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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMG1-SULT1A2 (FusionGDB2 ID:84101)

Fusion Gene Summary for SMG1-SULT1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG1-SULT1A2
Fusion gene ID: 84101
HgeneTgene
Gene symbol

SMG1

SULT1A2

Gene ID

23049

6799

Gene nameSMG1 nonsense mediated mRNA decay associated PI3K related kinasesulfotransferase family 1A member 2
Synonyms61E3.4|ATX|LIPHAST4|P-PST|P-PST 2|ST1A2|STP2|TSPST2
Cytomap

16p12.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinasesulfotransferase 1A2aryl sulfotransferase 2arylamine sulfotransferasephenol sulfotransferase 2phenol-preferring phenol sulfotransferase2phenol-sulfating phenol sulfotransferase 2phenolic-metabolizing (P) form of PSTsulfotransferase family, cytosoli
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000389467, ENST00000446231, 
ENST00000565224, ENST00000567737, 
ENST00000335715, ENST00000395630, 
ENST00000533150, 
Fusion gene scores* DoF score28 X 23 X 9=57963 X 3 X 3=27
# samples 313
** MAII scorelog2(31/5796*10)=-4.22471747428269
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMG1 [Title/Abstract] AND SULT1A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG1(18907374)-SULT1A2(28606996), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG1

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

11544179

HgeneSMG1

GO:0018105

peptidyl-serine phosphorylation

11544179|15175154

HgeneSMG1

GO:0046777

protein autophosphorylation

11331269|11544179

HgeneSMG1

GO:0046854

phosphatidylinositol phosphorylation

11331269

HgeneSMG1

GO:2001020

regulation of response to DNA damage stimulus

15175154

TgeneSULT1A2

GO:0006068

ethanol catabolic process

23207770

TgeneSULT1A2

GO:0006805

xenobiotic metabolic process

20417180

TgeneSULT1A2

GO:0018958

phenol-containing compound metabolic process

20417180

TgeneSULT1A2

GO:0050427

3'-phosphoadenosine 5'-phosphosulfate metabolic process

23207770

TgeneSULT1A2

GO:0051923

sulfation

20056724|23207770


check buttonFusion gene breakpoints across SMG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SULT1A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMY-01ASMG1chr16

18907374

-SULT1A2chr16

28606996

-


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Fusion Gene ORF analysis for SMG1-SULT1A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389467ENST00000335715SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000389467ENST00000395630SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000389467ENST00000533150SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000446231ENST00000335715SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000446231ENST00000395630SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000446231ENST00000533150SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000565224ENST00000335715SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000565224ENST00000395630SMG1chr16

18907374

-SULT1A2chr16

28606996

-
In-frameENST00000565224ENST00000533150SMG1chr16

18907374

-SULT1A2chr16

28606996

-
intron-3CDSENST00000567737ENST00000335715SMG1chr16

18907374

-SULT1A2chr16

28606996

-
intron-3CDSENST00000567737ENST00000395630SMG1chr16

18907374

-SULT1A2chr16

28606996

-
intron-3CDSENST00000567737ENST00000533150SMG1chr16

18907374

-SULT1A2chr16

28606996

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000389467SMG1chr1618907374-ENST00000533150SULT1A2chr1628606996-15017751531415420
ENST00000389467SMG1chr1618907374-ENST00000335715SULT1A2chr1628606996-16007751531514453
ENST00000389467SMG1chr1618907374-ENST00000395630SULT1A2chr1628606996-15987751531514453
ENST00000446231SMG1chr1618907374-ENST00000533150SULT1A2chr1628606996-15518252031465420
ENST00000446231SMG1chr1618907374-ENST00000335715SULT1A2chr1628606996-16508252031564453
ENST00000446231SMG1chr1618907374-ENST00000395630SULT1A2chr1628606996-16488252031564453
ENST00000565224SMG1chr1618907374-ENST00000533150SULT1A2chr1628606996-1104378441018324
ENST00000565224SMG1chr1618907374-ENST00000335715SULT1A2chr1628606996-1203378441117357
ENST00000565224SMG1chr1618907374-ENST00000395630SULT1A2chr1628606996-1201378441117357

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389467ENST00000533150SMG1chr1618907374-SULT1A2chr1628606996-0.008207620.99179244
ENST00000389467ENST00000335715SMG1chr1618907374-SULT1A2chr1628606996-0.0076323470.9923677
ENST00000389467ENST00000395630SMG1chr1618907374-SULT1A2chr1628606996-0.0075991420.9924009
ENST00000446231ENST00000533150SMG1chr1618907374-SULT1A2chr1628606996-0.0074479860.99255204
ENST00000446231ENST00000335715SMG1chr1618907374-SULT1A2chr1628606996-0.0073593330.9926407
ENST00000446231ENST00000395630SMG1chr1618907374-SULT1A2chr1628606996-0.0073874280.9926126
ENST00000565224ENST00000533150SMG1chr1618907374-SULT1A2chr1628606996-0.0041384820.9958616
ENST00000565224ENST00000335715SMG1chr1618907374-SULT1A2chr1628606996-0.0021591990.99784076
ENST00000565224ENST00000395630SMG1chr1618907374-SULT1A2chr1628606996-0.0021324050.9978676

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Fusion Genomic Features for SMG1-SULT1A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMG1-SULT1A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:18907374/chr16:28606996)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000033571518227_23249296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000033571518255_25949296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST000003357151848_5349296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000039563018227_23249296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000039563018255_25949296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST000003956301848_5349296.0Nucleotide bindingNote=PAPS
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000033571518106_10849296.0RegionSubstrate binding
TgeneSULT1A2chr16:18907374chr16:28606996ENST0000039563018106_10849296.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG1chr16:18907374chr16:28606996ENST00000446231-3631283_18661373662.0DomainFAT
HgeneSMG1chr16:18907374chr16:28606996ENST00000446231-3632150_24781373662.0DomainPI3K/PI4K
HgeneSMG1chr16:18907374chr16:28606996ENST00000446231-3633629_36611373662.0DomainFATC
HgeneSMG1chr16:18907374chr16:28606996ENST00000446231-3631817_18521373662.0RepeatNote=HEAT


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Fusion Gene Sequence for SMG1-SULT1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84101_84101_1_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000335715_length(transcript)=1600nt_BP=775nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA
CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT
GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC
AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC
TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA
GGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAG
AAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCAC
CCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAG
CTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTG
GGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACC
ACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCG
CAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAG

>84101_84101_1_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000335715_length(amino acids)=453AA_BP=18
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLA
LLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKR
EIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFR

--------------------------------------------------------------
>84101_84101_2_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000395630_length(transcript)=1598nt_BP=775nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA
CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT
GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC
AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC
TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA
GGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAG
AAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCAC
CCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAG
CTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTG
GGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACC
ACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCG
CAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAG

>84101_84101_2_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000395630_length(amino acids)=453AA_BP=18
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLA
LLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKR
EIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFR

--------------------------------------------------------------
>84101_84101_3_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000533150_length(transcript)=1501nt_BP=775nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA
CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT
GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC
AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC
TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA
GGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGAT
GGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGT
CAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCC
CTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGC
CGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAG
CGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAG

>84101_84101_3_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000389467_SULT1A2_chr16_28606996_ENST00000533150_length(amino acids)=420AA_BP=1
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGVCVLGARGVEEDRAGASAHQ
TFPDPLLRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKN

--------------------------------------------------------------
>84101_84101_4_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000335715_length(transcript)=1650nt_BP=825nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA
AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG
ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT
CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA
TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA
TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCC
TGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATG
TGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTG
GAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAG
ACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTG
AGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCT
TCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGG
CAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAG

>84101_84101_4_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000335715_length(amino acids)=453AA_BP=18
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLA
LLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKR
EIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFR

--------------------------------------------------------------
>84101_84101_5_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000395630_length(transcript)=1648nt_BP=825nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA
AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG
ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT
CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA
TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA
TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCC
TGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATG
TGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTG
GAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAG
ACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTG
AGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCT
TCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGG
CAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAG

>84101_84101_5_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000395630_length(amino acids)=453AA_BP=18
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLA
LLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKR
EIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFR

--------------------------------------------------------------
>84101_84101_6_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000533150_length(transcript)=1551nt_BP=825nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA
AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG
ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT
CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA
TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA
TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACA
GGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAG
ACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTC
AGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGT
CGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGA
AAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCA
GCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAGGCTCCAGAA

>84101_84101_6_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000446231_SULT1A2_chr16_28606996_ENST00000533150_length(amino acids)=420AA_BP=1
MRCGLRRNPERPSSSPALRRLLLLLLLLLLLLLGFLLSPGPERGVGGGRFGRRLALLWAAALGHVVSGKVMSRRAPGSRLSSGGGGGGTK
YPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRV
NNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGVCVLGARGVEEDRAGASAHQ
TFPDPLLRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKN

--------------------------------------------------------------
>84101_84101_7_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000335715_length(transcript)=1203nt_BP=378nt
ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT
TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG
ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA
AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG
ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC
CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGAC
TCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGG
ATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGG
CTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATG
AAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGG
TTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCC
CCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGA
TGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAA

>84101_84101_7_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000335715_length(amino acids)=357AA_BP=109
MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP
EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTL
LDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKIL

--------------------------------------------------------------
>84101_84101_8_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000395630_length(transcript)=1201nt_BP=378nt
ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT
TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG
ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA
AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG
ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC
CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGAC
TCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGG
ATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGG
CTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATG
AAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGG
TTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCC
CCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGA
TGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAA

>84101_84101_8_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000395630_length(amino acids)=357AA_BP=109
MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP
EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTL
LDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKIL

--------------------------------------------------------------
>84101_84101_9_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000533150_length(transcript)=1104nt_BP=378nt
ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT
TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG
ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA
AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG
ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC
CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAG
ACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTG
AAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTG
CTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACA
CGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGA
GGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCT
GCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAGGCTCCA

>84101_84101_9_SMG1-SULT1A2_SMG1_chr16_18907374_ENST00000565224_SULT1A2_chr16_28606996_ENST00000533150_length(amino acids)=324AA_BP=2
MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP
EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGVCVLGARGVEEDRAGASAHQTFPDPL
LRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMG1-SULT1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG1chr16:18907374chr16:28606996ENST00000446231-3631_1977137.333333333333343662.0SMG8 and SMG9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG1-SULT1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG1-SULT1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource