In-frameENST00000407823ENST00000409369SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
intron-3CDSENST00000477749ENST00000264260SMEK2chr2

55785911

-IL18RAPchr2

103053672

+
intron-3CDSENST00000477749ENST00000409369SMEK2chr2

55785911

-IL18RAPchr2

103053672

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000272313SMEK2chr255785911-ENST00000264260IL18RAPchr2103053672+4132252717837471189
ENST00000272313SMEK2chr255785911-ENST00000409369IL18RAPchr2103053672+3951252717837471189
ENST00000407823SMEK2chr255785911-ENST00000264260IL18RAPchr2103053672+4300269518739151242
ENST00000407823SMEK2chr255785911-ENST00000409369IL18RAPchr2103053672+4119269518739151242
ENST00000345102SMEK2chr255785911-ENST00000264260IL18RAPchr2103053672+4361275615239761274
ENST00000345102SMEK2chr255785911-ENST00000409369IL18RAPchr2103053672+4180275615239761274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000272313ENST00000264260SMEK2chr255785911-IL18RAPchr2103053672+0.000289520.9997105
ENST00000272313ENST00000409369SMEK2chr255785911-IL18RAPchr2103053672+0.0003119380.999688
ENST00000407823ENST00000264260SMEK2chr255785911-IL18RAPchr2103053672+0.0002392890.9997607
ENST00000407823ENST00000409369SMEK2chr255785911-IL18RAPchr2103053672+0.0002578020.9997422
ENST00000345102ENST00000264260SMEK2chr255785911-IL18RAPchr2103053672+0.0001155810.99988437
ENST00000345102ENST00000409369SMEK2chr255785911-IL18RAPchr2103053672+0.0001234650.9998765

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Fusion Genomic Features for SMEK2-IL18RAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMEK2chr255785910-IL18RAPchr2103053671+6.15E-070.9999994
SMEK2chr255785910-IL18RAPchr2103053671+6.15E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SMEK2-IL18RAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55785911/chr2:103053672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMEK2chr2:55785911chr2:103053672ENST00000272313-1415719_724733765.0Compositional biasNote=Poly-Glu
HgeneSMEK2chr2:55785911chr2:103053672ENST00000345102-1617719_724818850.0Compositional biasNote=Poly-Glu
HgeneSMEK2chr2:55785911chr2:103053672ENST00000407823-1516719_724786818.0Compositional biasNote=Poly-Glu
HgeneSMEK2chr2:55785911chr2:103053672ENST00000272313-14151_100733765.0DomainNote=WH1
HgeneSMEK2chr2:55785911chr2:103053672ENST00000345102-16171_100818850.0DomainNote=WH1
HgeneSMEK2chr2:55785911chr2:103053672ENST00000407823-15161_100786818.0DomainNote=WH1
TgeneIL18RAPchr2:55785911chr2:103053672ENST00000264260412251_353193600.0DomainNote=Ig-like C2-type 2
TgeneIL18RAPchr2:55785911chr2:103053672ENST00000264260412406_559193600.0DomainTIR
TgeneIL18RAPchr2:55785911chr2:103053672ENST00000264260412378_599193600.0Topological domainCytoplasmic
TgeneIL18RAPchr2:55785911chr2:103053672ENST00000264260412357_377193600.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMEK2chr2:55785911chr2:103053672ENST00000272313-1415831_838733765.0Compositional biasNote=Poly-Glu
HgeneSMEK2chr2:55785911chr2:103053672ENST00000345102-1617831_838818850.0Compositional biasNote=Poly-Glu
HgeneSMEK2chr2:55785911chr2:103053672ENST00000407823-1516831_838786818.0Compositional biasNote=Poly-Glu
TgeneIL18RAPchr2:55785911chr2:103053672ENST00000264260412149_235193600.0DomainNote=Ig-like C2-type 1
TgeneIL18RAPchr2:55785911chr2:103053672ENST0000026426041220_356193600.0Topological domainExtracellular


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Fusion Gene Sequence for SMEK2-IL18RAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84053_84053_1_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000272313_IL18RAP_chr2_103053672_ENST00000264260_length(transcript)=4132nt_BP=2527nt
AGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACG
GGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCT
GAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAG
GAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTA
TACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCT
GGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGT
TTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCA
AGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCT
GATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAA
GCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTT
ACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGA
TGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGT
TATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATC
TGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAA
GTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTG
TGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGT
AATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTT
TGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCT
AGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGA
ATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAA
TATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAA
TCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGT
TATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGAT
TGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTAT
ATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAA
AGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGA
AAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAAC
AAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGC
CACCAAGAATGGAAAACTCCTCTCTGTGGAAAGGAGCAACCGAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATG
TGATTACACTCAGTCGGATACTGTGAGTTCGTGGACAGTCAGAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACC
AGATATTCTGGATCCTGTCGAGGACACACTGGAAGTAGAACTTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAG
GGTCTTTAACCCTGTCATAAAATGGTACATCAAAGATTCTGACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCAC
TTTAAAGGATGAAATCATTGAGCGTAATATCATCTTGGAAAAAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAA
CTCCATTGGAAACACAACCCAGTCCGTCCAACTGAAAGAAAAGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCT
GGTGGCCGTGCTGGCGGCGAGTGCCCTCCTCTACAGGCACTGGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGAC
GCTTGGGGATAAAAAGGATTTTGATGCTTTCGTATCCTATGCAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGA
ACACTTGGCCCTGAGCCTATTTCCTGATGTTTTAGAAAACAAATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGG
AGTGTATGCAGAAGACATTGTGAGCATTATTAAGAGAAGCAGAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTAT
CTTTGAACTACAAGCAGCAGTGAATCTTGCCTTGGATGATCAAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGA
GTCTCTACCTCATCTCGTGAAAAAAGCTCTCAGGGTTTTGCCCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTT
CTGGGCCAAAATGCGCTACCACATGCCTGTGAAAAACTCTCAGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTG
GAAAGGACTCAGTAGAACAGAAACCACTGGGAGGAGCTCCCAGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCC
CTGGGATAGAGATGTTGCTGGACAGAACTCACAGCTCTGTGTGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACC
AAGCAAGCTTGATGGACAATGGAGTGGGATTGAGACTGTGGTTTAGAGCCTTTGATTTCCTGGACTGGACTGACGGCGAGTGAATTCTCT
AGACCTTGGGTACTTTCAGTACACAACACCCCTAAGATTTCCCAGTGGTCCGAGCAGAATCAGAAAATACAGCTACTTCTGCCTTATGGC

>84053_84053_1_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000272313_IL18RAP_chr2_103053672_ENST00000264260_length(amino acids)=1189AA_BP=783
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
NIVGSNKNNTICPGALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALES
IEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAK
ESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYV
CDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKS
TLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQ
TLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPS
IFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQ

--------------------------------------------------------------
>84053_84053_2_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000272313_IL18RAP_chr2_103053672_ENST00000409369_length(transcript)=3951nt_BP=2527nt
AGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACG
GGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCT
GAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAG
GAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTA
TACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCT
GGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGT
TTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCA
AGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCT
GATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAA
GCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTT
ACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGA
TGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGT
TATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATC
TGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAA
GTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTG
TGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGT
AATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTT
TGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCT
AGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGA
ATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAA
TATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAA
TCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGT
TATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGAT
TGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTAT
ATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAA
AGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGA
AAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAAC
AAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGC
CACCAAGAATGGAAAACTCCTCTCTGTGGAAAGGAGCAACCGAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATG
TGATTACACTCAGTCGGATACTGTGAGTTCGTGGACAGTCAGAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACC
AGATATTCTGGATCCTGTCGAGGACACACTGGAAGTAGAACTTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAG
GGTCTTTAACCCTGTCATAAAATGGTACATCAAAGATTCTGACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCAC
TTTAAAGGATGAAATCATTGAGCGTAATATCATCTTGGAAAAAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAA
CTCCATTGGAAACACAACCCAGTCCGTCCAACTGAAAGAAAAGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCT
GGTGGCCGTGCTGGCGGCGAGTGCCCTCCTCTACAGGCACTGGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGAC
GCTTGGGGATAAAAAGGATTTTGATGCTTTCGTATCCTATGCAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGA
ACACTTGGCCCTGAGCCTATTTCCTGATGTTTTAGAAAACAAATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGG
AGTGTATGCAGAAGACATTGTGAGCATTATTAAGAGAAGCAGAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTAT
CTTTGAACTACAAGCAGCAGTGAATCTTGCCTTGGATGATCAAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGA
GTCTCTACCTCATCTCGTGAAAAAAGCTCTCAGGGTTTTGCCCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTT
CTGGGCCAAAATGCGCTACCACATGCCTGTGAAAAACTCTCAGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTG
GAAAGGACTCAGTAGAACAGAAACCACTGGGAGGAGCTCCCAGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCC
CTGGGATAGAGATGTTGCTGGACAGAACTCACAGCTCTGTGTGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACC

>84053_84053_2_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000272313_IL18RAP_chr2_103053672_ENST00000409369_length(amino acids)=1189AA_BP=783
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
NIVGSNKNNTICPGALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALES
IEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAK
ESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYV
CDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKS
TLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQ
TLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPS
IFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQ

--------------------------------------------------------------
>84053_84053_3_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000345102_IL18RAP_chr2_103053672_ENST00000264260_length(transcript)=4361nt_BP=2756nt
GGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAA
GTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCG
GGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGG
CGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGG
ACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCAC
TACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATT
TGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCA
CACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCA
ATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAG
GCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAG
GAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACC
CTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAA
GGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTA
CTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAAT
TAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTC
AAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCA
GATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTG
ATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGAC
TTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATT
GTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTT
GGAGTTTCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAA
ACAACACAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACAT
ATCACATAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTG
CCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAA
ATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGT
CTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATG
AGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGG
AAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATG
ATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTG
GTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTT
CTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGAATGGAAAACTCCTCTCTGTGGAAAGGAGCAACC
GAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATGTGATTACACTCAGTCGGATACTGTGAGTTCGTGGACAGTCA
GAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACCAGATATTCTGGATCCTGTCGAGGACACACTGGAAGTAGAAC
TTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAGGGTCTTTAACCCTGTCATAAAATGGTACATCAAAGATTCTG
ACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCACTTTAAAGGATGAAATCATTGAGCGTAATATCATCTTGGAAA
AAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAACTCCATTGGAAACACAACCCAGTCCGTCCAACTGAAAGAAA
AGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCTGGTGGCCGTGCTGGCGGCGAGTGCCCTCCTCTACAGGCACT
GGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGACGCTTGGGGATAAAAAGGATTTTGATGCTTTCGTATCCTATG
CAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGAACACTTGGCCCTGAGCCTATTTCCTGATGTTTTAGAAAACA
AATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGGAGTGTATGCAGAAGACATTGTGAGCATTATTAAGAGAAGCA
GAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTATCTTTGAACTACAAGCAGCAGTGAATCTTGCCTTGGATGATC
AAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGAGTCTCTACCTCATCTCGTGAAAAAAGCTCTCAGGGTTTTGC
CCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTTCTGGGCCAAAATGCGCTACCACATGCCTGTGAAAAACTCTC
AGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTGGAAAGGACTCAGTAGAACAGAAACCACTGGGAGGAGCTCCC
AGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCCCTGGGATAGAGATGTTGCTGGACAGAACTCACAGCTCTGTG
TGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACCAAGCAAGCTTGATGGACAATGGAGTGGGATTGAGACTGTGG
TTTAGAGCCTTTGATTTCCTGGACTGGACTGACGGCGAGTGAATTCTCTAGACCTTGGGTACTTTCAGTACACAACACCCCTAAGATTTC
CCAGTGGTCCGAGCAGAATCAGAAAATACAGCTACTTCTGCCTTATGGCTAGGGAACTGTCATGTCTACCATGTATTGTACATATGACTT

>84053_84053_3_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000345102_IL18RAP_chr2_103053672_ENST00000264260_length(amino acids)=1274AA_BP=868
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
FFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMN
SKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQ
TFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDK
ENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQ
SDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDE
IIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDK
KDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQ
AAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLS

--------------------------------------------------------------
>84053_84053_4_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000345102_IL18RAP_chr2_103053672_ENST00000409369_length(transcript)=4180nt_BP=2756nt
GGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAA
GTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCG
GGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGG
CGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGG
ACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCAC
TACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATT
TGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCA
CACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCA
ATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAG
GCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAG
GAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACC
CTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAA
GGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTA
CTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAAT
TAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTC
AAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCA
GATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTG
ATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGAC
TTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATT
GTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTT
GGAGTTTCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAA
ACAACACAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTTACTCACATTTTGTGTGGAACATCACACAT
ATCACATAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAATTCAAAGCACACTTTTCTGGCCTTGTGTG
CCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCACCAAGGGAAATCTTTTTGAGCCAGTTATAA
ATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTTTGAATTTATAAGAGTGGAAGATATCAAGT
CTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCAGACATTCAAAGGATTGAAGACTAAATATG
AGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAACAGATTTCGCAGAGATGCAAAAGCCTTGG
AAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGCACCAGTGGAAAAACCTAAGCCAGAAGATG
ATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAAGGAAAACCTTCCCAAAAGGACATCTCCTG
GTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATCTGTAGTGGCTCAGATACCACCAGCAACTT
CTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGAATGGAAAACTCCTCTCTGTGGAAAGGAGCAACC
GAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATGTGATTACACTCAGTCGGATACTGTGAGTTCGTGGACAGTCA
GAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACCAGATATTCTGGATCCTGTCGAGGACACACTGGAAGTAGAAC
TTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAGGGTCTTTAACCCTGTCATAAAATGGTACATCAAAGATTCTG
ACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCACTTTAAAGGATGAAATCATTGAGCGTAATATCATCTTGGAAA
AAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAACTCCATTGGAAACACAACCCAGTCCGTCCAACTGAAAGAAA
AGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCTGGTGGCCGTGCTGGCGGCGAGTGCCCTCCTCTACAGGCACT
GGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGACGCTTGGGGATAAAAAGGATTTTGATGCTTTCGTATCCTATG
CAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGAACACTTGGCCCTGAGCCTATTTCCTGATGTTTTAGAAAACA
AATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGGAGTGTATGCAGAAGACATTGTGAGCATTATTAAGAGAAGCA
GAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTATCTTTGAACTACAAGCAGCAGTGAATCTTGCCTTGGATGATC
AAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGAGTCTCTACCTCATCTCGTGAAAAAAGCTCTCAGGGTTTTGC
CCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTTCTGGGCCAAAATGCGCTACCACATGCCTGTGAAAAACTCTC
AGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTGGAAAGGACTCAGTAGAACAGAAACCACTGGGAGGAGCTCCC
AGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCCCTGGGATAGAGATGTTGCTGGACAGAACTCACAGCTCTGTG
TGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACCAAGCAAGCTTGATGGACAATGGAGTGGGATTGAGACTGTGG

>84053_84053_4_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000345102_IL18RAP_chr2_103053672_ENST00000409369_length(amino acids)=1274AA_BP=868
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
FFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMN
SKHTFLALCALRFMRRIIGLKDEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQ
TFKGLKTKYEQEKDRQNQKLNSVPSILRSNRFRRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDK
ENLPKRTSPGGFKFTFSHSASAANGTNSKSVVAQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQ
SDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDE
IIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDK
KDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQ
AAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLS

--------------------------------------------------------------
>84053_84053_5_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000407823_IL18RAP_chr2_103053672_ENST00000264260_length(transcript)=4300nt_BP=2695nt
GGAAGAGAAAGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGC
AAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTT
CTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCT
AAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGT
GAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGAT
GTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATAC
ATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTG
TCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAAC
TAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCG
TAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACAC
TGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTG
TATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTT
CAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCC
CACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGA
AGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAA
GGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCT
TGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGT
CCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGA
TCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGA
AAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGA
AAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTT
ACTCACATTTTGTGTGGAACATCACACATATCACATAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAA
TTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCAC
CAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTT
TGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCA
GACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAA
CAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGC
ACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAA
GGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATC
TGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGAATGG
AAAACTCCTCTCTGTGGAAAGGAGCAACCGAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATGTGATTACACTCA
GTCGGATACTGTGAGTTCGTGGACAGTCAGAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACCAGATATTCTGGA
TCCTGTCGAGGACACACTGGAAGTAGAACTTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAGGGTCTTTAACCC
TGTCATAAAATGGTACATCAAAGATTCTGACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCACTTTAAAGGATGA
AATCATTGAGCGTAATATCATCTTGGAAAAAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAACTCCATTGGAAA
CACAACCCAGTCCGTCCAACTGAAAGAAAAGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCTGGTGGCCGTGCT
GGCGGCGAGTGCCCTCCTCTACAGGCACTGGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGACGCTTGGGGATAA
AAAGGATTTTGATGCTTTCGTATCCTATGCAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGAACACTTGGCCCT
GAGCCTATTTCCTGATGTTTTAGAAAACAAATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGGAGTGTATGCAGA
AGACATTGTGAGCATTATTAAGAGAAGCAGAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTATCTTTGAACTACA
AGCAGCAGTGAATCTTGCCTTGGATGATCAAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGAGTCTCTACCTCA
TCTCGTGAAAAAAGCTCTCAGGGTTTTGCCCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTTCTGGGCCAAAAT
GCGCTACCACATGCCTGTGAAAAACTCTCAGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTGGAAAGGACTCAG
TAGAACAGAAACCACTGGGAGGAGCTCCCAGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCCCTGGGATAGAGA
TGTTGCTGGACAGAACTCACAGCTCTGTGTGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACCAAGCAAGCTTGA
TGGACAATGGAGTGGGATTGAGACTGTGGTTTAGAGCCTTTGATTTCCTGGACTGGACTGACGGCGAGTGAATTCTCTAGACCTTGGGTA
CTTTCAGTACACAACACCCCTAAGATTTCCCAGTGGTCCGAGCAGAATCAGAAAATACAGCTACTTCTGCCTTATGGCTAGGGAACTGTC

>84053_84053_5_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000407823_IL18RAP_chr2_103053672_ENST00000264260_length(amino acids)=1242AA_BP=836
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
NIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKG
NLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRF
RRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVV
AQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPV
EDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTT
QSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSL
FPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLV

--------------------------------------------------------------
>84053_84053_6_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000407823_IL18RAP_chr2_103053672_ENST00000409369_length(transcript)=4119nt_BP=2695nt
GGAAGAGAAAGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGC
AAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTT
CTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCT
AAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGT
GAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGAT
GTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATAC
ATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTG
TCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAAC
TAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCG
TAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACAC
TGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTG
TATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTT
CAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCC
CACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGA
AGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAA
GGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCT
TGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGT
CCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGA
TCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGA
AAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGA
AAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGATAATTATCAAACAGCACAGCTACTTGCCTTAATTTTAGAGTT
ACTCACATTTTGTGTGGAACATCACACATATCACATAAAAAACTATATTATGAACAAGGACTTGCTAAGAAGAGTCTTGGTCTTGATGAA
TTCAAAGCACACTTTTCTGGCCTTGTGTGCCCTTCGCTTTATGAGGCGGATAATTGGACTTAAAGATGAATTTTATAATCGTTACATCAC
CAAGGGAAATCTTTTTGAGCCAGTTATAAATGCACTTCTGGATAATGGAACTCGGTATAATCTGTTGAATTCAGCTGTTATTGAGTTGTT
TGAATTTATAAGAGTGGAAGATATCAAGTCTCTTACTGCCCATATAGTTGAAAACTTTTATAAAGCACTTGAATCGATTGAATATGTTCA
GACATTCAAAGGATTGAAGACTAAATATGAGCAAGAAAAAGACAGACAAAATCAGAAACTGAACAGTGTACCATCTATATTGCGTAGTAA
CAGATTTCGCAGAGATGCAAAAGCCTTGGAAGAGGATGAAGAAATGTGGTTTAATGAAGATGAAGAAGAGGAAGGAAAAGCAGTTGTGGC
ACCAGTGGAAAAACCTAAGCCAGAAGATGATTTTCCAGATAATTATGAAAAGTTTATGGAGACTAAAAAAGCAAAAGAAAGTGAAGACAA
GGAAAACCTTCCCAAAAGGACATCTCCTGGTGGCTTCAAATTTACTTTCTCCCACTCTGCCAGTGCTGCTAATGGAACAAACAGTAAATC
TGTAGTGGCTCAGATACCACCAGCAACTTCTAATGGATCCTCTTCCAAAACCACAAACTTGCCTACGTCAGTAACAGCCACCAAGAATGG
AAAACTCCTCTCTGTGGAAAGGAGCAACCGAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTATGTGATTACACTCA
GTCGGATACTGTGAGTTCGTGGACAGTCAGAGCTGTTGTTCAAGTGAGAACCATTGTGGGAGACACTAAACTCAAACCAGATATTCTGGA
TCCTGTCGAGGACACACTGGAAGTAGAACTTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAAAGGGTCTTTAACCC
TGTCATAAAATGGTACATCAAAGATTCTGACCTAGAGTGGGAAGTCTCAGTACCTGAGGCGAAAAGTATTAAATCCACTTTAAAGGATGA
AATCATTGAGCGTAATATCATCTTGGAAAAAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAGAACTCCATTGGAAA
CACAACCCAGTCCGTCCAACTGAAAGAAAAGAGAGGAGTGGTGCTCCTGTACATCCTGCTTGGCACCATCGGGACCCTGGTGGCCGTGCT
GGCGGCGAGTGCCCTCCTCTACAGGCACTGGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAGACGCTTGGGGATAA
AAAGGATTTTGATGCTTTCGTATCCTATGCAAAATGGAGCTCTTTTCCAAGTGAGGCCACTTCATCTCTGAGTGAAGAACACTTGGCCCT
GAGCCTATTTCCTGATGTTTTAGAAAACAAATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGAGGAGTGTATGCAGA
AGACATTGTGAGCATTATTAAGAGAAGCAGAAGAGGAATATTTATCTTGAGCCCCAACTATGTCAATGGACCCAGTATCTTTGAACTACA
AGCAGCAGTGAATCTTGCCTTGGATGATCAAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCAGAGTCTCTACCTCA
TCTCGTGAAAAAAGCTCTCAGGGTTTTGCCCACAGTTACTTGGAGAGGCTTAAAATCAGTTCCTCCCAATTCTAGGTTCTGGGCCAAAAT
GCGCTACCACATGCCTGTGAAAAACTCTCAGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAGTGGAAAGGACTCAG
TAGAACAGAAACCACTGGGAGGAGCTCCCAGCCTAAGGAATGGTGAAATGAGCCCTGGAGCCCCCTCCAGTCCAGTCCCTGGGATAGAGA
TGTTGCTGGACAGAACTCACAGCTCTGTGTGTGTGTGTTCAGGCTGATAGGAAATTCAAAGAGTCTCCTGCCAGCACCAAGCAAGCTTGA

>84053_84053_6_SMEK2-IL18RAP_SMEK2_chr2_55785911_ENST00000407823_IL18RAP_chr2_103053672_ENST00000409369_length(amino acids)=1242AA_BP=836
MNLWSHGEFGPLRSRRRRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSL
LVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSH
LIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIM
DVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDE
KFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVRE
FVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKD
NIVGSNKNNTICPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYNRYITKG
NLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQNQKLNSVPSILRSNRF
RRDAKALEEDEEMWFNEDEEEEGKAVVAPVEKPKPEDDFPDNYEKFMETKKAKESEDKENLPKRTSPGGFKFTFSHSASAANGTNSKSVV
AQIPPATSNGSSSKTTNLPTSVTATKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPV
EDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTT
QSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSL
FPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMEK2-IL18RAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMEK2-IL18RAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMEK2-IL18RAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource