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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMG6-VPS53 (FusionGDB2 ID:84133)

Fusion Gene Summary for SMG6-VPS53

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG6-VPS53
Fusion gene ID: 84133
HgeneTgene
Gene symbol

SMG6

VPS53

Gene ID

23293

55275

Gene nameSMG6 nonsense mediated mRNA decay factorVPS53 subunit of GARP complex
SynonymsC17orf31|EST1A|SMG-6|hSMG5/7aHCCS1|PCH2E|hVps53L|pp13624
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptiontelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1Avacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunit
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263073, ENST00000354901, 
ENST00000536871, ENST00000544865, 
ENST00000573166, 		ENST00000446250, 
ENST00000291074, ENST00000401468, 
ENST00000571805, ENST00000574029, 
ENST00000576149, ENST00000437048, 
Fusion gene scores* DoF score19 X 14 X 6=159613 X 13 X 8=1352
# samples 1916
** MAII scorelog2(19/1596*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1352*10)=-3.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMG6 [Title/Abstract] AND VPS53 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG6(2075952)-VPS53(565135), # samples:1
VPS53(600658)-SMG6(1989195), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087


check buttonFusion gene breakpoints across SMG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VPS53 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-3A-A9IN-01ASMG6chr17

2075952

-VPS53chr17

565135

-


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Fusion Gene ORF analysis for SMG6-VPS53

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263073ENST00000446250SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-5UTRENST00000354901ENST00000446250SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-5UTRENST00000536871ENST00000446250SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-5UTRENST00000544865ENST00000446250SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000263073ENST00000291074SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000263073ENST00000401468SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000263073ENST00000571805SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000263073ENST00000574029SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000263073ENST00000576149SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000354901ENST00000291074SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000354901ENST00000401468SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000354901ENST00000571805SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000354901ENST00000574029SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000354901ENST00000576149SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000536871ENST00000291074SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000536871ENST00000401468SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000536871ENST00000571805SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000536871ENST00000574029SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000536871ENST00000576149SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000544865ENST00000291074SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000544865ENST00000401468SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000544865ENST00000571805SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000544865ENST00000574029SMG6chr17

2075952

-VPS53chr17

565135

-
5CDS-intronENST00000544865ENST00000576149SMG6chr17

2075952

-VPS53chr17

565135

-
In-frameENST00000263073ENST00000437048SMG6chr17

2075952

-VPS53chr17

565135

-
In-frameENST00000354901ENST00000437048SMG6chr17

2075952

-VPS53chr17

565135

-
In-frameENST00000536871ENST00000437048SMG6chr17

2075952

-VPS53chr17

565135

-
In-frameENST00000544865ENST00000437048SMG6chr17

2075952

-VPS53chr17

565135

-
intron-3CDSENST00000573166ENST00000437048SMG6chr17

2075952

-VPS53chr17

565135

-
intron-5UTRENST00000573166ENST00000446250SMG6chr17

2075952

-VPS53chr17

565135

-
intron-intronENST00000573166ENST00000291074SMG6chr17

2075952

-VPS53chr17

565135

-
intron-intronENST00000573166ENST00000401468SMG6chr17

2075952

-VPS53chr17

565135

-
intron-intronENST00000573166ENST00000571805SMG6chr17

2075952

-VPS53chr17

565135

-
intron-intronENST00000573166ENST00000574029SMG6chr17

2075952

-VPS53chr17

565135

-
intron-intronENST00000573166ENST00000576149SMG6chr17

2075952

-VPS53chr17

565135

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544865SMG6chr172075952-ENST00000437048VPS53chr17565135-16449377551159881825
ENST00000263073SMG6chr172075952-ENST00000437048VPS53chr17565135-1608234085156211856
ENST00000354901SMG6chr172075952-ENST00000437048VPS53chr17565135-136029282323141969
ENST00000536871SMG6chr172075952-ENST00000437048VPS53chr17565135-135498752423088948

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544865ENST00000437048SMG6chr172075952-VPS53chr17565135-0.000931390.9990687
ENST00000263073ENST00000437048SMG6chr172075952-VPS53chr17565135-0.0005925190.99940753
ENST00000354901ENST00000437048SMG6chr172075952-VPS53chr17565135-0.0004314660.9995685
ENST00000536871ENST00000437048SMG6chr172075952-VPS53chr17565135-0.0004348920.99956506

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Fusion Genomic Features for SMG6-VPS53


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMG6-VPS53


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:2075952/chr17:565135)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2075952chr17:565135ENST00000263073-1319163_19311191420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000263073-1319567_62511191420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000354901-612163_193211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000536871-511163_193211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000544865-1319163_19310881389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000544865-1319567_62510881389.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:2075952chr17:565135ENST0000029107401897_1380671.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:2075952chr17:565135ENST0000043704832297_13895833.0Coiled coilOntology_term=ECO:0000255
TgeneVPS53chr17:2075952chr17:565135ENST0000057180531997_13895700.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2075952chr17:565135ENST00000263073-13191197_123911191420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000354901-6121197_1239211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000354901-612567_625211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000536871-5111197_1239211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000536871-511567_625211512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000544865-13191197_123910881389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2075952chr17:565135ENST00000263073-13191246_139711191420.0DomainNote=PINc
HgeneSMG6chr17:2075952chr17:565135ENST00000354901-6121246_1397211512.0DomainNote=PINc
HgeneSMG6chr17:2075952chr17:565135ENST00000536871-5111246_1397211512.0DomainNote=PINc
HgeneSMG6chr17:2075952chr17:565135ENST00000544865-13191246_139710881389.0DomainNote=PINc


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Fusion Gene Sequence for SMG6-VPS53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84133_84133_1_SMG6-VPS53_SMG6_chr17_2075952_ENST00000263073_VPS53_chr17_565135_ENST00000437048_length(transcript)=16082nt_BP=3408nt
GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG
GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT
AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA
TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC
CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA
ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG
GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT
AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG
GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC
TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG
GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT
GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT
AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG
GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT
CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG
CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG
AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG
GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG
GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG
TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG
CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG
CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG
TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA
CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC
ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA
GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC
AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA
GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG
CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG
GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG
AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT
GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG
ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGACTGCTTCTCGGAGGAGTGCCGCTCTGTGATCCAGGAACAAGCCGCAGCT
CTGGGCTTGGCCATGTTTTCTCTACTGGTCCGCCGCTGCACCTGCTTACTTAAGGAGTCCGCCAAAGCTCAGCTGTCCTCTCCTGAGGAC
CAGGATGACCAAGACGACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAAGGAGCTGCTCCCCAGTGTCAAAGTCTGGTCAGATTGGATG
CTCGGCTACCCGGACACCTGGAATCCTCCTCCCACATCCCTGGATCTGCCCTCGCATGTTGCTGTGGATGTATGGTCGACGCTGGCTGAT
TTCTGTAACATACTGACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAAGGACCCGGATGATGACCTCACCCTTCTTATCCTGGAAGAG
GATCGGCTTCTCTCGGGCTTTGTCCCCTTGCTGGCTGCCCCTCAGGACCCCTGCTACGTGGAGAAAACCTCGGATAAGGCGCTTGAAGAG
GCTCAGAAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACC
CGTGATATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTC
GACTCCCTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCAC
AAGTATATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTT
GAAGAAGCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGAT
CCCAGGATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCC
TGGCTGGACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAG
TGGTGCATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATT
GAAGTGAAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGAT
GGGACCCTGAAAAAGCTTGAGTCTCCACCCCCATCTACCAATCCCTTCCTGGAAGATGAGCCAACACCAGAGATGGAGGAACTGGCAACG
GAGAAAGGAGATTTAGATCAACCAAAGAAGCCTAAAGCCCCAGACAATCCATTTCATGGCATTGTTTCCAAGTGTTTTGAGCCTCATCTC
TACGTGTATATCGAATCCCAAGACAAGAACCTCGGAGAGCTGATAGATCGGTTTGTGGCTGATTTCAAAGCCCAGGGGCCACCTAAGCCC
AACACTGATGAAGGGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGTCTACTACAAGAAGTGCATGGTGCAATGCTCTCAGCTCAGT
ACTGGGGAGCCCATGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCGAGAATACGCCTGGAAAATCCTCTCTGGCAACCTGCCCAAA
ACCACAACCAGCAGTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAAGGAGGGCTCAGAAGTAGCCAAGTTCACTCTGGAGGAGCTC
TGCCTCATCTGTAACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCACCCAGCAGCTAGAAGAAAAACTCAAAGAAAAAGTGGATGTA
AGTCTGATTGAACGAATCAATCTGACTGGAGAGATGGACACGTTCAGCACCGTCATCTCCAGCAGTATTCAGCTGCTGGTTCAGGATCTG
GATGCTGCCTGTGATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAGAGCCCCTACGTCACC
TCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACTCAGTTCTGCGTTAAA
TTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAACAGCTGCTGCTGGAC
ACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGCTACACCAAGATCGTT
GTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTTGACAACTACATCAAA
CTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCTGGAACTC
CTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCAGAGCAAGAGTCGTCA
CGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAGACCCTCAGCGCCCGT
TCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATGTGGGTTGTTACTGAG
TCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATTTAGGTGATCTCTGGT
TCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCACACCCTCTTGACACG
TGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGA
TCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACAGGCGTGAGCCACCGA
GCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACTTGGAAGACGTTTCCT
AGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACCTTCAGGTCCACAGCA
CTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAGTCTGGGGTTCTGGAT
GCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCCGCCCTTCCTGTCCAC
CGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGGCAGCATATCAAGCCG
TTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGCTGTTGCTGCCTGCTT
TTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGGAGGATCACTTGAGTC
CAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCACCTGTAGTCCCAACT
GCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAAAAATACAAAAAATTG
GCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAATTCGAGACCAGCCT
GCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATCCCAGCTACTGGGGAG
GCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGCCTGGGTGACAGAGCA
AGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGTAGGAATAAGGTTTGG
AAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCTCTCTGCCAGGCTTTC
TCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTTGACTCTCACGCATCA
AGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTATTAGGAAAAGATTCC
AAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCATGGAGTTGCTATGGTT
AAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTGTCCTCAACCCAGGAG
AGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCTTTTTGGTTCATTGTT
GAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACAGCCAGGGAAGTTGCT
GTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCCTTGATGGGGACTCAG
TACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGATGCCGGCCGGGCGCCG
TGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATCCTTGCCAATATGGTG
AAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATC
GCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTATCTCAAAACA
AACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCCATAGGTAGTTATAAC
GTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATACATGTCTATTTTTCTG
ACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGCTTTCATTTTAAACTT
GTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAGGTCACGAGTTTGAGA
CCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGGCGGGTGCCTGTAATC
CCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCACTCCAGC
CTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCTCTCTCCATACTGATG
AGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTATCAAAGGGGCACCCTA
GGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAGGACTTCAAGACAAGC
CTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCACTTTGGGAGGCCGAG
GCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAATACAAAATTAGCCAGG
CGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCCG
AGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCTGTGGATGAAAGCAGC
AGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCCCTTTAAAAACCAAAA
AACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTCTTACTGAGGGGACTT
GTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGCAATGGACAAGGTGTT
CTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAGTACCCAGGGCTCTGC
CCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGCAGACAAGCTGAGACC
AGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAACCCTTCCTGAATTGC
CATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGGGTTCCTTCTCTAGGA
AGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAG
GAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTACCT
AGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCC
CTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTT
CGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCC
TTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATT
CCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGA
TTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGG
GATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAAT
GGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAA
ATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCAGAACAACCTGCCTG
CTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCAATGGGCAATTTAAGC
AAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAAAAATTCCCAGTCCTG
TTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAATAAAGGGATTGCTTCT
TTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTTAATTAAAGCATTACT
GGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGTCCGTGACCCTGGCCG
CTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGAGCCCAGTCCTGACCT
GCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTGTGAATTTCTATCCTG
TGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCCTGCACGCATGAGTCC
ATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATTTCTCTCCTGCACGCA
TGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTTTCAACAGGGGAAAAC
TGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTTACTAGGGAAGCCAAG
GGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTCACCTATGTGAACAGG
AGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGATTGGAAGCATCCACAG
AAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCATTTTCAATATTGGTG
AGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGCAGTGTGAAGTGTGTT
CGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACAAATCCTGCGGCCGTG
TGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTACACGAGAGTTTTAAA
AGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGAAGAGAGCTTCCTCCC
TCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTGCCAAAGCCTCCCTTC
CAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCCTTTCTTTTTCTTTTT
TTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAGATTAACTTGGGACAG
GCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGACTTTTCCCAAGGCCAG
CTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAACCTGGGGCAATATGAG
ATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGCTTCTGCTCAGTCATC
AAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTCTCAACAAACTTCCCT
CTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAGAAACCCCAGCTCCCT
TCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTTCACAAAATCAAGCAC
TGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAGAAAACATCTGTTTAC
ACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAGCCCCCCACAACCTCA
TACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCATGCCTGTCACATCTT
TGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGGAGTGGAGGTCAGTTG
GGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGCCTGGGCAATTCAGTG
CTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCATCGGATGAAATTCCTG
CTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCCTAGTGAGGGGTGAGC
CAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTCATATGGGACTAGTAA
GGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATTCGATATG
TGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGA
TTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGC
GAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTG
GTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGAT
ATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCA
GGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCAGGATTTGATATGTGG
CTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAGGGGTGAGCCAGGATT
CAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTGACCAGTGAGGGGCGA
GCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATTTGATATGTGGCTACT
GAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTCAGCCAGGATTCGATA
CGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAGTGAGGGGTGAGCCAG
GATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATATGTGGCTAGTAAGGG
GTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATAT
GTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAG
GATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGTACTTCACCAGCAGTT
TTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATTTTATGAGTTCAAATA
TTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGATGAAAATGTGTGTGT
ATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAGTATCCATTTTGTTTT

>84133_84133_1_SMG6-VPS53_SMG6_chr17_2075952_ENST00000263073_VPS53_chr17_565135_ENST00000437048_length(amino acids)=1856AA_BP=1119
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG
TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG
AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG
TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD
IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF
EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLL
KESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK
DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSI
TTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSN
VLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRA
ELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNP
FHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLR
EYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFST
VISSSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCK
PISMVGAEQLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMK

--------------------------------------------------------------
>84133_84133_2_SMG6-VPS53_SMG6_chr17_2075952_ENST00000354901_VPS53_chr17_565135_ENST00000437048_length(transcript)=13602nt_BP=928nt
GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG
TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC
ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA
TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG
CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGACTGCTTCTC
GGAGGAGTGCCGCTCTGTGATCCAGGAACAAGCCGCAGCTCTGGGCTTGGCCATGTTTTCTCTACTGGTCCGCCGCTGCACCTGCTTACT
TAAGGAGTCCGCCAAAGCTCAGCTGTCCTCTCCTGAGGACCAGGATGACCAAGACGACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAA
GGAGCTGCTCCCCAGTGTCAAAGTCTGGTCAGATTGGATGCTCGGCTACCCGGACACCTGGAATCCTCCTCCCACATCCCTGGATCTGCC
CTCGCATGTTGCTGTGGATGTATGGTCGACGCTGGCTGATTTCTGTAACATACTGACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAA
GGACCCGGATGATGACCTCACCCTTCTTATCCTGGAAGAGGATCGGCTTCTCTCGGGCTTTGTCCCCTTGCTGGCTGCCCCTCAGGACCC
CTGCTACGTGGAGAAAACCTCGGATAAGGCGCTTGAAGAGGCTCAGAAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGA
CAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAAT
CACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAA
TCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGC
TGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAA
TGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTC
AGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGT
GGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGC
AGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGG
GTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGAAAAAGCTTGAGTCTCCACCCCCATCTACCAATCCCTTCCT
GGAAGATGAGCCAACACCAGAGATGGAGGAACTGGCAACGGAGAAAGGAGATTTAGATCAACCAAAGAAGCCTAAAGCCCCAGACAATCC
ATTTCATGGCATTGTTTCCAAGTGTTTTGAGCCTCATCTCTACGTGTATATCGAATCCCAAGACAAGAACCTCGGAGAGCTGATAGATCG
GTTTGTGGCTGATTTCAAAGCCCAGGGGCCACCTAAGCCCAACACTGATGAAGGGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGT
CTACTACAAGAAGTGCATGGTGCAATGCTCTCAGCTCAGTACTGGGGAGCCCATGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCG
AGAATACGCCTGGAAAATCCTCTCTGGCAACCTGCCCAAAACCACAACCAGCAGTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAA
GGAGGGCTCAGAAGTAGCCAAGTTCACTCTGGAGGAGCTCTGCCTCATCTGTAACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCAC
CCAGCAGCTAGAAGAAAAACTCAAAGAAAAAGTGGATGTAAGTCTGATTGAACGAATCAATCTGACTGGAGAGATGGACACGTTCAGCAC
CGTCATCTCCAGCAGTATTCAGCTGCTGGTTCAGGATCTGGATGCTGCCTGTGATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCA
GAACGTGGAGCACGTTGGTGACCAGAGCCCCTACGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCT
GGCTTCCACACGCAAGTACTTCACTCAGTTCTGCGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAA
GCCAATTAGCATGGTGGGAGCAGAACAGCTGCTGCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCA
GGTGGTGAGGAAGGCACCCGCCAGCTACACCAAGATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCC
TCATGAACCGTTGGTGGTGTTTGTTGACAACTACATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAA
GGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCTGGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTC
ACTGTCCCTGACGGCGCCAACACCAGAGCAAGAGTCGTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCA
AGGGGCCCTTTGCTCCTGGCTGGAGACCCTCAGCGCCCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGT
CGGTCTTCAAACTTCCTGGGACATGTGGGTTGTTACTGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTA
AGGGCTGGGCTCTAAGAGGGCGATTTAGGTGATCTCTGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGAC
TCATGTAGCCTCCCCATGGCAGTCACACCCTCTTGACACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAG
AGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCC
TCAGCCTCCTGAGTATCGGATTACAGGCGTGAGCCACCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTA
GGGAAGGGAAACCAGGAAGTTCACTTGGAAGACGTTTCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTC
TCAAACCCCTTTCTGCCCACTCACCTTCAGGTCCACAGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGA
TGTGTTCCTGTGTTATGAGAAGGAGTCTGGGGTTCTGGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCT
GGCACGCAGCCTGCCCGCCCCCCCCGCCCTTCCTGTCCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTC
ATGTCATCCTGCATCCAGAGAATGGCAGCATATCAAGCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATG
ACCACAGCTACAGGCAAACCGCTGCTGTTGCTGCCTGCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCG
CAACACTTTGGGAGACCAAGGCAGGAGGATCACTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAA
AATTTGCAAGGTGTGGTGGCATGCACCTGTAGTCCCAACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACC
AGTCTGGGCAACCTGGCAAAACCAAAAATACAAAAAATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAG
GCAGGTGGATCACCTGAGGTCAGGAATTCGAGACCAGCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCG
GGTGTCATGGCGAGTGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGC
CAAGATTTCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCC
ATAAAACTTGTAACAGCCGTACAGTAGGAATAAGGTTTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACAT
AACCACTGCTCTGTGCCCCTGCCCTCTCTGCCAGGCTTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTT
CCAGGCTGTCCTTGCTAGCTGGTTTGACTCTCACGCATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGG
AGATGCGGCCTTCAGTTGAGGTCTATTAGGAAAAGATTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCC
TGTAGATGCCCCCACCCCAGCCCATGGAGTTGCTATGGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAA
ATAGCACAGCCAGTTCAGCCGTCTGTCCTCAACCCAGGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCG
TTTGTGTACAGATCACCACTTCTCTTTTTGGTTCATTGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTG
CTGTTTTCCACAGTTGGTGGTCACAGCCAGGGAAGTTGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCA
GTAGGAGTTTCTGTTAAATGTCTCCTTGATGGGGACTCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCA
CTGGGGCCTTTTAAAATCTACAGATGCCGGCCGGGCGCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATC
ACAAGCGCAGGAAATTGAGACCATCCTTGCCAATATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTG
CACACCTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGC
ACTCCAGCCTGGCGACAGAGTGAGACTCTATCTCAAAACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGG
CCTGGCATACAGGTTTAAAAGTTCCATAGGTAGTTATAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAA
GGGCTCCTGCCACGCATTTTCATACATGTCTATTTTTCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTG
GTGAAGATTCTCTACTGATAACAGCTTTCATTTTAAACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGTGGGCGGATCACATGAGGTCACGAGTTTGAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAA
AAAAAAAAAAAAAGCAGGCAGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCG
GAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGG
TGGGGACCATGCCCAGGATTGGGCTCTCTCCATACTGATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTAT
TAACATCACTTCAAAAATAACGTATCAAAGGGGCACCCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTG
AGGTGGGAAGATTGCTTGAGCCCAGGACTTCAAGACAAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATG
GTGGCTCACACTGGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATG
GTGAAACCCTGTCTTTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGA
GGATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAA
AAATAATAAGGTAAAAGGAGTACCTGTGGATGAAAGCAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTT
CCCCTCAGTCCATTTTCTGTAGCCCCTTTAAAAACCAAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTAT
AATCAATAAAGAGTTCACTCTGCTCTTACTGAGGGGACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGA
CTCTTAACAATGAAACAGGAGCCGCAATGGACAAGGTGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTT
CCTCTCTCGAAGAACAAAGAGCCAGTACCCAGGGCTCTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCT
GTGCAGATCAGACAGGACTGAGAGCAGACAAGCTGAGACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGC
TGCTCGATGCAGGGTATGACACCAACCCTTCCTGAATTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATG
CTGCATGTGCACAGCTGGAAATGGGGTTCCTTCTCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAG
CACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAG
AGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGA
AGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAG
GAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCT
AGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCC
CTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTT
CGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCC
TTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATT
CCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGA
TTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGG
GATTCCTTCGCTAGGAAGAGCACTCAGAACAACCTGCCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGA
TTCCTAAAAATAAAATAGAGCTCCAATGGGCAATTTAAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTA
CGATGACATTTTATATATTAAATAAAAATTCCCAGTCCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTT
TGGGAGATATAAATTTCCTTAAAATAAAGGGATTGCTTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCA
TGTTGGAGCACAAAATACTGCAGTTAATTAAAGCATTACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAAC
AGACTCTAGGAAAGAAGTAGCAAGTCCGTGACCCTGGCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGC
GTGGGAGCAGAATGTGGCCGACTGAGCCCAGTCCTGACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTT
CTGACTTGGAACCCTACTTGCCCTGTGAATTTCTATCCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCC
AGTGACGGCCAAGTGATTTCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTG
GGAAGTCTTGTGTCCTTTAGTGATTTCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAA
ACTCTTCGGGAAGTCCTGTGTCCTTTCAACAGGGGAAAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTC
TTTCTTTTCAACAGCTCCCCACTTTACTAGGGAAGCCAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGC
ATTGCCTGCCAGCTCCTTCCTTCTCACCTATGTGAACAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCC
ATCAGAAATGAAAGCAGCCTGGGATTGGAAGCATCCACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGC
GAGTCACTGATCCCCTGAGCATCCATTTTCAATATTGGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCT
ATATGCACTTGCTCTGCCATAAGGCAGTGTGAAGTGTGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTT
TTTTAAACATGGATGAGTGGTGACAAATCCTGCGGCCGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTA
GGTCATGACTGTAATATCAAGCTTACACGAGAGTTTTAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTT
AGGGATAAACCTGCAGACACTGAGAAGAGAGCTTCCTCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTC
CTGTGAATGCGAATTGCGAGGGTTGCCAAAGCCTCCCTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCG
ACAGGGACAAAAATTCTTGCCTGCCTTTCTTTTTCTTTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTAT
GATGCCCCCCAAAAAACTAAGCAAGATTAACTTGGGACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCC
AATTGTGTTTCAAAGATGTTTAGACTTTTCCCAAGGCCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCC
CTTTGAGGGTGTTGACTCAGAGAACCTGGGGCAATATGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCT
CACTTCATCCGAGGGTTCTGGGAGCTTCTGCTCAGTCATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAA
CAAGTGAGAAATTAAGAACAGCTTCTCAACAAACTTCCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAG
GGGTCTCAGGTGAAATGGTGGCAAGAAACCCCAGCTCCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCC
AGAGACCACATTCCACAGGGTTCTTCACAAAATCAAGCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGG
AATACATATCAAATGCTATATAAAGAAAACATCTGTTTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATA
AAGAAACATCAGTTTACACACAGAGCCCCCCACAACCTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACAC
AGAGTCCCCCACAGCCTCATACCCATGCCTGTCACATCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCG
GAGGCCAGAGGAGGGTGCTGAGGGGAGTGGAGGTCAGTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCAT
GTGGTATCTTAGGTCATGAGAGGGCCTGGGCAATTCAGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTA
CTGTGTCCTGGATACATTATCTCATCGGATGAAATTCCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTA
AGTGACAGGCCCAAGGATATGTGCCTAGTGAGGGGTGAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGA
CTAGTAAGGGGTCAGCCAGGATTTCATATGGGACTAGTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATT
TGATATGTGACTAGTGAGGGGCGAGCCAGGATTCGATATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGA
GACAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGT
GAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATAT
GTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGG
ATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGG
CGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATG
TGGTTAGTGAGGGGTTAGCCAGTCAGGATTTGATATGTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGC
CAGGATTCAATACGTGACAAGTGAGGGGTGAGCCAGGATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGA
GGGGCGAGCCAGGATGCGATACGTGACCAGTGAGGGGCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGT
GAGTAGTGAGGAGTGAGCCAGGATTTGATATGTGGCTACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGAT
TTGATACGTGACTAGTCAGGGGGTCAGCCAGGATTCGATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGT
GAGCCAGGATTTGACATGTGACTAGTGAGGGGTGAGCCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTA
GTGAGGGGTCAGCCAGGATTTGATATGTGGCTAGTAAGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATT
TGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGT
GAGACAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCT
TCATTCCAACATCCATGCCTTTTGTACTTCACCAGCAGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATA
GATAAAAGTATTTTATGAATACATTTTATGAGTTCAAATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGG
AAGCACTTTAAACCAAGGTTATGGATGAAAATGTGTGTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTT
AATCCAGCTAAGAATTTTCAAATAGTATCCATTTTGTTTTGTTTTAAACAGCTCTTCTTGCAATGGTAGAGGCTCTTCAATTAAACAGAG

>84133_84133_2_SMG6-VPS53_SMG6_chr17_2075952_ENST00000354901_VPS53_chr17_565135_ENST00000437048_length(amino acids)=969AA_BP=232
MNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLA
MFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNI
LTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIK
QLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAF
PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMA
ERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGD
LDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEP
MIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIE
RINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANS
FIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTD

--------------------------------------------------------------
>84133_84133_3_SMG6-VPS53_SMG6_chr17_2075952_ENST00000536871_VPS53_chr17_565135_ENST00000437048_length(transcript)=13549nt_BP=875nt
ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA
GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA
TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA
AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT
TTGCAGTACACAACTCCCAGCTGAAAGACTGCTTCTCGGAGGAGTGCCGCTCTGTGATCCAGGAACAAGCCGCAGCTCTGGGCTTGGCCA
TGTTTTCTCTACTGGTCCGCCGCTGCACCTGCTTACTTAAGGAGTCCGCCAAAGCTCAGCTGTCCTCTCCTGAGGACCAGGATGACCAAG
ACGACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAAGGAGCTGCTCCCCAGTGTCAAAGTCTGGTCAGATTGGATGCTCGGCTACCCGG
ACACCTGGAATCCTCCTCCCACATCCCTGGATCTGCCCTCGCATGTTGCTGTGGATGTATGGTCGACGCTGGCTGATTTCTGTAACATAC
TGACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAAGGACCCGGATGATGACCTCACCCTTCTTATCCTGGAAGAGGATCGGCTTCTCT
CGGGCTTTGTCCCCTTGCTGGCTGCCCCTCAGGACCCCTGCTACGTGGAGAAAACCTCGGATAAGGCGCTTGAAGAGGCTCAGAAAGCTA
TCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGC
AATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAG
CCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGA
TTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTC
CTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAAC
AGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAA
TCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTG
AGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGC
TTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGAAAA
AGCTTGAGTCTCCACCCCCATCTACCAATCCCTTCCTGGAAGATGAGCCAACACCAGAGATGGAGGAACTGGCAACGGAGAAAGGAGATT
TAGATCAACCAAAGAAGCCTAAAGCCCCAGACAATCCATTTCATGGCATTGTTTCCAAGTGTTTTGAGCCTCATCTCTACGTGTATATCG
AATCCCAAGACAAGAACCTCGGAGAGCTGATAGATCGGTTTGTGGCTGATTTCAAAGCCCAGGGGCCACCTAAGCCCAACACTGATGAAG
GGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGTCTACTACAAGAAGTGCATGGTGCAATGCTCTCAGCTCAGTACTGGGGAGCCCA
TGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCGAGAATACGCCTGGAAAATCCTCTCTGGCAACCTGCCCAAAACCACAACCAGCA
GTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAAGGAGGGCTCAGAAGTAGCCAAGTTCACTCTGGAGGAGCTCTGCCTCATCTGTA
ACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCACCCAGCAGCTAGAAGAAAAACTCAAAGAAAAAGTGGATGTAAGTCTGATTGAAC
GAATCAATCTGACTGGAGAGATGGACACGTTCAGCACCGTCATCTCCAGCAGTATTCAGCTGCTGGTTCAGGATCTGGATGCTGCCTGTG
ATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAGAGCCCCTACGTCACCTCTGTCATTCTGC
ACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACTCAGTTCTGCGTTAAATTTGCAAACTCCT
TCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAACAGCTGCTGCTGGACACCCACTCGCTGA
AGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGCTACACCAAGATCGTTGTCAAAGGCATGA
CCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTTGACAACTACATCAAACTTCTCACAGACT
GCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCTGGAACTCCTGCGCCAGCGGC
TCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCAGAGCAAGAGTCGTCACGCATCCGCAAGC
TCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAGACCCTCAGCGCCCGTTCCCCAGAAGCCC
CCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATGTGGGTTGTTACTGAGTCTCTCCCATGCC
CTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATTTAGGTGATCTCTGGTTCGTGAAGCAGAG
GCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCACACCCTCTTGACACGTGGGCCCCACCCG
TCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTG
CAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACAGGCGTGAGCCACCGAGCCCAGCCCCTTC
CTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACTTGGAAGACGTTTCCTAGGTTTTCTCATC
AGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACCTTCAGGTCCACAGCACTTTCCAGCGTCA
TCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAGTCTGGGGTTCTGGATGCCTCAGGAACAG
AATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCCGCCCTTCCTGTCCACCGCGGGCTCTCTG
CAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGGCAGCATATCAAGCCGTTAACCCTGATTC
ACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGCTGTTGCTGCCTGCTTTTGCTGAAGAATG
ATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGGAGGATCACTTGAGTCCAGGAGTTTGAGA
CCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCACCTGTAGTCCCAACTGCTAGGGAGGCTG
AGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAAAAATACAAAAAATTGGCTGGGTGTGGTG
GCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAATTCGAGACCAGCCTGCCCAACATGGCG
AAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAG
AATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCCTTCTCA
AAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGTAGGAATAAGGTTTGGAAATCTGCCTGGA
AACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCTCTCTGCCAGGCTTTCTCCCCGATGCCGT
CCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTTGACTCTCACGCATCAAGCGTCTCAAATT
TGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTATTAGGAAAAGATTCCAAATAAGACAAGG
GCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCATGGAGTTGCTATGGTTAAGCAGCCTGAGC
CGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTGTCCTCAACCCAGGAGAGCTGGGAAAGCC
AGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCTTTTTGGTTCATTGTTGAGGAGTCGTTTT
CCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACAGCCAGGGAAGTTGCTGTCTTGATTTGTT
ACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCCTTGATGGGGACTCAGTACTGTGTAGAGA
CGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGATGCCGGCCGGGCGCCGTGGCTCACGCCTG
GAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATCCTTGCCAATATGGTGAAACCCCATCTCT
ACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG
AGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTATCTCAAAACAAACAAAAAAACAG
ATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCCATAGGTAGTTATAACGTTTACACCTTGT
TAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATACATGTCTATTTTTCTGACTCTAAGCTAAA
AGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGCTTTCATTTTAAACTTGTGTTGGGTCAGG
CGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAGGTCACGAGTTTGAGACCAGCCTGGCCAA
CATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGG
AGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCACTCCAGCCTGGGAGACAGAG
TGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCTCTCTCCATACTGATGAGGATTCTTCTTG
TTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTATCAAAGGGGCACCCTAGGCCGGGTACTGT
GGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAGGACTTCAAGACAAGCCTGGGCAACAGAG
TGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAT
GTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGGGC
GCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCCGAGATCATGCCATT
GCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCTGTGGATGAAAGCAGCAGCTAACAGCTCT
GTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCCCTTTAAAAACCAAAAAACAACTTTGAAG
TCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTCTTACTGAGGGGACTTGTCTGAAAGCTGG
CTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGCAATGGACAAGGTGTTCTGATCTCCAAAC
CCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAGTACCCAGGGCTCTGCCCACCCCCGAGAA
GGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGCAGACAAGCTGAGACCAGCATGACCAGTA
CAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAACCCTTCCTGAATTGCCATCGGATGAGGA
GACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGGGTTCCTTCTCTAGGAAGAGCACTCGGAA
TAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAG
AATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTC
GGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCAC
TCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCGCTAGGAAGAGC
ACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGA
GCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAA
GAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGG
AAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTA
GGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCCC
TAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTC
GCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCAGAACAACCTGCCTGCTTGAGGGTGACA
GCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCAATGGGCAATTTAAGCAAAAGCCTTAGAA
ACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAAAAATTCCCAGTCCTGTTTTAGTATTCAT
CAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAATAAAGGGATTGCTTCTTTGTGTAAATAGC
TTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTTAATTAAAGCATTACTGGATGTCATTTGC
TAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGTCCGTGACCCTGGCCGCTCCTGGTGGCTG
CCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGAGCCCAGTCCTGACCTGCCCAGTTGCAGT
GGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTGTGAATTTCTATCCTGTGAACCTTCCCTT
CTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTT
AGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATTTCTCTCCTGCACGCATGAGTCCATCCTG
TTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTTTCAACAGGGGAAAACTGGCTGCGGCCCT
TCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTTACTAGGGAAGCCAAGGGATCAACCTAAT
GAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTCACCTATGTGAACAGGAGGGAAGATGCCG
GCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGATTGGAAGCATCCACAGAAGACTTGATCTG
CAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCATTTTCAATATTGGTGAGAGGGGATTATA
ATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGCAGTGTGAAGTGTGTTCGTGATCACTTGT
GGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACAAATCCTGCGGCCGTGTGCAGGCTACATC
CGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTACACGAGAGTTTTAAAAGACTGAGCAGTA
TCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGAAGAGAGCTTCCTCCCTCCTGGGGCTGGT
GGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTGCCAAAGCCTCCCTTCCAAGAAACTTGCT
TAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCCTTTCTTTTTCTTTTTTTTCCTTTTACTT
ATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAGATTAACTTGGGACAGGCAGTTCTAACTG
GGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGACTTTTCCCAAGGCCAGCTGAATCCTTATA
ATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAACCTGGGGCAATATGAGATGTTAAAATAAA
AATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGCTTCTGCTCAGTCATCAAATGGAATTTGC
ACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTCTCAACAAACTTCCCTCTACTTCCAGGGC
CAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAGAAACCCCAGCTCCCTTCATGTGTTTGCC
TTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTTCACAAAATCAAGCACTGCAGTGGACCAA
CTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAGAAAACATCTGTTTACACAGAGTCCCCCA
CAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAGCCCCCCACAACCTCATACCCACACCGAA
TATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCATGCCTGTCACATCTTTGCACAGCCCTAA
AGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGGAGTGGAGGTCAGTTGGGGTAGCCCTGGG
CCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGCCTGGGCAATTCAGTGCTATCTGTACATG
TTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCATCGGATGAAATTCCTGCTAAGTTAAGCTC
CGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCCTAGTGAGGGGTGAGCCAGGATTCGATGT
GTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTCATATGGGACTAGTAAGGGGTCGGCCAGG
ATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATTCGATATGTGACTAGTAAGGG
GTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATTTGATATGTGAC
TGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTG
ATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGC
CAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGA
GGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGT
GACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCAGGATTTGATATGTGGCTAGTGAGGGGCG
AGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAGGGGTGAGCCAGGATTCAATACGTGACCA
GTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTGACCAGTGAGGGGCGAGCCAGGATTCCAT
ACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATTTGATATGTGGCTACTGAGGGGCGAGCCA
GGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTCAGCCAGGATTCGATACGTGACTAGTAAG
GGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAGTGAGGGGTGAGCCAGGATTCAATATGTG
ACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATATGTGGCTAGTAAGGGGTGAGCCAGCCAG
GATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTAGTAAGG
GGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGCTATGTG
ACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGTACTTCACCAGCAGTTTTCAAATTTATGG
GACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATTTTATGAGTTCAAATATTTTTCAGAAGAA
ATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGATGAAAATGTGTGTGTATCAACCCCAGTT
TACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAGTATCCATTTTGTTTTGTTTTAAACAGCT

>84133_84133_3_SMG6-VPS53_SMG6_chr17_2075952_ENST00000536871_VPS53_chr17_565135_ENST00000437048_length(amino acids)=948AA_BP=211
METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQL
SSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTL
LILEEDRLLSGFVPLLAAPQDPCYVEKTSDKALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHM
LAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLV
ANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRT
RAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKC
FEPHLYVYIESQDKNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILS
GNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQL
LVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGAE
QLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQS

--------------------------------------------------------------
>84133_84133_4_SMG6-VPS53_SMG6_chr17_2075952_ENST00000544865_VPS53_chr17_565135_ENST00000437048_length(transcript)=16449nt_BP=3775nt
AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC
TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC
CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC
CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC
AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA
TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG
CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG
TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT
GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG
TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG
TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT
TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG
AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG
GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG
CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA
GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA
CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA
TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT
TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG
ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC
TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC
ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC
CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC
AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT
GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA
GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA
GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG
GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA
AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG
CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT
TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG
CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA
AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC
TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG
CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC
ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA
GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGACTGCTTCTCGGAGGAGTGCCGCTCTGTGATCCAGGAACAAGC
CGCAGCTCTGGGCTTGGCCATGTTTTCTCTACTGGTCCGCCGCTGCACCTGCTTACTTAAGGAGTCCGCCAAAGCTCAGCTGTCCTCTCC
TGAGGACCAGGATGACCAAGACGACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAAGGAGCTGCTCCCCAGTGTCAAAGTCTGGTCAGA
TTGGATGCTCGGCTACCCGGACACCTGGAATCCTCCTCCCACATCCCTGGATCTGCCCTCGCATGTTGCTGTGGATGTATGGTCGACGCT
GGCTGATTTCTGTAACATACTGACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAAGGACCCGGATGATGACCTCACCCTTCTTATCCT
GGAAGAGGATCGGCTTCTCTCGGGCTTTGTCCCCTTGCTGGCTGCCCCTCAGGACCCCTGCTACGTGGAGAAAACCTCGGATAAGGCGCT
TGAAGAGGCTCAGAAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGA
AATCACCCGTGATATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGG
AGGTGTCGACTCCCTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCA
CTTCCACAAGTATATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGC
AGATTTTGAAGAAGCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATAT
TCTAGATCCCAGGATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGA
TGTTGCCTGGCTGGACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCC
ACGTGAGTGGTGCATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAA
GGAAATTGAAGTGAAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCT
GACCGATGGGACCCTGAAAAAGCTTGAGTCTCCACCCCCATCTACCAATCCCTTCCTGGAAGATGAGCCAACACCAGAGATGGAGGAACT
GGCAACGGAGAAAGGAGATTTAGATCAACCAAAGAAGCCTAAAGCCCCAGACAATCCATTTCATGGCATTGTTTCCAAGTGTTTTGAGCC
TCATCTCTACGTGTATATCGAATCCCAAGACAAGAACCTCGGAGAGCTGATAGATCGGTTTGTGGCTGATTTCAAAGCCCAGGGGCCACC
TAAGCCCAACACTGATGAAGGGGGTGCCGTGCTCCCCAGCTGCGCCGACCTCTTTGTCTACTACAAGAAGTGCATGGTGCAATGCTCTCA
GCTCAGTACTGGGGAGCCCATGATCGCCCTGACCACCATTTTCCAGAAGTACCTCCGAGAATACGCCTGGAAAATCCTCTCTGGCAACCT
GCCCAAAACCACAACCAGCAGTGGAGGACTGACTATCAGCAGCCTCCTCAAGGAAAAGGAGGGCTCAGAAGTAGCCAAGTTCACTCTGGA
GGAGCTCTGCCTCATCTGTAACATCCTGAGCACGGCAGAGTACTGTCTGGCCACCACCCAGCAGCTAGAAGAAAAACTCAAAGAAAAAGT
GGATGTAAGTCTGATTGAACGAATCAATCTGACTGGAGAGATGGACACGTTCAGCACCGTCATCTCCAGCAGTATTCAGCTGCTGGTTCA
GGATCTGGATGCTGCCTGTGATCCTGCCCTGACTGCCATGAGCAAGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAGAGCCCCTA
CGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACTCAGTTCTG
CGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAACAGCTGCT
GCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGCTACACCAA
GATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTTGACAACTA
CATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCT
GGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCAGAGCAAGA
GTCGTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAGACCCTCAG
CGCCCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATGTGGGTTGT
TACTGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATTTAGGTGAT
CTCTGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCACACCCTCT
TGACACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGT
GGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACAGGCGTGAG
CCACCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACTTGGAAGAC
GTTTCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACCTTCAGGTC
CACAGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAGTCTGGGGT
TCTGGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCCGCCCTTCC
TGTCCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGGCAGCATAT
CAAGCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGCTGTTGCTG
CCTGCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGGAGGATCAC
TTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCACCTGTAGT
CCCAACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAAAAATACAA
AAAATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAATTCGAGA
CCAGCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATCCCAGCTAC
TGGGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGCCTGGGTGA
CAGAGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGTAGGAATAA
GGTTTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCTCTCTGCCA
GGCTTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTTGACTCTCA
CGCATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTATTAGGAAA
AGATTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCATGGAGTTGC
TATGGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTGTCCTCAAC
CCAGGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCTTTTTGGTT
CATTGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACAGCCAGGGA
AGTTGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCCTTGATGGG
GACTCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGATGCCGGCCG
GGCGCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATCCTTGCCAA
TATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGCTGAGGCAG
GAGAATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTATCT
CAAAACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCCATAGGTAG
TTATAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATACATGTCTAT
TTTTCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGCTTTCATTT
TAAACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAGGTCACGAG
TTTGAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGGCGGGTGCC
TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCA
CTCCAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCTCTCTCCAT
ACTGATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTATCAAAGGGG
CACCCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAGGACTTCAA
GACAAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCACTTTGGGA
GGCCGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAATACAAAATT
AGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGAGGCTGCAG
TGAGCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCTGTGGATGA
AAGCAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCCCTTTAAAA
ACCAAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTCTTACTGAG
GGGACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGCAATGGACA
AGGTGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAGTACCCAGG
GCTCTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGCAGACAAGC
TGAGACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAACCCTTCCT
GAATTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGGGTTCCTTC
TCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCT
TGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTC
CTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGT
TCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGG
GTTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATG
GGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAA
TGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGA
AATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTG
GAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGC
TGGAAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCT
GCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCAGAACAAC
CTGCCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCAATGGGCAA
TTTAAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAAAAATTCCC
AGTCCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAATAAAGGGAT
TGCTTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTTAATTAAAG
CATTACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGTCCGTGACC
CTGGCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGAGCCCAGTC
CTGACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTGTGAATTTC
TATCCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCCTGCACGCA
TGAGTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATTTCTCTCCT
GCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTTTCAACAGG
GGAAAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTTACTAGGGA
AGCCAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTCACCTATGT
GAACAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGATTGGAAGCA
TCCACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCATTTTCAAT
ATTGGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGCAGTGTGAA
GTGTGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACAAATCCTGC
GGCCGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTACACGAGAG
TTTTAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGAAGAGAGCT
TCCTCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTGCCAAAGCC
TCCCTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCCTTTCTTTT
TCTTTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAGATTAACTT
GGGACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGACTTTTCCCA
AGGCCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAACCTGGGGCA
ATATGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGCTTCTGCTC
AGTCATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTCTCAACAAA
CTTCCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAGAAACCCCA
GCTCCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTTCACAAAAT
CAAGCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAGAAAACATC
TGTTTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAGCCCCCCAC
AACCTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCATGCCTGTC
ACATCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGGAGTGGAGG
TCAGTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGCCTGGGCAA
TTCAGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCATCGGATGAA
ATTCCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCCTAGTGAGG
GGTGAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTCATATGGGA
CTAGTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATT
CGATATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTGAGGGGCGA
GCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGT
GAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATAT
GTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGG
ATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGG
CGAGCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCAGGATTTGA
TATGTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAGGGGTGAGC
CAGGATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTGACCAGTGA
GGGGCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATTTGATATGT
GGCTACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTCAGCCAGGA
TTCGATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAGTGAGGGGT
GAGCCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATATGTGGCTA
GTAAGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGAT
TTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAGTGAGGGGT
GAGCCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGTACTTCACC
AGCAGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATTTTATGAGT
TCAAATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGATGAAAATG
TGTGTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAGTATCCATT

>84133_84133_4_SMG6-VPS53_SMG6_chr17_2075952_ENST00000544865_VPS53_chr17_565135_ENST00000437048_length(amino acids)=1825AA_BP=1088
MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF
PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA
AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST
DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK
QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD
EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ
HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD
PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA
RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS
TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP
SPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKE
LLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPC
YVEKTSDKALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANL
LQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSE
YLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGF
LAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRF
VADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKE
GSEVAKFTLEELCLICNILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDAACDPALTAMSKMQWQN
VEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSISSQV
VRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQSSMLELLRQRLPAPPSGAESSGSL

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Fusion Gene PPI Analysis for SMG6-VPS53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSMG6chr17:2075952chr17:565135ENST00000263073-1319114_5031119.01420.0telomeric DNA
HgeneSMG6chr17:2075952chr17:565135ENST00000544865-1319114_5031088.01389.0telomeric DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG6chr17:2075952chr17:565135ENST00000354901-612114_503211.0512.0telomeric DNA
HgeneSMG6chr17:2075952chr17:565135ENST00000536871-511114_503211.0512.0telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG6-VPS53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG6-VPS53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource