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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMG6-SHPK (FusionGDB2 ID:84129)

Fusion Gene Summary for SMG6-SHPK

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG6-SHPK
Fusion gene ID: 84129
HgeneTgene
Gene symbol

SMG6

SHPK

Gene ID

23293

23729

Gene nameSMG6 nonsense mediated mRNA decay factorsedoheptulokinase
SynonymsC17orf31|EST1A|SMG-6|hSMG5/7aCARKL|SHK
Cytomap

17p13.3

17p13.2

Type of geneprotein-codingprotein-coding
Descriptiontelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1Asedoheptulokinasecarbohydrate kinase-like protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263073, ENST00000354901, 
ENST00000536871, ENST00000544865, 
ENST00000573166, 		ENST00000572705, 
ENST00000225519, 
Fusion gene scores* DoF score19 X 14 X 6=15963 X 3 X 3=27
# samples 193
** MAII scorelog2(19/1596*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMG6 [Title/Abstract] AND SHPK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG6(2139786)-SHPK(3518831), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087

TgeneSHPK

GO:0005975

carbohydrate metabolic process

19413330

TgeneSHPK

GO:0016310

phosphorylation

19413330

TgeneSHPK

GO:0071222

cellular response to lipopolysaccharide

22682222


check buttonFusion gene breakpoints across SMG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SHPK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8265-01BSMG6chr17

2139786

-SHPKchr17

3518831

-


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Fusion Gene ORF analysis for SMG6-SHPK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263073ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000354901ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000536871ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000544865ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000263073ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000354901ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000536871ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000544865ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
intron-3CDSENST00000573166ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
intron-intronENST00000573166ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544865SMG6chr172139786-ENST00000225519SHPKchr173518831-6199328751139001129
ENST00000263073SMG6chr172139786-ENST00000225519SHPKchr173518831-583229205135331160
ENST00000354901SMG6chr172139786-ENST00000225519SHPKchr173518831-33524402321053273
ENST00000536871SMG6chr172139786-ENST00000225519SHPKchr173518831-32993872421000252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544865ENST00000225519SMG6chr172139786-SHPKchr173518831-0.0014189530.99858105
ENST00000263073ENST00000225519SMG6chr172139786-SHPKchr173518831-0.0010283320.9989717
ENST00000354901ENST00000225519SMG6chr172139786-SHPKchr173518831-0.0203452760.9796547
ENST00000536871ENST00000225519SMG6chr172139786-SHPKchr173518831-0.0206599270.9793401

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Fusion Genomic Features for SMG6-SHPK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMG6-SHPK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:2139786/chr17:3518831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019163_1939561420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019567_6259561420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019163_1939251389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019567_6259251389.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-10191197_12399561420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-3121197_123948512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312163_19348512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312567_62548512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-2111197_123948512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211163_19348512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211567_62548512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-10191197_12399251389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-10191246_13979561420.0DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-3121246_139748512.0DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-2111246_139748512.0DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-10191246_13979251389.0DomainNote=PINc


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Fusion Gene Sequence for SMG6-SHPK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84129_84129_1_SMG6-SHPK_SMG6_chr17_2139786_ENST00000263073_SHPK_chr17_3518831_ENST00000225519_length(transcript)=5832nt_BP=2920nt
GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG
GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT
AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA
TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC
CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA
ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG
GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT
AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG
GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC
TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG
GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT
GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT
AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG
GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT
CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG
CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG
AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG
GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG
GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG
TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG
CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG
CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG
TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA
CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC
ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA
GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC
AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA
GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG
CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG
GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG
AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT
GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG
ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGA
TTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTC
AACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTAT
TCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAG
CTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCAC
TCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAG
CAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGA
CACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTG
TGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGA
ACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATG
TCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAG
ATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCG
TTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCT
TTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGAT
GCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACT
GCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTG
ACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGA
TGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGG
CGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAA
GCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCC
CAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCT
CAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGC
AAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGG
GAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGC
CGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGA
GCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTG
TGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGG
GAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTA
GTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAA
CAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTT
CCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTC
AGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCG

>84129_84129_1_SMG6-SHPK_SMG6_chr17_2139786_ENST00000263073_SHPK_chr17_3518831_ENST00000225519_length(amino acids)=1160AA_BP=956
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG
TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG
AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG
TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD
IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF
EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFP
YFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHV

--------------------------------------------------------------
>84129_84129_2_SMG6-SHPK_SMG6_chr17_2139786_ENST00000354901_SHPK_chr17_3518831_ENST00000225519_length(transcript)=3352nt_BP=440nt
GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG
TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC
ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA
TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG
CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACAT
CAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCC
ATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGAT
GGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCAT
CACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGT
GACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGAT
GGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGT
GGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACT
GCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCT
TGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGT
GCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGT
CAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGT
GGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAG
TTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGAT
TGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAG
CTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAG
GGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGT
TTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAG
AACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCA
TTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGG
CCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGG
GAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTT
TACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGG
CCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTG
ACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGC
AGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTG
TCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCA
CAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAG
AAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGT
CAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAG
TCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTC
AGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTG
GTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCTTTAAGTGAAAAGATGGGAAGAAAACAGTCATATGCTG

>84129_84129_2_SMG6-SHPK_SMG6_chr17_2139786_ENST00000354901_SHPK_chr17_3518831_ENST00000225519_length(amino acids)=273AA_BP=69
MNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPA
QTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASV
TRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQ

--------------------------------------------------------------
>84129_84129_3_SMG6-SHPK_SMG6_chr17_2139786_ENST00000536871_SHPK_chr17_3518831_ENST00000225519_length(transcript)=3299nt_BP=387nt
ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA
GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA
TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA
AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT
TTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCAC
AGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATG
TGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTC
AGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGA
CCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGA
TTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGA
GGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGA
AGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTT
CCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATA
ATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGA
GAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACT
TCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCT
GAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCAT
CCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTG
CCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAG
GTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGC
AGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAG
ACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCT
GGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGAT
TGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAG
GCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGAC
AGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCA
CTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGG
GTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGC
GCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGC
CATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAA
ACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGA
TCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATC
CACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTT
TTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGG
CCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTAC
TTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCT

>84129_84129_3_SMG6-SHPK_SMG6_chr17_2139786_ENST00000536871_SHPK_chr17_3518831_ENST00000225519_length(amino acids)=252AA_BP=48
METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLG
VAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGI

--------------------------------------------------------------
>84129_84129_4_SMG6-SHPK_SMG6_chr17_2139786_ENST00000544865_SHPK_chr17_3518831_ENST00000225519_length(transcript)=6199nt_BP=3287nt
AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC
TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC
CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC
CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC
AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA
TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG
CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG
TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT
GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG
TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG
TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT
TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG
AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG
GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG
CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA
GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA
CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA
TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT
TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG
ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC
TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC
ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC
CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC
AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT
GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA
GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA
GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG
GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA
AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG
CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT
TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG
CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA
AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC
TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG
CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC
ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA
GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCC
TTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGC
GTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCAC
TGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCC
GGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAA
CCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGT
GCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCT
CCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACA
CCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTAC
CTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTT
ACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAG
AGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTG
ATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGA
GGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGA
AGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAG
CACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCA
GAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGG
GAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTT
CGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGC
GTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAA
AGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTC
TCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGA
TGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGC
ACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAA
TACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTT
GCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAG
AGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTG
CTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTC
CACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATT
CTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCC
CTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGT
TCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGA

>84129_84129_4_SMG6-SHPK_SMG6_chr17_2139786_ENST00000544865_SHPK_chr17_3518831_ENST00000225519_length(amino acids)=1129AA_BP=925
MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF
PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA
AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST
DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK
QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD
EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ
HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD
PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA
RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS
TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP
SPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMA
DLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMG6-SHPK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019114_503956.33333333333341420.0telomeric DNA
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019114_503925.33333333333341389.0telomeric DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312114_50348.333333333333336512.0telomeric DNA
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211114_50348.333333333333336512.0telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG6-SHPK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG6-SHPK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource